The present research is devoted to the study of the dynamics of antioxidant status indices in sportsmen going in for orienteering in the state of their maximum tiredness (right after competition) and after rest. The article presents the results of the research of malondialdehyde (MDA), catalase (C), superoxide dismutase (SOD) andglutathione-S-transferase (GST) content in venous blood erythrocytes. We revealed significant differences in the activity of enzymes of antioxidant defense system and malondialdehyde content depending on the previous level of physical activity. It was determined that restoration processes of an organism after the period of intensive physical activity were characterized by the decrease of MDA content and increase of the activity of enzymes of antioxidant defense system.

The frequency characteristics of gene polymorphisms of MTHFR677T, MTHFR1298C, MTRRA66G that determinate folate metabolism and are associated with perinatal or pregnancy complications were studied in 50 Russian and 50 Buryatyoung healthy women of 19-27 years. The frequency of MTHFR677TT mutant genotype was 6 % (10 % among Russian, 2 % among Buryat women). MTHFR1298CC and MTRR66GG mutant genotypes were detected in 9 % and 31 % respectively without any differences between ethnic groups. Multigenic inheritance of MTHFR677TT and MTH-FR 1298CC, MTHFR677CT and MTRR66AG that multiply increase risks of miscarriage and development of defects of nervous tube of fetus were found only in the group of Russian women (2 %).

The original techniques of bronchus stump closure, modeling and disjunction of non-neoplastic tracheoesophageal fistula, replacement of postresectional defects of the trachea, pericardium, diaphragm and the thoracic wall using titanium nickelide implants have been developed and tested. It was ascertained that these methods were highly effective and simplified and standardized surgical procedures, provided anatomic and physiologic reconstruction of the injured area.

23 women with a chronic form of coronary heart disease (CHD) were examined before and after two months of taking simvastatin at doses of 40 and 80 mg/day. Regardless of the dosage the reduction in total cholesterol (TC) level, low-density lipoprotein cholesterol (LDL-C) and atherogenic index (Al) was found that pointed at the strengthening of receptor-mediated endocytosis in LDL-C cells with all portable fatty acids (FA) in them by apoB-100 cells, in various forms of esters. The spectrum of FA in the erythrocyte membrane phospholipids (FL) was researched by gas-liquid chromatography-mass spectrometry. Redistribution of FA was revealed after treatment with different doses: reduction of the unsaturation index (UI) of the membranes erythrocytes indicated a violation of physical, chemical and functional properties of cell membranes. The content of the FA-membrane substrates and substrates of vitamin F, triglycerol substrates (TGL) decreased and FA-energy substrates cells increased. Probably, the ability of statins to activate the desaturase enzymes had an effect of the increasing of long-chain ω-9 FA content. In this case the reduction of oleic ω-9 FA influenced the reduction of TGL. Unlike doses of 40 mg/day treatment at a dosage of 80 mg/day in women resulted the increase of relation ω-3/ω-6 LC and the decrease of dihomo-γ-linolenic LCD. It indicated the formation of favorable conditions of the normalization of cell function in vivo. Under these conditions the level of palmitic FA and, correspondingly, the activity of atheromatosis decreased.

The article presents the method of examination of patients with knee-joint pathology (consecutive slipping patella) that includes collection of anamnestic data, evaluation of state of the joint, complex X-ray examinationfor determination of patella-femoral congruence degree. In some questionable cases additional MR-image examination of joint is necessary. The most informative indices were: Blumensaat determination of line, lnsall - Salvati index, criteria of determination of patella height by Blackburne - Peel, criteria of vertical position of patella, angle of patella opening by Wiberg, angle of opening of femoral block of femoral bone by Ficat or sulcular angle, congruence angle by Merchant, lateral patella-femoral angle and less studied patella-femoral index.

The article describes method of research of lymph nodes of different groups, their main echographic and echometric indices in norm. The role of ultrasonic research in diagnostics of pathological changes of lymphatic system was showed. The advantages of method and the indications to their use at the pathology in children are described. The mostfrequent pathological changes of peripheral, intraperitoneal and retroperitoneal lymph nodes at various diseases in children are determined. Echographic picture of abscessed lymphadenitis is reliable in 100 % of cases, that was proved postoperatively.

The article presents pathomechanical grounding of application of designed method of hippotherapy in treatment of manifestations of dysplastic and dystrophic syndrome with evaluation of remote outcomes of complex treatment in 5 years in 120 children. The basics of therapeutic impact of horse riding lie in natural movements of a horse, helping a rider to organize and systematize his or her movements. Hippotherapy (with performing special correcting exercises) as a method of complex treatment of children with dysplastic and dystrophic syndrome forms the skill of space orienting, improves coordination of movements, strengthens and trains muscles. Together with all that it improves psychoemo-tional state of a patient. This method of treatment of combined pelvis and spine deformity in children in comparison with other known techniques provides expressed therapeutic effect due to simultaneous correction of pelvic and spinal muscles, development of muscular-articular perception and muscular-sensor coordination, and also due to reconstruction and formation of a new movement stereotype.

The aim of the study was to prove a role of candidosis-bacterial and viral infections in formation of vulvitis and dysplasias, and to receive grounded results of etiotropic therapy. We surveyed and treated 209 patients with vulva diseases of contraction type, atrophy, ulcers, cracks and vesicles accompanied with itching, dispareunia and lack of effect from standard treatment. Patients were examined for infections and were divided into 3 main groups by character of infections found: genital candidiasis - in 77 patients, viral affections - 52, opportunistic flora - 19. The control group included 6 patients. Methods of verification of infections were PCR, inoculations, bacterioscopy. All patients underwent vulvoscopy, cytological scrapes from vulva and biopsy. According to data on duration of disease, expressiveness and dissemination of disease we revealed the severity of process. Results of the conducted research showed that infection of uterus cavity in modern conditions leads to difficult diagnosed chronic inflammatory process in endometrium and is one of the important reasons of formation of intrauterine pathology, which in its turn causes failures of assisted reproductive technology.

The research included data on the postoperative treatment of 120 patients after one-side total hip replacement. In 40 patients of clinical comparison group we used traditional program of postoperative intensive therapy. Program of intensive treatment in main group consisted of 80 patients was optimized. Higher clinical effectiveness of intensive therapy in patients of main group was proved by significant decrease of duration of staying in Intensive Care Unit. Significant intergroup differences were revealed only at the comparison of index of consumption of oxygen by myocardium that characterizes type of adaptation reaction. At that realization of adaptation by resistant (active) type testified to the attempts of an organism to achieve adaptation and, consequently, to the insufficient effectiveness of program of postoperative intensive therapy. Achieved data allows to conclude about possibility of an estimation of general effectiveness of the program of postoperative intensive therapy with use of determination of the type of adaptation strategy.

The article presents the analysis of the results of surgical treatment of 896 patients with muscle non-invasive bladder cancer who were operated in the period from 2000 to 2011: 662 (73,9 %) men and 234 (26,1 %) women of 31-84 years (average age - 61,6 years). The authors describe experience of using bipolar transurethral resection (TURis) and vaporization (vap) for a urinary bladder tumor. The article represents the study of frequency and nature of the recurrence and survival rate (common, oncology-specific, disease-free) after transurethral surgery of patients with non-muscle invasive bladder cancer (BC) of Ta, T1 and Tis stages. The obvious advantage of the technique bipolar transurethral resection (TURis) and vaporization (vap) over others suggests that in the nearest future the TURis-vap will serve as the "golden standard" in non-muscle invasive bladder tumors surgery.

The aim of this study was to perform comparative analysis of biochemical composition of synovial fluid in patients with osteoarthrosis of various etiology. Studies were conducted on samples of synovial fluid of patients which were divided into two groups. Thefirstgroup consisted of 16 patients with patellofemoral arthrosis of the 2^nd stage, the second group included 54 patients with bilateral gonarthrosis. The samples of synovial fluid of 11 cadavers of suddenly dead people of both sexes (4 men and 7 women) of 23-79 years who didn't have articular pathology registered by an expert were considered as a norm. Conducted study testifies significant imbalance of prooxidant and antioxidant processes in the synovial fluid and development of oxidative stress the intensity of which depends on the severity of the pathological process but is regardless to its etiology.

While studying the results of combining different variants of electrical stimulation in patients with neurologic deficits together with mechanotherapy using "Arthromot" device we revealed the most effective combination of epidural or epineural proximal stimulation of spinal cord and involved nerve trunk by implanted electrodes combined with distal electrical stimulation of the muscle groups of autonomous zones by surface electrode leads and potentiation of achieved effect by "Locomat" complex.

We studied the role of opportunistic pathogens in the progression of inflammatory diseases of men's urogenital tract which result infertility dysfunction. We examined the patients with qualitative and quantitative changes in spermogram, with the absence of sexually-transmitted infections. At the study of ejaculates of these patients we revealed changes of all main parameters: volume, period of sperm dilution, concentration of spermatozoa in 1 ml, their quantity in all ejaculate, their mobility, increase of contents of pathologic forms of spermatozoa. Microflora discharged from the urethra and the prostate in some cases had resistance to traditionally used antibacterial drugs and demanded careful selection of effective antibiotics by establishing the antibiograms. Obtained data testified to the high quantitative contents of opportunistic microorganisms in the urethra, prostate secretion and ejaculate and also to the prevailing role of gram-positive cocci microflora in the development of inflammatory diseased of urogenital tract in men.

In the study based on teleuts population, which are the primary in Kemerovo region, the prevalence of toxic, compression-ischemic, diabetic and atherosclerotic polyneuropathy were determined. It was established, that the frequencies of these diseases are different depending on the sex, age, social status, profession, house site. In men population toxic polyneuropathy prevails in social group of «unemployment» of 30-39 and 40-49 years. Compression-ischemic polyneuropathy has the highest frequency in women population of 50-59 years in «unemployment» and «clerks» social groups. Diabetic and atherosclerotic polyneuropathy prevail in women population of 70 years and older and the most impairment social group is «pensioners».

It is known, that preservation of ligamentum flavum while microdiscectomy allows to improve results of treatment in patients with lumbal intervertebral disk herniations, promoting prevention of epidural fibrosis that may cause failed back syndrome. Microdiscectomy with flavopreservation with the help of high-speed drill increases possibilities of ligamentum flavum saving while microdiscectomy in a case of narrow interlaminal interval, expressed spondylarthrosis and osteoarthrosis in the lumbosacral vertebral area at different levels and promotes to prevention epidural fibrosis. The offered way of a ligamentum flavum preservations while microdiscectomy differs from existing in carrying out interlaminectomy with the help of high-speed drill by processing of the up- and underlaying vertebras and ligamentum flavum is released from a place of its attachment to bone structures with preservation of its attachment to an inters-pinous ligament in length of 3-4 mm in the site of medial edge of the lamina of an overlying vertebra. The ligamentum flavum is taken away by the ligature and after excision of a disk hernia it comes back to original position and is fixed with surrounding tissues.

Under our supervision there were 123 patients with terms of supervision till 7 years, with fractures,fracture-dislocations of an area of a shoulder joint and chronic damages of this area. There were 57 men and 66 women. All the patients were from 38 to 83 years old, the average age was 55,8 years. 44 patients had various kinds of an osteosynthesis and 79 - endoprosthesis of a shoulder joint. It was proved, that in patients of the senior age group, the expressed bony rarefication, a heavy accompanying pathology of a shoulderjoint (arthrosis of 2-3 grades, defeat of a joint at a number system diseases, etc.) and also at the treatment of consequences of traumas are unconditional, the preference should be given to endoprosthesis of a humeral joint, as to more effective method of treatment.

The article presents the occurrence of temporomandibular joint pathology (20,9 %) in children of prepubertal age. It was revealed that habitual dislocation that appears on the background of asymmetric occlusion with close position of teeth in frontal and lateral areas of dentition is typical for this age group. It was determined that clinical signs of TM] pathology in children and adults are different: pain syndrome and noise effect at the lower jaw movements are not typical for children in contrast to the adults. According to the data of outpatient's cards the structure of nosologic forms of pathology during different periods of occlusion formation is defined. It was determined that TM] pathology begins to form in preschool age and later on its frequency increases. The analysis of morbidity by sex showed that women have TM] pathology more often and also they have age tendency to the aggravation of the pathology that develops in future in appearance of dislocations of intraarticular disks. The article suggests the differentiated approach tactics for the treatment of TM] diseases that was rather effective.

The article is devoted to the analysis of the results of examination and treatment of patients with spine pathology in lumbar segment. The data on the actuality of the problem of spine pathology (frequency of occurrence, invalidization). On the basis of their experience the authors propose complex approach to the treatment of patients with discogenic lumbar-sacral rediculitis, complicated by the disks hernias and pain syndrome, based on the definite algorithm in the form of treatment program. Lumbodynia and lumbar ischialgia prevailed in neurological status of the patients (45,2 %). Radicular disorders (radiculopathy, radiculoneuritis) are registered in 13,1 % of patients. Pain syndrome by the visually analogue scale corresponded to 7-6 (40 % of patients) and 5-4 points (60 % of patients). Protrusion of the disks (bulging of the disk up to 4 mm) are revealed in 24,3 % of cases. Median and paramedian hernias of disks (bulging of the disk from 4 to 8 mm) are revealed in 57,4 % patients. Posterolateral hernias of disks (bulging of the disk from 4 to 7 mm) are revealed in 18,3 % of patients. At the estimation of the effectiveness of treatment of 115 patients favorable results of treatment in the terms up to 1 year were registered in 99 of them.

The authors state that capillary electrophoresis of blood and urine proteins is one of the defining method in revealing and confirmation of the presence of paraprotein at multiple myeloma. Simplicity and availability of this method as well as the advantages which it provides at the performing of measurements allow to hope for dynamic development of methodic supplying and the nearest including of capillary electrophoresis in mandatory list of biochemical methods of analysis, the mostfrequently used by clinical physicians in everyday laboratory practice.

In the study there were 35 overweighed patients with GERD (study group - SG), clinical comparison group (CCG) consisted of 20 standard patients with GERD. Alkaline reflux was revealed in 22 patients (62 %) of SG and 7 patients (33 %) of CCG, while acid reflux was revealed in 13 persons (38 %) of SG and 13 persons (67 %) of CCG. The comparison of the groups showed that the alkaline reflux was more common in patients of SG, significant differences were determined between the acidity rate in an esophagus at rest and during stimulation (p < 0,05). In patients of the groups with acid reflux significant differences were determined in the esophagus at rest and during stimulation (p < 0,05), in forestomach - at rest and after stimulation (p < 0,05). In overweighed patients complaining of heartburn alkaline reflux is more common while patients with normal weight have acid reflux. In SG life activity (p < 0,05), social function (p < 0,05), mental health (p < 0,05) were statistically reduced, pain in the upper epigastric severely limits daily activity (p < 0,05) compared to the CCG. Our results demonstrate that patients need to be treated of GERD in a different way considering the body weight.

The article presents an actual problem of myocardial infarction in the aspect of atypical variants of its development with a variety of clinical manifestations, prevalence and the most exposed cohorts of patients. A practical difficult-to-differentiate case that demonstrates a rare atypical form of acute coronary syndrome with peripheral equivalent of angina pectoris, with timely diagnosis defined the early onset of adequate treatment and a favorable course of the disease is presented in the article.

The aim of the study was to assess therapeutic efficacy, tolerance and safety of biologically active additives. This biologically active additives was used as an immunostimulant in complex treatment for acute respiratory diseases in 86 children at the age from 6 to 14 years, who suffer frequently and durably against the background with concomitant infectious and physical abnormality. The aim of the research identifying pharmacotherapeutic efficiency and safety of biologically active additives "Baikal-5". Biologically active additives "Baikal-5" is expectorant, consists of the following species of plants, grass thyme, grass violet fragrant, fruits dill fragrant, rhizomes and roots of elecampane, licorice root. We used reactions indirect immunofluorescence with the panel of monoclonal antibodies with the definition of parameters of cellular link of immunity: relative and absolute indicators of the total number of lymphocytes as well as the population the composition of the peripheral blood lymphocytes (CD3+, CD4+, CD8+ cells).

The necessity of use of cryoprecipitate (CP) in clinic as a basis of biocomposite for creation of interstitial barrier to prevent the spread of retroperitoneal abscesses in necrotizing pancreatitis. The research of the influence of CP on the growth of microorganisms with three types of cultures (E. coli, Acinetobacter, E. faeccalis) was realized. Incubation of bacteriological environment (51 series) was carried out under standard conditions in the presence of CP, antibiotics and retroperitoneal adipose tissue with a visual assessment in vitro and by the change of the densitometric density of environments on the MicroScan Turbidity Meter (Siemens) unit. As it was stated, the presence of CP in pure form in bacteriological environment as well together with an antibiotic or adipose tissue does not affect the growth of investigated microflora and in combination with the antibiotic inhibits it suppresses growth. Taking into consideration the indifference of CP to microflora, its use as a drug interstitial barrier to the migration of retroperitoneal phlegmon in necrotizing pancreatitis the activation of abdominal infection is safe.

The purpose of this study was to determine priority directions of anti-epidemic readiness of the Russian Federation Region for emergency situations associated with infectious diseases dangerous for humans, at the present stage. Readiness of the Russian Federation region for emergency situations associated with infectious diseases dangerous for humans (anti-epidemic readiness) implies a set of preventive and anti-epidemic measures, implementation of relevant management decisions at the Regional level, which aim to ensure the safety of people living (temporarily located) in conditions of epidemiological risks. Anti-epidemic readiness is provided through targeted distribution of logistics, human resources, scientific methods, and informational resources of public health of the region, taking into account the priority of the organization of preventive measures especially for those infectious diseases that define dominant epidemiological risk in a particular municipality. Efficient use of resources is not possible without administrative, legal and financial support. As the result of the research priority directions of anti-epidemic readiness of the Russian Federation region for emergency situations associated with infectious diseases dangerousfor humans, taking into account the dominant epidemiological risks, are formulated.

The article presents the data on the high level of suicides in Buryatia. Unfavorable situation is observed in areas with prevalence of indigenous population. In Kizhinginskiy, Eravninskiy, Khorinskiy, Okinskiy, Severobaikalskiy areas number suicides in recentyears was more than 100 cases per 100 thousand population. The largest number of suicide was registered at the age of 16-25 years: in 2007 the percent of these suicides was 30,1 % of the total number of suicides. The influence of socio-economic and health conditions of organizational factors on population suicide rate is unfavorable. It was suggested that level of suicides depends on the belonging to different ethnic groups. There are huge differences between regions of Russia by the number of suicides. It was suggested that ethnic behavior, including so-called suicidal behavior, of the representatives of different ethnic groups is determined by the stage of ethnogenesis. The individuals with an increased risk of suicide among young people of different nationalities were determined. Also we revealed large number of people with an increased risk of suicide. It was determined that belonging to different ethnic groups had no significant effect on the number of persons with increased risk of suicide.

Conflict situations in the sphere of medical services lead to economic losses, cause human and moral costs that leads to higher prices and lower quality of care. A sociological monitoring of patients with arterial hypertension (211 of elderly, 107 of senile and 108 patients of working (middle) age) was realized with use of specially developed original questionnaire. 57,1-68,8 % patients of all ages and gender groups have never been in conflict with health care workers at the treatment of arterial hypertension. The main causes of the conflict between doctors and patients are being able to get on to another doctor reluctance to appoint a physician number of necessary diagnostic and therapeutic procedures. The level of medical management where patients complained was mainly the administration of medical institutions. Patients of older age groups in most were satisfied with the response to their complaints. The alarming trend is the fact that 10,0-28,6 % of patients received no response to their complaints. It's necessary to develop a system of measures to review complaints of the patients in clinic by specially authorized specialists (ombudsmen).

The article is devoted to the description of all main milestones of development of neurosurgical ward from the foundation of Scientific Research nstitute of Traumatology and Orthopaedics in İ946 to nowadays. The problems of development of the ward, scientific and practical paradigm of scientific-clinical department of neurosurgery of Scientific Center of Reconstructive and Restorative Surgery SB RAMS are reviewed in the article. The periods of activity of Scientific Research Institute of Traumatology and Orthopaedics from the positions of clinical and scientific achievements are observed. The article presents the facts on the work of clinical and scientific officers that prove close connection of scientific researches and clinical developments in different spheres of neurosurgery. The stages of formation of professional growth of Scientific Research Institute of Traumatology and Orthopaedics in close relation with periods of the development of the country. Also the article presents main dissertation researches performed by the employees of Scientific Research Institute of Traumatology and Orthopaedics, shows their significance in science and clinical work and also illustrates main problems of development of neurosurgery nowadays and determines ways of their solving.

The article presents history of development of thoracic surgery on the example of the surgical thoracic department of Republic Clinical Hospital named after N.A. Semashko. Brief characteristics of both employees who started working in surgical thoracic department and those who work in this department now.

The aim of the research was to study influence of dexamethasone and adrenaline on the concentration of energy metabolism substrates in blood of Chinchilla rabbits under the conditions of multiple skeletal trauma. We performed stabilization of the bones of right forearm and left shin in 35 animals by wire external fixation device with further osteotomy of bones of corresponding segments. We observed the decrease of activity of metabolism in rabbits on the background of standard treatment. Maintenance of normal activity of metabolism by prescription of adrenaline and dexamethasone caused more intensive use of energy resources of an organism. Imitation of hyperergic reaction of stress-realizing systems in rabbits caused the increase of concentration of glucose in blood and the decrease of concentration of triglycerides. High consumption of energy substrates was provided by more expressed catabolic reaction. The result of hypercatabolism was development of hypoproteinemia, hypoalbuminemia and increase of the risk of fluid shift from bloodstream into the tissues with formation of organ insufficiency.

The effect of derivative 1-aIkenilimidazole under code name Allim-1, 2,4-dinitrophenol and their combinations on some indices of oxidative metabolism of mice is examined for the first time. Allim-1 in normal conditions and under the influence of 2,4-dinitrophenol reduces the values of indicators of oxidative metabolism. It is possible, the connection Allim-1 has a beneficial effect on the mitochondrial functions under extreme conditions, reducing the separation of oxidation with phosphorylation.

The article presents the comparative results of morphological and histochemical studies of internal at the toxic affection caused by CCl₄ and at their correction by nanocomposite selenium. It was showed that nanoselenium obtained on the arabinogalactan matrix had hepatoprotective features that develop in the protective effect of hepatocytes from the toxic carbon tetrachloride damage. The activity of enzymes and glycogen remains, the lipid contents decreases.

It is experimentally proved that the new zinc chelate compound 2,8,9-trihydrozinkatrane has a protective effect on the organism of experimental animals contributing to the improvement of essential metabolic processes. Single intragastric introduction of 2,8,9-trihydrozincatrane in protective dose of 4 mg/kg is an effective method of limitation of development of acute alcoholic poisoning in experimental rats that promotes an increase of tolerance of animals' organisms to multiple negative effects of ethanol and its metabolites.

The aim of the present study is to analyze the dynamics of free circulating mtDNA level in blood after occlusion of the upper one-third left descending branch of the coronary artery. We showed that the concentration of free circulating mtDNA of blood tends to decrease 24 hours after ligation; it increased and reached values close to control samples 48 and 72 hours after ligation. These data define the need in further investigation of the dynamics of this parameter during later periods of myocardial infarction modeling that will contribute to objective evaluation of its significance for acute myocardial damage diagnostics and prognosis.

The simple and effective method of the leakage test in thoracic surgery using laser photo-acoustic leak detector «LaserGasTest» was suggested and tested in experiment on mongrels. Sulfur hexafluoride used for the work of leak detector is an inert and biologically harmless gas of the 4^th class of danger and its concentration in medical ventilation apparatus does not exceed 5000 mg/m³ (0.077 %). The proposed technique provides real-time high-frequency determination of location and size of leakage.

An experimental preclinical study of combined antitubercular preparation "Protub-3®" was conducted. Under conditions of performed research "Protub-3®" in dose 8 mg/kg didn't cause pharmacological effect in all registered indices in experiment. But it was established that the preparation in doses more than 8 mg/kg caused a number of dose-dependent pharmacological effects. Increase of rectal temperature, systolic arterial pressure, sum-liminal index, consumption of oxygen and simultaneous decrease of carbonic gas emission, decrease of duration of hexenal sleep, decrease of heart rate, suppression of spontaneous motive activity, rats' research reflex can be related to the number of estimation effects of "Protub-3®".

Pharmacotherapeutic efficiency of the dry extract from Lomatogonium carinthiacum in toxic hepatitis was studied. Experimental hepatitis was caused by the introduction of tetracycline hydrochloride to Wistar white rats in the dose of 1,0 g/kg of the animal weight once a day during 7 days. The extract from L. carinthiacum was administered per os in the dose of 100 mg/kg during 26 days. It was established that the extract from L. carinthiacum had a marked hepatoprotective effect in the case of tetracycline hepatitis in white rats that is characterized by inhibition of the disturbances in choleretic and cholate-synthetic functions of the liver: the increase of bile secretion rate, preservation of cholate concentration in the bile, the decrease in the content of cholesterol triacylglycerides and alkaline phosphatase activity in the animal blood serum during the whole period of experiments. The tested remedy diminishes dystrophic and necrotic processes in hepatocytes, decreases the intensity of inflammatory infiltration in the liver and stimulates regeneration of liver cells in tetracycline hepatitis. The decrease of MDA content in the liver homogenate and increase in catalase activity against the same indices in control animals testify the marked antioxidant effect of L. carinthiacum.

The article presents the results of experimental biological modelling of single and subacute introduction of Ciprofloxacin to the rabbits. State of an organism of animals was estimated by biochemical, hematological, hemostatic and morphologic indices. Introduction of preparation samples was intravenous, according to the Instruction of medical use. Main result of the experiments is determination of toxic effects that are typical for fluorinequinolone and developed on the background of multiple introduction of preparation in the doses higher than therapeutic.

The article presents the review of inventive and patent work of employees of Scientific Center of Reconstructive and Restorative Surgery SB RAMS from the foundation of institute of surgery till nowadays. Main areas of researches (in the form of patents) are determined: prevention and treatment of surgical infection, methods of treatment of actual surgical pathology of neck, chest, abdomen and soft tissues and also instrumental and laboratory diagnostics of these conditions. The models of pathological processes developed in experiment and cell technologies are patented. The level of patent defense of researches is considered to be corresponding.

This review presents the most studied genetic markers which are risk factors for adverse drug reactions in patients who are treated with statins and/or associated with resistance to them. We have considered the possible practical advice for individual therapy with statins in patients with a known genotype. Identification of the gene variant SLCO1B1*5 is a risk factor for myopathy and rhabdomyolysis and HMGCR gene haplotype H7 is associated with less reduction in LDL cholesterol in patients receiving statins. Pathological effect of a particular genetic marker is modified by statin class or calculated personal dose. The use of pharmacogenetic testing will reduce the frequency of adverse outcomes of statins and make a prediction their performance in a specific patient. Howeverfurther studies on the translation of these personalized medicine tests to clinical practice are needed.

The review presents modern ideas about morphology of afterbrain malformations - Chiari, type I. Main criteria of introscopic diagnistics of Chiari malformation of type I and of combined anomalies of development of craniovertebral articulation are discussed. The theories of pathogenesis of craniocervical dysplasias of afterbrain and development of intramedullary cavities are presented. The criteria of differential diagnostics of hydromyelia and syringomyelia and also modern methods of surgical treatment of bone and neural dysplasias are determined. Main clinical features of the course of disease that appears in mosaic picture of cerebellum affection, caudal group of craniocerebral nerves, medulla, brain hemispheres and spine cord are revealed, the characteristics of the mostfrequent syndromes is given. The reconstruction of anatomic symmetry of cone and neural structures of craniocervical articular and restoration of circulation of cerebrospinal fluid through outcomes of the IV ventricle guarantees favorable results of treatment. Promptly and adequately performed operation at the pathology of afterbrail allows to prevent development of irreversible and low-curable morphofunctional defects of neural system.

Degenerative dystrophic diseases of spine and hip joints are considered by the most of the authors as united pathogenic process. The common and connecting element is change of spatial orientation of spine with redistribution of loads on hip joints and sacroiliac articulations, i.e. disorder of topographic-anatomic interrelations of bone-joint formations of "Chacklin triada". For objectification of estimation offunctional disorders of locomotor system biomechanical methods are widely used in clinical practice, the most informative of them is study of locomotions. In spite of achievements in studying of individual degenerative-dystrophic affections of locomotor system there is no single solution of the problem of combined diseases of hip joints and lumbar segment of spine and their mutual influence that determines actuality of further study.

The article is devoted to angiogenesis as one of the ways to increase the stability of the ischemic tissue. It is shown that the reduction in ischemic tissue damage is based on four basic processes - vasculogenesis of endothelial progenitor cells, angiogenesis and arteriogenesis with the growth and subsequent stabilization of the outgrowths of mural cells and the growth of collaterals (expansive growth of pre-existing vessels). However, despite the great progress in the understanding of ischemia-induced angiogenesis, and a lot of positive results from its stimulation using the disclosed arrangements natural response to the reduction of tissue perfusion is still an unsolved problem is the practical use of this knowledge to improve the metabolic processes of organs and tissues with compromised vascular bed. The effect of a variety of recombinant growth factors is not enough long-term, and besides, is not without serious side effects. From this perspective, the greatest opportunities is the development of techniques using natural pool of pluripotent cells with high angiogenic potential.