Preview

Acta Biomedica Scientifica

Расширенный поиск

ПРЕПАРАТЫ БОРА В ПСИХИАТРИИ И НЕВРОЛОГИИ: ИХ ВЗЛЁТ, ПАДЕНИЕ И ВОЗОБНОВЛЕНИЕ ИНТЕРЕСА

https://doi.org/10.29413/ABS.2018-3.4.13

Полный текст:

Аннотация

Применение препаратов бора (буры и чистом виде. Минеральная вода борсодержащих  источников исторически применялась для лечения кожных заболеваний, промывания глаз,  гноящихся ран и т.п., и, что особенно интересно в контексте данной статьи, в качестве  успокаивающего, противотревожного, противосудорожного и способствующего улучшению  сна средства. В 1777 г. из минеральной воды одного целебного источника во Флоренции  была впервые выделена в чистом виде борная кислота. Исторически первым её названием  было sal sedativum («успокаивающая соль»). Однако обнаружившаяся впоследствии  токсичность бора привела к прекращению его применения в психиатрии и неврологии. В  последние десятилетия было обнаружено, что бор является микроэлементом, необходимым  для нормального протекания многих метаболических процессов в организме, влияющим на функционирование нервной системы, память, когнитивные функции, уровень  тревожности, сон, настроение, на обмен лития, кальция и магния, витамина D и половых  стероидов. Было также показано, что некоторые случаи резистентности, например,  эпилепсии, тревожных состояний, депрессий к стандартной терапии имеют отношение к  дефициту бора в организме. В связи с этим интерес к применению препаратов бора в психиатрии и неврологии, но уже в гораздо меньших дозах и на новых научных  основаниях, вспыхнул вновь.

Об авторах

Р. А. Беккер
Университет им. Давида Бен-Гуриона в Негеве
Израиль

8410501, г. Беэр-Шева, б. Бен-Гурион, Израиль

программист, инженер-математик, магистр в области компьютерных наук, исследователь лаборатории автономных роботов, факультет электроники и  компьютерных наук, Университет им. Давида Бен-Гуриона в Негеве 

тел. (+972) 8 61224-07



Ю. В. Быков
ФГБОУ ВО «Ставропольский государственный медицинский университет» Минздрава России
Россия

355017, г. Ставрополь, ул. Мира, 310, Россия

врач анестезиолог-реаниматолог, врач психиатр-нарколог, кандидат медицинских наук, ассистент кафедры анестезиологии, реаниматологии и  скорой медицинской помощи, педиатрический факультет, ФГБОУ ВО «Ставропольский государственный медицинский университет Минздрава России

тел. (652) 71-87-51



Список литературы

1. Akiskal HS. (2017). Mood disorders: clinical features. Kaplan and Sadock’s comprehensive textbook of psychiatry, Wolters Kluwer, NY, 4184-4256.

2. Alexander GV, Nusbaum RE, McDonald NS. (1951). The boron and lithium content of human bones. J Biol Chem, 192 (2), 489-496.

3. Barr RD, Clarke WB, Clarke RM, Venturelli J, Norman GR, Downing RG. (1993). Regulation of lithium and boron levels in normal human blood: environmental and genetic considerations. J Lab Clin Med, 121 (4), 614-619.

4. Barranco WT, Hudak PF, Eckhert CD. (2007). Evaluation of ecological and in vitro effects of boron on prostate cancer risk (United States). Cancer Causes Control, 18 (1), 71-77. DOI: 10.1007/s10552-006-0077-8

5. Benderdour M, Bui-Van T, Dicko A, Belleville F. (1998). In vivo and in vitro effects of boron and boronated compounds. J Trace Elem Med Biol, 12 (1), 2-7. DOI: 10.1016/S0946-672X(98)80014-X

6. Bicho RC, Gomes SI, Soares AM, Amorim MJ. (2015). Non-avoidance behaviour in enchytraeids to boric acid is related to the GABAergic mechanism. Environ Sci Pollut Res Int, 22 (9), 6898-6903. DOI: 10.1007/s11356-014-3921-5

7. Cakir S, Eren M, Senturk M, Sarica ZS. (2018). The effect of boron on some biochemical parameters in experimental diabetic rats. Biol Trace Elem Res, 184 (1), 165-172. DOI: 10.1007/s12011-017-1182-0

8. Canli T. (2014). Reconceptualizing major depressive disorder as an infectious disease. Biol Mood Anxiety Disord, 4 (1), 10. DOI: 10.1186/2045-5380-4-10

9. Cetin I, Nalbantcilar MT, Tosun K, Nazik A. (2017). How Trace Element Levels of Public Drinking Water Affect Body Composition in Turkey. Biol Trace Elem Res, 175 (2), 263-270. DOI: 10.1007/s12011-016-0779-z

10. Chen X, Schauder S, Potier N, Van Dorsselaer A, Pelczer I, Bassler BL, Hughson FM. (2002). Structural identification of a bacterial quorum-sensing signal containing boron. Nature, 415 (6871), 545-549. DOI: 10.1038/415545a

11. Clarke WB, Clarke RM, Olson EK, Barr RD, Downing RG. (1998). Binding of lithium and boron to human plasma proteins. Biol Trace Elem Res, 65 (3), 237-249. DOI: 10.1007/BF02789099

12. Clarke WB, Guscott R, Downing RG, Lindstrom RM. (2004). Endogenous lithium and boron red cell-plasma ratios. Biol Trace Elem Res, 97 (2), 105-115. DOI: 10.1385/BTER:97:2:105

13. Clarke WB, Guscott R, Lindstrom RM. (2004). Binding of lithium and boron to human plasma proteins II: results for a bipolar patient not on lithium therapy. Biol Trace Elem Res, 97 (2), 117-124. DOI: 10.1385/BTER:97:2:117

14. Clarke WB, Webber CE, Koekebakker M, Barr RD. (1987). Lithium and boron in human blood. J Lab Clin Med, 109 (2), 155-158

15. Çolak S, Geyikoğlu F, Keles ON, Türkez H, Topal A, Unal B. (2011). The neuroprotective role of boric acid on aluminum chloride-induced neurotoxicity. Toxicol Ind Health, 27 (8), 700-710. DOI: 10.1177/0748233710395349

16. Corrigan FM, Besson JA, Ward NI. (1991). Red cell caesium, lithium and selenium in abstinent alcoholics. Alcohol Alcohol, 26 (3), 309-314.

17. Cui Y, Winton MI, Zhang ZF, Rainey C, Marshall J, De Kernion JB, Eckhert CD. (2004). Dietary boron intake and prostate cancer risk. Oncol Rep, 11 (4), 887-892. DOI: 10.3892/or.11.4.887

18. da Silva JA, Holm NG. (2014). Borophosphates and silicophosphates as plausible contributors to the emergence of life. J Colloid Interface Sci, 431, 250-254. DOI: 10.1016/j.jcis.2014.02.034

19. Dawkins R. (2016). The extended phenotype: The long reach of the gene. Oxford University Press. 20. Dembitsky VM, Al Quntar AA, Srebnik M. (2010). Natural and synthetic small boron-containing molecules as potential inhibitors of bacterial and fungal quorum sensing. Chem Rev, 111 (1), 209-237. DOI: 10.1021/cr100093b

20. Doğan A, Demirci S, Apdik H, Bayrak OF, Gulluoglu S, Tuysuz EC, Gusev O, Rizvanov AA, Nikerel E, Şahin F. (2017). A new hope for obesity management: Boron inhibits adipogenesis in progenitor cells through the Wnt/β-catenin pathway. Metabolism, 69, 130-142. DOI: 10.1016/j.metabol.2017.01.021

21. Duydu Y, Başaran N, Ustündağ A, Aydın S, Undeğer U, Ataman OY, Aydos K, Düker Y, Ickstadt K, Waltrup BS, Golka K, Bolt HM. (2016). Is boric acid toxic to reproduction in humans? Assessment of the animal reproductive toxicity data and epidemiological study results. Curr Drug Deliv, 13 (3), 324-329. DOI: 10.2174/1567201812666151029101514

22. Ernst W. (1950). Die Behandlung der traumatischen Epilepsie [Treatment of traumatic epilepsy]. Med Monatsschr, 4 (12), 909-911.

23. Farfán-García ED, Castillo-Mendieta NT, Ciprés-Flores FJ, Padilla-Martínez II, Trujillo- Ferrara JG, Soriano-Ursúa MA. (2016). Current data regarding the structure-toxicity relationship of boron-containing compounds. Toxicol Lett, 258, 115-125. DOI: 10.1016/j.toxlet.2016.06.018

24. Feng B, Li X, Li S, Wang J. (2009). [Effect of drinking boron on blood composition in rats]. [Article in Chinese]. Wei Sheng Yan Jiu, 38 (4), 485-488.

25. Garrett DE. (1998). Borates: Handbook of deposits, processing, properties, and use, 483 p.

26. Gonzalez A, Peters U, Lampe JW, White E. (2007). Boron intake and prostate cancer risk. Cancer Causes Control, 18 (10), 1131-1140. DOI: 10.1007/s10552-007-9052-2

27. Hansen AF, Simić A, Åsvold BO, Romundstad PR, Midthjell K, Syversen T, Flaten TP. (2017). Trace elements in early phase type 2 diabetes mellitus – A population-based study. The HUNT study in Norway. J Trace Elem Med Biol, 40, 46-53. DOI: 10.1016/j.jtemb.2016.12.008

28. Hasbahceci M, Cipe G, Kadioglu H, Aysan E, Muslumanoglu M. (2013). Reverse relationship between blood boron level and body mass index in humans: does it matter for obesity? Biol Trace Elem Res, 153 (1-3), 141-144. DOI: 10.1007/s12011-013-9680-1

29. Herren C, Wyss F. (1964). Chronische Borsäurevergiftung. [Chronic boric acid poisoning]. Schweiz Med Wochenschr, 94, 1815-1818.

30. Hunt CD. (2012). Dietary boron: progress in establishing essential roles in human physiology. J Trace Elem Med Biol, 26 (2-3), 157-160. DOI: 10.1016/j.jtemb.2012.03.014

31. Irschik H, Schummer D, Gerth K, Höfle G, Reichenbach H. (1995). The tartrolons, new boron-containing antibiotics from a myxobacterium, Sorangium cellulosum. J Antibiot (Tokyo), 48 (1), 26-30. DOI: 10.7164/antibiotics.48.26

32. Jemmis ED, Jayasree EG. (2003). Analogies between boron and carbon. Acc Chem Res, 36 (11), 816-824. DOI: 10.1021/ar0300266

33. Jensen JP. (2006). The rise and fall of borax as an antiepileptic drug. Arch Neurol, 63 (4), 621-622. DOI: 10.1001/archneur.63.4.621

34. Johnson K, Stollings JL, Ely EW. (2017). Breaking Bad Delirium: Methamphetamine and Boric Acid Toxicity with Hallucinations and Pseudosepsis. South Med J, 110 (2), 138-141. DOI: 10.14423/SMJ.0000000000000599

35. Kent NL, McCance RA. (1941). The absorption and excretion of ‘minor’ elements by man: Silver, gold, lithium, boron and vanadium. Biochem J, 35 (7), 837-844.

36. Khaliq H, Juming Z, Ke-Mei P. (2018). The physiological role of boron on health. Biol Trace Elem Res, 1-21. DOI: 10.1007/s12011-018-1284-3

37. Koc ER, Gökce EC, Sönmez MA, Namuslu M, Gökce A, Bodur AS. (2015). Borax partially prevents neurologic disability and oxidative stress in experimental spinal cord ischemia/reperfusion injury. J Stroke Cerebrovasc Dis, 24 (1), 83-90. DOI: 10.1016/j.jstrokecerebrovasdis.2014.07.037

38. Koc F, Aysan E, Hasbahceci M, Arpaci B, Gecer S, Demirci S, Sahin F. (2016). Relationship not found between blood and urine concentrations and body mass index in humans with apparently adequate boron status. Biol Trace Elem Res, 171 (2), 246-250. DOI: 10.1007/s12011-015-0533-y

39. Korkmaz M, Uzgören E, Bakırdere S, Aydın F, Ataman OY. (2007). Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells. Environ Toxicol, 22 (1), 17-25. DOI: 10.1002/tox.20229

40. Kramer E. (1950). Die Behandlung der Epilepsie mit Bor-Calcium-Präparaten. [Treatment of epilepsy with boron-calcium preparations]. [Article in German]. Nervenarzt, 21 (3), 127-129.

41. Kramer E. (1950). Neue Methoden in der Behandlung von Epilepsie mit Glyboral-Forte. [New methods in the treatment of epilepsy with glyboral-forte]. [Article in German]. Med Monatsschr, 4 (7), 525-527.

42. Kucukkurt I, Akbel E, Karabag F, Ince S. (2015). The effects of dietary boron compounds in supplemented diet on hormonal activity and some biochemical parameters in rats. Toxicol Ind Health, 31 (3), 255-260. DOI: 10.1177/0748233712469648

43. Kurtoğlu F, Kurtoğlu V, Celik I, Kececi T, Nizamlioğlu M. (2005). Effects of dietary boron supplementation on some biochemical parameters, peripheral blood lymphocytes, splenic plasma cells and bone characteristics of broiler chicks given diets with adequate or inadequate cholecalciferol (vitamin D3) content. Br Poult Sci, 46 (1), 87-96. DOI: 10.1080/00071660400024001

44. Locatelli C, Minoia C, Tonini M, Manzo L. (1987). Human toxicology of boron with special reference to boric acid poisoning. G Ital Med Lav, 9 (3-4), 141-146

45. Mahabir S, Spitz MR, Barrera SL, Dong YQ, Eastham C, Forman MR. (2008). Dietary boron and hormone replacement therapy as risk factors for lung cancer in women. Am J Epidemiol, 167 (9), 1070-1080. DOI: 10.1093/aje/kwn021

46. Miljkovic D, Miljkovic N, McCarty MF. (2004). Up-regulatory impact of boron on vitamin D function – does it reflect inhibition of 24-hydroxylase? Med Hypotheses, 63 (6), 1054-1056. DOI: 10.1016/j.mehy.2003.12.053

47. Miller ST, Xavier KB, Campagna SR, Taga ME, Semmelhack MF, Bassler BL, Hughson FM. (2004). Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2. Mol Cell, 15 (5), 677-687. DOI: 10.1016/j.molcel.2004.07.020

48. Naghii MR, Darvishi P, Ebrahimpour Y, Ghanizadeh G, Mofid M, Hedayati M, Asgari AR. (2012). Effect of combination therapy of fatty acids, calcium, vitamin d and boron with regular physical activity on cardiovascular risk factors in rat. J Oleo Sci, 61 (2), 103-111. DOI: 10.5650/jos.61.103

49. Naghii MR, Samman S. (1993). The role of boron in nutrition and metabolism. Prog Food Nutr Sci, 17 (4), 331-349.

50. Naghii MR, Samman S. (1997). The effect of boron supplementation on its urinary excretion and selected cardiovascular risk factors in healthy male subjects. Biol Trace Elem Res, 56 (3), 273-286. DOI: 10.1007/BF02785299

51. Naghii MR. (1999). The significance of dietary boron, with particular reference to thletes. Nutr Health, 13 (1), 31-37. DOI: 10.1177/026010609901300104

52. Nakagawasai O, Nemoto W, Onogi H, Moriya T, Lin JR, Odaira T, Yaoita F, Ogawa T, Ohta K, Endo Y, Tan- No K. (2016). BE360, a new selective estrogen receptor modulator, produces antidepressant and antidementia effects through the enhancement of hippocampal cell proliferation in olfactory bulbectomized mice. Behav Brain Res, 297, 315-322. DOI: 10.1016/j.bbr.2015.10.033

53. Nielsen FH. (1996). How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential? J Nutr, 126 (suppl_9), 2377S-2385S. DOI: 10.1093/jn/126.suppl_9.2377S

54. Nielsen FH. (2000). Possibly essential trace elements. In: Clinical nutrition of the essential trace elements and minerals, 11-36. Humana Press, Totowa, NJ. 56. Nielsen FH. (2014). Should bioactive trace elements not recognized as essential, but with beneficial health effects, have intake recommendations. J Trace Elem Med Biol, 28 (4), 406-408. DOI: 10.1016/j.jtemb.2014.06.019

55. Nielsen FH. (2014). Update on human health effects of boron. J Trace Elem Med Biol, 28 (4), 383-387. DOI: 10.1016/j.jtemb.2014.06.023

56. Orhan C, Şahin N, Tuzcu Z, Komorowski JR, Şahin K. (2017). Combined oral supplementation of chromium picolinate, docosahexaenoic acid, and boron enhances neuroprotection in rats fed a high-fat diet. Turk J Med Sci, 47 (5), 1616-1625. DOI: 10.3906/sag-1701-54

57. O’Sullivan K, Taylor M. (1983). Chronic boric acid poisoning in infants. Arch Dis Child, 58 (9), 737-739.

58. Pahl MV, Culver BD, Vaziri ND. (2005). Boron and the kidney. J Ren Nutr, 15 (4), 362-370. DOI: 10.1053/j.jrn.2005.05.001

59. Per H, Canpolat M, Sahin U, Gumus H, Konuskan B, Kumandas S. (2012). Serum and urine boron and selenium levels in children with resistant epilepsy. Saudi Med J, 33 (9), 942-947.

60. Pham-Huu-Chanh, Sokan I, Quessada MH. (1974). Etude comparative de l’action des acides borique, benzène boronique et p-méthylbenzène boronique sur le système nerveux central. [Comparative study of the action of boric, benzene boronic and p-methyl-benzene boronic acids on the central nervous system]. [Article in French]. Agressologie, 15 (1), 61-72.

61. Pieczyńska J, Grajeta H, Weber R, Biernat J. (2007). Dietary carbohydrate content influences boron’s effect on lipid and protein indices in rats. Biol Trace Elem Res, 115 (2), 137-146. DOI: 10.1007/BF02686025

62. Pizzorno L. (2015). Nothing boring about boron. Integr Med (Encinitas), 14 (4), 35-48.

63. Popova EV, Tinkov AA, Ajsuvakova OP, Skalnaya MG, Skalny AV. (2017). Boron – a potential goiterogen? Med Hypotheses, 104, 63-67. DOI: 10.1016/j.mehy.2017.05.024

64. Rana G, Vyakaranam K, Maguire JA, Hosmane NS. (2005). Boron Compounds as Therapeutic Drugs. In: Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine, 19-49.

65. Regunath H, Ariyamuthu VK, Dalal P, Misra M. (2012). Bath salt intoxication causing acute kidney injury requiring hemodialysis. Hemodial Int, 16 (Suppl. 1), S47-S49. DOI: 10.1111/j.1542-4758.2012.00750.x

66. Restuccio A, Mortensen ME, Kelley MT. (1992). Fatal ingestion of boric acid in an adult. Am J Emerg Med, 10 (6), 545-547. DOI: 10.1016/0735-6757(92)90180-6

67. Scorei R, Popa R Jr. (2010). Boron-containing compounds as preventive and chemotherapeutic agents for cancer. Anticancer Agents Med Chem, 10 (4), 346-351. DOI: 10.2174/187152010791162289

68. Scorei R. (2012). Is boron a prebiotic element? A mini-review of the essentiality of boron for the appearance of life on Earth. Orig Life Evol Biosph, 42 (1), 3-17. DOI: 10.1007/s11084-012-9269-2

69. Semmelhack MF, Campagna SR, Hwa C, Federle MJ, Bassler BL. (2004). Boron binding with the quorum sensing signal AI-2 and analogues. Org Lett, 6 (15), 2635- 2637. DOI: 10.1021/ol048976u

70. Sheng MC, Taper LJ, Veit H, Qian H, Ritchey SJ, Lau KW. (2001). Dietary boron supplementation enhanced the action of estrogen, but not that of parathyroid hormone, to improve trabecular bone quality in ovariectomized rats. Biol Trace Elem Res, 82 (1-3), 109- 123. DOI: 10.1385/BTER:82:1-3:109

71. Sheng MC, Taper LJ, Veit H, Thomas EA, Ritchey SJ, Lau KW. (2001). Dietary boron supplementation enhances the effects of estrogen on bone mineral balance in ovariectomized rats. Biol Trace Elem Res, 81 (1), 29-45. DOI: 10.1385/BTER:81:1:29

72. Simić A, Hansen AF, Åsvold BO, Romundstad PR, Midthjell K, Syversen T, Flaten TP. (2017). Trace element status in patients with type 2 diabetes in Norway: The HUNT3 Survey. J Trace Elem Med Biol, 41, 91-98. DOI: 10.1016/j.jtemb.2017.03.001

73. Sisk DB, Colvin BM, Merrill A, Bondari K, Bowen JM. (1990). Experimental acute inorganic boron toxicosis in the goat: effects on serum chemistry and CSF biogenic amines. Vet Hum Toxicol, 32 (3), 205-211.

74. Soriano-Ursúa MA, Farfán-García ED, López-Cabrera Y, Querejeta E, Trujillo-Ferrara JG. (2014). Boron-containing acids: preliminary evaluation of acute toxicity and access to the brain determined by Raman scattering spectroscopy. Neurotoxicology, 40, 8-15. DOI: 10.1016/j.neuro.2013.10.005

75. Sun W, Uchida K, Takahashi N, Iwata Y, Wakabayashi S, Goto T, Kawada T, Tominaga M. (2016). Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes. Pflugers Arch, 468 (9), 1527-1540. DOI: 10.1007/s00424-016-1846-1

76. Tascilar ME, Ozgen IT, Abaci A, Serdar M, Aykut O. (2011). Trace elements in obese Turkish children. Biol Trace Elem Res, 143 (1), 188-195. DOI: 10.1007/s12011-010-8878-8

77. Vithana EN, Morgan P, Sundaresan P, Ebenezer ND, Tan DT, Mohamed MD, Anand S, Khine KO, Venkataraman D, Yong VH, Salto-Tellez M, Venkatraman A, Guo K, Hemadevi B, Srinivasan M, Prajna V, Khine M, Casey JR, Inglehearn CF, Aung T. (2006). Mutations in sodium-borate cotransporter SLC4A11 cause recessive congenital hereditary endothelial dystrophy (CHED2). Nat Genet, 38 (7), 755-758. DOI: 10.1038/ng1824

78. Watanabe K, Hirata M, Tominari T, Matsumoto C, Endo Y, Murphy G, Nagase H, Inada M, Miyaura C. (2016). BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice. Biochem Biophys Res Commun, 478 (1), 279-285. DOI: 10.1016/j.bbrc.2016.07.027

79. Yalçin SS, Yalçin S. (2018). Blood boron levels and anthropometric measurements in prepubertal children. J Trace Elem Med Biol, 47, 31-36. DOI: 10.1016/j.jtemb.2018.01.010

80. Zhang SH, Yu X, Guo F, Wu ZY. (2011). Effect of interspecies quorum sensing on the formation of aerobic granular sludge. Water Sci Technol, 64 (6), 1284-1290. DOI: 10.2166/wst.2011.723

81. Zhao X, Xiaoli, Zong H, Abdulla A, Yang ES, Wang Q, Ji JY, Pessin JE, Das BC, Yang F. (2014). Inhibition of SREBP transcriptional activity by a boron-containing compound improves lipid homeostasis in diet-induced obesity. Diabetes, 63 (7), 2464-2473. DOI: 10.2337/db13-0835


Для цитирования:


Беккер Р.А., Быков Ю.В. ПРЕПАРАТЫ БОРА В ПСИХИАТРИИ И НЕВРОЛОГИИ: ИХ ВЗЛЁТ, ПАДЕНИЕ И ВОЗОБНОВЛЕНИЕ ИНТЕРЕСА. Acta Biomedica Scientifica. 2018;3(4):85-100. https://doi.org/10.29413/ABS.2018-3.4.13

For citation:


Bekker R.A., Bykov Y.V. BORON PREPARATIONS IN PSYCHIATRY AND NEUROLOGY: THEIR RISE, FALL AND RENEWED INTEREST. Acta Biomedica Scientifica. 2018;3(4):85-100. (In Russ.) https://doi.org/10.29413/ABS.2018-3.4.13

Просмотров: 143


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2541-9420 (Print)
ISSN 2587-9596 (Online)