Using the neurospecific proteins as the markers of different pathological changes in CNS is known to be one of the perspective trends of the modern neurophysiology and medicine. That's why, this work aimed to reveal the change regularities in the antibody (AB) content to the neurospecific proteins in chronic exposure to the neurotoxicants of different chemical nature of employees. 170 workers males have been examined including 79 employees working at the production of vinyl chloride and exposed to vinyl chloride plus dichloroethane, as well as 81 males working at the production of caustic under conditions of the exposure to the metallic mercury vapours including . Measuring the autoantibody concentration to the myelin-associated glycoprotein (MGA) (AT to MAG) in the blood sera was performed using the standard hard-phasic immune-enzymic method by means of the test-system of the Company BUHLMANN (Sweden). As a result of studies it was foud that the increase in the AB concentration has been revealed in the healthy employees with a long-term working period and the persons with the initial manifestations of neurointoxication, working under conditions of the exposure to vinyl chloride and dichloroethane compared with the control group. The study results have allowed to reveal the increase in the AB levels to MAG in the employees with the initial manifestations of neurointoxication compared with the control group. It is worth to be noted that the AB concentration to MAG was significantly found to increase in the patients with chronic mercury intoxication compared to the healthy employees and the persons with the initial manifestations of neurointoxication. Thereto, it should be noted that the mean index values in the patients with CMI in the clinical picture in whom the asthenic disorders prevailed and in the patients with the prevalence of the cognitive disorders were significantly found to differ both between them and relatively to the persons with the initial manifestations of neurointoxication as well as the control group. Moreover, the higher AB levels have been revealed in the patients with the prevalence of the cognitive disorders compared with the patients with the prevalence of the asthenic disorders. The differences revealed in the intensity of the autoimmune responses in the employees induced by the exposure to mercury and vinyl chloride (more expressed in exposure to mercury) may possibly testify the different mechanisms based on the neurointoxication development. Determining the neuronal antibodies may serve not only as the diagnostic tool of the pathological process development in the nervous tissue but it may testify the need of performing the measures of prevention and rehabilitation of the employees exposed to the neurotoxicants.

The article describes neonatal and pediatric neurology researching. Among the causes of childhood disability first place belongs to diseases of the nervous system. Among perinatal brain damage leading place is occupied by cerebrovascular pathology. One of the main causes of hemorrhagic and ischemic brain damage is impaired cerebral hemodynamics. However there is no single point of view on the processes underlying the development of ischemic brain lesions and intracranial hemorrhage in premature infants. It reveals necessity of immunobiochemical neurospecific proteins defining during neonatal period. Proteins, namely neurospecific enolase, a neurotrophicfactor of nerve growth, vascularendothelial growth factor, allow early finding of pathological disorder. What is a profitable advantage compared to the widely used clinical and instrumental examination and laboratory methods to assist in determining location and extent of the brain. Articleshows importance for a multifunction-oriented model of studying peculiarities of the child, starting with finding patterns in complex processes, due to the influence of internal and external factors on the functional state of the organism based on its individual characteristics, and ending with the solution of problems of differential diagnosis. Thus enabling to seek for hidden dependencies in complex processes conditioned by internal and external factors, leading us to performing differential diagnosis. As for mathematical models and data processing algorithms, the authors used an artificial neural network. These algorithms are used when there is no a precise decision-makingsystem. The medical diagnosis of ischemic and hemorrhagic perinatal central nervous system lesions of newborns maybe added in the list problems to be solved by artificial neural networks. The paper gives valuable information aboutinvestigating child's body properties with neural networks algorithms. Results of applying these algorithms are aimed to increase accuracy of differential diagnosis of ischemic or hemorrhagic perinatal damage to the central nervous system in newborns of different gestational ages are presented.

The diagnostic possibilities of the neurophysiological study methods were studied in the process of examining the patients with chronic mercury intoxication, discirculatory encephalopathy and chronic alcoholism to reveal the disorders of the bioelectrical activity, indicating the organic brain injury in the encephalopathy of the occupational and non-occupational genesis. 36 patients with the postponed chronic mercury intoxication (CMI) working at the chemical enterprise in shop on manufacture soda and chlorine a method mercury electrolyses (group I) were chosen for study. The average age of the patients in this group was 50,8 ± 6,0, average work period -14,7 ± 1,05years. The second group consisted of 30 patients with discirculatory encephalopathy (DE) (average age - 50,8 ± 5,2 years old). The third group consisted of 30 persons with chronic alcoholism (average time period of the alcoholization was 16,7 ± 2,1 years, average age - 47,5 ± 6,6 years old). The control group consisted of 30 practically healthy men (average age - 50,8 ± 5,2 years old, average total working period -14,2 ± 1,2 years) who were not occupationally exposed to the harmful substances (group IV). The persons examined in all the groups were males. The complex analysis of the available neurophysiological indices allowed to reveal the expression of the brain deficiency, to assess the specificity of the disorders revealed in the encephalopathies of different genesis. The multinidus brain injuries were revealed indigently of the etiological factor in encephalopathies. The presence of the equivalent sources of pathological activity in the field of the dyencefalic structures which may be clinically characterized by the emotional and cognitive disorders was found to be a common sing. The injury of the corny body was considered as the specific character for mercury-induced encephalopathy evidenced by the presence of the expressed depressive responses. More frequent presence of the pathological nidus activity in the cerebellar field which were clinically followed by the cerebellar disorders were presented as the characteristic difference for alcohol encephalopathy. The temporal brain regions were considered as the more typical source of the pathological activity in the discirculatory encephalopathy.

Purpose: to study the content changes of the antioxidants-chelators in dynamics of examining the persons exposed to the toxic substances. The cohort examination (with the interval of 4 years) of the employees exposed to the metallic mercury vapours, vinyl chloride (VC) and epichlorohydrin (EPCH) has been performed. All the employees were divided into groups in dependence on the working period at the moment of the first examination. The content of ceruloplasmin (CP), the uric acid (UA) and the activity of superoxide dismutase (SOD) in the blood have been studied. Statistical processing the results was performed using the packet of applied programs "Statistica 6.0". The compensatory mechanisms of the responses were found to be different for the antioxidants-chelators in exposure to mercury and chlorine-bearing compounds. The exposure to mercury may promote the increase in the level of CP at the background of the decrease in the activity of SOD and have the stable character in time after 5 years of work and exposure to toxicant. In exposure to VC the analogous compensatory changes were found to begin after 10 years of production working careere and keep for the following 5 years of work. The further exposure to this toxicant may lead to the de-compensatory changes in the system of SOD-CP. The chronic exposure to EPCH may be followed by the increase in the level of UA, acquiring the pathogenetic character in 25 % of persons worked more than 10 years and the increase in the activity of SOD for the working period more than 15 years. The findings allow to conclude about the necessity of performing the timely preventive measures for the persons above. However, the trend and the time period of their initiation may be different. In the case of exposure to mercury the necessity of using the antioxidants (ascorbic acid, unsaturated fatty acids) may arise already after 5years of exposure to the toxicant. In exposure to vinyl chloride the analogous measures have to begin after 10 years of work. There to, using vitamin C is considered as purposeless. On the contrary, the preventive use of this antioxidant, beginning from 10 years of the production working period, is indicated for the employees exposed to epichlorohydrin.

The following groups were examined under clinical condition: the 1^st group (47 persons) - the employees with a long work period working at the Joint-Stock Company "Sayanskchimplast" exposed to mercury compound. The mean age - 49,2 ± 4,4 years old, the mean working period -18,1 ± 5,6 years. The 2^nd group (51 persons) consisted of the employees working at the Joint-Stock Company "Usolyechimprom" in Irkutsk Region with the diagnosis of chronic mercury intoxication (CMI), the mean age - 42,7 ± 4,3 years old and the mean time period of exposure to mercury - 12,3 ± 2,7 years. The postcontact period amounted 8,5 ± 2,6 years. The examination data of 26 persons (males) who were not exposed to the harmful production factors were used as the control one. All the persons examined were subjected to the ultrasonic dopplerography of the extracranial vessels and the registration of the somatosensoric induced potentials. This study allowed to assess the state of the cerebral hemodinamics manifested as the autoregulation disorder of the brain bloodflow along the metabolic contour in the employees examined in both groups. It should be noted the presence of the change correlation in the state of the central afferent inductive structures consisting in growing the time period of the central conductive capability, that is, the conductance from the lower sections of the stem up to the brain cortex and the functional change in the metabolic diameter regulation of the cerebral vessels in the patients exposed to the metallic mercury at the production. As compared with the control the more expressed index change of the somatosensoric induced potentials were registered in the subgroup of the patients in the postponed period of chronic mercury intoxication with the revealed regulation disorders of the cerebral vessels. The change were found to correlate with the impulse conductance disorders at the level of the thalamic and cortical structures. The attention should be paid that the change revealed were registered in the group of the patients exposed to the metallic mercury at the production but without the revealed diagnosis of chronic mercury intoxication with allow to consider the presence of the changes in the state of the conductive structures in this group of the patients examined.

The aim of the work was to estimate the quality of life of patients with mild traumatic brain injury in the acute and longterm periods. The complex study of 65 patients (42 men and 23 women) aged 20 to 60 years in acute traumatic brain injury of mild severity (40 of them with a concussion, 25 - with a mild brain contusion) was carried out. 35 patients were examined in the long term. All patients had clinical and neurological examination. We used the NIHSS, Barthell scales, skull radiography, computer tomography of the brain, Montgomery - Asberg Depression scale, Hospital Anxiety and Depression scale, Spielberger test, a questionnaire and a scheme developed by the national central autonomic diseases. Quality of life was examined using a MOS SF-36 questionnaire. Study of the emotional status in the acute period showed slight levels of depression, highly reactive and moderately expressed personal anxiety. Quality of life was decreased on all scales of the MOS SF-36. Correlation analysis revealed the dependence of the quality of life of mental and emotional status. In the long-term continued to remain increased level of depression, high reactive and moderate personal anxiety, increased subjective and objective manifestations of autonomic dysfunction. Self-assessment of quality of life has revealed the results are the same as in the acute period of brain injury on the Social Functioning, Role-Physical, Vitality, Mental Health scales. The high quality of life in the acute period reduces the risk of psycho-autonomic syndrome in the long term. In the acute period of mild traumatic brain injury need to use a diagnostic questionnaire mOs SF-36, which will in these patients to predict the level of social and psycho-emotional components of quality of life.

At present the pathology of laryngeal and respiratory organs is known to prevail in the structure of the child and adolescent morbidity in the industrial centers of the northern and eastern regions of the country and their proportion reaches 70 %. The disease symptoms of the respiratory tracts (the obstacle nose, discomfort and throat tickling as well as the hoarseness) and especially their complications may lead to the decrease in the life quality of children and adolescents. Taking into account that at present time it is impossible to remove technogenic air pollution totally, the complex studies on revealing the unfavorable factors, which may influence the organisms of the children and adolescents, are known to be the prior task of the preventive medicine. The aim of the study was to examine the frequency chronic respiratory pathology and influence on the adolescents life quality of industrial centers of Irkutsk region with different levels of technogenic pollution. 410 adolescents (14-17 years) for a long time living in the regions with the different air pollution levels air with the developed oil-chemical and industries were examined. The differences in the structure of chronic respiratory pathology were revealed in the examined adolescents: under conditions of the air pollution with a complex of chemical compounds with a high Hasard Index (HI = 17) the respiratory diseases prevail, and with the medium level (HI = 3,6) the nasal diseases prevail. It was found that that about 12,6 % of the morbidity variability in the category of the respiratory organs, in particular the throat pathology in the teenagers may be correlated with the air pollution. The more significant factors of forming the chronic respiratory pathology were found to be the health state, characterized by the laboratory indices (common microbial number of the nasal cavity and the pharynx; activity of lysocyme); chemical inhalation exposure; the work of the parents under harmful conditions during the period before child birth. The study results may be considered as the basis for the optimization of the approaches to the diagnostics and prevention of the respiratory pathology of adolescents.

According to the survey the effect of the conditions of family life on the reproductive behavior of women was studied, as well as the comparative characteristic of matrimonial and reproductive orientations of women with children and women without children (female students) living in the cities of Irkutsk region. The dependence between the housing and the material conditions of the family and the number of children ever born was determined: the average number of children born by women from families with their own housing and living separately from other relatives were higher, average number of children from women from families with rather high income was lower than from ones who considered theirfamilies to have low and extremely low income. Reproductive intentions the two-child and one-child women give birth to another baby hampers the availability of material and housing problems. The average number of children was higher in women with secondary special education, employees in private enterprises and workers in large industrial enterprises. Achieving success in family life is a factor for the well-being for the majority of women with children, and does not depend on the number of children. For the girls, along with success in family life the opportunity to "power over people" is also important. The fact of having children does not affect the formation of marital and family systems: both categories of respondents are not sufficiently developed to implement the installation of household functions of the family and the low importance of sexual relations in marriage, they are more focused on achieving social viability and prone to egalitarianism. The girls have more developed focus on the educational function of children than women. Indicators ideal medium, the expected and desired number of children in two and three-child women is higher than the ones in single-child women and girls who do not have children.

The estimation of the total effect of the environment on immune-metabolic parameters of people living in industrial areas of Primorsky region was conducted. The study involved 1128 healthy people living in the Primorsky region for at least 10 years. Integrated exposure index (HE) that takes into account the gradient of "response of the body" to the combined effects of multiple environmental factors (climatic, technological, socioeconomic, etc.) was developed. With use of gradient approach in Primorye 4 categories of areas were identified: the relatively favorable (IIE > 0,4), moderate (IIE = 0,3-0,4), relatively unfavorable (IIE = 0,2-0,3) and unfavorable environment (IIE < 0,2). In the second phase of the study database of normalized immune-metabolic parameters of healthy people living in the industrial centers of the Primorsky region was established. The valuation was carried out relatively to the values of the studied parameters of healthy individuals living in the mostfavorable conditions (IIE > 0,4). With the use of cluster analysis the classification of objects method К-means was performed, which revealed three immune-metabolic phenotypes. Compensated phenotype corresponds to the first phase of the adaptation of the organism - the activation parameters. Increased exposure leads to the formation of subcompensated phenotype, and the destruction of the body of the adaptation fund - to the formation of decompensated phenotype. The distribution of the proportion of healthy individuals with selected phenotypes in the population living in the areas with different environmental pressure shows the following dependencies: compensated and subcompensated phenotypes prevalent in areas with better living conditions, the percentage of decompensated phenotype increased environmental degradation. In areas where environmental load exceeds the capability to adapt the body subcompensated and decompensated phenotypes prevail. Violations identified unfavorable combination of endogenous and exogenous risk factors may be the basis for the formation of disease.

The aim of this work was the study of the association of biochemical markers of genes with the risk of the development of professional and work-related fluorosis in people, working in the aluminum industry. From 303 to 387 employees of Novokuznetsk aluminum factory were examined for various polymorphic genetic systems. The main group consisted of patients with fluorosis who were tested in the clinic of Research Institute of Complex Problems of Hygiene and Occupational Diseases RAMS. The control group (110 people) consisted of apparently healthy individuals of the same professions, working on Novokuznetsk aluminum factory, but without a diagnosis of occupational disease. We studied the serum proteins haptoglobin (HP), group-specific component GC, erythrocyte acid phosphatase ACP, fluorescent esterase EsD, protease inhibitor a-1-antitrypsin AAT. The material for the study was the venous blood samples. The study was conducted with the use of electrophoresis in polyacrylamide and the starch gels followed by histochemical staining electrophoregrams. Variants of protease inhibitor a-1-antitrypsin (AAT) were separated by isoelectric focusing in polyacrylamide gel. For analyzing the association studies of gene markers of the risk of develop ment (or resistance to the development) of fluorosis the criteria χ² and OR were used. It was revealed that variants AcP aa, AcP bb, AcP bc, EsD 2-2, PI M3M3 and GC, combinations (1-1) + PI (MR), GC (11) + PI (M3M3), PI ( MR) + EsD (2-2), GC (1-1) + PI (M2M3), EsD (2-2) + AcP aa, GC (1-1) + EsD (2-2) referred to the risk genotypes of development of fluorosis. Two-component combinations of genotypes that were also associated with an increased risk of development of professional fluorosis were identified: GC (1-1) + PI (MR), GC (1-1) + PI (M3M3), PI (MR) + EsD (2-2 ); GC (1-1) + PI (M2M3), EsD (2-2) + AcP aa; GC (1-1) + EsD (2-2). For three-way combinations of genotypes are GC (1-1) + PI (MR) + AcP AA and GC (1-1) + EsD (2-2) + AcP cc. Genotypes resistant variants are: PI M1M1, EsD 1-1, AcP ab, AcP ac.

The article presents the results of research of nano- and microparticles of the atmospheric suspensions containing in snow of Birobidzhan in winter of 2011/2012 by means of scanning electronic microscopy with the power dispersive analysis. To exclude secondary pollution by anthropogenous aerosols tests (an atmospheric precipitation in the form of snow) were gathered during snowfalls. Only the top layer (5-10 cm) fresh-dropped out snow was collected. Snow was placed in the 3-liter sterile containers. The material analysis of suspensions was carried out on a light microscope Nikon SMZ1000 and scanning electronic microscope Hitachi S-3400N with power dispersive spectrometer Thermo Scientific. It was shown that in atmospheric suspensions of Birobidzhan particles of rocks, vegetable detrite and technogenic (black, slag and not-defined) educations prevail in decreasing order. Influence of combined heat and power plant and motor transportation outcomes on qualitative structure of atmospheric suspensions was revealed. In the typical sample taken around a railway crossing we defined (in decreasing order): not-defined technogenic particles, parts of rocks, plant detrite, metal microparticles (by results of the power dispersive analysis - mostly Fe). In a typical sample from the area of the ring highway we revealed (in decreasing order): not-defined technogenic particles, black spherules, plant detrite, parts of rocks (by results of the power dispersive analysis - mainly alyumosilicates), metal microparticles (by results of the power dispersive analysis - mostly Fe). In the typical sample taken around combined heat and power plant black spherules and not-defined technogenic particles were defined in major. In an inspection pure zone, despite removal from dusting sources, black and metallic (Fe, Ti, Co, W) particles are found. Among features of qualitative structure of tests in Birobidzhan city big specific weight of plant detrite in them, in comparison with other Far East cities, should be noted. The analysis of qualitative structure of atmospheric suspensions of Birobidzhan confirms its status as the cities with small population, one combined heat and thermoelectric power station (working on coal), moderate press of motor transport and an average as a whole level of atmospheric pollution.

Among the occupational and work-related diseases of employees in pharmaceutical industry the leading positions belong to the diseases caused by long-term work under the conditions of relatively low concentrations of hazard substances. The study and evaluation of risks will eliminate or reduce the impact, thereby, enhancing the quality of life. Synthetic drugs - benzodiazepine derivatives by the values of middle-lethal doses are substances of the 111 class of hazard and cause slight irritating effect to the skin and mucous membranes of the eyes; skin-resorptive and sensitizing effects have not been identified. For the studied benzodiazepine derivatives the safe exposure levels have been approved in the following values: nozepam -1 mg/m³; mezapam - 0.3 mg/m³; sibazon - 0.2 mg/m³; alprazolam - 0.1 mg/m³. On the base of the toxicological studies the parameters of the hazardous effects on the body have been identified allowing for a final risk characterization. The article presents the results of the calculation of the potential dose that may be received by the employee during the working shift in the synthesis of products of this series. Calculation of safe level of exposure is based on a threshold concentration of substances. Drags risk factors by inhalation have been calculated by comparing the value of the potential dose of a xenobiotic received for one shift by inhalation with its level of safe effect under the same route of exposure. The estimated hazard ratios for the studied substances demonstrate a low probability of adverse effects on the workers during the production of nozepam and alprazolam. High risk of negative impact on the health of workers has been identified during the production of sibazon and mezapam. This information can then be used to control the working environment during the synthesis of drugs - benzodiazepine derivatives, aimed at creating a safe working environment and, consequently, improving the workers' life quality.

The protection of physical health in rising generation has special significance under unfavorable demographic situation. Purpose: complex assessment of level of physical development of preschool children of the various ethnic groups living in the Republic of Tyva. Results of inspection of 1822 native children and 678 children of the alien population of the Republic of Tyva aged from 3 till 7 years are presented. The somatometry of preschool children is carried out (body length and body mass, thorax circle); the assessment of level and a harmony of physical development according to regional and interregional standards is given; methodic Ketle₂ (BM1) and «stenii» indexes of Verveka-Vorontzov are used. We used the scheme for somatotypes definition by R.N. Dorohov and 1.1. Bahrah modified by 1.M. Vorontzov. 1t is established that the considerable part of the surveyed preschool children has disharmonious options of physical development. Among preschool children of the alien population the number of children with a length of a body exceeding age standards (32,6-26,5 %) is higher; among Tuvinians - with the low growth (18,5-22,7 %). Average physical development was revealed in 39,0-48,3 % at Tuvinians and 42,0-50,0 % children of the alien population according to the proportion of body mass to its length. Deficiency of weight of a body is registered more often at children of the alien population (12,5-22,2 %); the excess mass of a body is noted more often at Tuvinians (43,2-51,5 %). There is a big number of preschool children with high intensity of growth processes (dolichomorphia: 19,8- 29,2 % at Tuvinians and22,2-43,2 % children of the alien population) that allows to put them into the group of risk of probable decrease in resistance and working capacity. At the same time it is revealed that considerable part of children is defined to have a microsomatotype (23,2-26,1 % at Tuvinians and 22,2-29,9 % children of the alien population). For children ofindigenous people it can be ethnic feature of a constitution, but for children of the alien population probably it can be manifestation of complex influence of factors of environment. The most probable and operated factors promoting emergence of deviations in physical development, can be an irrational, unbalanced food and breaking of food behavior at children.

1,2-dichloroethane comes in the air of the working area. Workers exposed to this production of low concentrations of toxic substances that may lead to the development of various pathologies. It is important not only for the assessment of health data of professional examinations, but also for a subjective self-assessment of the workers. Investigation of health-related quality of life is widespread among patients with various pathologies and among the working population. The aim was to evaluate the quality of life in persons exposed to vinyl chloride and 1,2-dichloroethane. The objects of the study were 154 polyvinyl chloride workers (main group), 84 males, who comparable with those of the main group by sex, age and social conditions, not in contact in his work with the harmful physical and chemical factors (comparison group). Quality of life studied by a questionnaire MOS SF-36. An automated system of quantitative risk assessment of the major pathology syndromes (ASKORS) is used for prenosological diagnostics. Mathematical and statistical analyzes were conducted using Statistica 8. The fewer number of people with the highest level of risk were in the main group, which can be linked to strict pre-employment medical screening and annual professional examinations in the chemical industry. Investigation of quality of life have shown excess of all its components in the main group in relation to the comparison group. The lowest ratings of quality of life, obtained on the scale of role physical and emotional functioning in both groups suggests that the restriction of daily activities related to health problems and emotional instability has production stipulation. The structure of the risks of the major syndromes were similar in the studied groups, and can be considered a response to the impact of production and psychosocial factors. In general, polyvinyl chloride workers assess their quality of life is much higher than the control group.

The analysis of the environmental factors of child and adolescent agencies Irkutsk region, the primary indicator of disease and preventive screening children for 2001-2011 years to identify adverse factors affecting the health of children. The study used standard methods for the analysis of time series ranking. In the Irkutsk region during the study period in 1,6-6,0 times while the share of child and adolescent agencies that do not meet sanitary requirements, the level of noise, electromagnetic radiation, light, microclimate and furniture. In the region remains high proportion of child and adolescent agencies that do not meet health legislation, in terms of light and electromagnetic radiation - in 2011 All-Russian regional indices exceeded by 4.6 and 2.7 percentage points respectively. To factors are disadvantaged and nutrition. Despite the positive trend, in 2011, the regional indicators of the nutritional status of children in the child and adolescent institutions exceeded the all-Russian, first of all, by microbiological -1.8 times and calorie content, completeness attachments ready meals - to 1.5 times. Over 2001-2011 years primary indicator of child morbidity Irkutsk region increased by 37 %, the growth of the incidence of 16 types of diseases. In 2011, the regional figures exceeded all-Russian and 9 of the 19 classes of diseases. According to the results of preventive medical examinations, the number of children with low vision and poor posture in 2011 compared to 2001 in all age groups, with scoliosis - in the middle and upper classes. In 2001, six out of 12 regional indices analyzed exceeded the all-Russian According to medical examinations, in 2011 these figures were already 11. During the study period, the children's health deteriorated in the Irkutsk region and is assessed as unsatisfactory.

In the electrolytic aluminium production fluorides in the form of hydrogen fluoride and solid fluorides, alumina-containing dust, carbon monoxide, resinous substances and benz(a)pyrene are released into the air of the working zone representing a hazard to the workers' health. The paper presents the results of the researches of the working conditions of the workers employed in the electrolytic aluminium production. The concentrations of toxic substances in the air of working areas of those engaged in anode works and electrolysis, and crane operators are given; on their basis the risks of occupational diseases (fluorosis), of acute toxic effects, of chronic intoxication, and of cancer are calculated. The average-shift concentrations of hydrogen fluoride in the air of working areas of those engaged in electrolysis are 0.40-0.46 MPC, soluble fluorine salts - 0.31-0.38 MPC, insoluble fluorine salts -0.08-0.09 MPC. In the air of the working areas of those engaged in anode works MPC excess is noted for the aerosols of mostly fibrogenic action - in 1.25 times, for resinous substances - in 1.10 times. In the air of the working areas of those engaged in electrolysis MPC excess for resinous substances is registered in 1.06 times. The average-shift concentration of insoluble fluorine salts, and carbon monoxide in the air of the working areas of those engaged in anode works and electrolysis and crane operators are within the MPC. The risk of occupational disease development (fluorosis) due to the air pollution of the working zone in the aluminium production for the workers of the major occupational groups is ranging from 0.045 to 0.0482. Hydrogen fluoride is the most hazardous contaminant in air of the working zone contributing more than 55 % to the risk of fluorosis. The risk of acute toxic effects for the workers of the major occupational groups associated with the achievement of the concentrations of the contaminants in the air of the working areas of their maximum values are ranging from 0.181 to 0.230.

The aim of the work was to develop a way of the forecast the risk of occurrence in time disability at the workers occupied with shipbuilding. 577 persons, occupied in shipbuilding and ship repair, have taken part in research. Objective data on disease (were estimated according to disease with time disability, morbidity rate and medical surveys), harmful production factors, levels functional intensity of the basic systems of an organism, and also subjective: working conditions and a life, quality of a life. Results: With the help of the factorial analysis it was possible to lower dimension of a correlation matrix with 142 to 34 variables. The close interrelation of the factors describing an estimation of a degree of satisfaction of relations in collective, material compensation of work and pleasure from carried out work with a self-estimation of conformity of work to health, objective parameters of a state of health has been found out. It is established, that up to 35 % of disease it is possible to prevent the competent organization of work within the precincts of the enterprise (normalization of relations in collective, material compensation of work and formation of installations on importance and necessity of carried out work). The most part (53,5 %) at the same time is enough the factors connected to health, poorly gives in to updating as is caused or features of technological process, or features of a way of life working. The problem of the forecast of risk of time disability at the workers occupied in shipbuilding branch has been solved with the help of the consecutive analysis on method of A. Wald in updating E.V Gubler (1990). The received solving rule took into account the characteristics including data on a way of life, character of labour activity, the experience, age, a field, a functional pressure of cardiovascular system. The mistake of the forecast has made less than 10 %. Thus, use of the received mathematical model allows not only it is correct to predict occurrence of time disability at the workers borrowed in ship-building branch, but to define things in common between a state of health, working conditions and quality of a life.

Climatic, geographical, industrial and welfare factors make on the body of shift worker claims exceeding its reserves, which excludes the possibility of complete adaptation to these conditions and leads to the existence of occupational health hazards. In extreme conditions, shift work in the Far North would be assessed not only occupational risks, but also the risks to the health and psychological risks. Assessment of the risks to health workers suggests a wide range of criteria and indicators, which improves the timely development and implementation of preventive measures. Psychological assessment of risks in a professional activity would develop technology and conduct management activities, as moral hazard and risks to health.

The analysis of the results of medical examinations of workers in Baikal and North-Muya Tunnels East-Siberian Railway. Health studied groups rated as unsatisfactory, which is associated with an the influence of unfavorable factors of production complex: high humidity and air mobility, low positive air temperatures, the lack of natural light, noise and vibration, chemicals, dust, severity of the labor process, hypogeomagnetic field, radon. The number of healthy individuals is insignificant. It is established that the structure of the accumulated incidence among workers of two tunnels significant differences were found. In both groups, registered respiratory disease with prevalence of chronic bronchitis, infectious and parasitic diseases represented mainly fungal infections of nails and feet, and diseases of the eye (more than half of the cases - violation of refraction and accommodation). It is shown that a greater number of cases of respiratory disease in a group of workers of the North Muya tunnel due to the higher (2.5 times) volume activity of radon in the air of the working area, and the availability of sites with high (greater than 2) attenuation geomagnetic field. Defective light climate can cause changes not only in the functional condition of individual organs and systems, but also adversely affects the visual analyzer. The presence of drainage water and humidity favor the spread of fungal diseases of the skin and its appendages. In the preservation of health workers serving the railway tunnels, it is necessary to focus on the regular medical examinations for early detection, treatment, and prevention of diseases, as well as individual and group recreation workers who are exposed to adverse health effects of production factors. Substantiated basic preventative health maintenance workers of railway tunnels through individual sanitation and health preventive measures, avoiding harmful habits, rationalization of supply, the maintenance of the physiological antioxidant and immune-system reactions.

The products of free radical oxidation are known to exert the harmful effect on the cellular membranes which, in turn, may promote the development of the pathological processes at the level of the whole organism. The excessive process activation of the lipid peroxidation (LPO) may occur under the influence of many factors including the chemical ones, thereto, it is supposed that the LPO products may promote the toxic effects of different chemical compounds which may enter the organism from outside. The studies of the LPO state in the employees of Pulp and Paper productions were not performed. This study aimed to investigate the change features of LPO and the indices of the antioxidant defense in the employees of the main occupations at the production of sulfate cellulose exposed mainly to the methylsulfuric compounds (MSC). The study objects were the employees of main occupations of the sulfate cellulose production in Eastern Siberia. The system state of lipid peroxidation (LPO) was assessed using the determination of the primary, intermediate and final LPO products in blood plasma. The activity of the antiperoxide ferment of glutathione reductase (GR) as well as the content of SH - glutathione in the blood and the common SH - groups of the whole blood were determined to assess the state of the antioxidant defense. Statistical processing the data was performed using the computer software STATISTICA v. 6 for WINDOWS by means of the average value calculation, the standard errors of the average values, the significance assessment of the differences was performed using the STUDENTs Criterium. The significant accumulation of the primary, intermediate and final LPO products in the blood plasma was found to occur in the employees exposed to the chemical factor. Thereto, the significant decrease in the activity of glutathione reductase antiperoxide ferment of thiol disulfide metabolism as well as of SH - glutathione and the significant content decrease in the common SH-groups in blood were revealed in the employees of the boiling shifts exposed to MSC compared to the control and comparison groups. The significant statistical content dependence of the intermediate and final LPO products in the blood as well as the antioxidants on the long- term exposure to the chemical factor has been revealed. The more significant products accumulation of LPO and the index decrease in the antioxidant defense was observed to be in the employees with working period more than 10 years exposed mainly to MSC.

The concept of existential-humanistic approach and method of primary personality-oriented prevention of addictions was done. Science-based organizational and functional mechanism of prevention had based on a model of prevention the addictions in children and adolescents. It is found out that the leading personal and psychological mechanism of formation at school students of an emotional and activity component of motivation of refusal of addictions is the interiorization of values and meanings of «healthy lifestyle» with reduction of manifestations of psychological infantility at the expense of increase in a cognitive component and existential «responsibility transfers». After training statistically reliable difference of experimental group from control group in each of the parallels of the 8, 9 and 10 classes presented in research is revealed. The quantity increased in experimental group quiet, counterbalanced and the number of irritable, uneasy school students decreased, in control group of statistically significant changes isn't revealed. Measurement of level of uneasiness on Bek's scale showed that before preventions maintenance among pupils of the 8, 9 and 10th classes of experimental group the number of persons with low level of a depression and uneasiness made 40,66 %, and by the end of the year and their quantity increased to 52 % (р ≤ 0,007). In control group by the end of the year the number of disturbing school students decreased from 32,33 % to 24,66 % (р ≤ 0,047). Number of persons having situational uneasiness (average level) and their dynamics authentically didn't change in both groups. High level of personal uneasiness at school students of experimental group was observed in 22,33 % of cases at the beginning of a year, and in the end of the year decreased to 9,33 % (р ≤ 0,0001). The number of school students with high level of a depression and uneasiness increased in control group from 32,33 % to 39,33 % (р ≤ 0,089). Thus, the model allows to lower levels of predictors of risk of abuse of addiction's, to make active antiaddiction motivation, to gain skills of counteraction to pressure of group additive norms. Dynamics of epidemiological indicators of the main addiction's diseases and frustration in 1999-2003 (years of forming experiment) and 2004-2011 (a stage of long supervision) across Mezhdurechensk in comparison with three control cities of the Kemerovo region where such work wasn't carried out was analyzed. The received epidemiological results in dynamics in 10years in the experiment region in comparison with control territories and with the Kemerovo region allowed to describe a scientific and practical phenomenon «social stability of positive effect of measures of primary prevention of dependence on addictions» which is characterized by steady statistically reliable decrease in addiction's morbidity and incidence among the population.

The study of functional status in 122 boys aged 16,5 ± 1,5years, with varying intensities of physical activity. Given that the autonomic nervous and cardiovascular systems reflect adaptive reserve capacity of the organism, functional status was assessed by heart rate variability using the device «VNSmikro-3» (OOO «Neurosoft», c. 1vanovo). Optimal generation of heart rate (111 type of heart rhythm regulation) was observed in 75,0 % of boys with low, 68,8 % moderate and 38,9 % of high-intensity exercise. Rhythmogram persons of this type of regulation reflect the impact of a balanced system of generating units heart rate. 1ndividuals with type 1 regulation of heart rate were observed inyoung men with low (3,6 %) and moderate (8,3 %) intensity of physical activity, indicates an increase in activity of s^rasegmental component of the cardiac rhythm generation. People with type 11 regulation of heart rate observed in the group of young men with low (7,1 %) and moderate (5,3 %) intensity. Features rhythmogramsyoung men with type 11 regulation of heart rate is the predominance of: central regulation and low values of the spectral characteristics, the presence of extreme tension of the cardiovascular and autonomic nervous systems. Adolescents with type 1V regulation found among young men with moderate (12,5 %), low (16,7 %) and high (61,1 %) intensity of physical activity. 1n physically active boys availability of this option demonstrates the regulation of over-training will occur and the body, a possible violation of the sinus node automaticity. Found that the functional effects of a regulatory system are: 25 % of young men with low-intensity physical activity, 31,2 % of young men of moderate intensity physical activity, and 61,1 % of boys with high intensity exercise. These findings support the need for careful medical supervision at the stage of sports specialization, as well as during training and competitive periods. The results reflect the optimal interaction of all components of the cardiac rhythm generation in a large part of young men with low-intensity physical activity, indicating that the optimally chosen exercise. The presence of a third of young men with low-intensity physical activity to reduce signs of adaptive capacity demonstrates the importance of medical monitoring of the health of students and the timely adjustment of the intensity of physical training.

The purpose this research was to investigate the quality of life machine operators of agriculture, depending on the status of the age and length of service in the profession. To assess the quality of life was used widely used international Russian-language health a validated questionnaire SF-36. Studies have been conducted practically healthy quality of life (based on the results of periodic medical examinations) machine operators of agriculture Saratov region (102 people) aged 30 to 59 years of experience in the profession from 3 to 35 years. Average values of an indicator for age groups 2 and 3 made "the general health", respectively, 95,2 and 78,7 % from level characteristic for younger age group. Intergroup distinction was noted between average sizes of this indicator at persons at the age of 30-39 years and 50-59 years, and also 40-49 summer machine operators and workers of advanced age (50-59 years). 1t is established that with increase in calendar age at machine operators of agriculture statistically significant decrease in values of indicators of quality of life to scales the general health, physical functioning, physical and role functioning and viability. With increase in length of service at machine operators decrease in values of indicators of physical functioning and role physical functioning. A statistically significant weak negative correlation between the level of quality of life, age (r = -0,39) and professional experience (r = -0,31). 1n this case, the highest correlation between the age of the examined patients and quality of life was typical of the general health scale (r = -0,37), physical functioning (r = -0,41), and role physical functioning (r = -0,34). Professional experience correlated with the level of physical functioning (r = -0,30) and role^hysical functioning (r = -0,32), has practically no effect on the subjective assessment of general health (r = -0,22). Results of researches allow recommending questionnaire SF-36 use when forming individual and group improving programs for machine operators of agricultural production.

The production vibration is known to be a powerful stressor which may induce the complex of disorders leading to the vibration-induced disease development. Along with the appearance of the clinical syndromes the neurosis-like, the psychoemotional disorders, the ipochondric, asthenic and asthenovegetative syndromes, the diffuse disorders of the bioelectrical brain activity with the participation of the cortex of the large hemispheres as well as the stem and diencephalic brain structures were observed to occur in the patients with the vibration-induced disease. However, at present there are no clear arguments in favour that namely the exposure to vibration may promote the occurrence of the neurotic disorders, the neurosis-like disorders of psychic activity, the disadaptation signs, the emotional disorders as well as the pathological changes in the bioelectrical brain activity in exposure to vibration. This work aimed to reveal the changes in the central nervous system (CNS) based on the study results of the behavior and bioelectrical brain activity in the animals. The experimental studies were performed using the mature inbreeding rats males. The chronic experiment was performed by means of the modificated vibrostend VEDS-10a, the vibration levels taken corresponded to the exposure in reality to vibration under production conditions. The studies were performed based on 4 study series: for 15 days, one, two, and four months of exposure to vibration. The intact rats were used as the control ones. The animal behavior responses with assessing the motor activity, the orientating and learning as well as the emotional behavior components were observed in the «юрen field». Recording and processing the electroencephalographic data were performed using the electroencephalograph Neuron-spectrum 4 (Joint-Stock Company «Neurosoft», Russia). The information was processed using the standard methods of the variation statistica, statistical processing the data was performed by means of the Packet of Applied Programs EXCEL Packet Office 2003 (in OS «W1NDOWS Xp»), «Statistica for windows - Version 6». The study of the behavior activity in the animals has shown that the increase in the common motor activity, the nonspecific character, the high emotional strain of the negative character, the negative emotional state were found to occur in the rats exposed to vibration, thereto, the orientating and learning activity was at the previous level. The change in the bioelectrical brain activity was characterized by the increase in the slow-wave activity of the delta-range after one month of exposure to vibration and the latent period prolongation of the visual induced potentials (V1P) after 15 days of exposure to vibration.

Evaluation of features forming a local variant of population health, depending on local conditions is one of the urgent tasks for the study of preventive measures to improve the level of health and quality of life in specific areas. The aim of the work was the formation of local type of population health and environmental health components of quality of life in the industrialized areas of the Irkutsk region with use of indicators of the risk of disease. To solve this purpose the data of the prevalence of certain diseases and all classes of primary uptake of children and teenagers in the industrial cities of Irkutsk region with high levels of air pollution was used. Changes in environmental load assessed by the dynamics of total emissions of harmful substances and by terms of air pollution. Prevalence of environmentally caused diseases of children and teenagers in the research area and the degree of intensity of medical and environmental situation of the different areas with the definition of the category of its distress was assessed in terms of the relative risks of morbidity diseases of individual classes and all classes in the dynamics of the data and five-year periods. The local type of health of the industrial city in terms of ecological-depended morbidity was ranked by the number of classes of diseases and they determine the category of tension health and environmental situation. The possible impact of air pollution on the health of the population was analyzed with the possible evolution of the state of nonspecific increased resistance of children and teenagersfrom exposure to pollutants and other environmental factors. The presented results of the evaluation of the dynamics of health and environmental situation in the industrialized cities of Irkutsk region suggest that the relative risks of morbidity allows to define a local version of population health and to assess the environmental health component of quality of life in industrialized areas.

This article presents the results of experimental studies of adverse effects of environmental and occupational exposures on the morphofunctional state of the central nervous system in offspring rats. The results of this study show that newborn offspring of rats exposed to vinyl chloride and mercuric chloride lagged behind the controls in sensory-motor development. There was violated the whole structure of behavior in adult offspring characterized by reduces motor and exploratory activity, increased anxiety in rats. There was abnormal impulse conduction in the neuromuscular apparatus of the hind legs of albino rats and morphological changes in the structure of nervous tissue. Developmental disorders in the offspring may be associated with the processes of accumulation, influence on the genetic apparatus of cells or mediated by epigenetic mechanisms of CNS disorders. A comparative study of the behavioral and cognitive effects of toluene, cerebral bioelectrical activity in rats with a normal embryogenesis and background prenatal hypoxia has been found that toluene neurotoxicity are more pronounced in adult rats exposed to chronic prenatal hypoxia. The results suggest a possible decrease in the sensitivity of neurons to the action of neurotoxicants because of prenatal hypoxic damage. The significance of experimental modeling is to develop approaches to personalized medicine, because knowledge of the previous prenatal pathology or neurointoxication of parents allow study of individual measures of prevention, treatment, and decisions about employment of the younger generation.

At the present stage of development of society the problem of quality of life of young people, including young students, as a social group, is quite relevant. Despite the significant discrepancies in the interpretation of the concept of «quality of life», most authors agree that the defining components of this concept are the health status and satisfaction with the individual's own life. In the study of problems of the quality of life of students in the form of the original definition was accepted definition of quality of life as a phenomenon that entails psycho-physiological and physical health of man, his spiritual and cultural values, the level of civilization of a society and its economic development. The article presents the results of the hygienic assessment of students' quality of life, which suggest the applicability of both objective and subjective characteristics of life quality in studies. It is associated with the dynamics of life quality indicators, the changeability of the influencing factors, and the necessity of regular monitoring of life quality indicators and factors supposed to be focal in its formation. Basing on the material obtained in the course of the experimental work, the authors formulate the fundamental principles of the comprehensive approach to the hygienic assessment of quality of life. This concept, in contrast to the WHO concept of quality of life assessment in clinical medicine, based on four principles: multi-dimensionality, the change indicators over time, the active participation of the individual in the assessment of their condition, a comparison of subjective assessments with objective measures.

The paper presents the results of the analysis of the dynamics of the pollutant emissions from stationary sources into the air space in the industrial center. It is established that the dynamics of the emissions of the major air pollutants has a stable tendency to decrease. An exception is the inclusion of black carbon in the atmospheric air; the dynamics of its emission is characterized by the trend to increase. It is shown that the concentration of many metallurgical enterprises in the limited territory creates a high degree of the surface air pollution that induces the increased risk of adverse reflex reactions among the population of the city. Coke production characterized by high constancy of atmospheric emissions during a year makes a stable contribution to the risk of chronic intoxication of the inhabitants of the residential areas adjacent to the sanitary-protection zone of the metallurgical complex.

Nowadays there have been significant changes in the structure and quality of food in the territories of the various regions of the Russian Federation due to the dramatically changed economic and social conditions. Today there is no doubt that the major negative impact on the degree of negative action on the human body is a chronic shortage of micronutrients - vitamins, macro-and micronutrients and other biological compounds. Inadequate use of mineral elements with food in childhood has negative influence on the performance of physical development, promotes for developing of metabolic disturbances and chronic diseases. This is the base to expand the research for investigating of macro-and micronutrients composition of the children diets. Great impact on the health of the population has a natural-caused deficits or surpluses of the elements. First of all it is very importantfor Siberia and the Far East. With the use of modern laboratory studies there were conducted investigations of the content of macro-and micronutrients in the daily diet of organized pre-school children in Irkutsk. According to the analysis of laboratory studies, diets that given to children in Irkutsk in comparison with the diets of the children in Ulan-Ude are characterized by low content of most macro-and micronutrient elements and high levels of mercury (in1.9 time, p < 0,05) and iodine (in 4.0 time, p < 0,05). Comparison with normative values showed that the diet of Irkutsk preschoolers revealed deficiency of calcium, magnesium, iron, cobalt, and excess sodium and silicon. Investigation of the element balance in the pediatric population may have an important influence on the management decisions, could be the base in the activities of the preventive and clinical medicine and public health specialists as well as to serve as a methodological base for carrying out medical and environmental research in other regions of Russia.

Modern society implies a shift of public relations from industrial to post-industrial or information society. In the conditions of post-industrial society the training system unprecedentedly extends, information loading that demands reconsideration of influence of informatization on health of children (as in background (or public), and an educational mode) and development of new hygienic requirements to a mode of educational institutions repeatedly increases. In research, on the example of preschool educational institutions of Irkutsk in the conditions of change of level of informatization of society in the temporary period from 1998 to 2012, changes in physical development and intellectual efficiency of children are revealed. In total 174 children, 96 children in 1998 and 78 children in 2012 aged from 5,5 till 6,5 years of two preschool educational institutions are investigated: 82 children in the 1st preschool institution and 92 children in the 2nd preschool institution. The obtained data testify to increase in anthropometrical indicators of children of the senior group in 2012 in comparison with children visiting preschool educational institutions in 1998. Also in research it is shown that for children of the senior groups of the preschool institutions located in the central region of Irkutsk, gratsilization and detseleration processes aren>t characteristic. However, some distinctions of anthropometrical indicators of children of the studied preschool educational institutions demand additional hygienic studying. Research of intellectual working capacity in Anfilov>s test revealed that the efficiency indicator from 1998 for 2012 statistically significantly didn>t change. Despite it statistically significant increase in quantity of mistakes (from 1,5 to 2,3 times in comparison with 1998) and quantities of the seen lines (from 3,9 to 9,8 times in comparison with 1998) (р < 0,05) is noted that testifies to increase in speed and decrease in quality of information processing of children at the present stage of development of society.

The methodology and methodological approaches to research on mental health in relation to quality of life and data of subjective health status assessment are presented. The research was performed over a period of 2004-2011. Medical social monitoring data were obtained for a total of 3975 people living in the protective actions zones of chemical weapons storage and destruction facilities in three administrative regions. Qualitative assessment of satisfaction with various aspects of life, taking into account the specificity of potentially facilities was performed. Correlations of the quality of life and the self-rating of health with the factors affecting human health are established. Almost half of the population under study (47.1 %) wasfound to require supervision and treatment by specialists in boundary psychiatry and mental medicine. It was found that negative effects of human health are multifactorial, and the contribution of each individual factor in the immediate and delayed the deterioration of somatic and mental health, associated with the quality of life, is quite difficult to quantify.

In article the emphasis is placed on one of the most important elements of the labor potential, characterizing quality of labor human life, - health. Being a basis of a labor potential of the worker, at the same time health is a factor which action is beyond communication of losses of working hours with an incidence. In the conditions of ecology deterioration increases the probability of the torn health of future generations. Many of modern types of diseases, including professional diseases, for a long time bring people out of an able-bodied condition, and quite often result in disability. The technical, organizational, socio-economic and cultural factors influencing indicators of employee's health at the enterprises are considered. Ambiguous nature of influence of these factors is noted.

Reproductive health is an essential part of population health and qualitative characteristics of population reproduction. The purpose of this article is to estimate the most important characteristics of reproductive health in the last years in the socio-hygienic conditions of the Siberian Federal district. As the main indicators of reproductive health are considered the incidence of reproductive sphere of women, the prevalence of abortions, maternal, perinatal, infant mortality, infertility. It is shown that the prevalence of diseases that have emerged in the period of pregnancy and the postnatal period, the Siberian Federal district has steadily been in the top three of disadvantaged territories of Russia. Morbidity of pregnant women in the Siberian Federal district by 2010, above the Russian average: on diseases of blood circulation system - by 22,7 %, diseases of urine-genital sphere - by 13,8 %, violations of generic activity - by 12,8 %. In conditions of reduction of the level of reproductive health found a high level of oncological diseases of the reproductive system of women. Incidence of cancer of the mammary gland is growing. However, in the Siberian Federal district has been positive trend in reducing the number of abortions, maternal, infant and perinatal mortality. So, for the period of 2005-2010 prevalence of abortions has decreased by 20,6 %, the maternal mortality rate decreased from 54,5 in 2000 to 19,1 in 2010, per 100 000 live births. However, in spite of a relatively steady decline in the number of cases of maternal mortality, the difference of this indicatorfor the residents of the towns and villages increases. This unfavorable situation points to the need for greater availability of high-quality obstetric-gynecologic assistance to inhabitants of villages. At the present time it can be assumed violation of long-term dynamics of infant mortality rate due to more intensive inclusion in the procreation of marginalized groups of women (medico-social effect of the measures under the name of «mother's capital»). Thus, already in 2007, increased number of born full term children with a syndrome of intrauterine development, which may be the result of inclusion in the process of the birth of a new, qualitatively different groups of women, which leads to the transformation of the social structure of the parturient women. This has a tremendous impact on the dynamics of all reproductive indicators.

It is emphasized that according to the WHO cancer is one of the leading causes of death in the world. The dynamic evaluation of the primary incidence rate of malignant neoplasms among the inhabitants of Novokuznetsk, Kemerovo Region, Siberian federal district of Russian Federation is given. It is shown that in Novokuznetsk value of an indicator of primary cancer incidence grew from 333,9 cases by 100 thousand population in 2005 to 372,5 cases on 100 thousand population in 2009 (totally for 18,4 %) and exceeds values of similar indicators in Russian Federation and Siberian federal district for 5 %, and indicators in the Kemerovo Region for 12 %. The ratio of the indicators in Novokuznetsk to the data in other territories is presented. It suggests that among designated territorial units the highest incidence of malignant tumors registered in Novokuznetsk. The deficit of health system capacity for inpatient care to cancer patients in the terminal stage of the disease is marked. During the 7-year period of supervision (2005-2011) the availability of hospital beds for the population of the Kemerovo Region was 11 ± 2,5 % lower than in the whole in Siberian federal district. The emphasis is placed on the fact that the deficiency of health care system limits the ability to satisfy the need for hospitalization of patients with a terminal stage of an oncological disease. The need of improvement of approaches to optimization of health system is indicated. The causes of the problems of palliative care for oncological patients are designated, the main ones are: lack of staging of rendering the palliative help, lack of integration of work of health system on ensuring the palliative help, imperfection of information support, etc. The direction for solving the existing problems is shown. Scientific and methodical base in support of its development is determined. The expected results are marked. They are the following: obtaining of reliable indicators about a condition of cancer incidence, development and implementation of improved models of palliative care in conditions of regional subordination of oncological service of Novokuznetsk, improving satisfaction of cancer patients in a terminal stage of cancer.

The results of long standing investigations on studying the features of forming the main indices characterizing the losses of the demographic potential in the contingents of teenagers and young people of Irkutsk Region during 1990-2000^th are presented in this paper. The index of general morbidity among the teenagers was found to increase 2,8 times for the period of this study: the prevalence indices of the endocrine system, the pathology of the urogenital system, the digestion organs as well as the parasitic and infectious diseases were found to increase in the highest degree. Among the girls of 15-17 years old the prevalence index of the inflammatory diseases of the female pelvic organs increased more than 20 times; the disorder frequency of the menstrual cycle - 9,1. In studying the lifestyle in the young people a number of the factors which may exert the negative influence on their health state (the early beginning of sexual life, smoking and alcohol consumption) has been revealed. The structural-quantitative invalidity features among the children and teenagers were revealed: the index of common invalidity increased 1,8 times among the boys and 1,9 times among the girls in the age groups of 10-14 years old; 1,4 times among the boys and 1,3 times among the girls in the age group of 15-17 years old; the indices of common invalidity were found to be higher in the boys than in the girls; the main pathology which may stipulate the invalidization may be associated with the psychical disorders and the behavior disorders, the diseases of the nervous system and the inborn anomalies. The rate of common mortality was found to be higher than the average Russian level among the youths and girls. The main proportion of the irrevocable losses of the teenagers is stipulated by the external causes of death: the mortality rate among the youths and girls was stipulated by such causes as suicides and murders in 78,6 % and 62,2 % of cases in 2010. The analysis of the value - motivation aspects of reproductive behavior among the students has shown that the largest proportion of the students were oriented to forming the families with few children in the future. These factors are characterized by the society states such as anomia which may stipulate the desocialization of the teenagers and young people which may on later form the deviant behavior and the health-destroying lifestyle.

The paper presents the results of retrospective (21-year period) analysis of the mortality of the population of adolescent age (10-19 years) living in Angarsk. Using epidemiological methods the intensity, structure and dynamics of mortality have been estimated and compared with regional, national averages and European indices. As a result, it was found that the mortality rates of boys and young men are 4 times more than the ones of girls. In the dynamic changes in mortality of young men of 15-19 years two marked rises have been seen: in 1992-1997 and in 2000-2003, and its level was lower than the regional average, but higher than Russian mid-level. The difference between the values of the indicator in the Irkutsk region and Angarsk significantly reduced mortality in periods of growth, and the excess above the national averages values in these years has reached 55 %. Structural analysis of the averaged long-term data showed that in the structure of mortality in the city of Angarsk of 10-19 years, 51-74 % are external causes, and even 11-19 % are the symptoms not classified in other headings, which, according to some researchers, are hidden by external causes. The death rate of young men of 15-19 years of different pain-necks severity of the external causes of mortality in general than the one among girls. In the hierarchy of external causes of death the first place is occupied by accidents, excluding traffic accidents - 35 to 46 % of all external causes. Unacceptably large segment of the population mortality of adolescent age are responsible for violent causes and completed suicides. The share of the latter in the structure of the leading class of the external causes of mortality ranges from 18 to 30 % and from 18 to 20 % respectively. Levels of homicide and suicide in general in the Irkutsk region are ten times higher than the ones in wealthy European countries. Ratio of self-murders and killings reaches 1,1: 1,0 at the time, both in Western and Eastern Europe, mortality from violent causes is 5-10 times lower than the rate of suicide.

The objective of this article is to analyse fluorine’s toxic effect on the health of children s population and population in general. Here are summarized the up-to-date data about the influence of natural and anthropogenic fluorine and its compounds on the health of different population groups. The researches conducted in zones of placement of aluminum productions in the Russian Federation, showed that priority specific polluting substances in the exhibited territory are compounds of the fluorine which average annual concentration make in atmospheric air of 6,2-1,4 maximum concentration limits, in the soil of 5,9-11 maximum concentration limits. The coefficient of danger of gaseous fluorine made (QH) = 1,1, risk of pathology of bone and muscular system (IH) = 1,9. It is established that compounds of fluorine get through a placenta, collect in an organism of a fruit and have toxic effect during the post-embryonic period, causing blood supply deterioration, braking of cell fission of a plate of growth of bones, easing of functional activity osteoclasts and osteoblasts, result of that is delay of growth of bones both in length, and thickness. The average levels of fluorine in biosubstrata of children living in industrial centers, above the reference sizes offered in documents of WHO. The analysis of joint action of factors of environment (lack of iodine and fluoric pollution) showed that excess intake of fluorine in an organism is one of the reasons of increase in a thyroid gland at children Thus, regardless of ways of receipt and/or influence conditions, fluorine, getting to a human body, makes toxic impact on the whole complex of bodies and systems, including cardiorespiratory, neuroendocrine, bone and muscular systems. Studying of influence of fluorine and its connections on health of the population is the important task, allowing to plan ways of prevention and correction of negative impact. Analysis of new results of researches allowed to reveal the direction of future explorations.