First stratification scheme of the anorectal dysfunction after low rectum, resection was described and its appliance was shown in 32 cases with "ileoascendocecalneorectum" creation. It was shown that this method, of neorectum, creation allowed, to get good, functional results and high quality of life quality in early postoperative period. Described, stratification, scheme of anorectal dysfunction, was approved, to be good, tool to unify objective clinical information, about patients' anorectal functions after the low rectal surgery.

The article describes the experience of surgical treatment of 391 patient with postoperative ventral hernias with use of different variants of elimination of hernial defects. It is shown that the search of optimum, variant of plastic operation in each case is necessary for elimination, of hernial defects.

The aim. of the study was to determine the rational method, of surgical treatment of chronic pancreatic pseudocysts. The analysis of treatment of 82 patients with, chronic pancreatic pseudocysts cysts is presented, in the article. 68 patients had. punctures and drainage. On the basis of performed research, we found, out that chronic pancreatic pseudocysts of any size and. location developed, on the background, of pancreatitis in the absence of signs of sequestration, were an indication, for puncture and. drainage under ultrasound, guidance. The absence of recovery effect of mini-invasive treatment causes reasonable indications for open surgery.

We performed retrospective analysis of the results of treatment of 386 patients with, acute bleeding ulcers and erosions of upper digestive tract. It was determined, that relapses of bleeding more frequently appear in patients with, acute gastroduodenal ulcers and. erosionss (12,3 %) in comparison with erosive ulcerative esophagitis (9 %), increase the percentage of surgical procedures to 26,9 % and percentage of lethal outcomes — to 42,3 %. The effectiveness of endoscopic hemostasis at vigorous esophageal bleeding and. its relapses in complex with haemostatic, replacement and. antisecretory therapy was 90,9 %, at gastroduodenal bleeding — 88,8 %.

A clinical analysis of 51 patient treated, in surgical ward of Republican. Clinical Hospital named, after N.A. Semashko during the period, of 1993—2011. All patients had. pancreatoduodenal resection for chronic pancreatitis (7) and pancreatic cancer (44). In the nearest postoperative period, mortality was 7,8 %. In the remote postoperative period, terms of survivability in 8 patients with cancer were 18—34 months. One patient lived 10 years.

An. analysis of treatment of 174 patients with acute pancreatonecrosis with use of low-invasive surgical interventions (laparoscopic and puncture-draining surgery) was realized. It is shown that the efficiency of low-invasive surgery for pancreatonecrosis depends on the spread of pathological process. The use of step-by-step approach with use of low-invasive technologies as a start method greatly improves the results of treatment of patients with pancreatonecrosis. For limited forms of pancreatonecrosis low-invasive surgery is the method of choice, and. this surgical approach plays one of the leading roles in improving of treatment outcomes in the population of patients with pancreatonecrosis.

Case histories of patients with complicated forms of diverticular disease of the colon were retrospectively studied. Diverticulum perforation prevailed in the structure of the complications of diverticular disease of the colon. The most common complication was perforation of diverticulum, of sigmoid colon. In the age + group the patients of 50—60 years dominated. Both one-step operations and multi-stage intervention, were used in the surgical treatment of patients with perforations of diverticulum of the colon. The preference was given to surgical interventions with the formation of colostomy.

An. original method of intracardiac sanation of infection nidus with use of the preparation of bacterial proteinases immobilized on polymeric matrix was offered and proved on the resulta of surgical treatment of 226 patients with infectious endocarditis. The results of treatment were analysed and. the effectiveness of the method was proved.

The aim. was to study peculiarities of ischemic and idiopathic dilated cardiomyopathy and. aggregative activity of thrombocytes and. also the response to the therapy by beta-blockers (Atenolol and Bisoprolol). Material and. methods: study of aggregative activity of thrombocytes in patients with ischemic and. idiopathic dilated cardiomyopathy, study of dynamics of aggregative activity of thrombocytes in patients with ischemic and. idiopathic dilated cardiomyopathy under the influence of 3-months therapy by Atenolol and. Bisoprolol. Research of aggregative activity of thrombocytes in patients involved in the research demonstrated reliable increase of speed and. maximum amplitude of thrombocytes aggregation at addition of 0,5 normal solution of ADP and. reliabie decrease of time of reaching of maximum amplitude of aggregation. Comparison of patients with idiopathic and. ischemic dilated cardiomyopathy revealed reliable increase of all the indices of aggregative activity in patients with ischemic dilated cardiomyopathy in comparison with ones with idiopathic form in both groups of therapy. The research shows that patients with dilated cardiomyopathy have an activation of aggregative activity of thrombocytes that is more evident in patients with ischemic form. Prolonged use of Bisoprolol allows to achieve more evident antiaggregative effect of used base therapy in comparison with use of Atenolol.

Chronic liver disease is a serious problem for public health service. As a result of increasing alcoholization of population, drug addiction, number of patients with parenteral hepatitis (B, C, D) the conditions for significant increase of number of patients with hepatocirrhosis appear. The aim. of our study was to determine the most optima! methods of diagnostics of patients with toxic and cirrhotic lesions of liver. The object of the research was 67 patients treated, in Irkutsk Municipal Clinical Hospital N 1 during 2007—2011 years with liver cirrhosis. All the patients had. diagnostic laparoscopy with determination. of the level of cytokines, albumins and. gamma-globulins with further clinicomorphological and. statistical analysis of the results. It was revealed that complex use of instrumental and. laboratory methods allows to diagnose liver cirrhosis at the early stage of its progress very precisely..

We had a purpose to study the change of indices of regional blood flow at the building of defects of shin-bone in patients with chronic traumatic osteomyelitis. The rheographic research was carried out in 47 patients with fractures of shin-bone complicated with generalized, form of chronic osteomyelitis. It was determined, that studied indices — rheographic index and maximum speed of fast blood-fill — allow to estimate process of regeneration. and forming of distraction reclaim in patients with chronic traumatic osteomyelitis at the replacement of shin bone defects. Furthermore the change of these indices can be constitutive at the choose of distraction speed. Obtained results prove dependence of the course of regeneration process on the state of regional blood-flow.

Causes of acute perforations of the small intestine were studied in the survey of 60 patients with postoperative peritonitis. A morphological study of the wall of the small intestine at different terms of peritonitis, mesenteri-cography intraoperative duplex scanning of small and large mesenteric arteries, as well as the interpretation of the major changes in the hemostatic system and humoral parameters in the systemic circulation and the intestinal contents. Found that in the pathogenesis of acute small bowel perforation peritonitis against the leading role of microcirculatory disorders caused by reperfusion syndrome, which occurs in the appearance of the development process and sometimes in the treatment of enteral insufficiency.

The application of single-layer suturing in urgent abdominal surgery is actual and unsettled problem that demands further inquiry. The object of this study was to evaluate the results of application of single-layer suturing in making of intestinal anastomoses in urgent abdominal surgery. 63 cases with urgent abdominal pathology are included, in the study. Forming of anastomose was realized with atraumatic suture material. A continuous suture was used in 41 (65 %) case. A separate knot suture was used, in the case of intestinal wall edema. 5 (7,9 %) complications were registered in postoperative period, which were not connected with the method, of the forming of anastomoses. Lethal outcomes occurred in 4 (6,3 %) cases. There was no anastomosis insufficiency. The usage of continuous suturing in forming of intestinal anastomoses is safe and. doesn't cause increase of number of postoperative complications.

The article show the efficiency of Doppler ultrasonography for the determination of hemodynamic criteria, which determine tactics of treatment of patients with, uncomplicated nephroptosis. Survey design included ultrasonic Doppler ultrasonography of kidneys' vessels in sitting and standing positions. The degree of disorder of hemodynamics in renal artery was determined in orthostasis in comparison with clinostasis. The indications for the operative treatment of uncomplicated nephroptosis were the disorders of hemodynamics in orthostasis more than 30 % in comparison with clinostasis. All operated patients had. laparoscopic nephropexy. Blood flow in renal artery in postoperative period restored in all operated patients with uncomplicated nephroptosis. The research of renal blood flow shows objective idea of the degree of change of hemodynamics in pathologically movable kidney. Patients with uncomplicated nephroptosis and. disorders of hemodynamics in orthostasis more than 30 % need operative treatment for the prevention of the complications of the desease.

Galectin-3 (human Galectin-3 ELISA Bender MedSystems) was researched by the method of immune-enzyme analysis as an oncomarker in blood serum and. swabs of thyroid nodules of the patients with cancer (18) and. non-cancerous diseases of thyroid gland. (26) in the preoperative period. All the patients with thyroid cancer had. galectin-3. Average levels of galectin-3 in patients with thyroid cancer in blood serum. (0,72 ± 0,1 ng/ml) and. swabs from the thyroid, nodules (2,86 ± 0,9 ng/ml) were significantly higher than similar indices at non-cancerous diseases (0,42 ± 0,19 and 0,83 ± 0,2 ng/ml respectively). Obtained results allow to suppose the possibility of determination, of galectin-3 as an additional parameter for the complex differential diagnosis of a highly differentiated thyroid cancer by the method of immune-enzyme analysis.

Treatment of 3 groups of patients with purulent surgical infection was analyzed. In the first group of patients (15) with extensive purulent necrotic wounds hydrosurgical method. (Versajet) was used, that allowed to prepare the wound for autoplasty or to achieve self-epithelization. In the second group of patients (64) with the most common forms of purulent surgical infection at the local treatment electroactivated water solutions (anolyte, catholyte) were used. Their application promoted smooth course of wound process and decrease of terms of treatment. In the third group of patients (16) with vast traumatic area existing during the long time in the regeneration. phase heterogeneous fibrin was locally applied. Activation of granulation process and of islet and. marginal epithelialization was marked.

А rare clinical case of trihobezoar of ileum, in the child of 6 years was characterized. The operation included, laparotomy, partial resection of intestine with, anastomosis. The child, was discharged, from the hospital after recover.

The study of the nearest and remote results of off-pump coronary artery bypass. The nearest results are analyzed, in 2176 patients. Complications in the early postoperative period, were observed in 227 patients (10,4 %). Time of stay of patients after surgery in ICU was 21 (18—32) hour and in the hospital after surgery — 7,1 (5—9) days. 30-day mortality was 0,9 (0,5—1,3) %. Remote results of treatment were studied in 1146 patients (53 % of operated patients). Survival rate of patients during 9 years after surgery was 73 %. Freedom, from cardiovascular events during the same period was 64 %.

The work is based, on the analysis of the results of complex conservative and surgical treatment of 50 patients with infected, forms of pancreatic necrosis, who were treated in surgical wards of Republican, hospital № 2 — Center of Emergency Medical Care of Sakha Republic (Yakutia) during the period of 2008—2011 years. During the research it became possible to adapt and improve the scheme of antibacterial therapy applied in treatment of pancreatogenic infections in a multifield surgical hospital. Carrying out of monitoring of antibacterial resistance and efficiency of antibacterial therapy substantially raised probability of a favorable outcome in treatment of patients with, pancreatogenic infection.

We analyzed the results of treatment of 110 patients who had. cystectomy with, different types of urinary diversion. In the early postoperative period next complications occurred: prolonged intestinal paresis, dynamic ileus, thrombosis of the external iliac artery failure of intestinal anastomosis and the uretero-reservoir anastomosis, lymphocele formation, exacerbation of chronic pyelonephritis. In the late postoperative major complications were: urinary incontinence, stricture of the uretero-reservoir anastomosis, bladder stone formation. Conducted. operational and conservative methods of treatment allowed the arrest caused complications.

We analyzed the results of treatment of 57 patients who had. cystectomy with forming of orthotopic cystoplastte urinary bladder. Cystoplastis was performed by the original method. The approach to the choice of method, for creating orthotopic bladder was complex. Take into account the length of ileum resection, the technique of formation and the shape of the bladder, pre-calculated volume of orthotopic urinary bladder technique was used to create antireflux ureteral-intestinal anastomosis. Such an approach to reduce the risk of postoperative complications and to maintain the high, quality of life for patients.

The results of treatment of 63 patients with tumors of pancreaticoduodenal zone are analyzed. 52 patients had. obstructive jaundice, 47 were older than 50 years. Transcutaneous transhepatic drainage of biliary tracts is preferable as a preoperative method of biliary tracts decompression. Radical operation (pancreaticoduodenal resection) was possible in 10 patients. There were no cases of lethality at this operation. 39 patients had. palliative operations with 1 fatal outcome.

The article reviews the problems of diagnostics and. treatment of myasthenia. The authors consider that thymectomy in modern conditions is founded, expedient and. safe for the patients surgery at the treatment of different forms of myasthenia. Promptly realized thymectomy saves patients from myasthenic crises, decreases gravity of clinical manifestations of generalized myasthenia and intercurrent diseases, improves life quality. The results of surgical treatment of patients by thymectomy are reliably better than of prolonged drug treatment and life interval after thymectomy is reliably longer.

Anatomic and clinical research of duodenojejunal change in norm, and at the chronic duodenal obstruction, of functional character was realized. Peculiarities of motor-evacuation disorders + were revealed with help of X-ray method and peripheral computed, electrogastroenterography. Sizes, variants of forms of duodenojejunal change in norm, and in pathology were determined with, use of endoscopic method.

The article reviews problem, of changes of gastric and esophageal motor activity at the pathologies of gastrointestinal tract. Obtained data allow to estimate value of gastric motor activity in the pathogenesis of such diseases as chronic gastritis, ulcerous disease and. others, to give more definite recommendations for the diagnostics and. treatment of patients with diseases of gastrointestinal tract.

The article proves choice of the method of treatment of patients with esophageal cancer. The authors suppose that combined treatment of esophageal cancer with, preoperative and postoperative radio- and chemotherapy allows to improve remote results of surgical treatment.

The results of treatment of 9 patients with mechanical injury of trachea and of 22 patients with cicatricial stenoses of trachea are presented, in this article. 18 patients had. staged, reconstructive and plastic operations at the cicatricial stenosis, 2 patients had. endoscopic recanalization of tracheal lumen and. 2 patients had. sleeve resection of trachea with, anastomosis. An. original medical complex including argon-plasmatic, cryosurgical and. lymphotropic technologies. In all cases we managed, to recover respiratory tract integrity and. to provide adequate breath through, natural respiratory tract.

The improvement of haemodialysis quality requires longer functioning of vascular access nowadays. We demonstrate that surgical method provides high efficiency of formation and supporting of permanent vascular access for haemodialysis. The application of additional methods (fistulography, duplex Doppler sonography) allows to diagnose the development of complications of vascular access that promotes their successful prophylaxis and correction.

The article reviews the problem of course of postoperative period, in patients operated on account of different kinds of inguinal hernias. Age and. gender of patients, kind of hernioplasty, anatomic peculiarities of inguinal hernias were the factors determining intensity and continuance of postoperative pain syndrome. 239 patients had operations during 2007—2011 years. The pain was evaluated by the subjective 10-points scale on the 1^st and the 3^rd day of postoperative period. Retrospective analysis was used. The aim. of the research was to determine the most significant factors in development of postoperative pain syndrome. Data of retrospective analysis showed that the age of patients is independent prognostic factor that determines pain syndrome in postoperative period at the inguinal hernias, but the gender, anatomic characteristics and surgical technique (not the type of operation) don't influence pain syndrome. Thus the age of patients should be taken into consideration at the prescription of analgetics in postoperative period.

The aim of this study was to evaluate the condition of mineral density of bone tissue at the terminal pulmonary pathology, to determine correlations between lungs functional parameters and. pre-transplantation bone mass. Materials and methods: we realized retrospective analysis of 74 case histories of patients with terminal pulmonary pathology, waiting for lung transplantation. MDBT in lumbar segment of spine (L2—L4) and. femoral neck (FN) was evaluated, with help of double-energy X-ray absorptiometry (Hologic). Function of external respiration was researched, gasometry and 6-minutes walking test were realized, in all the patients. Results: osteopenic syndrome in any zone of interest was registered in 69 % of patients. Normal indices of MDBT both in L2—L4 and. in FN were registered only in 11 % of patients. On our data the indices of T-criterion (both, in L2—L4 and. in FN) had. direct relation with, body weight index (BWI) and. total fatty mass. Direct correlation between MDBT, volume of forced expiration for 1 second. (FEV) (r = 0,49, p < 0,05 in L2—L4 and. r = 0,52, p < 0,05 in FN) and. indirect correlation with, total lungs capacity (TLC) (r = —0,53, p < 0,01) with residual lungs volume (RV) (r = —0,48, p < 0,05) only in FN. We revealed, reliable negative interrelation, of MDBT only with pCO₂ of arterial blood (r = —0,54, p < 0,01 in L2—L4 and r = —0,48, p < 0,05 in FN). There were no reliable correlation between DLCO, 6-minutes walking test and. MDBT both in L2—L4 and. in FN. 11% of patients had. atraumatic fractures of different localization. Conclusion: thus, osteoporosis is sufficiently frequent system, manifestation, in patients with, different terminal pulmonary pathology in pre-transplantation period. Worsening of lungs functional parameters, low BWI and. decrease of total fatty mass can be strong predictors of osteoporosis at the serious respiratory pathology.

The retraspective analysis of blood indices of 524 patients with vanous forms of stæptococcal infections of soft tissues was earned out. 282 of them had erysipelas and. cellulitis, 110 had a purulent cellulitis (erysipelas phlegmoneuse), 321 had necrotizing fasciitis and. myositis. It is established, that at the development of necrotizing fasciitis and. myositis levels of bilirubin rnea intermediate mass molecules increase in blood, activity of alkaline phosphatase increases and the levels of the cm.de protein and albumin decrease. At the development of erysipelas and. cellulitis these indices were within normal values. Therefore these indices can be used for differential diagnostics of deep and. supeficial forms of streptococcal infections of soft tissues.

The results of treatment of 27 patients with confirmed. acute alcoholic pancreatitis are studied. It is shown that application of thioctic acid in a dose of 600 mg in a day allows to localize process and to turn it on an aseptic way.

The article is devoted to the research of indices of microcirculation and coagulation hemostasis after endosurgery treatment of gallstone disease in patients depending on the body weight index. It was established that significant microcirculatory changes are observed in the early postoperative period. These changes are caused by the disorder of active and. passive mechanisms of regulation of blood flow oscillations. The changes were more evident in patients with obesity. It is expedient to realize anticoagulant therapy for the correction of disorders of the hemostasis system and. microcirculation in the postoperative period. The ratio of early prediction of thromboembolitic complications after laparoscopic cholecystectomy was developed on the basis of this.

The detection of the symptoms of endogenous intoxication in patients colorectal cancer patients is a difficult problem and should include not only evaluation of quantitative changes of blood clinical analysis but otheг standard methods. It was shown that adequate preoperative preparation of patients with eespieatory disorders con:ection let us to decrease the risk of perioperative complications in descnbed cases.

991 patient with, pancreatonecrosis was studied, in 2000—2011. 224 (22,6 %) of them. died. Males prevailed among all the patients (72,5 %). Average age was 46,9 yeaκ. 802 (85,3 %) patients had. 1—6 episodes of acute panaeatitis in past histoιγ. 51 (5,1 %) patient had. conseirwative treatment (all of them. died, of enzymatic toxemia. 940 (94,9 %) patients had. different operations, 173 (18,4 %) patients died. 6 patients had. 20—22-minutes intraoperational hypothemia of panaeas residuary tissues after nerectomy. Hypothermia was realized with help of either 20—30 ml of chlomethyl oг pieces of 1 kg of melting ice placed, in 2 thin polyethylene bags, and then it lasted for these patients through bursomentostoma during the firs 7—10 days after the opemtion and on the 12—14^th and 16—18^th days after it.

We observed 42 patients with, confirmed diagnosis of acute pancreatitis. We studied, the dynamics of spontaneous and stimulated. NBT-test and. the myeloperoxidase activity in conjunction, with, traditional clinical and. hardware methods of examination. The benchmarks of oxygen-enzyme systems of neutmphils and their conelation are important. Analysis of these indices makes it possible to predict the seventy of the disease, to determine the optimal timing opemtion and possible complications in the postoperative period.

We examined 1546 patients with, acute pancreatitis. Activity of alkaline phosphatase (АР) of neutrophils was studied in dynamics in 227 patients with, acute pancreatitis. The study was conducted on the 1^st, 3^rd, 5^th, 7—10^th days at the conservative therapy and. on the 1^st, 2^nd, 3^rd, 5^th, 7^th, 10^th and. 12^th days after the operation, and. then — as necessary. Activity of АР of neutrophils in patients with acute pancreatitis regardless of the degree of gravity is reliably increased, and. the more severe disease process is the higher activity of alkaline phosphatase of neutrophils is. IAAN has more diagnostic and. prognostic value. When interpreting the AAN index it is expedient to mark out two values of IAAN from our point of view. The first value is when IAAN is in the range from +1 to 0, it shows that destructive process is unlikely and. the patient needs conservative treatment. The second, value is a negative value of IAAN from 0 to 1. When using these values of IAAN destructive process doesn't cause doubts and. these patients need surgeries.

Clinical and functional results of the "low" resection with foring of "neorectum" by ileoascendocecal complex tmnsposition and reveron were studied, in 32 patients. It was shown that this method, permits to get good functional results and. to prevent "low anterior resection syndrome" development.

Institute of General and Experimental Biology SB RAS, Ulan-Ude Baikal Institute for Nature Management SB RAS, Ulan-Ude Buryat State University, Ulan-Ude Irkutsk State Medical Academy of Continuing Education, Irkutsk Traditional Medical Science Technology and Production Corporation of Mongolia, Ulaanbaatar The effect of multicimponent medicinal preparations of plant origin is considered, with the use of system approach and the influence of their biologically active substances on the regulatory centers of living processes control is discussed.

In the article the analysis of professional disease of workers of Aircraft plant of Ulan-Ude is presented.

In work data about disease of a stomach ulcer in Republic Buryatiya are cited. For preventive maintenance of aggravations it is offered, to use of plant remedies.

In this article psychotropic influence of the new natural remedy "Adaptophyt-15" is discussed. It is established that investigated remedy possesses nootropic and anxiolytic effects which leads experimental animals to faster adaptation to new unfamiliar conditions.

A complex plant remedy developed on the base of the Tibetan recipes was shown to possess anti-inflammatory and immunomodulating activites in experiments on rats. Phytoremedy was also shown to possess an antiexudative activity, to decrease the expression of alteration processes in tissues and. almost not to influence on the proliferative stage of inflammation. Besides, phytoremedy are capable to decrease suppressive effect of azatioprin on indices of cellular and. humoral chains of immune response.

The object of study — complex plant remedy has been developed on the basis of Tibetan medicine recipes. Course preventive introduction of the phytoremedy decreases the formation of products of peroxidation and increases antioxidant capacity. One of the mechanisms underlying hypolipidemic action of phytoremedy is the inhibition of the processes of lipid peroxidation.

In the present study the influence of dry extract derived from Astragalus membranaceus (Fish.) Bunge on the stability to the hemic, hystotoxic and hypercapnic hypoxies at rats was investigated. It was established that the course administration of the remedy under study in the doses of 50 mg/kg of the weight increased the stability at the experimental animals in hypoxies of different genesis.

This paper presents the results of experimental studies of intraoperative sanation of abdominal cavity at diffuse purulent peritonitis (in 25 dogs), compared with the results of readjustment of the abdominal cavity with diffuse purulent peritonitis (74 patients) using the universal domestic antiseptic "anolyte". The results of experimental and clinical studies show that presented method of readjustment of the abdominal cavity can be used in clinical practice.

We carried out comparative analysis of the results of microbiological researches and antibiotic resistance of main pathogens of nosocomial infections from 2005 to 2010 years. During this period quota of MRSE (65—74 %), MRSA (22,7—35 %) is stably high and. especially quota of producers of different β-lactamases among other Enterobacteriaceae pathogens (3,2—65 %) increased that caused, significant expenses for antibiotic therapy by carbapenems (22,7—40 %), glycopeptides (2,7—10 %). Monitoring of tendencies of resistance of the most important pathogens of hospital infections optimication of antimicrobial therapy and introduction, of the system of preventive measures allowed, to decrease economic expenses for antimicrobial means to 17,5 %.

The article on the immunodeficiency model describes the influence of autolysates isolated from yaks spleen on the performance of cellular and. humoral immune response of experimental animals (mice). Neurotropic activity of these funds was estimated. Found, that thymic growth stimulate activity correlates with immunomodulatory and. neurotropic.

70 white rats (Wistar) of both sexes with the initial body weight 160-180g were used in the carried out research. It is defined, that the phytoremedy "Polynoophyt" has antioxidant effect in narcosis of natrium thiopental. It is established, that the phytoremedy "Polynoophyt" inhibits lipid peroxidation and. activates antioxidative system, of body in serum and brain homogenate in narcosis of natrium thiopental.

Our investigation showed that the stress-induced alteration of liver, preceding poisoning and toxic stress, accompanying poisoning and. having lingering character, intensify lesion of organ, leading to considerable injury of its parenchyma and. stroma.

The basic phenolic compounds of components of the adaptogenic remedy Adaptophyte were identified by using thin layer chromatographic method with corresponding mobile phases that allow to confirm presence herb of Polygonum, aviculare L. (hyperoside), leaves black of Bergenia crassifolia (L.) Fritsch. (rutin, gallic acid), inflorescences of Calendula officinalis L. (narcissin), fruits of Punica granatum. L. (gallic acid, gallotannin) in its composition.

Antioxidant activity of adaptogenic remedy Adaptophyte and its components was studied. The most effective antioxidants are the components of Adaptophyte: Bergania crassifolia (L.) Fritsch, Polygonum, aviculare L., Cinnamomum. cassia which inhibit formation МDА in the least concentration (less than 100 mkg/ml). Water-soluble substances of Punica granatum. L., Myristica fragrans Houtt., Rhaponticum. сarthamoides (Willd.), Zingiber officinale Rodcoe, Calendula officinalis L. have average indexes antioxidant activity (IC₅₀ from 100 to 500 mkg/ml). Decoctions from Althaea officinalis L., Piper longum. L., Elettaria cardamomum. Maton., Inula helenium. L., Acorus calamus L. show antioxidant activity in high concentrations.

Experimental researches were realized in 54 rats with. modeling of wound defects of lower extremities. Study of effectiveness of combined. local appIication of miliacyl and. light therapy in complex treatment of festering wounds was realized. in 20 patients and. another 20 patients with similar wounds were included in the control group. Clinical, microbiological, morphofunctionaI and experimental-histological researches proved high efficiency of local appIication of miliacyl and. light therapy in the complex treatment of festering wounds.

The article presents data on the influence of the Poligonum aviculare L. dry extract on the functional state of kidneys of white rats at the nephropathy by bichloride of mercury. It was determined that the extract had. nephroprotective and antioxidative activity.

In the experiment on the model of contaminated wound in rats clinical efficiency of antioxidant preparation. (dim.etilselen.it) is studied. It was determined that local application of dim.etilselen.it improved reparation processes, reduced terms of wounds healing.

In experiments on white rats choleretic activity of l-hydroxy-2,3,5-trimethoxyxanthone and 1-hydroxy-2,3,4,5-tetramethoxyxanthone was determined. Their alliloxy- and. acetoxy-derivatives are more effective that native substances.

It was determined that liquid extract of herbal remedy «Noophyt» had. a sedative effect in unpunishable behaviour conditions. The remedy reliably increases number of exits and duration of stay in open branches of uplifted. X-shaped labyrinth number of transitions and. duration of stay in a light part of dark/light chamber.

In this article the influence of fats containing polyunsaturated fatty acids on bifidobacteria growth was studied.

The article presents the results of experimental study of the biological model of single intragastric introduction of multivitamin set in different doses, which signify the response of the organism in the form of changes in a number of indices of animals condition.

We carried out an experimental research of infusion solution of potassium, and magnesium asparaginate at the single and. repeated introduction to the animals (rabbits). We determined the fact of the demonstration of toxic features of the preparation at single introduction in shock doze (243,5 mg/kg): increase of hepatic enzymes activity and. of some other biochemical indices, decrease of cardiac beat rhythm and. appearance of plural extrasystoles.

The article presents the estimation of structural-functional changes in erythrocytic membranes accompanied with the change of activity of different enzymes that determine normal functioning of erythrocytes. Change of lipid-protein and protein-protein interactions causes the reapportionment of charges on the surface of erythrocytes and. the decrease of total charge of cell and. leads to the increase of aggregation of erythrocytes and. the change of rheological properties of blood. In the end. it reflects on the effectiveness of oxygen transportation, transcapillary diffusion and perfusion of blood in microcirculation channel.

Small pelvis varicosis is a disorder the frequency of which is not yet clear to modern medicine, but its existence is unquestionable. Many problems in women's lives are connected with this pathology, but lack of developed diagnostics and necessary information about the disease make the women of this category dissatisfied with the achieved results of treatment.