We researched the influence of components of metabolic syndrome on the indices of patients' life quality. Patients with abdominal obesity and different combination of components of metabolic syndrome were studied. The assessment of indices of life quality was conducted using MOS SF-36 enquirer. It was found that each component of metabolic syndrome might decrease indices of physical and mental health. In case of long existence of single components of metabolic syndrome the combination of most of them and aggravation of physical activity, emotional state, general and mental health.

At the analysis of neuromyographic indices of patients with central spinal stenosis it was determined that evident decrease of electroneuromyographic parameters corresponds to the clinical manifestations of stenosis, that give an indication offunctional suppression of motoneurons in consequence of metastasis ad nervos. Obtained data allows the clinicians to develop an adequate and pathogenetically proved scheme of treatment of patients with spinal stenosis.

189 preschool age children (3-6 y.o.) of Irkutsk have been surveyed. By means of a centile method all the surveyed children have been divided into three groups according to their physical development (PD): the 1st group - children with harmonious PD, the 2nd group - children with disharmonious PD due to body weight deficiency, the 3rd group - children with disharmonious Pd due to body weight surplus. Results of research revealed PD deterioration, which was expressed in body weight increase in children of 3-6 years of age. Index method PD assessment showed that calculations received with this method do not correspond with groups of harmony of preschool children physical development.

The aim of the study was to investigate the anti-inflammatory effect of minimum dosages of enterosorbent containing carbon and aluminum oxide on the background of standard treatment for patients with chronic heart failure after myocardial infarction. After two weeks of receiving enterosorbent containing carbon and aluminum oxide in patients with CHF (n = 39) showed a reduction in the level of C-reactive protein, as well as marked improvement in microcirculation, which is a manifestation reduce systemic inflammation characteristic of chronic heart failure.

During the analysis of valdoxan (agomelatine) effectiveness in the treatment of depressive disorders (50 patients) clinical predictors of the most complete response to the point of remission are marked. Among patients who completed the study (40 patients), 36 were responders (90 %). The remission was seen in 27 patients of 40. Primary response after 1-2 weeks of therapy was defined as a prognostic factor of remission.

The authors present the result of the research of peripheral blood flow of upper extremity in patients with diaphyseal fractures of forearm bones at transosseous osteosynthesis by external fixation devices of different set. Significant difference between rheographic indices and the set of external fixation device: greater effectiveness of transosseous osteosynthesis by rod external fixation devices with saving of moves in joints interfacing with injured segments was determined.

Goal of the study: to examine histological changes in the mucosa of patients with clinical remission of ulcerative colitis and compare these changes with endoscopic parameters. Methods: 25 patients with clinical remission of ulcerative colitis underwent fibrocolonoscopy with biopsy and histological assessment of disease activity on the Gebos scale. Due to limited number of observations, it was possible to identify comparable study and control groups only for two parameters: increased eosinophil count and increased density of infiltrate in the mucosa. Results of the study: erosions, cryptitis, hyperplasia of lymphoid structures and infiltration of the intestinal mucosa with neutrophilic leukocyte often observed in the presence of increased eosinophil count in the mucosa and/or increased density of the cellular infiltrate. Conclusion: increased eosinophil count and/or increased density of the cellular infiltrate in the mucosa often accompanied by other signs of lack of the mucosa healing. Confirmation of complete remission of the disease requires histological control for exclusion of the inflammation signs.

The status of vitamin D in the population of Irkutsk region has been determined by the contents of 25(OH)D₃ in blood serum of268 people of different age. The highest rates were found in children - 37,78 ± 1,74 ng/ml. In men the level of activity of 25(OH)D₃ was equal to 24,64 ± 2,33 ng/ml, in women up to 70years - 21,22 ± 0,85, older than 70 years -15,13 ± 2,24 ng/ml. The lowest rates are found in children with celiac disease -13,43 ± 2,14. More than 60 % of the population suffer from vitamin D deficiency. Yet wide-scale preventive measures are not possible due to limited range offortified food in the trade network.

There is a large variety of basidiomycetes in the world including xylotrophicfungi which pharmacological properties are scarcely studied. So they are a promising research object for pharmacology, biotechnology, medicine, and veterinary medicine. This paper considers ways to create medicines based on wood-destroying fungi, producing pronounced immune stimulating effect, antimicrobial, antioxidant, antitumor activity.

A study of the antioxidant activity of the in vitro dry extracts DER-1 and DER-2 derived from Rhaponticum uniflorum (L.) DC. It was established that the extracts have pronounced antiradical activity against DPPH-radical binding (IC₅₀ (DER-2) = 2.0 mkg/ml). When studying the effect of the dry extracts a number of reactive oxygen species (O^•-₂, NO) revealed that they exhibit their ability to inactivate. With respect to Of-anion radical extracts show moderate and against NO - expressed antiradical activity (IC₅₀ (DER-2) = 311.0 mkg/ml). We also revealed the presence of moderate Fe²+-chelating activity of the extracts studied. This effect is caused by apparently content of phenolic compounds, phenol carbonic acids, triterpene saponins and tannins.

Therapeutic effect of terpenoidisobornylacetate-containing preparation Antiran on the inflammatory process in paradontium in 56 white outbread rats was researched. Animals of control group wasn't provide the treatment, animals of treatment group had antibiotic dialysis from 1^st till 3^rd day, ultrasound curettage with Antiran solution on the 4^th day, Antiran dialysis in the paradontium tissues for 20 minutes OD from 5^th to 14^th day. Inflammatory process was studied using morphological methods. It was showed that Aniran arrests an inflammation, prevents secondary alteration of tissues, promotes reparative processes and recovery of damaged tissues.

Newborn Wistar and August rats (20 rats in each experimental group) were exposed to acute postnatal hypoxic hypoxia (by the mixture of 95% nitrogen and 5% oxygen). Determination of activity of aminolevulinate synthase (ALA-synthase) in bone marrow and liver were in control group, and on the 1^st and 3^rd days of life (in liver - only on the 3^rd day). Infant rats of various lines differed by the response of an organism to hypoxic exposure that confirms its genetic predetermination. Activities of ALA-synthase in bone marrow and liver were reciprocal both in normal development and after hypoxia. K

Micro-ecological interrelation between intestinal, vaginal and nasopharyngeal biocoenoses as parts of microbiome of a macroorganism was determined by the latest researches. The research included 44 women with inflammatory diseases of genital tract and reproductive disorders and 28 healthy women. Genospecies structure of enterococcus for each biotope (intestinal, vaginal and nasopharyngeal) had original differences with the most full spectrum of species in intestinal biotope. The contract between the groups is evident at the conclusion of the pathogenicity genes tests.

The article presents data on the dynamics of some biochemical indices in blood serum of rabbits (total protein, alanine aminotransferase, ureal, creatinine, total cholesterol, glucose) during phototherapy of local skin thermal injury using "Bioprone", "Rikta", "Azor", OKN-11M, BOP-4 devices in 5-15 days after wounding. Obtained data testifies to the development of the response of an organism in the form of metabolic processes aimed at the maintenance of constant internal environment but expressed less that at vast burns. Course of phototherapy quite effectively but without distinct differentiation by the method of therapy has positive effect on the normalization of biochemical indices of blood serum.

Stress-protective and antioxidant effects of Humulus lupulus dry extract were studied in experiments on white Wistar rats at prolonged emotional stress. It has been established that the H. lupulus dry extract had stress-protective effect, reducing the manifestation of degenerative catabolic changes in the internal organs of white rats in chronic emotional stress. The antistress activity of Humulus lupulus dry extract is caused by the pronounced antioxidant activity. On the background of the test extract introduction the MDA content decreased and the activity of catalase, SOD and the GSH content in the blood increased.

The influence of the dry extract from Serratula centauroides roots on the resistance to the hemic, hystotoxic and hypercapnic hypoxias was investigated in the experiments on white rats. It was established that the course administration of the remedy in the doses of50,100,150 mg/kg increases the resistance of the experimental animals to hypoxias of different genesis. S. centauroides in the dose of 150 mg/kg has the most pronounced antihypoxic activity, increasing the lifespan of the animals with hemic and normobaric hypoxia on average by 60 % (p < 0,001) and and with histotoxic hypoxia - by 50 % (p < 0,001).

Both clinical observation of animals and data of laboratory researches testify to the fact that veterinary medicine Trametin has high prophylactic efficacy at experimental salmonellosis in mice and in on-the-farm conditions in pigs. At the introduction of the medicine in an optimal dose while modelling dark stress we observed an increase in weight gains. The results of laboratory studies showed an increase in the protein content in blood serum, an increase in the content of phosphorus and calcium, an increase in hemoglobin and red blood cells. Phagocytic activity of piglets' blood in the group that received Trametin increased by 25 % in comparison with control values.

The article considers variability of antigen protein E of different tick-borne encephalitis (TBE) strains at the level of physicochemical properties of amino acid residues. The authors evaluated variety of properties of protein amino acids involved in antigen-antibody interaction. 180 variants of TBEVE protein in database NCB1 were detected, differing in physical and chemical properties of amino acid residues. This implies that natural variants of TBEV strains can potentially be detected, that escaped from the immune response induced by standard vaccine.

We studied the natural connections between the amino acid sequences of proteins C, prM, E and NS1 virus strains of tick-borne encephalitis (TBE) and their three phenotypic traits -neuroinvasiveness, thermal stability and thermoresistance. Coupling strength is assessed using measures of competitive sequence similarity of each strain with reference strains. For such purposes subsets of strain sections are chosen amino acid composition specifics of which can predict the value of a phenotypic trait of interest. The possibility to predict missing elements in data both in amino acid composition, and in target properties is demonstrated. The relationships between pairs of phenotypic traits of strains were evaluated.

The molecular-genetic analysis of 13 strains of Western genotype TBEV isolated in Western and Eastern Siberia demonstrated two groups of strains differed geneticallyfrom each other and had a high level of E gene sequences homology within each group. Nevertheless, the heterogeneity of biological propertiesfor some strains within a group was observed.

This paper describes the detection of Piroplasmida DNA in the blood of horses. 166 blood samples of horses from five districts of the Irkutsk region were studied. The high piroplasms infection rate in horses (69 %) was found. For six positive samples nucleotide sequences were determined. The comparison of determined 18S rRNA gene sequences with previously published sequences showed that all revealed piroplasms DNA samples are Theileria equi. The data are presented on the lethal cases of equine piroplasmosis in the Irkutsk region in 2008.

The prevalence of genotypes and alleles of polymorphous locus 681G>A of CYP2C19 gene in Russian population of Eastern Siberia. We conducted comparative analysis of response characteristics with previous data of other world's populations. Genotyping was conducted using PCR method. Statistical processing was performed using «Hardy - Weinberg equilibrium calculator» and STATISTICA 8.0. Significant differences of prevalence of alleles of studied polymorphous locus between researched population and data of other researchers were discovered.

This aim of the study was to research the prevalence of genotypes and alleles of2756A>G polymorphism of gene of methionine synthase (MTR) gene in Russian and Buryat populations of Eastern Siberia. We used DNA blood database of children and teenagers of the Russian and Buryat nationality living in Eastern Siberia. Genotyping was carried out using standard PCR method. Prevalence of minor G-allele in Russian population was 25,7 %, in Buryat population - 13,2 %. We revealed differences in prevalence of genotypes and alleles between studied groups (p = 0,051; p = 0,032).

The article presents the analysis of distribution of alleles and genotypes of AIa16VaI polymorphism (rs4880) of superoxidedismutase 2 (SOD2) gene in Caucasoid teenagers with hypertension (n = 102) and in Caucasoid popuIation sampIing (n = 65), Iiving in the Eastern Siberia. Frequencies of aIIeIes in popuIation sampIing were AIa = 0,492 and VaI = 0,508, of genotypes - AIa/AIa = 0,277; AIa/VaI = 0,431 and VaI/VaI = 0,292. In the group of teenagers with arteriaI hypertension the frequency of aIIeIes was AIa = 0,495 and VaI = 0,505, of genotypes - AIa/AIa = 0,245; AIa/VaI = 0,500 and VaI/VaI = 0,255. There were no significant differences found at the comparison the data.

The article summarizes and analyzes scientific literature data concerning modern ideas about sleep as a key element in formation of cognitive functions in children, encephalographic patterns during the night as markers of intellectual abilities in healthy children are described. Decline in mental abilities of the child should be considered as one of the permanent symptoms in those or other sleep disorders. It is now known that about 90 % of sleep disorders is presented different types of respiratory disorders. Using of modern high-tech methods of sleep research, diagnosis and treatment of sleep disorders will prevent the formation of cognitive impairment and improve the overall intellectual potential of the younger generation.

The article presents the results of scientific fundamental and applies researches of Tatyana Dmitrievna Zyryanova on the problem of study of pelvic bones and coxal cavity fractures complicated and non-complicated with bladder, urethra and rectum injuries. T.D. Zyryanova studied and systematized problems on the statistics of this incapacitating pathology, its clinic and diagnostics. She determined indications for conservative and surgical treatment of certain pelvic bones and pelvic waist injury and an algorithm of rehabilitation measures after the treatment. T.D. Zyryanova and co-authors proposed system of transport immobilization at the injuries of pelvic bones and concomitant injuries of internals of cavity of the lesser pelvis.

The purpose of this work is the development of the connection between a level of geomagnetic activity and a quantity of emergency calls for cardiovascular diseases. To perform the study we analyzed data on the quantity of emergency calls in Irkutsk during 8years period (2001-2004, 2007-2010). In total we analyzed 1460 days, 8942 cases of acute myocardial infarction and 1953 cases of intra-cerebral hemorrhage. There is a significant positive correlation between the number of ambulance calls for acute vascular pathology (myocardial infarction, intracerebral hemorrhage) and the Kp index over all years of study.

This article describes the demographic situation in Irkutsk region for the last 50 years. Special attention is paid to the analysis of changes in population of the Irkutsk region with the concept of demographic waves. We have identified 4 stages on the basis of data analysis on natality and mortality оf population in Irkutsk region and dynamics of population changes since 1960. The first stage covers the period from 1960 to 1978; the second stage - from 1979 to 1989; the third stage - from 1990 to 2000; and the fourth stage - from 2001 to the present time.