The research was conducted among 625 patients aged from 25 to 70years with abdominal obesity (51,2 % women and 48,8 % men). Affective disorders (depressed mood) were revealed in 42,9 % of patients with various metabolic syndrome (MS) components. Affective disorders caused appearance and further advance of MS components, having negative influence on its course. At the increase of duration of existence of separate MS components the depressions were diagnosed more often.

We analyzed 29 fatal cases caused by non-Hodgkin lymphomas in the hospital. 89 % of deceased had advanced malignancy, morphologically aggressive type, 86,2 % had initially unfavorable prognosis for a disease. The most common cause of death was sepsis (55 %). The most often source of infection were pneumonia (68,8 %) and gastrointestinal tract (31,3 %). The frequency of decompensated hemorrhagic shock of patients died of non-Hodgkin lymphomas was 24 %. Tumor lysis syndrome was the cause of hospital mortality of non-Hodgkin lymphomas in 17 % of cases.

A retrospective analysis of clinical status of the recipients of biological prosthesis in mitral position was conducted: group 1 included patients with histologically confirmed calcification, group 11 included patients with normal morphology andfunctioning ofprosthesis. Follow-up depth was 94,5 %, average terms are 8,0 ± 4,4 years, follow-up scope is2792 patient-years. More severe clinical condition and prolonged cardiopulmonary bypass time while conducting primary surgical interventions are specific for the patients of the 1 group. The risk factors of prosthesis calcification are degree of cardiac failure decompensation, duration and traumatizing effect of surgical intervention.

A comparative analysis of depressions with or without somatoform disorders in their structure was conducted. The most significant predictors of formation of internal aspect of the disease for patients of border psych ward are reviewed. The most common types of disease reactions regardless of the intensity of somatization of the depression are determined. Accounting of these data has substantial significance in choosing approaches to psychotherapeutics and rehabilitation of the patients with somatized depression.

The article presents the results of comparative neuropsychological analysis of audio-verbal memory features in first- formers with different learning success: successful in learning or with partial and complex learning disabilities. The differences in the state of functions of memorization, storage, and replication of verbal information in junior schoolchildren depending on the learning successes. Low possibilities of phonemic awareness and processes of audio-verbal information storage affect unfavorably on the acquisition of fundamental school knowledge in children with complex learning disabilities.

Liver is a necessary participant of the metabolism of steroid hormones, so dysfunction of pituitary-gonadal system is possible at viral hepatitis A. We assessed functional state of pituitary-gonadal part of neuroendocrinal regulation system in fertile women with acute hepatitis A and detected changes that can be regarded as compensatory-adaptive shielding of an organism.

Genotype and smoking determined risks of myocardial infarction in patients with ischemic heart disease. Homozygous genotype C (rs16944) of IL1B is associated with myocardial infarction (OR = 3,17 (95% Cl = 0,92-10,89); р < 0,01) and heterozygous carrier state of this allelic gene doesn't increase risks (OR = 1,36 (95% CI = 0,83-2,2); р = 0,01). Smoking 5 times increases risk of myocardial infarction (OR = 5,16 (95% CI = 1,05-25,39); p < 0,05) in homozygotes, and 1,5 times (OR = 1,46 (95% CI = 0,77-2,78); p < 0,05) - in heterozygotes of 511Т/С lL1B. Haplotype СТ (rs1143634 - rs16944) of IL1B is connected with the decrease of risk of myocardial infarction in nonsmoking patients (OR = 0,43 (95% DI = 0,19-0,95); р < 0,01).

The most of studied pathogens of intestinal infections are capable of forming biofilms (Salmonella spp. - 84,2 %; Shigella spp. - 90,0 %; pathogenicE. coli - 75,0 %; opportunistic Enterobacteriaceae isolated from people with intestinal infections -100,0 %, isolated from diseased animals - 83,3 %). More active formation of biofilms in studied microorganisms was detected in conditions of cultivation at 37 °C, in comparison with lower temperatures (24 °C).

The aim of the research was to study the influence of p-thyrozol on the morphology and antioxidant-prooxidant balance in prostate of rats at sulpiride-induced benign prostatic hyperplasia. It was found that introduction of p-thyrozol promoted thwarting progress of pathological process that was proved by less degree of manifestation of proliferative processes in epithelium and of cellular infiltration of stroma. In addition, increase of antioxidant reserve of gland was registered.

The article presents the results of detection of genetic determinants of pathogenicity in 120 Klebsiella strains (Klebsiella pneumoniae, Klebsiella oxytoca) and 48 Staphylococcus aureus strains isolated from the intestinal habitat of infants with intestinal dysbiosis. Registration of the investigated determinants in Klebsiella spp. autostrains DNA, which are non-clinical isolates, indicates the circulation of pathogenicity factors and, consequently, their possible causation in the formation of intestinal dysbiosis in infants.

The problem of viral hepatitis is of huge medical and social importance, but is still far from being resolved. The severity of course and prognosis of development of liver diseases are closely linked to the functional state of oxidant and antioxidant systems of an organism. Based on the research results we found that pregnant women with blood-borne viral hepatitis B and C had significantly higher level of oxidized glutathione and significantly lower level of reduced glutathione in comparison with indices of both healthy pregnant women and the women of control group.

The article presents the results of the research of effect of metal-containing nanocomposites on the content of splenic Band T-lymphocytes of white mice. Phenotypic analysis of the spleen cells suspension was conducted by flow cytometry on BD FACSCanto ™ П. Stimulating effect of these medications on the immune response formation is showed and is proved by the increase of content of B-lymphocytes and T-helper cells and it indicates cooperative interactions between the cells of immune system. It was experimentally showed that the medications 2-N-HTP-Ag, GM-Ag can be recommended for the further research in order to increase protective properties of an organism.

The article presents the results of the research of some indices of lipid peroxidation and antioxidant defense in children of 11-13 years with essential arterial hypertension that were obtained by the methods of spectrophotometry and chemiluminescence. Quantity of products of lipid peroxidation - antioxidant defense in blood serum of patients with essential arterial hypertension significantly exceeds this index in control group. Intensity of the lipid peroxidation processes expressed by the indices of chemiluminescence was higher in patients with essential arterial hypertension than in control group.

The aim of the research was to define anticonvulsive effect of the dry extract from Paeonia anomala L. and comparison with its liquid dosage form. Convulsions in male SVA rats weighing 18-20 g were induced by single dosing of pentylenetetrazol, strychnine nitrate and thiosemicarbazide in a dose of DL_1gg Animals of the trial group had single intragastric introduction of peony extract solution in a dose of 150 mg/kg 1 hour before the introduction of above mentioned medicines. As the result it was found that dry extract of Paeonia anomala L. had evident anticonvulsant effect.

The article presents the results of screening research of influence of sodium alginate with different molecular weight on the development of transplantable tumor in mice and the effectiveness of cytostatic treatment. It was determined that sodium alginates with both high (М = 403 kDa) and low (M = 1-10 kDa and M = 1 kDa) molecular weight suppress growth of Ehrlich ascites carcinoma; using sodium alginate (M = 20-30 kDa) in the scheme of chemotherapy increases effectiveness of treatment. Alginates with low molecular weight arrest development of dissemination of Lewis lung carcinoma and sodium alginates (M = 403 kDa and M = 20-30 kDa) in combination with cyclophosphan increase its antimetastatic effect.

The article presents the data on the influence of Yersinia pestis plasmid profile on subpopulation structure of mononuclear cells of peritoneal fluid of mice at the early stages of infectious process. It was showed that change of cellular composition of peritoneal fluid of the experimental animals depended on the plasmid profile of Yersinia pestis strains. The phase character in the changes of quantitative composition of the mast cells of peritoneal fluid of white mice infected with Y. pestis strains with different plasmid spectrum was determined.

The article presents the research of substrate and prebiotic properties of natural nanopolysaccharides for several species of lactobacilli isolated from vaginal biotope of women, with assessment of their species combinations. Most of typeable lactobacilli species prefer to grow on media containing polysaccharides, mainly in nutrient broth supplemented with galactomannan and carageenan. Using galactomannan increases the frequency of detection, as compared with the isolation from the starting material, twice.

We analyzed antioxidant and antimicrobial activity of aqueous alcoholic extracts from mycothallus and mycelium of Inonotus rheades. It was found that 70% aqueous alcoholic extracts from mycelium of I. rheades had the biggest antioxidant activity. 30% aqueous alcoholic extracts from mycothallus and mycelium have antimicrobial activity against the variety of microorganisms (Salmonella еnteritidis IMVL, Enterococcus faecalis ATSS 29217, Salmonella Ngor IMVL, Streptococcus spp. 44, Staphylococcus aureus ATSS 209p, Escherichia coli ATSS3 5218, Escherichia coli TI). We determined fungistatic activity of 30% aqueous alcoholic extracts of mycelium against Saccharomyces cerevisiae.

In recent years nonalcoholic fatty liver disease transformed from uncommon clinical entity into common ailment along with alcoholic liver disease and viral hepatitis. Increase in the number of patients with nonalcoholic fatty liver disease is registered all over the world. Nevertheless the problem of pathogenesis of nonalcoholic fatty liver disease is still discussable. Oxidative stress is of first importance in the development of hepatitis on the background of hepatic steatosis. Glutathione system is the main defender of cells from oxidative stress that can be used in the formation of new approaches to the treatment of nonalcoholic fatty liver disease.

25-54 % of menopausal women have sleep problems that significantly reduces the quality of life. The aim of the review was to analyze the literature about the hormonal-metabolic profile of menopausal women with sleep disorders. It was shown that brain serotonergic systems are disrupted, melatonin production and activity of free-radical oxidation of lipids are altered in women with insomnia. This may lead to the development of different diseases.

Using polymerase chain reaction 316 strains of E. coli (strains with normal enzymatic activity, strains with weak enzymatic activity and strains with hemolytic activity) were examined for the presence of pathogenicity genes. They were isolatedfrom healthy children and children with functional disorders of the gastro-intestinal tract. The studies have shown that strains of Escherichia coli have pathogenic potential, as evidenced by the presence of genetic pathogenicity markers in them.

The prevalence of genotypes and alleles of polymorphic marker S1 /S2 Apolipoprotein C3 in healthy adolescent Caucasians (Russians) living in Eastern Siberia was studied. Material for research was the DNA extracted from the venous blood; genotype was determined by PCR-RFLP for each sample. In the studied sample in 88.9 % of cases genotype S1/ S1 was detected, genotype S1/S2 was found in 8.6 %, S2/S2 - in 2.5 %. The share of S2 allele was 6.8 %, which is not significantly different from the previously studied Caucasoid populations.

This study was performed to establish prevalence of alleles of polymorphism (-455)G>A of в-chain of fibrinogen gene in Russian and Buryat populations of Eastern Siberia. We used blood database of children and teenagers of Russian and Buryat nationality. Genotyping was carried out by a standard PCR method. Frequency of allele A in Russian population was 28,0 %, in Buryat population - 23,7 %. There were no statistically significant ethnic differences between these samples.

Functions of serial organization of movements and actions and their role in the formation and development of graphomotor skills (writing in particular) in primary school children (193 pupils of 1^st and 3^dgrades) were investigated using traditional neuropsychological and new computerized methods. It allowed to trace the processes of automatization of graphomotor skill in normally developed children and to describe specific difficulties of graphomotor activity in children with learning disabilities.