The impact of industrial aerosols (fluoride, aluminum oxide dust, coal tar distillates, aromatic and heterocyclic compounds) causes development of broncho-pulmonary pathology in professional workers. The aim of the work was to study the basic indicators of the quality of life and degree of influence of broncho-pulmonary pathology on the health status of patients with diagnosed occupational disease of respiratory system. 38 former employees of the basic professions of electrolysis aluminum production were divided into 2 groups. The first group consisted of 22 persons with FEV₁ (forced expiratory volume in 1 second) of 70-80 % of the proper values, the second group included 16 people with fEV¹ of 50-69 % of proper values. On the basis of the results of the COPD assessment test the patients of the first group marked moderate (18 %), strong (36 %) and extremely strong (46 %) impact of the disease on their lives. In the second group strong (37 %) and extremely strong (63 %) impact of the disease on patients' lives was registered. Total index of physical component of health in the first group was 37,3 ± 3,5 points, in the second group - 28,9 ± 2,3 points. The results of total index of mental component of health didn't differ significantly in both groups and were 44,1 ± 3,7 and 42,8 ± 2,8 points respectively. It was found that occupational respiratory diseases had negative influence both on summary mental component of health which characterized vitality, social and role functioning and mental health and also on total physical component of health which characterized physical and role functioning and patients' health. In this case lower values of total physical component of health were revealed in patients with moderate disorders of respiratory function in comparison with examined patients with slight decline in FEV₁. Thus occupational diseases of respiratory system have negative impact on quality of life of patients and especially on their physical status. The degree of negative impact of the disease on patients' quality of life is determined by the severity of the disease. Functional indicators of respiratory function don't always correlate with subjective evaluation of health status by the patient.

The first pregnancy and its outcome have great importance for the subsequent development of the individual as the subject of women of reproductive behavior, family relationships as well as the effectiveness of the professional selfrealization. It is known that personality traits affect the enjoyment by women of reproductive function. The article presents the results of a study to determine the role of age-related factors in the formation of personality traits and mental health of pregnant women with the birth of a child under the present conditions of socialization. The study was conducted in antenatal maternity Tomsk during 2003-2007 years, there have been psychological examination of 102 healthy pregnant women aged 19-37 years who were waiting for their first child. The study was conducted by a continuous method on a voluntary basis. Number of pregnant women under 20 years was 22, of 20-25-year-olds -42 and of 26 year olds and older - 38 women. Average age - 25,4 years, mean duration of pregnancy - 19 weeks. To study the structure and personality traits women test MMPI was used. Emotional relationship of pregnant women to significant persons and situations, partly bypassing the verbal defense mechanisms were examined by Etkind's color relationships. Computer processing and data analysis were performed using standard Microsoft Office programs and applied statistical package Statistica 6.0. The study showed that women in the period of pregnancy were characterized by an invariant state of personal, psychic sphere, which has both age determination and due to previous experience of sex-role behavior. At the same time there are typological differences not only in the structure of personality traits, but also in the features of value orientations and outlook of women, depending on the experience of their socialization as subjects of sexual and reproductive behavior. In particular, older women revealed the presence of a kind of "psychological defense" to explain the reasons for the relatively late birth of their first child. The study results complement the current theoretical understanding of the psychological aspects of female reproductive function, allows us to offer solutions to a number of important scientific and practical and social problems.

In the article the negative medico-demographic and social and economic value of consequences of sexually transmitted infections is indicated that causes their inclusion in the list of socially significant diseases which constitute danger to people around. It is specified that complications of sexually transmitted infections lead to formation of congenital diseases, break reproductive function of younger generation, negatively affect birth rate indicators, worsen a demographic situation, aggravating depopulation processes in Russia and its territorial units. The most significant in this respect is the disease of syphilis. The dynamic assessment of the incidence rate of syphilis in the Russian Federation, the Siberian Federal District and the Kemerovo Region in the period from 2006 to 2011 shows that as a whole across Russia incidence of syphilis in the last 5years has a tendency to decrease, in different degree expressed in the territorial units. Less favorable trends in the dynamics of syphilis in the Kemerovo Region in comparison with the Siberian Federal District and the Russian Federation are revealed. Namely, if during the period from 2006 to 2008, the differences between the indices of the Kemerovo Region and the Siberian Federal District held at the level of 7%; while in 2009 the difference increased to 12%, and in 2011 reached 25% (not in favor of the Kemerovo region). So, in 2011 indicator level in the Kemerovo region was 2.36 times higher than in the Russian Federation as a whole. Taking into account the emphasized medico-demographic importance of sexually transmitted infections and the expressed distinctions in the values of analyzed indicators, it is shown that the Kemerovo Region is the priority territory for the development of measures aimed at reducing the incidence of syphilis in the spectrum of approaches to improve the demographic policy Siberian Federal District.

The article presents data on the effect of pain syndrome in patients with dorsopathies on the quality of their life. Back pain is an actual problem of modern medicine. In 82-95 % of cases back pain is caused by dorsopathies. Chronic dorsopathies restrict patients' capacity for work, reduce quality of life, change minds and behavior. Therefore improvement of the quality of life of patients is an important aim of therapy. We studied the effect of back pain on the quality of life of patients with dorsopathy. To assess the quality of life we used non-specific questionnaire SF-36. This questionnaire allows to estimate "basic condition of the body", "physical functioning", "role functioning", "pain intensity", "social functioning", "emotional state", "life activity" and "mental health". The features of parameters of quality of life depending on the nature of pain in patients with dorsopathy were determined, the relationship between quality of life and the intensity of pain in patients with dorsopathy was showed as the result of the research.

452 miners at the age of40-55years (average age is 50,9 ± 0,2 years) with chronic obstructive pulmonary disease were studied. Chronic pulmonary heart was detected in 289 patients (63,9 %). Using Bayes' method based on the determination of prognostic factors we have elaborated the technique for the prediction of the development of chronic pulmonary heart in miners with chronic obstructive pulmonary disease. The technique is based on the presence of respiratory insufficiency, associated ischemic heart disease and arterial hypertension, blood groups by AB0, MN, and P systems, some structural and functional indicators of heart (a myocardium mass index of aortic ventricle heart, an index of relative thickness of walls of aortic ventricle heart, an index of sphericity of aortic ventricle heart and an average pressure in a pulmonary artery). The use of genetic markers of blood groups by AB0, MN, and P systems allows more detailed estimate genetic predisposition to disease. By increasing the number of analyzed factors influencing the development of chronic pulmonary heart and using of additional markers, we have more accurate prediction of this complication. All figures are reduced in the general prognostic table. The work with the table is the following, it is necessary to sum up all the prognostic coefficients taking into account a sign. At the value of total amount of+6 points or more predisposition to development of chronic pulmonary heart for a worker is more predicted, at the sum less than -6 points we predict the resistance to development of chronic pulmonary heart, at intermediate values the forecast is not defined. The main advantage of the technique is speed and minor material costs. So, while conducting a single assessment of the health of miners with chronic obstructive pulmonary disease in outpatient and polyclinic conditions it is simply to select a group of persons at high risk of developing chronic pulmonary heart for timely preventive actions.

The results of studies of cytokine production in the serum of experimental animals exposed by general vibration and noise of industrial frequency. The aim of the work was comparative research of pro- and anti-inflammatory cytokines in animals under the effect of physical factors. 2 experiments of 4 series of studies within 15, 30, 60 and 120 days were conducted. Intact male albino rats were used as a control group. In all animals serum levels of cytokines IL-1β, IL-10, TNF-a (species-specific diagnostic kits Bender MedSystems (Austria)) were evaluated by ELISA. Mathematical processing of the results was carried out by methods of nonparametric statistics. Experiments on outbred albino rats determined both general patterns and features of the cytokine balance changes depending on the nature of the influence of physical factors in the dynamics of development of disorders in immune system. The decrease of IL-10 level under the influence of vibration is observed in 15 days and the one under the influence of noise is observed in 60 days. The decrease of IL-1β in rats is typical only at the effects of noise in 30 days and doesn't change at the effect of vibration. It was concluded that changes in the contents of cytokines in experimental animals under the effect of general vibration and noise production rate shows different mechanisms basic for the regulation of immune response.

This work is aimed at the determination of the level of molecules of intercellular adhesion of sICAM-1 and sVCAM-1 in the persons exposed to mercury. All the examined persons (88 males of 31-62) were divided into three groups: the persons with the diagnosis of chronic mercury intoxication in the postponed postcontact period (1^st group); the persons with the first revealed diagnosis (2^nd group); the persons without professional disease working under harmful conditions for more than 5 years. Determination of the molecules was conducted using immune-enzymatic analysis method. The levels of sICAM-1 didn't differ in the 1^st and 2^nd groups and came to 466,2 and 430,2 ng/ml respectively, the level of sICAM-1 in the 3^rd group was 219,1 ng/ml. The sVCAM-1 concentration was 337,8,126,8 and 327,4 ng/ml in the 1^st, 2^nd and 3^rd group respectively. Increasing sVCAM-1 levels in the workers with long-term work period indicate the activation of endothelial vessel. Increased levels of sICAM-1 in patients with cardiovascular disease are related to the pathogenesis of cardiovascular disease or chronic mercury intoxication.

The importance of using the method of electroneuromiography examination in the occupational pathological practice was grounded. The peculiarities of the change of index of electroneuromiography examination were analyzed and generalized in the patients with occupation disease of different etiology: caused by the exposure to the local vibration (40 persons), with occupational polyneuropathy of extremity induced by the complex exposure to the local and whole-body vibration and the physical overstrain (30 persons), firefighters with the diagnosis revealed as the consequence of the intoxication with the complex of toxic substances (50 persons), the patients with the diagnosis of chronic mercury intoxication (45 persons). In spite of the numerous number of the parameters which are used in the electroneuromiography examinations we consider the following indices as more important ones for clinical studies in the studied occupational pathologies: the decrease of rate of the impulse conductance in the distal section of the motor component of the middle and elbow nerves in the vibration-induced disease after exposure to the local vibration; along with the rate decrease of the impulse conductance in the distal nerve sections of upper extremities the decrease in the rate impulse conductance in the peripheral nerves in lower extremities was registered in the compressive neuropathy and polyneuropathy after exposure to the complex of the unfavorable production factors; the time period of the residual latency indicating the decrease in the impulse conductance at the level of the ending non-myelinized fibres, in upper and lower extremities for studying the clinically manifested polyneuropathy processes (in examination of the patients with intoxication induced by the complex of toxic substances); the time period of the residual latency and delaying the conductance rate of the impulse in the motor component of the tibial nerve for the latent (subclinical) injuries of the peripheral nerves which were found to be diagnosed in the patients with chronic mercury intoxication.

Physical training and sport encourage the growth and development processes in optimal way The main aim of sport in this period of mass character is children's health promotion. The 3-year prospective investigations of preventive examinations results were conducted in 1210 athletes, engaged in schools of physical culture in Yekaterinburg city. Athletes engaged in mass kinds of sports (football, basketball, volleyball, tennis, gymnastics, ski races, track and field athletics, diving, figure skating, aerobics) were included in the study according to the sickness rate, physical development and morbidity. 58,9 % of childrens have an average height, 71,9 % - body weight corresponding to the height, 76,4 % - lung capacity of average or above the average value, 88,7 % - arm strength of average or above the average value. With the years the rate of athletes with body weight and arm strength of average or below the average value and with average value of lung capacity (р < 0,05) increases. For 3years the sickness rate was increased from 63,0 ± 1,4 to 73,9 ± 1,7 cases for 100 persons. In this structure the leading places are occupied by diseases of musculoskeletal system mainly because of the flat feet and scoliosis (25,8 ± 1,8), diseases of the eye and its appendages and diseases of circulatory system (5,8 ± 0,5) - because of the heart rate. Highest incidence was observed in soccer players and gymnasts. With the increase in the level of morbidity is observed the decrease of the index of health, or the percentage of children who do not have pathological deviations and chronic diseases: from 36,2 ± 2,1 % to 25,3 ± 2,8 % in the third examination. Among involved in gymnastics and football frequency of blood circulation system diseases is higher in comparison with the sportsmen of other kinds of sport. Lower incidence in other skaters and combative sports. Athletes have more self-esteem health than students of secondary schools, as well as a higher level of injury. The results indicate that exercise stimulates the processes of growth and development and promote the formation of their harmonious morphological status, and high self-rated health. However, the pressing tasks are monitoring the nature and mode of sports loadings, conditions of the training process of the trainers and medical staff, attention, medical rehabilitation and correction of the training process to the athletes with disabilities in health. Topical in separate kinds of sport is a high incidence of and complaints of poor health as a consequence of sports overloads.

Authors offer to make changes to technique of the estimation of life quality with three blocks of professional and nonprofessional risk factors: index of observance of requirements of sanitary legislations; index of way of life and index of social well-being. The index of observance of requirements of sanitary legislations pays off by result of an expert estimation of a workplace taking into account aggravating (absence of certification of workplaces, industrial inspection; insufficiency of the area and volume of premises; absence of ventilation, repairs, work and rest modes; neediness of good-quality potable water, sanitary-household premises, first-aid sets of the first medical aid; absence of system of informing of workers about an existing professional risk and ways of its decrease etc.) and normalizing factors (presence of complexes intrareplaceable and after a labor shift medical rehabilitations etc.). The index of way of life is offered to be counted taking into account major individual behavioral and biological factors of risk of death rate and invalidity in Russia: smoking, abusing alcohol, irrational food (in particular, the uses less than 400 g vegetables and fruit in day), insufficient physical activity, raised index of weight of a body, psychoemotional stress, raised levels of cholesterol and glucose in whey of blood, arterial pressure, burdened heredity. The index of social well-being pays off as the one-numerical indicator considering social and economic and socially-psychological factors: indicator of size of wages, indicator of satisfaction health, working conditions, work as a whole, life as a whole, an indicator of the individual importance of factors of psychological overload. Authors of article suggest to add an existing technique of an estimation of an indicator of the individual importance of psychological overload factors with indicators actual in modern industrial conditions: socially-psychological adaptation, degree of emotional burning out, quality of life. The estimation of quality of life can serve in this system to one of the most significant after experience medical and biologic criteria of an estimation of an individual professional risk.

In the paper thefirst results of mass and spectrometer research of snow cover of the largest city in the Far East - Vladivostok (mainland and Island Russky), dropped-out on the November 19 2012, are presented. To exclude secondary pollution by anthropogenous aerosols we used the top layer (5-10 cm) of just dropped-out snow placed in the 3-liter sterile containers. In a couple of hours, when snow in containers thawed, 10 ml of liquid were gained from each sample and were analyzed on a mass spectrometer of high resolution with inductive-connected plasma (MS-ICP) Element XR (Thermo Scientific). Measurements were carried out with use of a technique of TsV3.18.05-2005 Fr.1.31.2005.01714. Tests were selected in 20 points: 16 points - Vladivostok, 3 points - Island Russky (DVFU campus, the bridge, the settlement) and a comparison point - the bay Hero in the southwest of Peter the Great Bay. For the first time application of the most highly sensitive chemical method for an applied ecological task is shown today. Distribution of Pb, Cr, Mn, Fe, Co, Ni, Cu and Zn in areas of Vladivostok different by anthropogenous loading and on Russian Island is revealed. In districts of Vladivostok with high transport loading high contents of metals (Mn, Cu, Zn) which source is motor transport (exhaustgases, autopaint, catalysts) are fixed also. Tests from districts of the Academic Town have traces of influence of the sea coast (halite and potassium-containing minerals) and railroad tracks (a microparticle of iron and its oxides) that strongly pollutes environment iron because of continuous movement of trains. In the tests taken on the Eagle hill, the highest point of Vladivostok, high concentrations of Mn (the highest concentration from all tests) and Cu (the third concentration from all tests) are recorded. This point of selection is in the downtown and, apparently, isn't ecologically clear. It should be noted that height above sea level in an urban environment isn't in sufficient condition for ecological safety. Russian Island is a pure zone with low background contents of heavy metals. The raised maintenance of Cu, Ni and Zn in snow cover of the bay Hero is shown.

Ecology is the historical and evolutionary science that explores the nature of the system over time. Bringing people together and the family as a system is the central subject of social ecology as a science. An ecological approach is a general scientific approach that is driven by research and reflection relations and interactions of organisms and populations and in the special case of human society and the environment. The family is a social phenomenon, which is closely intertwined social and natural without losing its characteristics in the process of interaction, so the social ecology tries to show that well-being is based both on biological and social factors on well. In the historical and evolutionary changes of life of human communities transformation of the socio-economic status and quality of life of the family play a vital role. In the process of social development this transformations are the most significantly manifested in the emergence and resolution of conflicts between the growing needs of family groups and their capabilities to meet the conditions of the existing environment. Many of the vital needs of the individual can be met naturally only under specific roles and functions in the family as the primary basic social unit of society. A clear understanding of what environmental factors are and how to strengthen the family and to increase its resistance to stress, which, on the contrary, give rise to all sorts of dysfunction, reduced levels of well-being, and in the future, the degradation and even disintegration is required. Taking into account the dependence of family life on the implementation it is necessary to plan adequate social policies aimed at overcoming the crisis of the family, improving the quality of life. The development of such measures on the basis of an environmental approach can ensure the formation of a new family policy aimed at the preservation and development of a harmonious family. Currently in Russia there are prerequisites for the implementation of environmental paradigm of family as the foundation of society, because in Russia as a predominantly traditional society, the family suffered less erosion than in the West. Therefore, the family, which has appeared as a result of the crisis of civilization in the midst of all the negative, crisis processes, should be the center of attention of scientists, public figures and politicians, legislative and executive branches. The strategic goal of the state social policy must be seen above all in creating a prosperous financially, spiritually and intellectually well-off family, which should be developed for the sake of the relevant economic, political and social development strategy of the state.

The article presents important medico-ecological problems: preservation of an effect of influence of air pollution in the subsequent generations; environmental and medical consequences of the cumulative ecological danger; taking into account regional features at the harmonization of hygienic standards; use of modern approaches to formation of target preventive programs. Relevance of these problems is observed on the example of Irkutsk region. Irkutsk region is one of the largest advanced industrial subjects of Russian Federation. The leading industries are energy, pulp-and-paper and chemical, wood and woodworking, nonferrous metallurgy, mechanical engineering. Concentration of the industry in the south of the region has led to high man-caused environmental load. Under conditions of reduced ability to self-purification of environmental objects this fact results in formation of zones of ecological trouble. Environmental and medicosocial problems occurring in a long-term technogenic mercury pollution are very important and require more systematic studies. Bratsk water reservoir is strongly polluted by technogenic Hg. Among rural population living near the toxicant sources the signs of unfavorable mercury effects have been revealed: mercury microcirculation in the organism (10,5 % of cases with group level urinary mercury > 5,2 microg/l), disorders of vegetative nervous system (87 % in intact group vs 43 % in the group of comparison; р ≤ 0,05) and pathology of thyroid glands (14,6 % children in intact group vs 8,1 % in the group of comparison; р ≤ 0,05). The aims of ecological medicine must include prevention as well as safe remediation and translational therapeutic intervention in human populations after exposures. The conception of development of the programs aimed at the coordination of activity of preventing ecologically caused losses was proposed.

The aim of the present work was to study genetic risk factors for the development of professional fluorosis in workers of Novokuznetsk aluminum factory, the presence of which is associated with the risk of professional dental fluorosis and resistance to it. The study involved 79 male workers of Novokuznetsk aluminum factory Ltd. "RUSAL" of 35-60 years. The control group (212 people) consisted of healthy individuals working for the same company and without fluorosis. The material for the study were the venous blood samples. Polymorphism of null-alleles of genes encoding transferase phase 2 biotransformation of xenobiotics - GSTT1 and GSTM1 was studied. In this study DNA was isolated by phenolhloroformnym method performing polymerase chain reaction amplification products electrophoresed on agarose gel, and the products were visualized under ultraviolet light. The frequencies of alleles and genotypes in groups of patients and healthy subjects were compared using the χ² test with Yates correction for continuity. The association of different genotypes (or combinations thereof) was estimated by the magnitude of the disease odds ratio (OR). The frequencies of alleles and phenotypes in our sample were studied on an aluminum factory workers and were already comparable to previously published data on Russian Federation and Siberian federal district. Analysis of differences in genotype frequencies between patients with fluorosis and those of the control group using χ² criteria and OR shows that the largest contribution to the risk of developing the disease is making by null-allele of the GSTT1 gene (GSTT1(-)), as well as the "double zero" - a combination of GSTT1(-) and GSTM1(-). On the other hand the holders GSTT1(+)) as well as combinations of genotypes GSTT1(+) / GSTM1(-) are the most resistant to this disease genotype. The obtained data can be used in the formation of risk groups for development of fluorosis, for timely diagnosis and prevention of loss of workers' health.

The aim of this work was to evaluate the adaptive capacity of a technical college student living in an industrial city in Eastern Siberia. The paper presents the results of the assessment offunctionality of the cardiovascular system of students of technical and economic disciplines. In the present study we used physiological research methods, including the assessment of the functional state of the cardiovascular system, taking into account the reactions to physical exercise and evaluation of adaptive capacity with the calculation of the index of functional changes (1F1) by R.M. Baevsky. To assess the level of stress in the regulation of the cardiovascular system determines the type of self-regulation of blood circulation. Average levels of systolic blood pressure inyoung economists somewhat lower (128,3 ± 2,0 mm Hg) than in boys of technical specialties, which is more favorable prognostic sign. Do students and economists across the figure was significantly higher (119,5 ± 1,7 mm Hg; p < 0,05) than that of female students of technical specialties. 1n 27,3 ± 9,3 % of boys and 45,4 ± 15,0 % of girls of technical specialty we observed normotonic response to physical activity (p < 0,05). Among students of economics from the fixed normotonic type of reaction from 40,0 ± 21,9 % of boys and 50,0 ± 8,5 % of girls. Hypertensive type of response was found in 68,2 ± 9,4 % of boys and 45,4 ± 15,0 % of girls technical specialty (p < 0,05). 1n addition in 4,5 ± 4,3 % of surveyed youths and 9,1 ± 8,4 % of girls of the same type of specialty marked dystonic reactions to physical activity, which, as a hypertensive, is unfavorable. Among students of economics from hypertensive type of response was found in 60,0 ± 21,9 % of boys and 42,3 ± 8,4 % of girls. Dystonic reaction to physical activity only found in girls (7,7 ± 5,1 %). 1t was revealed that 63,9 % of students had reduced functionality of the functional voltage detected in 79,0 % of boys and 48,8 % girls among all the surveyed students. 1n male students of technical specialties functional stress occurred 2,4 times more often than in female students, in those of economic specialization -1,5 times more often than in girls. The girls who are enrolled in the economic stream functional stress occurred 1,6 times more often in comparison with girls of technological flow. The results show a decrease in adaptive capacity in a cohort of students.

The article presents the results of the environmental and hygienic assessment of the prevalence of diseases of the circulatory system in the adult population in the Primorsky Kray. The analysis was conducted on the incidence of Form 12 for the period of 1991-2011. To characterize the habitat 8 sanitation (according to the Form 18 provided by Center of Hygiene and Epidemiology in the Primorsky Kray) and 7 climatic factors of the modular that were formalized in a 5-point scale based on the developed normalized rating scale were taken. Each module consisted of a factor of 3 to 10 parameters of the environment. To establish the connection between environmental factors and the level of circulatory diseases we used regression analysis of the statistical package SSP. It was revealed that for the last 6 years for the first time the disease circulatory system in the adult population began to occupy first place in the structure of the entire morbidity and reached 43-49 %. Ranging of the administrative territories of Primorsky Kray as habitat and morbidity. With the use of Pearson (χ²) and regression analysis the patterns of environmental factors impacting on the level of cardiovascular diseases were determined. The prevalence of cardiovascular diseases in the adult population of the region depends on the bioclimatic zones, the degree of environmental stress of the situation and factors of the environment. The prevalence of cardiovascular diseases in adults as the organism's response to the impact of the environment influenced primarily hygienic parameters: the level of pollution of the atmospheric air, characterization of chemical pollution and adverse physical factors in urban and rural areas, transport load as well as the level of diseases of the circulatory system has a strong connection with climatic parameters: the number of days with BASR, latitude, speed of air movement.

According to the unified program with use of a questionnaire of MOS SF-36 quality of life and medico-social features of teenagers of 14-17 years in 5 regions of Russian Federation (Moscow, Omsk Region, Smolensk, Sankt-Petersburg, Pskov) studying in the senior classes and establishments of professional education (colleges, technical schools) were studied. The database containing results of poll more than 1200 people is created. Average sizes of indicators on 8 parameters of quality of the life, characterizing physical and mental components of health of teenagers are obtained. Rather high rates of physical health and rather lowered indicators characterizing mental health of the Russian teenagers attract attention. According to average data girls had indicators of quality of life authentically below, than the young men had. Medico-social features of modern teenagers are studied. According to the questioning a third of teenagers had chronic pathology, every fourth teenager can be carried to the often ill. In structure of repeating complaints the first place was taken by the complaints connected with system of digestion, complaints to irritability, weakness, headaches, a back and heart pains further followed. Prevalence of stereotypes of the behavior interfaced to risk of deterioration of health is shown: deficiency of a dream (two thirds of respondents), insufficient physical activity (44 %), tobacco smoking (32,6 %), the frequent use of alcoholic beverages (17,5 %), diet violations (up to 70 % of respondents). Work can be carried to risk factors in free time from study in which nearly 40 % of teenagers are engaged because the majority doesn't make out the labor relations and works informally. Efficiency of use of indicators of quality of life for an assessment of influence social (quality of a food) and educational risk factors (training in profile classes of school and professional colleges is shown at not created professional selfdetermination). Average sizes of indicators of quality of life of the teenagers, based on a representative material, can be used as standard sizes at an assessment of the results received in selective groups. Medico-social features of the Russian teenagers confirm high relevance of development and deployment of preventive programs for decrease in risks to health of persons of the teenage age caused by high prevalence of negative stereotypes of a way of life.

The article presents the results of the evaluation of life quality of teachers of industrial Kuzbass city using SF-36 questionnaire, an application form and conversation. The share of the surveyed teachers up to 30 years is 20 %, up to 40 years -13,3 %, the rest of the teachers are older than 40 years. A low level of life quality of the teachers due to the decrease of their role and social reaction, vital activity, psycho-emotional tonus is revealed. The majority of the surveyed teachers complain of headache, backache, pain in the joints of the lower extremities and numbness of the hands. The level of motor activity of the surveyed subjects according to the questionnaire survey and conversation is low. The level of psycho-emotional tension is high. One-third of surveyed teachers notes strong mental problems in the form of emotional instability, depressive and anxiety manifestations. The level of mental health is low, it is manifested through the presence of depressive and anxious feelings, mental and emotional problems, irritability, unstable moods. There is a big difference between good physical health of the surveyed teachers and their poor psycho-emotional condition. The publications devoted to the problems of teachers' health report about the decrease of level of teachers health in process of increase in an experience of years of pedagogical activity. This article reveals the weak correlations between the age of teachers, their work experience and integral indicators of health (physical and mental components), it is contrary to the directions on the dependence of the intensity of psycho-emotional disorders teachers on their age and length of teaching experience. A strong direct correlation between the index of psychological well-being and social indicators of functioning (r = 0,68), role emotional functioning (r = 0,76), the frequency of headaches (r = 0,47) and the subjective evaluation of health status (r = 0,42) is found. This suggests a prevalence of psycho-emotional disorders in surveyed teachers while the preservation of their physical health, which manifest themselves regardless of the age of the surveyed teachers and length of teaching experience.

Human health potential and regular lifestyle are the things that are fostered during childhood. Family and educational ambience make a significant contribution into the general state of wealth and welfare of our children, the ambience is considered as the main resource of the health and healthy lifestyle creation. A survey was conducted; the goal of the survey was to study the incidence of behavioral risk factors and the role of domestic and school factors in forming of the general education school students' lifestyle. Group of interest: 57 general education schools, 5960 7-11® grade pupils, 912 parents and 240 teachers from Yekaterinburg. Amongst the students the high incidence of behavioral risk factors takes place: disturbed daily regimen (16,6-40,4 % considering certain aspects), low physical activity (70,1 %), alcohol (43,4 %) and tobacco (21,5 %) consumption, insufficient preventive activity. With equally high level of self-assessment of the hygienic knowledge amongst the students of a different age, a lower lifestyle self-assessment and a higher risk factors frequency in regard to the 11^th grade pupils' lifestyle were registered. Teenage familiarization with the alcohol and tobacco is associated with a complex of factors characterizing students' personality traits, their school and home life organization. These factors are: low school progress; low motivationfor studying, social life and artistic activity; early labor activity; alcohol and tobacco-friendly family; lack of trust relationship, organization of child's life and behavioral and leisure activities control inside the family. More than half of the schools have certain defects in their health-improving activities, which are often connected with the insufficient level of preventive care-related education of teachers, poor physical training organization of students, lacking clear health promotion assistance policy for students at school, lacking external relations in the area of preventive care. The incidence of behavioral risk factors is associated with such school activity parts as teachers' preventive activity, interaction between school and parents, availability of a school health education system.

This study aimed to reveal air pollution and its influence on pathology of upper respiratory tract in teenagers of Angarsk and Sayansk. The quantitative content of chemical substances in the atmospheric air of the celitebic territory of Angarsk and Sayansk was studied based on the data of the hydro-meteorological center, the content of chemical substances in indoor air was assessed based on studying of the educational institutions. Two territories with a different pollution level were chosen to investigate in Angarsk. The higher summary risk of forming the respiratory organ pathology stipulated by the indoor air pollution and the atmospheric air with the tropic substances to the systems indicated was revealed to be in the schoolchildren in Angarsk. The studies performed in the educational school rooms have shown that on the whole the largest pollution degree was induced by the suspended substances. In the educational school rooms studied in Angarsk the increase in the hygienic normative on suspended substances was found to be in the educational classes in 43 % of samples, in the computer classes and in the sporting halls - in 44 % of samples. Sometimes the increase in the limited allowed concentration (LAC) was more than 2 times. The increase in the LAC of formaldehyde was observed to be in 13 % of samples in the educational classes. In the incidence structure according to applying for medical assistance the respiratory organ diseases were found to occupy the first place, at the same time the pathology of the upper respiratory ways prevailed in both towns. The chronic glandular and adenoid diseases as well as the allergic rhinitis were more often revealed. In comparison of the regions in Angarsk which are different in the pollution levels, it was found that the chronic pathology of the upper respiratory ways occurred 1,4 times more often in first region than in second one and 2,8 times more often than in Sayansk.

Development of technical progress causes increasing anthropogenic pressure that adversely affect human health. The most important environmental factor is the quality of atmospheric air. Children and adolescents are the most sensitive group to the effects of environmental factors. The aim of the study was to examine the performance of hemogram and cytokine status of healthy adolescents living in the industrial cities of Irkutsk region with different levels of technogenic pressure. The healthy adolescents of 14-17 years were examined. Group 1 consisted of teenagers, who are living in the city with high level of air pollution (Angarsk). The control group (group 11) consisted of adolescents from the city with medium level of pollution (Sayansk). Hemogram parameters, the content ofinterleukins-2 and -10, alpha- and gamma-interferon in serum were studied. Statistical processing of the results was performed by nonparametric tests using the software package Statistica 6.0. Differences were considered statistically significant at p < 0,05. An analysis of the performance of hemogram revealed that the number of teenagers from Angarsk stab neutrophils and basophils was significantly lower than in the peer group of Sayansk. The level of hemoglobin and erythrocyte sedimentation rate of teenagers from the group 1 were lower than in the comparison group. Average levels of interleukins-2 and -10 in serum in a group of schoolchildren from Angarsk exceeded those of the surveyed Sayansk. Despite the absence of between-group differences in the content of alpha- and gamma-interferon, the proportion of people with high levels of gamma-interferon in the group 1 was higher and amounted to 36,36 %. 1n this case average group values of all the studied parameters were within the reference levels. 1n general changes were determined for indicators of hemogram and cytokine status in healthy adolescents living in the town with high level of air pollution: specifically higher amount of granulocytic white blood cells and lower levels ofinterleukins-2 and -10. These changes may reflect the response of healthy adolescents to air pollution by chemical pollutants and indicate sensitivity to antigenic exposure and preparednessfor response to it.

This study aimed to reveal the health disorder peculiarities in the employees of the modern production ofepichlorohydrin (EPCH) based on using the automatized system of the quantitative risk assessment of the main common pathological syndromes (RMCPS) and the results of medical examinations performed in dynamics. The working conditions of the employees working at the production of epichlorohydrin are characterized by a complex of the unfavorable production factors among which the employees exposure to epichlorohydrin (EPCH) end allyl chloride (AC), the substances of class 2 of danger, is known to have the main hygienic importance. At present the category of occupational risk in chemical factor is considered as low and middle, this is stipulated by the significant decrease in the concentrations of harmful substances in the air of the working zone (EPCH-up to 0.5 LAC, AC - up to 0,3 LAC). It was found that in the structure of RMCPS the risks of the functional disorders of the cardio-vascular system, the portion of which was significantly found to increase (from 17,7 to 27,2 % respectively) in dynamics, were revealed as the higher percent in the employees examined in both the first and the second study periods. The risk prevalence features have been revealed in the persons of the main occupations. So, the statistically significant increase in the risk cases of the neurological and border psychical disorders, the functional disorders of the cardio-vascular and endocrine systems was observed to be in the fitters-repairers, unlike the operators of mechanical devices, by the second study period. In dynamics of medical examinations the increase in the incidence levels relatively to the diseases of the circulatory system was noted to occur in all the occupational groups including the portion of the persons who had often ill feeling. The most statistically significant levels of the incidence including the diseases of the circulatory system as well as the nervous system and the psychical disorders were found to be in the occupational group of the fitters-repairers. The occupational risk assessment taking into account the occupation and the exposure toxic load with allyl chloride and epichlorohydrin has shown that in the both study periods the largest exposure load to the toxicants was revealed in the fitters-repairers, thereby, this load was statistically significant higher in the fitters and engineering staff compared to the operators of mechanical devices in both the first and the second examination periods. The statistically significant increase in the health disorder risks was revealed in these employees in dependence on the values of the exposition load with the toxicants. Studying the health state in the employees taking into account the exposition toxic loads has allowed to correlate the organism changes revealed to the cumulative exposure to the chemical pollutants as well as to ground the need of using this index to reveal the production - stipulated and occupational diseases.

The study of the spectral characteristics of noise levels in the workers of main departments of the enterprises of aluminium and thermal power industries had shown that equivalent sound levels in electrolysis shops at the workplaces of those engaged in electrolysis and anodic production exceeded permissible indicators on 7,1 and 11,8 dBA; in boiler shops of a thermal power station at the workplaces of boiler machinists, machinists-inspectors of boiler equipment and mill machinists the excess in permissible indicators was 22,2 dBA, 21,4 dBA and 29,3 dBA accordingly. It was established that noise in boiler and turbine shops of a thermal power station was broadband and exceeded maximum permissible values in all parts of a spectrum. In the turbine shops of a thermal power station noise levels more often exceeded maximum permissible levels in low- and high-frequency parts of a spectrum.

The aim of the research was to give an assessment of quality of environment and ensuring sanitary and epidemiologic wellbeing of the population of Shelekhov region. The research was conducted with use of data of municipal information fund of social-hygienic monitoring of Territorial Department of Administration of Rospotrebnadzor of Shelekhov, Shelekhov and Slyudanka regions during 2007-2011. Complex assessment of pollution of atmospheric air in ground layer was conducted by Ktotal index and Hazard index (HI). Upon the results of laboratory researches the assessment of pollution of soils in residential area of the city. Data of control of contents of fluorine, zinc, cadmium, lead and copper is used, total hazard is estimated with use of Ksoil index. The analysis of morbidity was conducted on the data of report form N 12. As the result of insufficient measures on the sanitary protection of water-supply sources low effectiveness of water-treatment the large part of drinking water samples that didn't meet the hygienic requirements was found: 2,5-3,7 % - based on the sanitary-chemical indices and about 3 % - based on the indices of microbiological safety. It was found that 100 % of soil samples didn't correspond to the claims of hygienic normative in fluorine contents. The territory of the city is characterized by the high level of air pollution with harmful admixtures of anthropogenic nature. The dust with silicon oxides and gaseous compounds of fluoride, benz(a)pyrene, sulfur dioxide, manganese, nitrogen oxides, carbonic oxide, formaldehyde were found to be priority chemical substances which may pollute atmospheric air. Respiratory organs, blood, eyes, immune and nervous systems were found to be the most loaded with the non-cancerogenic risk that may conform with actual data on the children's morbidity rate. During the period of 2003-2011 the morbidity rate of respiratory organs, blood, eyes as well as nervous systems was found to be higher in the children in Shelekhov than the average one in Irkutsk region. Thus the main role of formation of unfavorable environmental situation in Shelekhov was found to be associated with the pollution by hydrogen fluoride as well as by benz(a)pyrene. The environmental pollution and other unfavorable factors may significantly deteriorate the state of population health of the city.

The aim of study was a hygienic assessment on sanitary and chemical, microbiological indicators of food and the food staples, realized in the territory of the Buryat Republic during 2008-2012. Preparation for processing of primary data and the subsequent statistical analysis made with Excel and the integrated package STATISTICA 6.0. Calculation of percent of tests of hygienic standards not conforming to requirements (%) on areas and as a whole on the republic is carried out. The specified sizes are determined as for separate years, and on the average for the period. To average values 95% confidential intervals (CI) are calculated. As significant deviations from the average levels the sizes which are going out of CI were considered. The performed result of assessment of the laboratory studies may testify that the stable high percent of the samples which don't accord to the normative in the sanitary-chemical indices is available at present. Using the cluster analyses allowed to reveal that according to the sanitary-chemical indices 52,4 % of all the regions in which the portion of the non-standard samples was found to be in the range of 95% confidence interval (CI) [6,5-9,0] % of the average level have formed the more numerous (1st) cluster. The second cluster consisted of the Zaigrayevskiy and Bichurskiy regions in which the statistically significant increase in the prevalence of the non-standard samples was revealed. In 5 regions and the capital of Republic (Ulan-Ude) in the third cluster the most significant percent of the samples which don't accord to the hygienic claims (CI [15,0-29,0] %) is continuously registered. The fourth cluster consisted of three regions situated in the northern part of Buryat Republic in which the non-standard samples are extremely rare revealed (CI [0,5-2,2] %). The samples portion which don't accord to the hygienic normative in the microbiological indices was found to increase by 1,4-fold compared to the 2009-2011 years and amounted 3,8 % in 2012 year. The analysis based on the territorial factor has shown that the high levels of the non-standard samples of the food products in the microbiological indices were found to be in the regions of the first cluster: Eravninskiy, Mukhorshibirskiy, Kabanskiy and Ulan-Ude (CI [5,1-7,8] %), the last revealed level is the regions of the third cluster: Zakamenskiy, Bichurskiy, Barguzinskiy, Kurumkanskiy, Okinskiy, Bauntovskiy (CI [0,10-0,24] %). The control of microbiological safety allowed to reveal the most significant, in epidemic relation, food products: milk, meat, fish products, the products of children's food as well as the poultry products.

Risk factors during the school period are continuous, systematic and long. Even the most minimum influences have their ability to be accumulate and are accompanied by violations of somatic, mental, physical and reproductive health. Change of system of school education increases influence of school factors on a state of health of pupils, and informatization and intensification of educational process are accompanied by decrease in level of health and physical development of children. The problem of health became the most actual now when transition from the mass unified education to differentiated education is carried out, thus training programs are extensive and correspond to age, physical and mental "forces" of the pupil a little. In research of influence of level of an intensification of education on physical development of children of an initial step of training studying of the main anthropometrical indicators (body length, weight, a thorax circle) children of 1-3rd classes of innovative and traditional schools of Irkutsk was carried out. In researches children, having low and moderate levels of stigmatization, risk factors in ontogenesis, biological and social anamneses took part. 465 children in total are investigated: in traditional school 72 children of 7-8 years and 69 children of 8-9 years, in innovative school 113 children of 7-8 years and 211 children of 8-9 years. It is shown that children starting training in innovative school differ from children of traditional school by higher rates of physical development. Against the raised academic load in children of innovative school some decrease of growth and weight indicators is observed and up to age of 8-9 years these indicators are compared to indicators of children of traditional school that testifies that the intensification of school training makes an adverse effect on indicators of physical development of children and demands further studying and hygienic rationing.

The article is devoted to development of modern telemetric methods for an on-line evaluation of functional status of vehicle drivers during their work. The study of occupational load effect on cardiovascular system was performed with the use of mobile devices included portable sensors and storage device to collect information (smartphone). The developed computer programs were used to calculate spectral indices of heart rhythm variability (HRV). A high self-descriptiveness of wavelet transform for identification offunctional status of cardiovascular system was shown. The reduction of HRV, increase of sympathetic component in regulation and increase of vegetative balance index were observed in drivers by fatigue. The intensity of HRV changes met with occupational load level and characterized degree of individual response as well as allowed to detect exposure induced the stress. A wireless cardiorhythmography is a perspective method for creating personal monitoring system for increasing quality of the drivers' life andfor their health preservation.

We conducted the research for detection of premorbid medico-social and personal features of related teenagers, using and not using psychoactive agents. Comparative analysis of 90 teenagers with drug addiction and their 90 healthy relatives (control group) was realized. Research was conducted by the method of anonymous questioning with use of specially developed questionnaire consisting of 88 questions, and also psychological methods -16 personal factors Kettell test, SMIL, and Zung depression test. Dispersive analysis was used to determine factors of medico-social character which can be considered informative for diagnostics of addiction deviations. Method of experimental psychology allowed to reveal individual and psychological features of teenagers leading to formation of addictive behavior. Teenagers suffering from drug addiction are much less socially successful than their healthy relatives. As compared to their healthy relatives, drug addicts' anamneses had more medico-social and premorbid factors of addictive risk: various neurotic episodes during childhood, craniocereberal traumas. They were exposed to actions of sexual violence more often. Their typical characteristics include tendency to internal aggression, parasuicide thoughts, suicide attempts and a paracriminal circle of contacts. Results of research at this stage gave the grounds to assume that under identical family conditions of education some teenagers are getting drug addiction, while others don't. This can be explained by the existence of individual and personal features which can already be induced by factors outside of the family. Experimental and psychological method revealed the individual and psychological features of teenagers promoting formation of dependent behavior. Unlike their healthy relatives teenage addicts have peculiar features such as aggressive tendencies, explosive nature of reaction, uneasiness and nervousness reflecting a condition of the extreme stress, hyper compensatory involvement of various protective mechanisms, hyperactivity in their search of an exit to their difficult situation, lower background of mood and narrow zone of contacts. Thus, in comparison with healthy relatives, anamnesis of teenagers addicts more often contain medico-social, behavioral and premorbid predictors of addictive behavior, and a number of specific features. All this needs to be considered while setting up individual programs of rehabilitation, and during development of primary prevention programs of psychoactive substances use in the youth environment.

The work presents modern demographic situation in Russian Federation. Statistical data on Russia and Siberian federal district are presented. The analysis of reproductive installations of young women in certain territories of Siberia was conducted. Some factors defining a demographic situation are considered in details: quantitative index of birth rate, increase of abortions number, social installation on late childbirth. In society in the period of an economic crisis such motives of interruption of pregnancy as work loss, decrease in level of the income, development of feeling of social vulnerability, were created and became main. There was even a new social group of women - those who does abortion because can't pay off on the bank credits. It is remarkable that men insist on the decision to make abortion in the conditions of economic instability. The tendency to change of values at young girls is noted: once all preferred family values, motherhood leave on minor positions, the modern generation valuable has career growth and professional realization. The provided data of researches in the Altai territory reflects discrepancy of desirable and possible number of children in families. In the majority of the woman who gave birth to less children, than it would be desirable. Economic difficulties and state of health are the factors that seriously complicate the birth not only of the second, but also of the first child in women living on the territory of Kemerovo region. Respondents in the Irkutsk region note that stable financial position and the resolved housing question can serve as incentive for the birth of the second child in a family. During the work following conclusions were made: the tendency to a the families with small number of children is observed; extra family values - the professional growth, material well-being, - come to the forefront; the increase in number of abortions both among young women and among teenage girls is noted; the tendency to the birth of the child at "late" reproductive age is described.

The intensification of production processes in coal, mining, metallurgical industry of Kazakhstan fundamentally changes not only working conditions, but also leads to the formation of unfavorable environmental conditions. The purpose of research scientific consortium of four Republican research centers was the control of the population health living in the areas of anthropogenic pollution, based on the analysis of environmental risks. The objects of study were the urbanized areas and the population of the Republic from a regional perspective on the priority industry sectors: energetics (Ekibastuz, Solnechnyi), uranium mining and the chemical industry (Taraz, Sozak, Sholakkorgan), non-ferrous metallurgy (Ust-Kamenogorsk, Glubokoe), oil extraction and processing (Aktau, Zhanaozen), ferrous metallurgy (Temirtau). Control was Schuchinsk and Burabai located on the territory of national park. The number of the surveyed population was up to 10-20 % of the total population, a retrospective of diseases included analysis of the previous 5 years. As a result were identified weather types and factors that aggravate environmental pollution (adverse type in both seasons of the year for the major territories), calculated levels of emission loads ("high degree" for the regions with ferrous and nonferrous metallurgy, coal and power industry) highlighted areas with a high environmental risk population living (Temirtau, Ust-Kamenogorsk, Glubokoe). When using the original software for the data visualization were created 156 maps of environmental contamination, placed in the public domain on the Center's website www.ncgtpz.kz. Among the non-medical determinants health status was affected by poor quality of life, the high prevalence of adverse behavioral risk factors (smoking, alcohol abuse, improper feeding, low physical activity, liability to stress). Established the effect of pollution priority factors on the health and quality of life in children and adults. Usage of administrative measures designed to protect the public, for the correction and rehabilitation of Health departments, Sanitary Inspection, local governments will reduce the environmental pressure on urban areas.

To our mind, the population alcoholization is the one of the major medical-social problems in Irkutsk region. According to official statistics it is established that in recent years the average index of incidence with diagnosis of an alcoholism and alcoholic psychosis established for the first time as a whole was higher in Irkutsk region, than in the Russian Federation and Siberian Federal district -1,7 and 1,5 times respectively. Sociological polls of the population of Irkutsk showed that 10 % of adult population and less than 20 % of youth do not take alcoholic drinks only. Abuse of alcohol makes a particular contribution to increase in number of lethal cases from diseases of system of blood circulation and the external reasons (mechanical trauma, suicides). It is not possible to estimate these indexes according to statistical data. The purpose of the real research was studying of a share of deadly outcomes among the population of Irkutsk, associated with ethyl alcohol. The profound personified analysis of mortality of the population of Irkutsk from the external reasons and some diseases (according to the international classification of diseases of the 10^th revision) was carried out according to archive of Irkutsk regional bureau of a forensic medical expertise during 2000-2012, in cases when ethyl alcohol was found in cadaver blood. It was established, that the share of acute poisonings with ethyl alcohol makes about 4 % in structure of common mortality of the population of Irkutsk. The share of persons of young age of the dead as a result of an acute alcoholic poisoning makes nearly 20 % in recentyears. The high level of suicide activity of the population of the city interfaced to alcohol intake was revealed. More than 50 % were in an alcohol intoxication of various degree, among the persons prematurely left life. The share of the lethal mechanical traumas, associated with alcohol intoxication, made about a half from all cases of a mechanical trauma. During the 13-year period the decrease of the share of death resulted from cardiovascular diseases, associated with ethyl alcohol, was observed (with 30 to 16 %). Thus among the persons of young age having diseases of cardiovascular system, more than 50 % were at the time of death approach in an alcohol intoxication. The conducted research shows that the actual"hidden" losses of the population interfaced to alcohol intake, are much higher. The alcoholization of the population influences not only formation of losses from acute alcoholic poisonings, but also from the external reasons and diseases against which there was an abuse of ethyl alcohol.

At present, many investigators pay their attention to studying the problem of life quality based on analysis of the objective and subjective indicators. Thereto, the numerous solutions, very unequal in both its objective grounding, choosing the concrete indices and in the methodical approaches used have been suggested. Moreover, the category of «life quality» is usually studied by the most authors at the individual level, rarely - at the group level. The specific category character «life quality» according to the big ethnological societies has been considered and the critical analysis of the available approaches to its study has been given in this work. The peculiarities of the population differentiation according to the levels of the material well-being in dependence on the salary sizes in the different branches of economy have been considered. The insufficient assessment of the society life quality in common extensive and averaged social-economic complex (the gross intrinsic product, the mean income level, the volume of the retail trades and so on) has been indicated. The complicity of reaching the wished life quality way he released informing the dangerous deformation of the adaptive strategies of the population. The sociological studies have shown that the increase in the deviant, extra-right strategies in the Russian society is the result of the reality adaptation of the available social-economic system, the method of the keeping and getting the wished life quality in contrast to all the eternal conditions and changes. The need of the population life quality assessment using the intensive, structural (qualitative) and social criteria (dependence on the world economic conjuncture, the quality of economics grows, the degree of the social-economic inequality, the registration or the oblivion of the requirements in the scientific-technical development, the problems of national safety) has been grounded. The society life quality assessment may not be considered as the adequate and complete if it is mainly based on the economic indices of vital activity (the level of the material well-being) and doesn't take into account the most important aspects such as the economic inequality, the social well-being, the state of human potential, the national safety and so on.

The processes of natural and mechanical movement of the population observed in the Transbaikal Territory in the past two decades testify to the extremely negative trends in the formation of the demographic potential of the region. Among these trends the following ones should be primarily named: low birth rate, high mortality rate, especially among men of working age, steady decrease in the proportion of rural population in the total population of the region, which is very unfavorable effect on reproduction (fertility in rural areas up to 1,3-1,4 times higher than in urban areas). The share of persons of retirement age increases. Negative changes occur in the family institution: increasing desire for small families. The attitude related to marriage and marital status changes: the stability of married unions decrease. The out-migration enhances, which entails, even natural growth, decline in population. These circumstances do not meet the economic and geopolitical interests. For investigation the factors affecting reproductive behavior in the Transbaikal Territory, the taxonomic method of multivariate analysis and the correlation analysis have been applied. Six groups of factors have been formed, which include: a healthy way of life, education, economic factors, habitat, social and domestic factors, social stability and moral-psychological factors. Results indicated that the greatest impact on the birth rate by factors: "Early childhood education" (r = 0,87); «Spiritual and moral education» (r = 0,76), «Housing Affordability» (r = -0,7) (for describing factor chosen as destabilizing indicators such as the proportion of families standing on the account, as in need of accommodation, the percentage of families, who have expressed a desire to participate in the sub-program "Housing for young families", but didn't get help), "Safety and the level of crime" (r = -0,52); "Material well-being" (r = -0,45). In 2013 the Russian Government approved the State Program of Russian Federation "Socio-economic development of the Far East and the Baikal region". Implementation of the program can be successful only on condition of the normalization of demographic trends and social conditions.

The aim of the article was analysis of morbidity with temporary disability in general and those of working age in Siberian federal district. To evaluate the morbidity with temporary disability of the population of the Siberian federal district analyzed the statistical data of annual reports on Form 16 BH for 2010-2011 (number of cases, and disability days per 100 employees). Analysis of the overall incidence of the working population in the Siberian federal district is made on the basis of new statistical form N 12 for 2011. In 2011 compared with 2010 in Siberian federal district decreased the duration of a single case of the disease with temporary disability from 15,1 to 14,8 days, it is in direct proportion to the incidence in the general population and those of working age. Morbidity with temporary disability in Siberian federal district is lower than the average for Russia, but there are significant variations in different regions. The level of overall morbidity in the working population of the Siberian federal district remains as high as possible over the years in the Altai region. Omsk region is in second place. The lowest figure of morbidity with temporary disability is in Buryat Republic and Transbaikal Territory. 2/3 of cases of temporary disability occur in women, in men the duration of one case is 17 % higher than in women. Number of days with temporary disability remains like on the maximal level in Novosiberskaya oblast (865,4 in Transbaikal Territory), Tomsk (858,2 per 100 employees) and Kemerovo regions (856,9 per 100 employees), and minimal level is in Transbaikal Territory (651,5 per 100 employees) and Tyva Republic (617,3 per 100 employees). These facts require to study the reasons caused this difference in terms of effective management and decision-making in the regions of Siberian federal district.

Methodology of polysystem analysis provides interesting possibilities for the development of evidence-based medicine and the formation of complex knowledge on the health. The peculiarity of the methodology is multi-faceted and through description of objects by means of various system axiomatic theories that organize the information by the generation of new knowledge from a set of basic concepts and laws. Various concepts related to the concept of health are considered as interpreting the way of life in different through system-theoretical constructions. The models that reflect the idea of the level, quality, style, way and standard of life of the population are proposed. The interrelations of these concepts and models are shown. Indices of the background mortality and the public health using data on the dynamics of the population in the Irkutsk region are calculated. Models of their non-linear dependence on the specific GRP per capita are made. The quality of life is revealed as the concept of "utility", reflecting the performance, vitality and feasibility of the individual in society. The utility is regarded as an analogue of the free energy and the function of partial potentials of the system and its environment according to the Euler equation. The biological and background mortality is described on the basis of the equations of the flow of events with the source. The background mortality is used to calculate an indicator of quality of life. Itsfluctuations are calculated by comparing with the data of year 1988 using functions by the Gompertz - Makeham. Indicator values were compared with values of potentials of economic development in the region and its ratios with help of the non-linear functions that satisfy the equation of utility with deviating variables. The significant relation the quality of life and poverty rate (percentage of population with incomes below the subsistence minimum) with value of the gross regional product per capita is demonstrated. The proposed system of concepts and models allows us to find new methods for calculating quality and level of life, solving direct and inverse problems of modeling.

The production of polyvinyl chloride has currently acquired a special significance because of the widespread using of polymeric materials based on it in many industries. Vinyl chloride is a monomer of polyvinyl chloride, which is considered extremely dangerous and highly carcinogenic to humans. This article provides a brief review of the literature on the role of bio transformation system in functional disorders of the liver in PVC production workers. We describe the first and second phases of the biotransformation of lipophilic xenobiotics in the human body, for example, vinyl chloride. The data on gene polymorphism of enzymes involved in the metabolism of vinyl chloride (isoform of cytochrome P450 - CYP2E1, glutathione transferase GSTM1 and GSTT1) were presented in this article. The results of experimental studies of the effect of vinyl chloride on the state of the biotransformation of xenobiotics were reflected. This article examined the factors affecting the activity of the system in terms of the production of vinyl chloride exposure - age, smoking and alcohol.