The results of genotyping of blood samples of russian and buryat children on I/D polymorphism of GSTM1, GSTT1 genes by polymerase chain reaction are given. Absence of ethnic particularities in frequency deletion genotypes of GSTM1, GSTT1 genes is shown in this article.

«Poor» ovarian response in standard IVF protocols leads to the difficulty or even impossibility of ensuring the stage of transfer of embryos. A technique of transvaginal puncture with washing of follicles by buffer solution is performed in patients with «poor» ovarian response. This article presents the analysis of TVP in 495 IVF initiated treatment cycles. A smaller number of mature oocytes and embryos are received in the process of controlled ovarian hyperstimulation in patients with washing of follicles, however, the possibility of pregnancy is comparable to the overall IVF results.

The article presents the results of prospective non-randomised comparative study of clinical efficacy of gestagens in parallel groups of women with uterine myoma and hyperpolymenorrhea. It was shown that by the 3d. month of treatment LNG-releasing intrauterine system in women of reproductive age is so effective in hyperpolymenorrhea correction as usage 20 mg of dydrogesterone in the 2^nd phase of menstrual cycle.

Serum lipoperoxidation variables were studied in 117 Buryat and Russian women with endocrine infertility. We found elevation of final lipoperoxidation substances in the most of infertile patients. In such case, decreasing of total antioxidative activity, tocopherol level and superoxide dismutase activity were found mostly in the buryat women with infertility.

The following research analyses relationships between antioxidative parameters and hormonal levels in men with infertility. The getting data could be used for differentiated approach to diagnostics and prophylactics of men infertility.

We present the results of lipid metabolism evaluation in 23 women during perimenopausal and 36 women during postmenopausal period. We also compared lipid profile in depends on present or absence of insomnia in this patients. We found that lipid profile in postmenopausal women does not depend on sleep disorders. But total cholesterol and cholesterol of low density lipoproteins are different in perimenopausal women.

The article presents results of the examination of 39 males with chronic trichomoniasis. Revealed a high frequency of inflammatory diseases of urogenital region: in 72 % of cases was detected chronic prostatitis, in 5 % of cases — epididymitis, in 2,5 % of cases — vesiculitis. In 62 % of men with chronic trichomoniasis was detected patospermia. This results evidence suggests a possible participation of Trichomonas vaginalis in the development inflammatory diseases of urogenital region and disorder of reproductive function of men.

The article presents the results of examination of 97 adolescent girls (mean age 14,96 ± 0,26 years) with hyperprolactinemia (PRL levels above 700 IU/ml): 30 adolescent girls with pituitary microprolactinoma (mean age 14,7 ± 3.2 years) and 67 adolescent girls with functional hyperprolactinemia (mean age 14,6 ± 3,4 years). The control group included 35 healthy adolescent girls (mean age 15,8 ± 0,89 years). Hyperprolactinemia (tumor and non-neoplastic) in puberty leads to disorders of sexual development and ovarian-menstrual cycle, followed by neurological symptoms. Elevated concentrations of testosterone, cortisol, DHEA, 17-OH-progesterone and LH/FSH ratio were shown in adolescents with hyperprolactinemia compared to the control group. Macroprolactinemia was estimated in 16,4—20 % of girls with hyperprolactinemia.

We did not observed significant differences in levels of inhibin B and follicle-stimulating hormone in serum samples of men with chronic urogenital trichomoniasis and different spermogram. It confirmed that spermatogenic testicular function in these men is preserved.

The article presents the results of organ-preserving treatment protocol of atypical endometrial hyperplasia and well-differentiated endometrial carcinoma in young women. This protocol was applied in 24 patients. The period of patients observation was 3—6 years. During 6—9 months the patients were given GnRG analogue with add-back therapy. Intrauterine levonorgestrel-releasing system was inserted with therapeutic purpose for the period of not less than 6 months in atypical endometrial hyperplasia and for 1 year for well differentiated endometrial carcinoma. Combined using of GnRG analogue and intrauterine levonorgestrel-releasing system is effective method for treatment of atypicalendometrial hyperplasia and endometrial carcinoma stage I А in young women, especially in cases of unrealized fertility and can be considered as an alternative way to hysterectomy.

The antioxidant system activity was studied in 74 patients undergoing infertility treatment by the vitro fertilization, depending on the effectiveness of the procedure.

Cryo-embryos transfer is less expensive and less aggressive method in compare with repeated ovarian stimulation and transfer of «fresh» embryos. The article presents the analysis of influence of various factors on the efficiency of cryo-embryo transfers in 118 IVF cycles. The main success criteria is the quality of thawed embryos.

The use of cardiotocography and Doppler of umbilical vessels allows to diagnose fetal hypoxia at early stages and to prognose the pregnancy outcomes.

We developed diagnostic protocol and studied cervical diseases in 733 women with HIV. There were found high incidence of sexual transmitted diseases and multifocal papilloma in these patients. We describe colposcopical signs of cervical papilloma virus infection in HIV-positive women. We suppose that low information content of cervical cytology could be connected with concomitant infections. We also found that HIV is not eliminated but cause to dysplasia of cervical epithelium. That is why we suppose to optimal to pay an attention to cervical neoplasms in women with HIV-PVI association. Severity of observed cervical changes was depended on the associations with sexual transmitted infections, CD4+ lymphocytes level and total virus load.

The article presents the frequency characteristics of polymorphisms *A *B *C, *D GSTP1 gene in women with endometriosis and healthy Russian and Buryat ethnic groups. The study shows that in the group of Russian AC genotype is more common in healthy women compared with patients with endometriosis (p = 0,02). Mutant allele *B was significantly more common among Russian women with endometriosis, compared with a group of Buryat with endometriosis (p = 0,05).

Ovarian hyperstimulation syndrome (OHSS) is the most frequent and dangerous complication of IVF programmers. Evaluation of OHSS risk factors allows to perform differentiated, approaches to controlled ovarian stimulation. This article presents the results of OHSS risk factors analysis in 775 IVF cycles. It was found that young age (< 35 years), PCOS, tubal factor of infertility and low BMI (< 25 kg/m²) are the significant risk factors for OHSS.

Cytokines levels, lymphocyte subsets and phagocytosis activity of peripheral blood neutrophils were studied in young puerperal women (aged 18—26 years). The level of IL-1a, TNFa, IL-8 was significant decrease, the number of CD4+ lymphocytes and immunoregulatory index (CD4+/CD8+) were increase, neutrophils phagocytosis activity rised in patients with puerperal endometritis.

The article presents the results of investigation of lipid peroxidation parameters in blood serum and follicile liquid of 78 patients with different IVF results. The increase of lipid peroxidation, products is shown in women with unsuccessful IVF procedure.

The article presents the results of the analysis of the distribution of genotypes and alleles of polymorphic loci gene GSTP1 (*A, *B, *C, *D), GSTT1 (del) and GSTM1 (del) in 28 women Russian and 30 women of Buryat ethnic groups. As a result, the work showed a statistically significant difference in genotype AC gene GSTP1 among the study groups. As carriers of other genotypes of genes GSTP1, GSTT1, and GSTM1 showed no significant difference

The aim of the study was the development of a cell biosensor system based on the fact that AR activator stimuli lead to redistribution of AR from cytoplasm to the nucleus. These changes could be measured and used for the diagnostics and personalized treatment of prostate cancer patient. The stably transfected cell lines with fluorescently tagged AR were generated. For the stable cell expression the non AR expressing HeLa cell line was used. The constructs of chimeric fluorescent proteins wild type AR or mutant AR^T877A were used for the transfection. The changes of the CFP-AR-YFP and CFP-AR^T877A-YFP proteins in the nucleus of HeLa cells under different concentrations steroids treatment was investigated. Moreover, the quantity of activated receptor in the nucleus was carried.

We examined lymphocyte subsets, levels of A, M, G immunoglobulins and Human leucocyte antigens of I-st class (A, B) in 90 patients with endometriosis. The most significant decrease of CD3+, CD4+ lymphocytes number, immunoregulatory index (CD4+/CD8+), increase of levels of immunoglobulins A, G, M was determined in patients with endometriosis at the length of disease up to 3 years. Endometriosis was associated with А28, В5, В16, В37, В41 Human leucocyte antigens. HLA-antigens А32, В44, В61 were found in endometriosis women only.

The morbidity of non-Hodgkin's lymphomas in last 11 years in Irkutsk region was increased in 5,5 times, in Irkutsk in 11,5 times. The mortality of NHL was increased in Irkutsk region in 5,5 times, in the region centre in 6,5 times. The risk to fall ill with NHL in 60 years are higher than in 20 years in 5 times. Men are ill more than women in 1,35 times. Number of patients with advanced stage of NHL was increased in 2 times.

We studied physical and sexual development of schoolgirls living in Irkutsk. It was shown that somatic pathology plays important role in reproductive health development.

We analyzed official statistical data of 2003—2011 concerning incidence and morbidity of genital tuberculosis in Ulan-Ude. We drown a conclusion that the getting data is not reflect the real problems and true data concerning these pathologies has not been studied yet.

The article presents the results of analysis of statistics and hospital records of women of reproductive age with infertility, who were examined in 2008—2011. It was shown that after the implication of active monitoring of infertile women tubercolosis prevalence in risk group increased from 0 to 18 %.

High frequency of infertility in the Irkutsk region (18—20 %) sharply limits population reproduction. Tubo-peritoneal factor (97,3 %), man's infertility (20 %) are leading factors of infertility in Irkutsk region. It predisposes wide using of IVF as the main way of reproductive problems solution in population. Efficiency of IVF programs depends on such factors as age of patients; duration and causes of infertility.

Molecular aspects of carcinogenesis of endometrium with analysis of scientific literature and own experimental data are considered. It was shown that in this process are involved as well classical signal transduction pathways like PI3K, Wnt, Bcl-2-regulated apoptosis as hormonal pathways from ERα to target genes. Gene expression of apoptosis inhibitor Bcl-2 was in 6 folds higher in malignant tumors in comparison with non cancer tissue. Expression level of ERα gene was higher in cancer tissue than in adjacent non-tumor endometrium. Matrix metallo-proteinases MMR-3, MMR-9 and angiogenesis gene Il-8 expressed mainly in malignant endometrial tissues, but not in non-cancer tissues that considers these genes as suitable candidates for the characteristic of endometrial carcinoma. Thus, Bcl-2, IL8, ERα and MMPs 2 proteins can be appropriate markers of endometrial carcinoma together with the members of PI3K- and Wnt-signal pathways like PTEN and β-catenin.

Analysis of published data on clinical effectiveness and safety of antimicrobial drugs indicates that original and generic antibacterial medicines sometimes significantly differ in the therapeutic equivalence and in the frequency and severity of side effects.

Activity of reproductive system is under the hypothalamic and hypophysial control, defining role in development and normal functioning of gonads is played by impulsive secretion of GnRH and gonadotropins. The congenital genetic defects leading to the central hypogonadism can be found at any level of a hypotalamo-hypophysial axis: from disturbance of secretion of GnRH to structural defects of gonadotropins. The majority of cases are sporadic though various ways of inheritance have also been reported. The acquired hypotalamo-hypophysial disturbances can be organic and functional. Organic disorders of such lesion include different types of tumors localized at chiasmo-sellar region (first of all, pituitary tumors), consequences of surgical or radial intervention concerning these neoplasms, brain injuries and also autoimmune, infiltrative and other more rare species of diseases. Functional neuroendocrine disturbances arise against absence of visible changes of structure of a brain as the main reasons consider superfluous exercise stresses, stresses and critical depression of mass of a body

Hyperprolactinemia is one of the most frequent neuroendocrinal disorders and consequently questions of diagnostics and treatment of this syndrome continue to remain actual. Diagnostics of hyperprolactinemia is not the simple task demanding not only determination of the prolactin levels, but also measurement of its fractions with an assessment of the bioactive prolactin levels, careful studying of the anamnesis, an exception of various somatic, endocrine and neuroendocrinal disturbances. Treatment of a pathological hyperprolactinemia demands the differentiated approach taking into account clinical and biochemical data and radiological data. A leading method of treatment is medical therapy by agonists of dopamin receptors. Diagnostics and treatment of hyperprolactinemia must be based on modern evidence-based guidelines.

Trichomonas infection is a scientific and clinical problem in dermatology, urology, obstetrics and gynecology. This infection in men and women is often causes to urethritis, cystitis, prostatitis, post-abortion infection, premature labor and other diseases. This literature review has shown that in spite of a lot of numbers of scientific data concerning the impact of trichomoniasis to urogenital bioceonosis of both men and women, there is no enough data about influence of trichomoniasis to urinary microecology in sexual partners. Meanwhile, this question is in the field of scientific and applied interest and need to be studied.