CAUSES OF DEVELOPMENT OF ACUTE AND CHRONIC THROMBOCYTOPENIA IN CHILDREN OF IRKUTSK REGION
https://doi.org/10.29413/ABS.2018-3.5.13
Abstract
Background. Immune thrombocytopenia in children is not a rare disease. Currently, this diagnosis is found in 2 times more often than 5-10 years ago. Acute immune thrombocytopenia is increasingly taking on a chronic course. Aims. At present, it is impossible to predict the outcome of the disease. But the chronic course of the disease significantly reduces the quality of life of children and their parents. The purpose of the study is to determine the likely causes of the development and chronicity of the disease. Materials and Methods. A retrospective analysis of 433 case histories of the cancer department of the Regional Children’s Hospital in Irkutsk was conducted. Statistical processing of the received data was carried out with the help of the Matlab program and statistical package “Statistica 6.0”. Results. The main trigger factor is ARVI and vaccination against poliomyelitis. Sensitization to herpes viruses can be a provoking factor in the development of the disease when re-encountering the virus. The brighter the clinic, the more children receive immunoglobulin treatment and the disease often ends with complete recovery. Children with minimal clinical manifestations are treated with hormones and more often the disease passes into a chronic form. Conclusion. If the child is discharged from the hospital with only a clinical improvement, then there is a greater likelihood of a chronic process.
About the Authors
N. N. Martynovich
Irkutsk State Medical University.
Russian Federation
Russian Federation
ul. Krasnogo Vosstaniya 1, Irkutsk 664003.
Doctor of Medical Sciences, Professor, Head of the Department of Pediatrics N 1.
O. P. Tolmacheva
Irkutsk Regional Clinical Hospital.
Russian Federation
Russian Federation
Yubileyniy 100, Irkutsk 664049.
Hematologist at the Department of Oncology.
V. A. Khyshova
Irkutsk State Medical University.
Russian Federation
Russian Federation
ul. Krasnogo Vosstaniya 1, Irkutsk 664003.
Student.
References
1. Ageenkova EV, Petrov VYu, Donyush EK, Soskov GI. (2010). The effectiveness of using intravenous immunoglobulin in children with immune thrombocytopenic purpura [Effektivnost’ primeneniya vnutrivennogo immunoglobulina pri immunnoy trombotsitopenicheskoy purpure u detey]. Innovatsionnye tekhnologii v pediatrii i detskoy khirurgii: Materialy IX Rossiyskogo kongressa. Moskva, 324.
2. Barkagan LZ. (1991). Hemostasis disorder in children [Narushenie gemostaza u detey]. Moskva, 58-111.
3. Efremov AV. (2002). Hemorrhagic diathesis in children [Gemorragicheskie diatezy u detey]. Moskva, 80 p.
4. Kurdeko IV, Nazarova RV, Shcherbinina LN. (2002). Variants of hemorrhagic syndrome in newborns [Varianty gemorragicheskogo sindroma u novorozhdennykh]. Omskiy nauchnyy vestnik, (19), 24-25.
5. Mazur EM. (2000). Thrombocytopenia [ Trombotsitopenii]. Patofiziologiya krovi. Sankt-Peterburg, 167-172.
6. Maschan AA, Rumyantsev AG, Kovaleva LG. (2010). Recommendations of the Russian Expert Council on Diagnosis and Treatment of Patients with Primary Immune Thrombocytopenia [Rekomendatsii Rossiyskogo soveta ekspertov po diagnostike i lecheniyu bol’nykh pervichnoy immunnoy trombotsitopeniey]. Onkogematologiya, (3), 36-45.
7. Shabalov NP, Ivanov DO, Shabalova NN. (2000). Hemostasis in the dynamics of the first week of life as a reflection of the mechanisms of adaptation to the extrauterine life of the newborn [Gemostaz v dinamike pervoy nedeli zhizni, kak otrazhenie mekhanizmov adaptatsii k vneutrobnoy zhizni novorozhdennogo]. Pediatriya, (3), 84-91.
8. Beck N. (2009). Diagnostic hematology. London, 488 p.
9. Busset JB, Buchman GR, Nugen DJ. Gnarra DJ, Bomgaars LR, Blanchette VS, Wang YM, Nie K, Jun S. (2011). A randomized, double – blind study of romiplastin to determine its safety and efficacy i children with immune thrombocytopenia. Blood, 118 (1), 28-36. DOI: 10.1182/ blood-2010-10-313908
10. Chevuru SC, Sola MC, Theriaque DW, Hutson AD, Leung WC, Perez JA, Nelson RM, Kays DW, Christensen RD; Florida Collaborative Neonatology Research Group. (2002). Multicenter analysis of platelet transfusion usage among neonates on extracorporeal membrane oxygenation. Pediatrics, 109 (6), 89.
11. Handin RI, Loscalzo J. (1992). Hemostasis, thrombosis, fibrinolysis and cardiovascular disease. Heart Disease: A Textbook of Cardiovascular Medicine. Philadelphia, 767-1789.
12. Portielje JE, Westendorp RG, Kluin-Nelemans HC, Brand A. (2001). Morbidity and mortality in adults with idiopathic thrombocytopenic purpura. Blood, 97 (9), 2549-2552.
Review
For citations:
Martynovich N.N., Tolmacheva O.P., Khyshova V.A. CAUSES OF DEVELOPMENT OF ACUTE AND CHRONIC THROMBOCYTOPENIA IN CHILDREN OF IRKUTSK REGION. Acta Biomedica Scientifica. 2018;3(5):82-86. (In Russ.) https://doi.org/10.29413/ABS.2018-3.5.13
Views:
1031
.png)
Email this article 
