Surgical treatment of neuroendocrine tumors of the duodenum

Background. Neuroendocrine tumors are rare malignant neoplasms. Recently, there has been a tendency towards an increase in the incidence of neuroendocrine tumors of the gastrointestinal tract in general and the duodenum in particular.

The aim. To analyze the methods of surgical treatment in patients with neuroendocrine tumors of the duodenum depending on the stage of the disease.

Methods. The object of the study were 35 patients with neuroendocrine tumors of the duodenum who were examined and treated at the Irkutsk Regional Oncology Dispensary from 2010 to 2022. Of these, 17 (48.6 %) were men and 18 (51.4 %) were women aged 33 to 81 years, with an average age of 61.9 years. The materials for the study were the medical records of patients. The study included a study of clinical, laboratory parameters and instrumental diagnostic methods, protocols of surgical interventions, and the results of immunohistochemical analysis.

Results. The study determined that in 80 % of cases the tumors were located in the duodenal bulb, and the size of the formations did not exceed 10 mm - 89.2 % of cases. According to the examination results, stage I of the disease was established in 31 (88.6 %) patients, stage II - in 2 (5.7 %), stage III - in 1 (2.8 %), stage IV - in 1 (2.8 %). Endoscopic intraluminal operations were most often performed, which were performed in 25 (71.4 %) patients at stage I of the disease. Traditional surgeries were performed in 5 (14.3 %) patients with stages I, II and III of the disease. Symptomatic treatment was performed at stage IV.

Conclusion. It was established that neuroendocrine tumors of the duodenum were most often diagnosed at stage I. As a result of the study analysis, it was determined that endoscopic intraluminal interventions at an early stage of the disease allow for successful minimally invasive organ-preserving treatment.

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