<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2026-11.1.14</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-5900</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОНКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ONCOLOGY</subject></subj-group></article-categories><title-group><article-title>Оперативное лечение нейроэндокринных опухолей двенадцатиперстной кишки</article-title><trans-title-group xml:lang="en"><trans-title>Surgical treatment of neuroendocrine tumors of the duodenum</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-5473-7352</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маточкин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Matochkin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маточкин Виталий Владимирович - кандидат медицинских наук, врач-эндоскопист, хирург, ГБУЗ ИркООД; ассистент кафедры онкологии и лучевой терапии, ФГБОУ ВО «ИГМУ» МЗ РФ; ассистент кафедры хирургии, сердечно-сосудистой хирургии и клинической ангиологии, ИГМАПО - филиал ФГБОУ ДПО «РМАНПО» Минздрава России.</p><p>664035, Иркутск, ул. Фрунзе, 32; 664003, Иркутск, ул. Красного Восстания 1; 664049, Иркутск, м/р Юбилейный,100</p></bio><bio xml:lang="en"><p>Vitalyi V. Matochkin - Cand. Sc (Med), endoscopist, surgeon, Irkutsk Regional Oncological Dispensary; Assistant Professor of the Department of Oncology and Radiation Therapy, Irkutsk State Medical University of the Ministry of Health of the Russian Federation; Teaching Assistant of the Department of Surgery, Cardiovascular Surgery and Clinical Angiology, Irkutsk State Medical Academy of Postgraduate Education - branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation.</p><p>Frunze St. 32, Irkutsk 664035; Krasnogo Vosstaniya St. 1, Irkutsk 664003; Yubileiny microdistrict, 100, Irkutsk 664049</p></bio><email xlink:type="simple">mavital@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3299-1924</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белобородов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Beloborodov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Белобородов Владимир Анатольевич - доктор медицинских наук, профессор, заведующий кафедрой общей хирургии.</p><p>664003, Иркутск, ул. Красного Восстания 1</p></bio><bio xml:lang="en"><p>Vladimir A. Beloborodov - Dr. Sc. (Med.), Professor, Head of the Department of General Surgery, Irkutsk State Medical University of the Ministry of Health of the Russian Federation.</p><p>Krasnogo Vosstaniya St. 1, Irkutsk 664003</p></bio><email xlink:type="simple">bva555@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5163-8408</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белоногов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Belonogov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Белоногов Александр Викторович - доктор медицинских наук, врач-эндоскопист, онколог, ГБУЗ ИркООД; заведующий кафедрой онкологии и лучевой терапии, ФГБОУ ВО «ИГМУ» Минздрава России; доцент кафедры хирургии, сердечно-сосудистой хирургии и клинической ангиологии, ИГМАПО - филиал ФГБОУ ДПО «РМАНПО» Минздрава России.</p><p>664035, Иркутск, ул. Фрунзе, 32; 664003, Иркутск, ул. Красного Восстания 1; 664049, Иркутск, м/р Юбилейный,100</p></bio><bio xml:lang="en"><p>Alexander V. Belonogov - Dr. Sc. (Med.), endoscopist, oncologist, Irkutsk Regional Oncological Dispensary; Head of the Department of Oncology and Radiation Therapy, Irkutsk State Medical University of the Ministry of Health of the Russian Federation; Associate Professor at the Department of Surgery, Cardiovascular Surgery and Clinical Angiology, Irkutsk State Medical Academy of Postgraduate Education - branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation.</p><p>Frunze St. 32, Irkutsk 664035; Krasnogo Vosstaniya St. 1, Irkutsk 664003; Yubileiny microdistrict, 100, Irkutsk 664049</p></bio><email xlink:type="simple">belonogov1962@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ Областной онкологический диспансер; ФГБОУ ВО «Иркутский государственный медицинский университет» Министерства здравоохранения Российской Федерации; Иркутская государственная медицинская академия последипломного образования - филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации</institution></aff><aff xml:lang="en"><institution>Regional Oncology Dispensary; Irkutsk State Medical University of the Ministry of Health of the Russian Federation; Irkutsk State Medical Academy of Postgraduate Education - branch of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Иркутский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution></aff><aff xml:lang="en"><institution>Irkutsk State Medical University of the Ministry of Health of the Russian Federation</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>26</day><month>03</month><year>2026</year></pub-date><volume>11</volume><issue>1</issue><fpage>155</fpage><lpage>162</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Маточкин В.В., Белобородов В.А., Белоногов А.В., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Маточкин В.В., Белобородов В.А., Белоногов А.В.</copyright-holder><copyright-holder xml:lang="en">Matochkin V.V., Beloborodov V.A., Belonogov A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/5900">https://www.actabiomedica.ru/jour/article/view/5900</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Нейроэндокринные опухоли являются редко встречающимися злокачественными новообразованиями. В последнее время наблюдается тенденция к увеличению заболеваемости нейроэндокринными опухолями желудочно-кишечного тракта в целом и двенадцатиперстной кишки в частности.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Проанализировать методы оперативного лечения у пациентов с нейроэндокринными опухолями двенадцатиперстной кишки в зависимости от стадии болезни.</p></sec><sec><title>Методы</title><p>Методы. Объектом исследования стали 35 больных с нейроэндокринными опухолями двенадцатиперстной кишки, которым было проведено обследование и лечение в Иркутском областном онкологическом диспансере за период с 2010 по 2022 гг. Из них было 17 (48,6 %) мужчин и 18 (51,4 %) женщин в возрасте от 33 до 81 лет, средний возраст составил 61,9 лет. Материалами для исследования были медицинские карты больных. Исследование включало изучение клинических, лабораторных показателей и инструментальных методов диагностики, протоколов оперативных вмешательств, результатов иммуногистохимического анализа.</p></sec><sec><title>Результаты</title><p>Результаты. В результате исследования определено, что в 80 % случаев опухоли были расположены в луковице двенадцатиперстной кишки, а размеры образований не превышали 10 мм - 89,2 % случаев. По результатам обследования I стадия заболевания была установлена у 31 (88,6 %) пациента, II стадия - у 2 (5,7 %), III стадия - у 1 (2,8 %), IV стадия - у 1 (2,8 %). Наиболее часто проводились эндоскопические внутрипросветные операции, которые выполнены у 25 (71,4 %) больных при I стадии заболевания. Традиционные хирургические операции выполнены у 5 (14,3 %) пациентов с I, II и III стадией болезни. При IV стадии проводилось симптоматическое лечение.</p></sec><sec><title>Заключение</title><p>Заключение. Установлено, что наиболее часто нейроэндокринные опухоли двенадцатиперстной кишки диагностировали на I стадии. В результате анализа исследования определено, что эндоскопические внутрипросветные вмешательства при ранней стадии заболевания позволяют успешно проводить малоинвазивное органосохраняющее лечение.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Neuroendocrine tumors are rare malignant neoplasms. Recently, there has been a tendency towards an increase in the incidence of neuroendocrine tumors of the gastrointestinal tract in general and the duodenum in particular.</p></sec><sec><title>The aim</title><p>The aim. To analyze the methods of surgical treatment in patients with neuroendocrine tumors of the duodenum depending on the stage of the disease.</p></sec><sec><title>Methods</title><p>Methods. The object of the study were 35 patients with neuroendocrine tumors of the duodenum who were examined and treated at the Irkutsk Regional Oncology Dispensary from 2010 to 2022. Of these, 17 (48.6 %) were men and 18 (51.4 %) were women aged 33 to 81 years, with an average age of 61.9 years. The materials for the study were the medical records of patients. The study included a study of clinical, laboratory parameters and instrumental diagnostic methods, protocols of surgical interventions, and the results of immunohistochemical analysis.</p></sec><sec><title>Results</title><p>Results. The study determined that in 80 % of cases the tumors were located in the duodenal bulb, and the size of the formations did not exceed 10 mm - 89.2 % of cases. According to the examination results, stage I of the disease was established in 31 (88.6 %) patients, stage II - in 2 (5.7 %), stage III - in 1 (2.8 %), stage IV - in 1 (2.8 %). Endoscopic intraluminal operations were most often performed, which were performed in 25 (71.4 %) patients at stage I of the disease. Traditional surgeries were performed in 5 (14.3 %) patients with stages I, II and III of the disease. Symptomatic treatment was performed at stage IV.</p></sec><sec><title>Conclusion</title><p>Conclusion. It was established that neuroendocrine tumors of the duodenum were most often diagnosed at stage I. As a result of the study analysis, it was determined that endoscopic intraluminal interventions at an early stage of the disease allow for successful minimally invasive organ-preserving treatment.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>нейроэндокринная опухоль</kwd><kwd>двенадцатиперстная кишка</kwd><kwd>хирургия</kwd><kwd>эндоскопия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>neuroendocrine tumor</kwd><kwd>duodenum</kwd><kwd>surgery</kwd><kwd>endoscopy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Modlin IM, Champaneria MC, Chan AK, Kidd M. A three-decade analysis of 3,911 small intestinal neuroendocrine tumors: the rapid pace of no progress. Am J Gastroenterol. 2007; 102: 1464-1473. doi: 10.1111/j.1572-0241.2007.01185.x</mixed-citation><mixed-citation xml:lang="en">Modlin IM, Champaneria MC, Chan AK, Kidd M. A three-decade analysis of 3,911 small intestinal neuroendocrine tumors: the rapid pace of no progress. Am J Gastroenterol. 2007; 102: 1464-1473. doi: 10.1111/j.1572-0241.2007.01185.x</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. Classification of Tumours Editorial Board. Endocrine and Neuroendocrine tumours. Lyon (France): International Agency for Research on Cancer. 2022, 5th ed. (8).</mixed-citation><mixed-citation xml:lang="en">WHO. Classification of Tumours Editorial Board. Endocrine and Neuroendocrine tumours. Lyon (France): International Agency for Research on Cancer. 2022, 5th ed. (8).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Dasari A, Shen C, Halperin D, et al. Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol. 2017; 3: 1335-1342. doi: 10.1001/jamaoncol.2017.0589</mixed-citation><mixed-citation xml:lang="en">Dasari A, Shen C, Halperin D, et al. Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol. 2017; 3: 1335-1342. doi: 10.1001/jamaoncol.2017.0589</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации Министерства здравоохранения Российской Федерации «Нейроэндокринные опухоли». - 2025. - Текст: электронный. Рубрикатор клинических рекомендаций. URL: https://cr.minzdrav.gov.ru/preview-cr/610_2. [date of access: June 06, 2025].</mixed-citation><mixed-citation xml:lang="en">Clinical recommendations of the Ministry of Health of the Russian Federation “Neuroendocrine tumors”. - 2025. - Text: electronic. Rubricator of clinical recommendations. (In Russ.)]. URL: https://cr.minzdrav.gov.ru/preview-cr/610_2. [date of access: June 06, 2025.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Rindi G, Klimstra DS, Abedi-Ardekani B, et al. A common classification framework for neuroendocrine neo-plasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Mod Pathol. 2018; 31(12): 1770-1786. doi: 10.1038/s41379-018-0110-y</mixed-citation><mixed-citation xml:lang="en">Rindi G, Klimstra DS, Abedi-Ardekani B, et al. A common classification framework for neuroendocrine neo-plasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Mod Pathol. 2018; 31(12): 1770-1786. doi: 10.1038/s41379-018-0110-y</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Shah MH, Goldner WS, Benson AB, et al. Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021; 19(7): 839-868. doi: 10.6004/jnccn.2021.0032</mixed-citation><mixed-citation xml:lang="en">Shah MH, Goldner WS, Benson AB, et al. Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021; 19(7): 839-868. doi: 10.6004/jnccn.2021.0032</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Артамонова Е.В., Горбунова В.А., Делекторская В.В. и др. Нейроэндокринные неоплазии желудочно-кишечного тракта и поджелудочной железы. Практические рекомендации RUSSCO, часть 1.1. Злокачественные опухоли. 2024; 14(3s2): 427-444.</mixed-citation><mixed-citation xml:lang="en">Artamonova EV, Gorbunova VA, Delektorskaya VV, et al. Neuroendocrine neoplasia of the gastrointestinal tract and pancreas. RUSSCO Practical Recommendations, Part 1.1. Malignant Tumors. 2024; 14(3s2): 427-444. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Panzuto F, Ramage J, Pritchard DM, et al. European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for gastroduodenal neuroendocrine tumours (NETs) G1-G3. J Neuroendocrinol. 2023; 35: e13306. doi: 10.1111/jne.13306</mixed-citation><mixed-citation xml:lang="en">Panzuto F, Ramage J, Pritchard DM, et al. European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for gastroduodenal neuroendocrine tumours (NETs) G1-G3. J Neuroendocrinol. 2023; 35: e13306. doi: 10.1111/jne.13306</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Raphael MJ, Chan DL, Law C, Singh S. Principles of diagnosis and management of neuroendocrine tumours. CMAJ. 2017; 189(10): E398-E404. doi: 10.1503/cmaj.160771</mixed-citation><mixed-citation xml:lang="en">Raphael MJ, Chan DL, Law C, Singh S. Principles of diagnosis and management of neuroendocrine tumours. CMAJ. 2017; 189(10): E398-E404. doi: 10.1503/cmaj.160771</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">TNM: Классификация злокачественных опухолей / Под ред. Дж.Д. Брайерли и др.; пер. с англ. и научн. ред. Е.А. Дубовой, К.А. Павлова. 2-е изд. на русском языке. - М.: Логосфера, 2018: 344 с.</mixed-citation><mixed-citation xml:lang="en">TNM: Classification of malignant tumors / ed. by J.D. Brierly, et al.; translated from English and scientific ed. by EA Dubova, KA Pavlov. 2nd ed. - M.: Logosphere, 2018. - 344 p. (In Russ.).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
