CARDIAC LESION IN CHURG - STRAUSS SYNDROME
https://doi.org/10.12737/23843
Abstract
Cardiac involvement is the most important prognostic factor in eosinophilic granulomatosis with polyangiitis (Churg - Strauss syndrome). We report a case of Churg - Strauss syndrome in 65-year-old women masquerading as a non-ST elevation myocardial infarction. She had chest discomfort, dyspnea and ST depression, high troponin level and so myocardial infarction was diagnosed. She had had asthma for 4 years but had no eosinophilia in peripheral blood and lesions in the lungs at the time of the first hospitalization. Her skin was clean without rashes. 3 months later she was hospitalized again having pulmonary infiltrates. Laboratory tests revealed that eosinophil was significantly increased. Cardiac involvement in a pathological process led to death. Histological examination of heart and lungs showed necrotic coronary vasculitis, granulomas and perivascular eosinophilic infiltrates in myocardium, endocardium, pericardium and pulmonary eosinophilic infiltrates.
About the Authors
E. S. Eniseeva
ГБОУ ДПО «Иркутская государственная медицинская академия последипломного образования» Минздрава России
Russian Federation
Russian Federation
G. P. Gurtovaya
ФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
O. V. Kanya
ГБУЗ Иркутское областное патологоанатомическое бюро
Russian Federation
Russian Federation
A. A. Stefanenkova
ГБУЗ Иркутское областное патологоанатомическое бюро
Russian Federation
Russian Federation
References
1. Aboukhoudir F, Pansieri M, Rekik S (2014) Chronic calcific constrictive pericarditis complicating Churg - Strauss syndrome: first reported case. Thorac. Cardiovasc. Surg., 62 (7), 631-633.
2. Baili L, Aydi Z, Soussi G, Ben Dhaou BB, Zidi A, Berraies A, Boussema F, Kammoun S, Hamzaoui A, Kraiem S, Ben Miled M’rad K, Rokbani L (2014). Cardiac tamponade and myocarditis in Churg - Strauss syndrome. Ann. Cardiol. Angiol. (Paris), 63 (4), 271-275.
3. Chen MX, Yu BL, Peng DQ, Zhou SH (2014). Eosinophilic myocarditis due to Churg - Strauss syndrome mimicking reversible dilated cardiomyopathy. Heart Lung, 43 (1), 45-47.
4. Chin JY, Yi JE, Youn HJ (2013). Churg - Strauss syndrome associated with rapid deterioration of left ventricular diastolic dysfunction and conduction disturbance. Echocardiography, 30 (9), 269-273.
5. Comarmond C, Pagnoux C, Khellaf M, Cordier JF, Hamidou M, Viallard JF, Maurier F, Jouneau S, Bienvenu B, Puéchal X, Aumaître O, Le Guenno G, Le Quellec A, Cevallos R, Fain O, Godeau B, Seror R, Dunogué B, Mahr A, Guilpain P, Cohen P, Aouba A, Mouthon L, Guillevin L, French Vasculitis Study Group (2013). Eosinophilic granulomatosis with polyangiitis (Churg - Strauss): Clinical characteristics and long-term follow-up of the 383 patients enrolled in the French Vasculitis Study Group cohort. Arthritis Rheum., 65 (1), 270-281.
6. Cui N, Su L, Wang H, Long Y, Pang C, Yang F, Liu D (2015). A case report of Churg - Strauss syndrome presenting with cardiogenic shock treated with extracorporeal membrane oxygenation. Medicine (Baltimore), 94 (43), 1757.
7. Dennert RM, van Paassen P, Schalla S, Kuznetsova T, Alzand BS, Staessen JA, Velthuis S, Crijns HJ, Tervaert JW, Heymans S (2010). Cardiac involvement in Churg - Strauss syndrome. Arthritis Rheum., 62 (2), 627-634.
8. Doo KW, Yong HS, Kang EY (2013). Coronary involvement in Churg - Strauss syndrome: a case report with CT findings. Jpn. J. Radiol., 31 (12), 819-822.
9. Groh M, Pagnoux C, Baldini C, Bel E, Bottero P, Cottin V, Dalhoff K, Dunogué B, Gross W, Holle J, Humbert M, Jayne D, Jennette JC, Lazor R, Mahr A, Merkel PA, Mouthon L, Sinico RA, Specks U, Vaglio A, Wechsler ME, Cordier JF, Guillevin L (2015). Eosinophilic granulomatosis with polyangiitis (Churg - Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management. Eur. J. Intern. Med., 26 (7), 545-553.
10. Hara T, Yamaguchi K, Iwase T, Kadota M, Bando M, Ogasawara K, Bando S, Ise T, Niki T, Ueda Y, Tomita N, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Sata M (2013). Eosinophilic myocarditis due to Churg - Strauss syndrome with markedly elevated eosinophil cationic protein. Int. Heart J., 54 (1), 51-53.
11. Korantzopoulos P, Papaioannides D, Siogas K (2004). The heart in Wegener's granulomatosis. Cardiology, (102), 7-10.
12. Lin YC, Oliveira GH, Villa-Forte A (2013). Churg - Strauss syndrome and persistent heart failure: active disease or damage? J. Clin. Rheumatol., 19 (7), 390-392.
13. Masi AT, Hunder GG, Lie GT, Michel BA, Bloch DA, Arend WP, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY (1990). The American College of Rheumatology 1990 criteria for the classification of Churg - Strauss syndrome (allergic granulamotosis angiitis). Arthritis Rheum, (33), 1094-1100.
14. Moosig F, Richardt G, Gross W (2013). A fatal attraction: eosinophils and the heart. Rheumatology, 52 (4), 587-589.
15. Triantafyllis AS, Sakadakis EA, Papafilippaki A, Katsimbri P, Panou F, Anastasiou-Nana M, Lekakis I (2015). Churg - Strauss syndrome masquerading as an acute coronary syndrome. Am. J. Emerg. Med., 33 (2), e5-6.
Review
For citations:
Eniseeva E.S., Gurtovaya G.P., Kanya O.V., Stefanenkova A.A. CARDIAC LESION IN CHURG - STRAUSS SYNDROME. Acta Biomedica Scientifica. 2016;1(6):210-213. (In Russ.) https://doi.org/10.12737/23843
Views:
713
.png)
Email this article 
