actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.12737/23843actabiomedica-349Research ArticleСЛУЧАЙ ИЗ ПРАКТИКИCASE REPORTSПОРАЖЕНИЕ СЕРДЦА ПРИ СИНДРОМЕ ЧАРДЖА - СТРОССАCARDIAC LESION IN CHURG - STRAUSS SYNDROMEЕнисееваЕ. С.EniseevaE. S.eniseeva-irk@yandex.ruГуртоваяГ. П.GurtovayaG. P.galina1947ab@mail.ruКаняО. В.KanyaO. V.ole1587@yandex.ruСтефаненковаА. А.StefanenkovaA. A.stefaly@yandex.ruГБОУ ДПО «Иркутская государственная медицинская академия последипломного образования» Минздрава РоссииРоссияФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава РоссииРоссияГБУЗ Иркутское областное патологоанатомическое бюроРоссия20162811201616210213Copyright © Енисеева Е.С., Гуртовая Г.П., Каня О.В., Стефаненкова А.А., 20162016Енисеева Е.С., Гуртовая Г.П., Каня О.В., Стефаненкова А.А.Eniseeva E.S., Gurtovaya G.P., Kanya O.V., Stefanenkova A.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/349

Представлен клинический случай синдрома Чарджа - Строссау 65-летней женщины. Клиническая картина, динамика ЭКГ и положительный троп-тест соответствовали диагнозу ИБС: передне-боковой инфаркт без Q. В анамнезе бронхиальная астма. Рентгенологических изменений в лёгких, эозинофилии не выявлено. При повторной госпитализации через 3 месяца обнаружены эозинофилия, очаговые образования в лёгких, наступил летальный исход. На аутопсии выявлен некротизирующий васкулит коронарных артерий, гранулематозное поражение и эозинофильная инфильтрациия миокарда, эндокарда, перикарда, лёгких.

Cardiac involvement is the most important prognostic factor in eosinophilic granulomatosis with polyangiitis (Churg - Strauss syndrome). We report a case of Churg - Strauss syndrome in 65-year-old women masquerading as a non-ST elevation myocardial infarction. She had chest discomfort, dyspnea and ST depression, high troponin level and so myocardial infarction was diagnosed. She had had asthma for 4 years but had no eosinophilia in peripheral blood and lesions in the lungs at the time of the first hospitalization. Her skin was clean without rashes. 3 months later she was hospitalized again having pulmonary infiltrates. Laboratory tests revealed that eosinophil was significantly increased. Cardiac involvement in a pathological process led to death. Histological examination of heart and lungs showed necrotic coronary vasculitis, granulomas and perivascular eosinophilic infiltrates in myocardium, endocardium, pericardium and pulmonary eosinophilic infiltrates.

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The authors declare that there are no conflicts of interest present.