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Acta Biomedica Scientifica

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Роль лизосом в онкогенезе: акцент на деградацию внеклеточного матрикса

https://doi.org/10.29413/ABS.2020-5.6.9

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Аннотация

Лизосомы – многофункциональные клеточные органеллы, которые не только обеспечивают деградацию макромолекул люменальными кислыми гидролазами, но также участвуют в регуляции клеточного метаболизма, поддержании ионного гомеостаза  и индукции программируемой клеточной гибели. Особый интерес вызывает изучение этого компартмента при различных патологических состояниях, в том числе при развитии онкологических заболеваний различного генеза. Метаболические и морфологические изменения клеток в процессе онкогенеза приводят к рН-зависимому перераспределению лизосом в пределах клетки, сопровождающемуюся секрецией  лизосомальных протеаз катепсинов во внеклеточное пространство. Цистеиновые,  сериновые и аргининовые катепсины, выделяемые как опухолевыми клетками, так и клетками, ассоциированными с опухолью, катализируют расщепление различных  компонентов внеклеточного матрикса и базальной мембраны или протеолитически активируют другие ферменты, также участвующие в этом процессе. При этом лизосомальные протеазы непосредственно влияют на способность клеток к инвазии и метастатический потенциал опухолевого образования. Кроме того, было продемонстрировано прогностическое значение некоторых катепсинов (особенно катепсинов B, K и D), количество и активность которых в опухолевой ткани и в её микроокружении сопряжены со  злокачественностью образования, а также с плохим прогнозом по выживаемости пациентов  и возможностью возникновения рецидивов.

Об авторах

И. С. Трухан
ФГБНУ «Иркутский научный центр хирургии и травматологии»
Россия

кандидат биологических наук, старший научный сотрудник

664003, г. Иркутск, ул. Борцов Революции, 1, Россия



Н. Н. Дремина
ФГБНУ «Иркутский научный центр хирургии и травматологии»
Россия

кандидат биологических наук, старший научный сотрудник

664003, г. Иркутск, ул. Борцов Революции, 1, Россия



И. А. Шурыгина
ФГБНУ «Иркутский научный центр хирургии и травматологии»
Россия

доктор медицинских наук, профессор РАН, заместитель директора по научной работе

664003, г. Иркутск, ул. Борцов Революции, 1, Россия



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Для цитирования:


Трухан И.С., Дремина Н.Н., Шурыгина И.А. Роль лизосом в онкогенезе: акцент на деградацию внеклеточного матрикса. Acta Biomedica Scientifica. 2020;5(6):77-87. https://doi.org/10.29413/ABS.2020-5.6.9

For citation:


Trukhan I.S., Dremina N.N., Shurygina I.A. The Role of Lysosomes in the Cancer Progression: Focus on the Extracellular Matrix Degradation. Acta Biomedica Scientifica. 2020;5(6):77-87. (In Russ.) https://doi.org/10.29413/ABS.2020-5.6.9

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