The electroencephalography can be used to obtain objective data on the level of situational anxiety in athletes. The dynamics of the psychoemotional state of the athletes during the annual training-competitive macrocycle is characterized by the following features: in the preparatory and transition periods of the athletes the levels of anxiety and psycho-emotional stress are lower than in the control group. Competitive period is usually characterized by a significant increase in anxiety. Competitive loads experienced by athletes on the background of low anxiety lead to a less pronounced decrease in functional activity of neutrophils and activity of the antioxidant defense system.

100 children were observed. Tuberculosis of inrathoracic lymph nodes was found in 79 (79,0 %) patients, complicated tuberculosis - in 29 (36,7 %) of 79 patients. The phase of reverse development of tuberculosis was detected in 47,0 % of children with TB. Due to the slow dynamics of the disease, the duration of chemotherapy in 75,0 % of children was 240 days. In the mode of treatment, drug resistance of a patient in lesion of tuberculosis infection is taken into account. As a result of treatment, resorption of infiltration in the lungs was observed in 15,0 %, fibrosis - in 26,0 %, formation of small calcifications - in 39,0 %, formation of multiple large calcifications - in 20,0 % of children. The cause of the formation of calcifications is the late detection of tuberculosis. In children with the formation of calcifications throughout the course of treatment the number of leukocytes decreased, the downward trend in the absolute number of lymphocytes to the 4th month of treatment was traced, the content of leukocytes increased to the end of primary treatment. In children without formation of calcifications the reduction of leukocytes and lymphocytes was not identified during the treatment. The decrease in the content of leukocytes and lymphocytes may explain long-term persistence of endogenous intoxication.

Database of recommended measures in individual rehabilitation programs of 119 disabled as a result of depressive disorders was analyzed by a continuous method. 24 (20,2 %) of them were recognized as disabled for the first time, 95 (79,8 %) - were recognized as repeatedly disabled; 80,7 % were of working age, but only 10 persons of them (10,4 %) worked. The need for medical rehabilitation was revealed in 100 % of people with disabilities, for professional rehabilitation - in 65,6 %, for social rehabilitation - in 23,5%, for adaptive physical training - in 0,8 %. Full rehabilitation in re-examination was achieved only in 1,3 % of cases, partial rehabilitation - in 1,3 %, employment - in 1 case. Weighting of disability was occurred in 5,2 %. In order to improve the efficiency of complex rehabilitation of disabled people it should include socio-psychological, socio-cultural rehabilitation and adaptive physical education in addition to medical and professional rehabilitation.

Rare occurrence, absence of specific clinical manifestations, difficult diagnostics on early stages, and insufficient experience in treatment of endometriosis genitalis externa deserve special attention. The study summarizes the results of treatment of scar endometriosis in four patients (three of reproductive and one of late reproductive age) describing clinical and diagnostic peculiarities of all cases. We revealed no specific laboratory diagnostic criteria of the pathology. The article is illustrated with photos of ultrasound findings, surgical field, a fragment of scar tissue removed during the surgery, and photomicrographies of surgical specimen histological sections. All presented pictures are described with indication of pathological process markers. We have stated the discrepancy between the sizes of endometrioid infiltrations in anterior abdominal wall revealed with echosonography and the sizes of those found during the surgery. During the surgery, we discovered that parietal peritoneum was not involved in pathological process. Basing on our observations, we have made recommendations on formation of scar endometriosis risk groups. In all four cases, surgical treatment with succeeding course of hormone therapy resulted in recovery of the patients.

The aim of this study was to assess 5-years catamnesis of children from mothers who had A(H1N1)pdm09 influenza during pregnancy. The design of the research: cohort cross-sectional retrospective "case - control" study. The study group included 227 children of mothers who had A(H1N1)pdm09 influenza during pregnancy, and the control group was consisted of 227 children whose mothers didn't have A(H1N1)pdm09 influenza in epidemic period during pregnancy. It was shown that 11,9 % of children born to mothers with influenza infection during pregnancy vs 1,8 % of children of the control group to 5-year age formed a cohort of patients with recurrent respiratory tract infections (p < 0,001). Acute respiratory infections were complicated by pneumonia in 15,4 % of study group children vs 8,8 % of children in the comparison group (p = 0,044). We founded a significant association between maternity A(H1N1)pdm09 influenza during 1^st and 2^nd trimesters of gestation and increased frequency of asthma in their children.

Three emergencies that occurred on the territory of the Republic of Khakassia, their potential influence on sanitary and epidemiological welfare of the population (using water factor as an example) were investigated. We used methods of data collection, analysis and further quality evaluation of fresh water. The results of 2956 analyses of fresh water from centralized sources of drinking water supply and water distribution network of the damaged areas were processed. It was determined that the most substantial deterioration of fresh water quality according to microbiological indicators was recorded in the flood period and upon the liquidation of the consequences of mass fire.

The analysis of work on identification and registration of complications of medicinal therapy in medical institutions of the Irkutsk region showed that the frequency of undesirable medicinal reactions at inpatients is more senior than 60 years makes from 10 % to 25 %. At advanced age the special place is taken by dysfunction of a digestive tract and allergic reactions at purpose of cardiovascular medicines, and also antibacterial and the antiglaucomous medicines. The number of cases of absence of therapeutic effect of PM in this age group made 18,9 %, reactions from the digestive tract - 15,5 % of cases, thus in 6,5 % pseudomembranous colitis was registered. It is established that risk factors of emergency of such reaction were the background pain or depressive syndrome, accompanying application of more than three drugs and absence of the scheme of a titration of dosages.

The aim of the research was to reveal main problems associated with the use of state programs funding mechanisms for basic research in health (medical) sciences in Russia, as main instruments of state policy. The source of information were “State Academies of Sciences Program of basic investigations for the period of 2013–2020 years” and other normative and legal acts in the sphere of planning and public financing of science and research. A study completed by using documentary, analytical methods, as well as methods of descriptive statistics and expert estimates. In analyzing financing from the federal budget for scientific research for civilian use within government programs calculations section, subsection of the budget classification, reflecting expenditure on scientific research (0110, 0112, 0208, 0313, 0403, 0411, 0504, 0604, 0708, 0803, 0908, 1005, 1104, 1203). Feature of the current situation is in an indeterminate state basic science after the liquidation of the Russian Academy of Sciences as a structure that generates through subordinate organizations the bulk of new knowledge and innovation in the country. Reform of the Russian Academy of Sciences led to the destruction of a coherent system of relations in science, to the Federal agency of scientific organizations for management of resources, Ministry of Education and Science and Russian academy of Sciences. Strict rationality and bureaucracy was extremely negatively perceived in academic science. The analysis of the subject structure of the medical unit actualized in 2015 of the Program of basic research of the state academies of sciences for the period of 2013–2020 showed that the distribution of the federal budget for basic research are not consistent with the priorities in the health sector, it does not account for changes in departmental affiliation Organizations of Medical Sciences. The authors prove the necessity of functional and managerial integration of academic medical institutions in the unified system of scientific research, creation and implementation of medical innovations into practical health care.

Key problems of the dental laboratories in public health sector include insufficient material and technical equipment, weakly theoretically and practically trained personnel and often a mismatch between the structure and organization of the laboratories themselves and modern requirements. To improve the functioning of the dental service, the actual problem remains the laboratory phase of providing dental orthopedic treatment to the population, which has an extremely important medical and organizational value in the quality assurance of orthopedic treatment and achievement of optimalfinal result. Until not distributed modern technology, they are not accessible to the majority of the population. Low competition in the field of high-tech prosthetics causes a high cost. The lag in manufacturing technologies and professional development leads to lowering the quality of public assistance, often inefficient and low-quality dental prosthetics, further enhances the problem, increases the level of need in dental orthopedic care for most of the population using the services of the state dentistry.

We studied distal colon of Wistar rats including descending transverse colon and rectum. Feature of distal colon in the left flexure are short mesenterium growing in size towards rectum, common mesenterium with small intestine attached to it on the right side and ligament forming left flexure and attached to it on the left side. It was found that one of the variants of normal blood supply is the absence of a. mesenterica caudalis. In this case blood supply comes from arterial arch formed by a. rectalis media and a. colica media. Moreover, in the classic variant of blood supply we revealed a variation in the amount of straight branches that go to this segment of colon wall from left colic and superior rectal arteries (from 3 to 5 from each artery). The structural features of rectum is weak expression of rectal ampulla that causes the depletion of fecal masses immediately after passing into rectum. Crypt compartment of colon of Wistar rats consists by 80,6 % of obligatory flora represented with Bacteroides ssp., Lactobacillus spp., Bifidobacterium spp., Enterococcus faecalis, E. coli (lac+), Grampositive rods. Facultative flora is represented with Proteus mirabilis, Peptococcus spp., Candida spp., Staphylococcus epidermidis, Citrobacter freundii and makes 19,4 %.

Zymographic analysis showed that all subcellular fractions of the serogroups possessed different degree of lipolytical activity. Maximal hydrolysis in the radial enzyme-diffusion reaction in agarose gel was observed in Tween-20, Tween-80, Triton Х-305 and Triton Х-405. Total hydrolase activity of urea extracts in Tween-20, Tween-80, Triton Х-405, Span-85 excelled those in the preparations of outer membranes. Maximal lipolytical activity in regard to the Tweens was shown by the preparations of urea extracts prepared from the nontoxigenic strains of O1 serogroups, while in relation to the Tritons - preparations of urea extracts from the toxigenic strains (p < 0,05).

To study the probable negative influence of the complex remedy "Tireoton" on the reproductive function of the laboratory animals the following tests have been carried out, namely the probable occurrence of embryo-toxicity, teratogenicity, foetotoxicity and its influence on the postnatal development of the laboratory animals progeny. The experiments have been carried out of the white Wistar rats. It has been established that the "Tireoton" at the doses of 75 and 750 mg/kg has no embryotoxic, teratogenic and fetotoxical effect. The introduction of the "Tireoton" at the dose of 750 mg/kg since 6^th to 19^th day of pregnancy does not influence on the postnatal development of white rats progeny.

Acute mesenteric ischemia is one of the most severe pathological conditions in terms of its course and prognosis. In the case of bowel infarction it is accompanied by an extremely high fatality rate. At the present day, despite there are ways to determine the patency of the vascular bed of the intestine accurately, developed principles and methods for the treatment of surgical interventions in different variants of acute occlusion of mesenteric vessels, it is not always possible to save the lives of patients with this disease. However, knowledge of the clinical picture of the disease, the consistent implementation of objective methods of diagnosis, timely decision on the need for surgical treatment can restore blood flow in the basin of the superior mesenteric artery and provide recovery and rehabilitation of these patients.