Among edema-producing neoplasms of central neural system, the meningiomas are unique. Meningiomas are histologically benign, slow growing and originate extracerebrally. The development of accompanying peritumoral brain edema (PBE) occurs in 40-60 % of meningiomas and often with a high degree of PBE with no obvious relation to the size and histologic features of the meningioma. The aim of our study was to determine the correlation between such parameters as gender, age of the patient, localization of the tumor tissue and the presence/severity of PBE. At meningiomas PBE was present in 70,1 % of patients. Meningioma with the presence of PBE occur more often than tumors without PBE. Olfactory groove tumors have more pronounced degree of PBE, unlike meningiomas of parasagittal localization and the region of the wings of the sphenoid bone. Mixed meningiomas had a greater degree of PBE unlike meningotheliomatozic and fibroblastic variants.

The article presents data from a study of 161 child with pneumonia. Two groups of patients with uncomplicated pneumonia and pneumonia with pleural pulmonary complication were formed. The study of coagulation hemostasis was realized in the studied groups. It was found that in children with uncomplicated pneumonia levels of SFMC and D-dimer were significantly higher than in normal conditions that indicates activation of coagulation hemostasis. When complicated by pneumonia hemostasis matches the current intravascular coagulation: thrombocytosis, increased levels of fibrinogen, hypo-or hypercoagulation on aPTT, changing TV thrombinemia (SFMC is 5 times higher than normal), and increased level of D-dimer, inhibition of fibrinolysis, which indicates more pronounced activation of coagulation in children with pneumonia.

The aim of the research was to determine the fluctuations of the autonomic nervous system based on the analysis of changes in certain heart rate variability (HRV) at patients after septoplasty and tonsillectomy. A study of Holter monitoring of 28 patients with nasal septum deviation and of 30 patients with chronic tonsillitis was conducted. Surgical procedures were performed under local infiltration anesthesia with 0,5% novocaine solution. We evaluated standard deviation of RR intervals (SDNN) - 24-hour monitoring, day and night data. After septoplasty for night and day validity period average SDNN did not differ (p < 0,05), but SDNN were significantly different (p < 0,05). Average values for the night and day were different from each other at the patients after tonsillectomy (p < 0,05). SDNN scatter was the same. SDNN in both groups did not differ per day both for average values and for variability (p < 0,05). Septoplasty provokes more pronounced stress response as compared with tonsillectomy. Local anesthesia for septoplasty and tonsillectomy causes a disturbance of adaptive reactions on the part of the autonomic nervous system. HRV analysis can be called an objective and individual method of diagnosis of acute stress conditions in the otorhinolaryngological surgery.

Perioperative acute myocardial dysfunction is an actual problem of cardiac surgery. Rational use of inotropes and mechanical circulatory support in the postoperative period remains a subject of debate. The outcomes of the combined coronary artery bypass grafting and heart valve prosthesis were analyzed in Irkutsk Cardiac Surgery Center after 80 patients were operated on. As a result of the conducted research, authors proposed a method of differentiated approach to the treatment of acute heart failure in the early postoperative period. Failure to escalate therapy beta agonists in the absence of adequate response hemodynamics and the transition to a mechanical circulatory support improves performance of the cardiovascular system and clinical outcomes, reduces hospitalization duration in the department of intensive therapy. The study showed the superiority of an early beginning of an intra-aortic balloon counterpulsation before traditional inotropic therapy in the treatment of postcardiotomy heartfailure at combined cardiac surgery.

Heel tendon injuries is the most common trauma of tendomuscular apparatus. Old ruptures of heel tendon occur in 58 % of cases in humans. The aim of the research was to estimate the effectiveness of treatment of the patients with old ruptures of heel tendon with Myerson type III defects who had tendon reconstruction on Chernavsky and short plaster splint immobilization of lower extremity for 4 weeks. We operated 10 patients using reconstruction on Chernavsky in our clinic from 2012 to 2014 (average age - 47,6 ± 12,0 years, 8 males and 2 females). All patients had old ruptures of heel tendon. Average time from the moment of trauma till the operation was 112,6 ± 80,4 days. Diastasis between the ends of tendon was 5,8 ± 0,7 cm that corresponds to Myerson type 111. Average term of staying at hospital was 10 ± 2 days. We didn't register any complications in postoperative period. Term of plaster immobilization of the operated extremity was 4 weeks. AOFAS score was 34,2 ± 6,8 points at the control examination in 1,5 months that corresponds to bad functional result. We registered good functional results (88,6 ± 3,5 points) in 3 months. 1n 6 months, functional results were 95,9 ± 1,6 points. 1n 12 months after the operation average score was 97,9 ± 2,1 points that corresponds to excellent functional result. Using heel tendon reconstruction on Chernavsky at the Myerson type 111 defects in combination with short plaster immobilization and early activization of patients allows to decrease term of rehabilitation of patients after the operation.

There were 105 patients with shoulder replacement under our supervision (terms of supervision were up to 10 years). There were 43 men and 62 women. Age of patients was from 29 to 80 years. Two ways of optimization of shoulder replacement are offered: "Method of preoperative determination of the sizes of a head of shoulder joint endoprosthesis" (Patent of the Russian Federation N 2469670 d.d. 12.20.2012) and "Method for intraoperative navigation of a shoulder stem of joint" (Patent of the Russian Federation N 2467725 d.d. 11.27.2012). We reached the improvement of quality of the operation due to the fact of an installation of the implants which are as much as possible close to the anatomy of a normal shoulder joint by size and position.

The features of emotional and personality status of patients with central serous chorioretinopathy are analyzed in this article. The study of emotional and personality features of 27 people from 27 to 62 years (average age - 47,7 ± 8,5years) which were in treatment with a sharp decrease in visual acuity from 0,8 to 0,05 as a result of developed central serous chorioretinopathy. It was found that patients with central serous chorioretinopathy in 50 % of cases are characterized by: 1) the severity of psychopathologic symptomatology; 2) super-strong and sometimes obsessive attitude to work, as well as an understatement of "significance" of the disease in favor of maintaining the working status; 3) the desire to overcome difficulties due to targeted analysis of stressful situations; 4) stable tendency to perceive a large range of situations as threatening the well-being; 5) the deterioration of the quality of life, which is characterized by dissatisfaction with the state of health (especially in visual acuity). Thus, these results show that patients with central serous chorioretinopathy have emotional and personality features aggravating the overall condition of the patient.

The article presents the study of features of formation and remodeling of distraction graft of rabbits' forearm bones at the passage of transosseous elements through acupuncture points. The aim of the work was to develop and perform quantitative estimation of regenerative process at the healing of forearm bone fractures using morphometric researches. We studied morphofunctional changes of graft on different stages of ossification using morphoscopy and morphometry and compared their quantitative characteristics with the ones in intact bone. Used index systems of estimation of regeneration processes at the healing of forearm bone fractures allow to reveal larger degree of statistical significance of obtained results not only in comparison with intact bone but also in over the time of experiment. Using quantitative variables and index estimation of regenerative processes at the healing of forearm bone fractures allow not only to objectify character of their changes but also to predict variability of its value.

HGF is one of the factors taking part in regeneration and recovery of liver after injury. The article is dedicated to the study of influence of single HGF intake on the indices of non-specific immune response in rats after 70% liver resection in the early postoperative period. Research was conducted on 42 six-months white male Wistar rats of 250-300 g. It was revealed that level of segmentonuclear neutrophils and lymphocytes in the group with HGF intake stand at normal level on the 2^nd day and normalizes to the 11^th day that testifies to the decrease of inflammatory response. Increased level of leukocytes and monocytes is registered in the group with HGF intake. Also integrity of non-specific resistance in the early postoperative period on the 2^nd day is registered. Suppression of phagocytosis indices with preservation of functional activity of phagocytes was registered to the 11^th day.

The article presents the examination of the ovaries of embryos, ovaries of human feti and ovaries of children of the tender age. The researches revealed the increase of the surface of follicles, nucleus and primary oocyte's cytoplasm that tells about the fact that further follicular maturation continues in the ovaries of a child of 2-4 months old. Also we registered the increase of nuclear cytoplasmic ratio, appearance of single mature follicles with cumulus oophorus that testifies to the fact that the ovary is functionally mature. Furthermore the research revealed increased content of lipids and DNA in follicular epithelium that also tells aboutfunctional maturity of the ovary. It was found that incretory activity of an ovary during the first year of life is provided by the cells originated from the connective tissue membrane of atresic follicles.

Blood samples were taken from 541 small mammal captured in 2013-2015 in Znamensky district of Omsk region from Ixodes persulcatus and Ixodes trianguliceps sympatric area and examined for the Babesia spp. presence by nested PCR with subsequent sequencing of positive samples. Babesia microti DNA was found in 31,1 % of positive samples; a proportion of infected mammals varied from 5,3 % to 61,6 % in different sampling periods. B. microti DNA was found in samples from three prevailing Myodes species as well as from a root vole (Microtus oeconomus), field voles (Microtus argestis) and Siberian chipmunks (Tamias sibiricus). It was shown that identified B. microti samples belong to two genetic groups: B. microti 'US'-type and B. microti 'Munich'-type; notably that > 90 % infected mammals contained DNA of nonpathogenic for human B. microti 'Munich'-type. We suppose that I. trianguliceps tick is the most probable vector of B. microti 'Munich'-type.

The review of domestic and foreign literary sources for 2002-2014 made it possible to deepen into the problem of interstitial cystitis and put together different points of view and also to systematize the store of knowledge. Interstitial cystitis is a complex disease with marked clinical manifestation and defeat of urinary bladder with varying severity. For the purpose of diagnostics and treatment optimization of the disease in point in the review they presented the criteria whose existence will make it possible to make the diagnosis of interstitial cystitis. The multifactorial etiology of the disease requires the multiplane causal and pathogenetic therapy but more often empirical and symptomatic In the article describe the algorithm of treatment of patients with the diagnosis of interstitial cystitis.

Urinary tract infections are one of the most common inflammatory disorders of urinary tract that occurs in 40 % of all cases of nosocomial infections. This pathology more often occurs in women, 50 % of them have urinary tract infection at least once in a lifetime. Urinary tract infections are chronic, pluricausal and frequently recurrent diseases. During many decades E. coli was considered to be main pathogenetic flora plated from urine at the urinary tract. Statistically Proteus mirabilis is ranked number two in the degree of incidence. At the moment the researches pay closer attention to Candida pathogens. Urinary tract infections appear in consequence of ingress of microorganisms in urinoexcretory system by ascending, hematogenic and lymphogenic ways. Culture-based, microbiologic study of urine with pathogen isolation and estimation of the bacteriuria degree is the gold standard of diagnostics of urinary tract infections.

We give an example of our own clinical observation of primary ciliary dyskinesia showing difficulties of this disease diagnosis. The complexity of this clinical picture is in the absence of situs viscerum inversus of the patient with early symptoms of chronic bronchitis and chronic sinusitis. From birth patient was noticed to have wheezing during acute respiratory viral infection (4 episodes), first year -bilateral pneumonia, and later - 3-4 pneumonias per year. Gastroesophageal reflux disease was diagnosed on third year of life, surgical treatment was used. Year 4 - according to computerized tomography data middle lobe syndrome was detected. We performed middle lobectomy. Then we revealed morphologically-cylindrical bronchiectasis. Severe bronchial asthma and allergic rhinitis were diagnosed in 4,5 years. Despite the fact that baseline inhalation and antimicrobial therapy was done, general condition of the patient did not get better. On year 9 we did bronchoscopy with brush biopsy of bronchial mucosa. The result is sharp decrease of ciliary function. All in all, even though the patient had classical symptoms of primary ciliary dyskinesia and first symptoms showed during the first year of life, right diagnose was stated only when the patient turned nine. Primary ciliary dyskinesia is classified as rare (orphan) diseases, that is why awareness of primary care physicians against this pathology is low, resulting in high disability of patients.