The paper considers specific features of type 1 Diabetes Mellitus in patients from Buryat populations. Characteristics of the incidence and prevalence of type 1 Diabetes Mellitus in patients of Buryat nationality are presented. Clinicalfeatures of type 1 Diabetes Mellitus in patients-buryats are highlighted. The aim of this study was to determine the ethnic characteristics of Diabetes Mellitus in patientsfrom Buryat population. It was found that the incidence and prevalence of type 1 Diabetes Mellitus in the Buryat population was below the relevant indicators of Russia and constituted 0.73 and 24.18 per 100 thousand population. Late vascular complications of the disease (diabetic nephropathy, diabetic retinopathy) occur in patients with type 1 Diabetes Mellitus of Buryat nationality less frequently than in the general population of patients with type 1 Diabetes Mellitus. Found that diabetic polyneuropathy (DP) was diagnosed in 25.8 % of patients.

4615 children have been screened: 2410 [52.2 %] are Russians, and 2205 [47.8 %] are Buryats; 2159 [46,8 %] of them are boys, and2454 [53,2 %] are girls. The widely spread risk factors of arterial hypertension development are heritable heart diseases, smoking (including passive smoking), overweight, as well as a sedentary way of life in different sex, age and ethnic groups. The results of the screening showed that the hypodynamia are more typical for city-dwellers, than for villagers. It is proved that high blood pressure prevalence is dependent on the phase of sexual development of girls belonging to both ethnic groups.

The study is devoted to the prevalence of chronic endometritis in women with reproductive disorders. There has been conducted a randomized clinical-epidemiological study of 327 women of fertile age who have applied with impaired reproductive function. Among them 125 (38 %) women showed primary infertility, secondary infertility was diagnosed in 98 (30 %) women, 104 (32 %) women complained of miscarriage. The in-depth survey allowed determining the structure of the causes of reproductive disorders. Endocrine factors and chronic endometritis were the most common causes in women with reproductive disorders. Chronic endometritis was identified in 78 (24 %) women. Among the causes in women with primary infertility the leading place belongs to the endocrine factor which constitutes 41 % (51). At secondary infertility endocrine factor and chronic inflammation were very significant; they were 18 % (18) and 21 % (21), respectively. In women with recurrent miscarriages chronic endometritis with a frequency of 39 % (41) takes the leading place. The results indicate the importance of chronic endometritis in the development of reproductive disorders, especially in miscarriage (39 % in miscarriage, 21 % in secondary infertility, 18 % in primary infertility, p < 0,05). The high frequency of chronic inflammation of the endometrium requires a comprehensive survey of women with reproductive disorders to conduct adequate medical therapy.

Currently the infertility is one of the most important reproductive problems. In the previous epidemiological studies the infertility rate in the different regions of Eastern Siberia was shown as 12-21 %. This article shows the results of the epidemiological study of infertility in Buryat Republic. The questioning and medical examination was done in the random sampling of 1495 urban and 545 rural women of reproductive age. Some ethnic aspects of infertility were investigated too. It was estimated that in Russian population the number of fertile women is higher in rural regions compare to urban ones, in Buryats it doesn't depend on region. The rate of unknown fertility and primary infertility is significantly higher in rural women of both ethnic group. In Russians the frequency of secondary infertility is higher in urban region, but in Buryats it doesn't depend on region and is similar to the infertility rate in urban Russians.

This article is devoted to analysis of pathologic affect of child's and adolescent's population, living on the Tofalariya territory, as well as socio-economic factors influencing the health of the native population in the study area according to a sociological study. In a study conducted a thorough medical examination of children living in Tofalaria. And also a sample case study of families was conducted. The article examines a set of negative socio-economic factors, typical to the territory of Tofalars habitation (one parent family, factors of poor housing, low family income, low levels of parental education, nutritional imbalances). We can identify the low availability of health care for this population group in combination with their low medical activity. The self-assessment of health among the population of Tofalariya is overstated, probably due to the significantly low level of information awareness about the prevention of disease and methods of solution these problems.

Article is devoted to the study of the epidemiology of juvenile arthritis in children in the Republic of Buryatia. All-Russian register of juvenile arthritis (JA) by the Republic of Buryatia (RB) is 48 patients aged 10,2 ± 5,1 years, with a mean disease duration of 3,4 ± 3,2 years, including 26 boys and 22 girls. There is a high incidence of JA in the Republic of Buryatia, which is 21,2 to 100,000 child population. Age of onset of the disease falls on school years and is 7,1 ± 4,5 years. Marked the beginning of the peak age 2 JA: 1-3 years 31,2 %, and 8-12 years 39,5 %. In 66,6 % of cases occur oligoarticular form JA. More than half of patients have extra-articular manifestations of JA, the majority of which occur in the reaction of lymphoproliferative (lymphadenopathy, hepatosplenomegaly). 56,2 % of patients with JA have a disability, 70 % of it is set in the first year of the disease. 90 % of patients with JA being treated with methotrexate, of whom 69 % are on conjoint immunosuppressive therapy, including 13 % genetically engineered biological agents.

We present the data on physical development, somatic pathology, reproductive disorders in children and teenagers from Tofalaria. Medical documentation and reports were analyzed, specialized surveys of children and teenagers by pediatricians, endocrinologist, gynecologist were carried out. Microscopy, oncocytology, PCR for detection sexually transmitted diseases (chlamidia, mycoplasma papillomavirus 16,18) and colposcopy were done in all teenaged girls. Evaluated morbidity was high. In indigenous Tofalaria population we found significant differences in rates of skeletal and conjunctive tissue disorders (incorrect posture, scoliosis, flatfoot) as well as endocrine disorders and nutrition (incorrect puberty, diffuse nontoxic goiter, growth retardation, hypotrophy). Reproductive health of girls in Tofalaria is characterized by early start of sexual activity, high number of abortion and high STD level and cervix condition is characterized by high rate of columnar epithelium ectopia to an ectocervix with often combination with inflammation. We suppose this situation as a consequences of its reproductive behavior. We believe that the target, long term program of educational, prophylactic and treatment efforts is needed to be developed for preservation of children and teenagers health in Tofalaria.

The paper presents the results of the cross-sectional epidemiological study of 96 teenagers of 14-17 years old of Mongoloid and Caucasoid populations living in countryside (village Bayanday, Irkutsk region). 3 ethnic groups were divided: 62 Mongoloid (Buryats, 65.3 %), 17 children of mixed marriages (metises; 17.9 %), 17 Caucasians (Russian, 16.8 %), including 47 boys(49.5 %, with an average age of 14,82 ± 0,79 years) and 49 girls (50.5 %, mean age 15,33 ± 0,15 years). The incidence of endocrine diseases, special ethnic characteristics of the endocrine and reproductive abnormalities and of certain hormones concentrations in Russian, mongrels and Buryat adolescents were established. Study of health major ethnic groups in Eastern Siberia, living in the countryside, set a higher frequency of reproductive abnormalities (with 43.7 % of girls and 31 % of boys). The high frequency of diseases of the endocrine system in Buryats and metises (50 % 52 %) compared to the Russian teens (12 %), basically hypothalamic syndrome of puberty and obesity. In 11-25 % of adolescents of studied ethnic and gender groups thyroid hyperplasia were established. However the median of FT4 and TSH were within the reference range, and the median of TSH was significantly higher in Russian teenagers both gender groups in comparison with the Mеtis and the Buryats. We have identified ethnic differences in the structure of the reproductive disease in boys: puberty delay and obesity, hyperprolactinaemia and testosterone decline, diagnosed more frequently in Mongoloids. Installed hormonal differences between groups of girls of the main ethnic groups suggest a role for testosterone in the reproductive disorders in Caucasians, prolactin the Mongoloid, which without appropriate correction can lead to infertility in reproductive age. The role of the environment on the development of hormonal disorders and the formation of the reproductive abnormalities in Caucasians, as identified by the hormonal changes teens Angarsk is 7-10 times higher than those found in adolescents Caucasian population living in countryside, which requires further study.

The paper presents the results of a retrospective analysis of reproductive and thyroid status in 1339 women (aged 27-45years) living in Eastern Siberia. 134 Mongoloid (Buryat) women and 1205 Caucasians (Russian women): 81 % women of infertile couples, 19 % of healthy women (control group) were established. High rates of hypothyroidism (18 %) in women with hyperprolactinemia and thyroid autoimmunity (7.9 and 7.2 %) in women with uterine fibroids, endometriosis and infertility, living in the Irkutsk region, was found. This study confirms the role of thyroid dysfunction in reproductive disorders. The median TSH in women with infertility Caucasians (Russian women) significantly exceeded the performance of TSH in the control group, especially in women with uterine fibroids and endometriosis. The median of FT4, the biologically active part of total thyroxin, in infertile women were in the range of reference values, were significantly lower than median of FT4 in the control group. In women with infertility, living in the Republic of Buryatia, thyroid disease was found in 2 times less compared to a resident of the Irkutsk region (14.1 % and 35 %; P (χ²) <0,05). There were no ethnic differences in the incidence (14 % and 14,4 %; P (χ²) > 0,05), in the structure of the thyroid diseases, in certain hormones concentrations TSH and FT4 in Russian and Buryat women with infertility, which requires further study. Discriminant analysis found the significance of changes in thyroid hormone for infertility in different ethnic groups: for infertile and fertile Russian women, living in the Republic of Buryatia, informative signs are indicators of TSH; for infertile and fertile Buryat women FT4; for women Caucasians with infertility, uterine fibroids and endometriosis, living in the Irkutsk region T3 and T4.

This paper presents the results of a retrospective analysis of epidemiological studies (2005-2011 years) continuous sampling method 320 adolescent boys aged 14-17 years living in the Irkutsk region (Irkutsk, Bratsk, Angarsk, v. Bay-anday): 282 boys Europeans, 30 Mongoloids, 8 Mitis. We compared the clinical, instrumental and laboratory data in adolescents, depending on where you live, the presence or absence of pathology and ethnic groups in the Russian, Buryat and Mitis. Ethnicity was determined by taking into account the phenotypic characteristics of the child and genealogical data history (children with parents in two generations of one ethnic group). The high frequency of goiter in teenage boys who live in the major industrial cities in the 2.63.4 times the figure given in the rural population (px² < 0,05). Delayed puberty and physical development associated with the goiter, hypothalamic dysfunction, obesity, hyperprolactinemia and gynecomastia diagnosed in 23.3 % of Mongoloids and 22.2 % of Russian teenagers (px² > 0,05), living in rural areas, with no significant ethnic differences. However, the teenagers Caucasians living in urban areas, the puberty and physical development delay met in 2,5-1,4 times more often (33,8-58,3 %; px² < 0,05). Our data support a role of thyroid dysfunction in the development of reproductive disorders, and therefore timely diagnosis, treatment and recovery of thyroid function is necessary for the prevention of infertility. The established differences in urban and rural adolescent boys suggest the influence of anthropogenic impact on the functioning of the endocrine and reproductive systems.

The purpose of this investigation was to study the ethnic peculiarities of sleep disorders in European and Mongoloid races living in Eastern Siberia. In this study we performed questioning of409 respondents of Europeans (Russian) 203 (49.63 %) and Mongoloid (Buryats) 206 (50.37 %) aged 20-60 years. Living in the Irkutsk region and the Buryat Republic. Gender structure: 270females (66.9 %) and 125 males (33.1 %). Standard questionnaire of Stanford Sleep Research Center (USA) included a complex of questions about problems of sleep and their subjective assessment: no problems; light problem, moderate problem, severe problem. PSG-monitoring applying system GRASSTELEFACTOR Twin PSG (Comet) with amplifier As 40 with integrated module for sleep SPM-1 (USA). It was revealed that "light" sleep problems note 25.1 % of native ethnic group respondents (Buryats) and 38.3 % of Russian respondents (p < 0.05). The moderate sleep disorders were characteristic of 8.7 % Buryats and 3.1 % Russian (p < 0.05), and the severe sleep disorders 5.3 % and 2.2 %, respectively (p < 0.05). Severe sleep disorders noted 7.2 % Buryat women versus 1.8 % in the group of Russian women (p < 0.05), among men the severe sleep disorders is significantly higher (23.8 % in the Buryats and Russian 14.6 %, p < 0.05). We identified correlation between body mass index (BMI) and obstructive sleep apnea (OSA) in males of Mongoloid race (with OSA BMI was 33.37 kg/cm², without 24.86 kg/cm², p < 0.05). According to the results of the PSG study in males of the both ethnic groups, a higher incidence of moderate and severe OSA in the Buryats (28.2 % and 20.1 %, respectively, p < 0.05). In general, these results confirm the presence of more severe sleep disorders in Mongoloids (including OSA), but certain anatomical features for the formation of OSA we have not found, that require further study.

The article presents the results of analysis of statistical data and medical cases of women with urogenital tuberculosis, examined at the Republic's clinical TB dispensary in Ulan-Ude (Buryat Respublic) in the 2008-2012. It was shown that in accordance with hospital register the genital TB incidence and the rate of infertility associated with tuberculosis in Buryats and Russian patients are similar.

Arterial hypertension (AH) is observed in 4-8 % of pregnant women. Even light previous AH increases the risk of pregnancy and delivery complications up to twice, thereby significantly degrading the prognosis of pregnancy and childbirth. The aim of the study is to evaluate the main cardiovascular and metabolic patterns in pregnant women with AH in depends on their ethnicity. We studied the pregnancy courses in 295 pregnant women with AH. The 1^st group was 138 Buryat women and the 2^nd group were Russian. In all patients we evaluated hematological, biochemical and hemostatic data as soon as perform daily monitoring of blood pressure. We observed some ethnic patterns of arterial hypertension. Buryat women had dyslipidemia and elevated fibrinogen. Also these patients demonstrated elevation of the value of morning rise in diastolic blood pressure during (DBP) their pregnancies with the most significant value of variability of night DBP. We found the direct link of serum fibrinogen with night DBP в In the 2^nd trimester of pregnancy.

Pre-eclampsia is one of the most dangerous complications of pregnancy and increases the risk of adverse outcomes for both mother and fetus. Objective: to study the course of pregnancy, circadian blood pressure profile, autonomic regulation of the heart and metabolic systems in pregnant Buryat women with pre-eclampsia. To achieve the objectives of the research we have studied pregnancy courses and birth outcomes in 581 women. For the analysis wereformed thefollowing groups; the Igroup 240 pregnant Buryat women with pre-eclampsia; II group 341 pregnant Russian women with pre-eclampsia. In all patients we evaluated hematological, biochemical and hemostatic data as soon as perform daily monitoring of blood pressure. Our studies have shown that Buryat women developed early severe pre-eclampsia early, demonstrated no response for treatment with requiring early surgical delivery. Hemostasis changes in preeclampsia in pregnant Buryat women indicate the prevalence of vascular-platelet disorders (F = 27,18). Their circadian blood pressure profile is characterized by a lack of pressure reduction at night, in a paradoxical increase of mean dynamic blood pressure at night (F = 27,18) as soon as Russian pregnant had higher rates of maximum systolic and diastolic blood pressure during the day (F=30,29). The autonomic regulation of the heart function in pregnant Buryat women with pre-eclampsia is characterized by imbalance in parasympathetic and sympathetic innervation with vagotonia domination as in the daytime and at night, which increasing with severity progression of the pre-eclampsia. High daytime level of VLF-in Buriat women with severe pre-eclampsia evidences of stress adaptation processes.

Aimed at studying the prevalence of emotional disorders and behavior disturbances in children and adolescents of Aginskiy district of Buryatskiy region (okrug), we had been examining 2 572 schoolchildren picked up by random (1 487 primary schoolchildren and 1 085 adolescents). We were using M.Ratter's questionnairy (B2 scale for teachers). Frequency of emotional disorders and behavior disturbances in primary school children was 8.6 %, and in adolescents it was 7.3 %. We marked disorders in boys 2-4 times more frequent than in girls. The shares of behavior disturbances and hyperkinetic disturbances are the largest in the structure.

The article presents the results of examination of 156 women from infertile couples (88 Russians, 68 Buryats). The uterine factor of infertility was observed more often in Buryats due to higher rate of uterine fibroids in Buryat women with secondary infertility in comparison with Russian infertile women: 69,7 % and 21,8 %, respectively. No significant difference was shown in adenomyosis and endometrium hyperplasia frequency.

Girls and teenaged girls of different ethnic groups living in Tofalaria during different age period were examined. The aim of this research was to establish the peculiarities of functioning of pituitary-thyroid system and metabolism of thyroid hormones in healthy girls and teenagers living under adverse climatic and geographical conditions depending on their ethnicity. It was set that in ethnic Tofs girls and in Europoids girls in age group of 7-11 there were differences in the content of the active fractions of thyroid hormones testifying different mechanisms of maintenance of thyroid homeostasis. These differences remain in age group of 12-14, when changes in pituitary section of the system are added to them. The functioning of pituitary-thyroid system-level of neuro-endocrine regulation in native girls of Tofalaria of 15-18 goes in more economical way. This is actually the result of genetically determined long-term adaptation of natives' organism to extreme climatic and geographical environmental factors.

Comprehensive epidemiological analysis of tuberculosis in the Republic of Buryatia (RB), including among different ethnicgroups (Russian, Buryat, Evenk) presents in the article. Assessment of the epidemiological situationfor 1994-2012 was examined on various parameters (incidence, prevalence and mortality). It was found that the epidemiological situation in RB in the last twenty years were characterized by high incidence of tuberculosis when compared with similar data for Russia as a whole (mean annual incidence 148,1 ± 6,9⁰/₀₀₀₀ и 77.6 ± 2,1⁰/₀₀₀₀ respectively). Among the various ethnic groups living in the RB, the most unfavorable epidemiological indicators identified for the Buryat population. "Safely" group of the population was Evenki. For each of the studied ethnic groups have been identified areas of tuberculosis risk, which had its own characteristics.

Purpose: to study nutritional habits as a risk factor of cardiovascular pathology as so as a role of apolipoprotein A1 gene in metabolism in native and alien population of Eastern Siberia. Methods: we used Kiselev questionnaire (1998) for estimation of "nutritional risk". Totally 863 adolescents were evaluated, including 445 (51,6 %) persons of the alien ethnogroup (Russian) and 418 (48,4 %) persons of the native ethnogroup (Buriat). We evaluated clinically, functionally and genetically healthy and hypertensive (having essential arterial hypertension) adolescents and compared the results. Out of 226 adolescents with essential arterial hypertension, 144 persons were from the alien ethnogroup (mean age is 16,22 ± 1,14 years) and 82 adolescents from the native ethnogroup (mean age is 16,57 ± 1,62 years). Out of 173 healthy adolescents (mean age is 15,12 ± 2,71 years), 79 (45,7 %) persons were buriats and 94 (54,3 %) persons were Russian. Ethnic data were gotten by questionnaire, which included information about nationality back to the third generation of ancestors. We studied a total genomic DNA, which was extracted from blood serum by non-enzymatic method. An amplification of DNA loci was performed by polymerase-chain reaction using an automatic thermocycler «Biometra» with «SNP-экспресс», «Litex» reagents. The results of our research indicated an imbalance of nutritional habits with domination of protein-lipid dietary compounds in adolescents of native and alien population ofEastern Siberia. We found differentiated contributions ofinsertion-deletional polymorphism of apolipoprotein A1 gene. We did no found differences of frequency response of alleles and genotypes. We found a positive linkofapolipoprotein Al gene deletion with increased level ofcholesterine, very low density lipoproteins, triglycerides as so as with elevation ofnumbers ofblood pressure indexes in the adolescents ofthe alien ethnogroup. We did not found such kind of links in adolescents of the native ethnogroup that, as we suppose, may be a reflection of the evolutionary developed nutritional stereotype with some predominance oflipid-protein dietary component. Developed through the millennia such kind ofdiet in the indigenous population of the North and Siberia is a response to cold stress and underlies formation ofthe genotype, which aimed to developing a biochemical phenotype with ability to compensate this nutritional atherogenic imbalance.

The aim of the present work was the study of children's health in the Northern areas of the Zabaykalsky Krai. The study was conducted on the territory of Tungokochenskiy, Tungiro-Olekmenskiy and Kalarskiy areas. A random sample of 1339 children and adolescents of indigenous population and newcomers to the Northern regions was examined, including 254 Evenks. Conducted examinations of employees of Regional Children Consultation and Diagnostic Center; functional diagnostics, ultrasound diagnostics; laboratory diagnostics: determination of urinary iodine ионоселективным method, ELISA screening helminthes, evaluation of the humoral immunity, evaluation of hormonal status, study GSTP1 polymorphism of genes (Ile105Val), TNF-alpha (G308A), IL-10 (G1082A) and IL-4 (C589T) using PCR-Rv children of indigenous peoples of the Northern regions of the Zabaykalsky Krai (Evenk). On the basis of the analysis of the results of field work the following results were received: pathological affection of the child population was 2542 %, Evenk children 4791 %; the main ranking place among somatic pathology among children, the alien population of the Northern regions, corresponds to those of the children of Slavic group. Besides, the fact that the rate of pathological prevalence among Evenk children in 2 times higher, than among children of the alien population, creates quite a different picture of the distribution of nosological forms. We identified the features of the distribution of polymorphic variants of genes GSTP1 (Ile105Val), TNF-alpha (G308A), IL-10 (G1082A) and IL-4 (C589T) Evenks, which, in our opinion, warrant, together with factors of the external environment, a pattern of morbidity among children of the indigenous residents of Northern Transbaikalia. The data we have on overall morbidity and pathological prevalence of children in studied areas of Transbaikalia correspond with the results of molecular-genetic research.

This study is devoted to study the prevalence of genotypes and polymorphic alleles of genes-candidates of arterial hypertension in children with endemic goiter (EZ) in the Zabaykalsky Krai. To identify the frequency of occurrence of adverse genotypes and alleles polymorphisms Gly16Arg ADRB2, Gln27Glu ADRB2 and Thr174Met gene AGT, as factors of risk of development of arterial hypertension, were examined 194 children aged 7-11 years with a diagnosis of endemic goiter. The frequency of mutant allele 16Gly genotype Gly16Arg associated with increased agonist-induced suppression of beta-2 adrenergic receptors has not been above (63,2 %) than in the group of healthy children (60,3 %) (p(j²) > 0.05). The frequency of allele Arg16 defining a greater degree of vasodilating effect, was 39.7 % and 36.8 %, respectively (p(x²) > 0.05). Thefrequency characteristics of alleles genotype Gln27Glu in group I were the following: wild type 27Glu 41 %, the mutant allele Gln27 59 %, in the control group 42,2 % (p(χ²) > 0.05) and 57.8 % (pfy²) > 0.05) respectively. The frequency of wild-type Thr174 genotype Thr174Met accounted for 85.3 % in group I and 86.2 % in the control group (p(x²) > 0.05) and the frequency of occurrence ofthe mutated allele 174Met 14.7 % in the group of children with diffuse nontoxic goiter and 13.8 % in healthy children, respectively (pCx²) > 0.05). Significant differences in the distribution of genotypes and alleles between groups are not identified, and the frequency characteristics were comparable with the prevalence in the population and the results of other authors. The distribution of genotypes and frequency of alleles of a gene Gly16Arg and Gln27Glu ADRB2, Thr174Metgene AGT in both groups corresponded to the expected according to the hardy-Weinberg equilibrium in the population sample. The results obtained in the course of molecular-genetic study led to the conclusion that polymorphisms Gly16Arg ADRB2, Gln27Glu ADRB2 and Thr174Met gene AGT are not factors of risk of development of arterial hypertension in children with endemic goiter.

An important role in the pathogenesis of male infertility belongs activation of free radical oxidation. Intensification lipoperoxide processes occur together with a decrease in antioxidant protection. According to a study of two ethnic groups found that in men of reproductive age with Russian nationality infertility is most pronounced imbalance in the lipid peroxidation antioxidant protection compared to infertile men Buryat nationality. Reducing the concentration offat-soluble antioxidants (retinol, α-tocopherol) in the blood of Russian men with infertility say about the development of oxidative stress. In men, the Buryat nationality decreasing trend of antioxidant defense enzyme, primarily reduced the level of superoxide dismutase. Perhaps the decreased activity of superoxide dismutase in our study is related either to the depletion of its activity, or the inhibition of lipid peroxidation products. The increased level of lipid peroxidation is associated with a reduction in the antioxidant capacity of the system, which is unable to cope with overproduction of reactive oxygen species and, as a result, the processes of oxidative modification of lipids. The materials for biochemical studies were blood serum and red cells. The total antioxidant activity of serum and the content of its components (superoxide dismutase, α-tocopherol, retinol, blood-reduced glutathione, oxidized glutatione) were evaluated by a spectrofluorofotometer "SHIMADZU-1501" (Japan). Statistical analysis was performed by parametric tests. The study was supported by grants of the President of the Council of the Russian Federation (Scientific School 494.2012.7).

Infertility is a problem of medicine with a large magnitude. It is believed that oxidative stress (OS) modulates the age-related decline in fertility. OS can arise as result of excessive production of free radicals and/or impaired antioxidant defense mechanism. Lipid state and «lipid peroxidation antioxidant protection» system were studied in 60 women with infertility and hyperprolactinemia The materialsfor biochemical studies were blood serum and red cells. Lipid components were evaluated by a automatic analyzer Cormay «BTS-330» with photometry method. The content of the substrates and products of lipid peroxidation (diene conjugates, ketodienes and coupled trienes, malondialdehyde), total antioxidant activity of serum and its components (superoxide dismutase, α-tocopherol, retinol, reduced and oxidized glutathione) were evaluated by a spektroflyuorofotometr «SHIMADZU-1501» (Japan). The concentration of prolactin was evaluated by a set of «Diaz» (Russia) and analyzer «Immunotest». Statisical analysis was performed by non-parametric tests. In women with infertility and hyperprolactinemia increase ofconcentraion of atherogenic and decrease of antiatherogenic lipoproteins and triglycerides takes place. In addition, atherogenic factor increases. It has been established that in evaluated infertile patients lipid peroxidation processes were excessed, while the level of output (TBA-active) products was reducing. Antioxidant protecion state in hyperprolacinemia and infertility is characterized by reduced levels of fatand water-soluble vitamins, increasing total antioxidant activity, an imbalance in the glutathione system. The study was supported by grants of President ofthe Council ofthe Russian Federation (Scientific School 494.2012.7).

Inflammatory diseases of the reproductive system continue to take one of the first places among the causes of reproductive disorders. A high frequency of chronic endometritis in women with reproductive disorders is registered and in modern conditions, it has no tendency to the decrease. The research is dedicated to the analysis of the data of the anamnesis of 127 women with chronic endometritis and reproductive disorders. Patients who visited doctor in connection with reproductive disorders underwent complex examination. It included the data of the anamnesis, general clinical and gynecological examinations, laboratory and instrumental methods. Verification of diagnosis of chronic endometritis was carried out following the results of the histological examination of the endometrium. In the group of women with chronic endometritis 56 % (71) of women complained of miscarriage, in 20 % (25) there was diagnosed primary infertility, and in 24 % (30) secondary infertility. It was revealed that in patients with chronic endometritis diseases of gastro-intestinal tract, kidneys, and upper respiratory tract dominated among somatic pathology. A high percentage of women had urogenital infections in the past. Those infections were determined in 49 % (62) of women, 65 % (40] of those patients had mono-infection. Chlamydia, trichomoniasis, and viral infections prevailed among pathogens. Women with chronic endometritis more often had operative interventions on the abdominal organs. Percentage of women 56 % (71) with indication for curettage of the uterus regarding terminated pregnancy (after spontaneous abortion or non-developing pregnancy) is high, 25 % (18) of them had both miscarriage and non-developed pregnancy in history and 20 % (15) of patients had from 2 to 4 curettage of the uterine cavity. The percentage of complicated deliveries and abortions was 28 % (35).

The article is devoted to the prevalence of polymorphism of genes responsible for thrombophilia among children. The study included 52 children with thrombosis and 59 children without thrombosis. Detects mutations factor V Leiden, G20210A prothrombin gene, the C677T mutation in the gene for 5,10-methylenetetrahydrofolate reductase and 4G/5G polymorphism of gene plasminogen activator inhibitor 1. Mutations thrombophilia markers are detected in 38 of 52 (73 %) children with thrombosis, and 36 of 59 (61 %) children without thrombosis (p=0,1). A combination of several mutations in genes had 38 of 69 (55 %) children having different polymorphisms. The highest percentage (86 %) of different combinations of mutations have children with venous thrombosis, wherein the presence of mutations in Factor V (Leiden) mutation and prothrombin gene was isolated, and in all cases with each other or combined with mutation of the MTHFR gene. The most significant in the development of thrombosis are the G20210A mutation in the prothrombin gene mutation and Leiden. An example of clinical thrombosis, the girl with the data mutations.

The kinetics of development of malignant oncological diseases under prolonged action of acrylionitrile on the people was studied, as well as the kinetics of the development of such diseases among the population of Krasnoyarsk. The frequency of genetically caused diseases Down's syndrome, depending on the age of the mother was studied. Malignant oncological diseases are supposed to be mostly genetically induced and to occur with the respective part of population. It is proved that among the diseased part of the population fatal sampling malignant oncological diseases develop over time on autocatalysis mechanism. Herewith, the logarithm of affection to non-affection probability ratio for a definite age has linear dependence on the life time. It is proved that acrylionitrile is a latent oncogenous. It is shown that the Down's syndrome also develops autocatalytycally starting from about thirty years of mother's age. It is also assumed that many age-related diseases have also autocatalytic development over the time.

The methodical particularities of the using happen to in medicalbiological correlation analysis quantitative variable, concerning conditions of the using, calculations, interpretations and determinations to true or mediated fresh relationships when undertaking medical-biological studies.

Oxidative stress is an acknowledged pathogenic mechanism in Type 1 diabetes mellitus. Acute increases in plasma glucose concentration may increase free radical production by the following mechanisms: labile glycation; auto-oxidation of glucose, and intracellular activation of the polyol pathway; which produces an imbalance in the NADh/NAD+ ratio and favours the production of free radicals. Incidence, severity, and rate of complications of Type 1 diabetes mellitus are associated with many factors including geographic location and ethnicity. The main features of lipid peroxidation in 30 women with type 1 diabetes in Buryat and Russian ethnic groups were examined. The materials for biochemical studies were blood serum and red cells. The content of the substrates and products of lipid peroxidation (diene conjugates, ketodienes and coupled trienes, malondialdehyde), total antioxidant activity of serum and its components (superoxide dismutase, α-tocopherol, retinol, reduced and oxidized glutathione) were evaluated by a spectrofluorophotometer «SHIMADZU-1501» (Japan). Statistical analysis was performed by non-parametric tests. It is shown that the intensity of lipid peroxidation processes in patients Buryat ethnic group is reduced in comparison with Russian ethnic group, that confirmed by the values of the coefficient of oxidative stress. The study was supported by grants of the President of the Council of the Russian Federation (Scientific School 494.2012.7).

This research is devoted to studying of features of antioxidant protection system in adolescent boys and girls of various ethnic groups of Eastern Siberia. Study of the peculiarities of processes of antioxidant protection of populations of people of different ethnicity, living in the same geographical conditions, is of undoubted scientific interest. It is especially important to assess metabolic status of a young, growing body to ensure in the future the preservation of reproductive ability. We biochemically evaluated 58 boys of 14-17 years old. Out of them 19 boys were Russian, 29 boys were Buryat population and 10 boys were metises. Also we biochemically evaluated 57 girls. Out of them 21 were Russian, 27 girls were Buryat population and 9 girls were metises. The materials for biochemical studies were blood serum and red cells. The total antioxidant activity of serum and the content of its components (superoxide dismutase, α-tocopherol, retinol, blood-reduced glutathione) were evaluatedbya spectrofluomphotometer «SHIMADZU-1501» (Japan). Statistical analysis was performed by parametric tests. The study was supported by grants of the President ofthe Council of the Russian Federation (Scientific School 494.2012.7). The detected features of antioxidant protection processes in observed adolescents had gender differences, also may be explained by their ethnicity and characterized by different degree of activity of metabolic processes in adolescent boys and girls of different ethnic groups of Eastern Siberia. Study the state of the antioxidant system of the organism can be used as an additional criterion for complex examination of practically healthy adolescents, which significantly enhance the representation about the adaptation possibilities of the organism to external conditions and can be a basis for effective monitoring of reproductive health in the future.

In order to study the peculiarities of emotion sphere and reactions under stress situations, we examined 556 adolescents of indegenion peoples of Siberia, inhabitants of three districts, located in Siberian region. Control was represented by 315 alien adolescents of Siberia. We implemented the technique of «Self-evaluation of psychic disorders» and determined the level of anxiety, frustration, aggression, private rigidity. Wefound out that psycho pathologic basis of suicidal behavior in native adolescents of Siberia is the increased level of anxiety, decreased tolerance to stress, blocked activity under stress situation.

Hokkaido hantavirus (HOKV) identified originally in the grey red-backed vole (Myodes rufocanus) in Hokkaido, Japan. Subsequent studies showed different genetic lineages of HOKV in Sakhalin, Buryatia and Far Eastern regions of Russia and in China. Tissuesfrom 68 arvicolid rodents, captured in regions south and west of Baikal Lake, were initially tested for hantaviral antigen by ELISA, and tissues from antigen-positive rodents were analyzed for hantavirus RNA by RT-PCr. Taxonomic identification of host species was based on phylogenetic analysis of partial cytochrome b gene sequences. Hantavirus Land S-segment sequences were detected in two antigen-positive M. rufocanus, from the Tunka region of Buryatia Republic (south side) and the Olhon region of Irkutsk Oblast (west side). Sequence analysis showed that the newfound hantavirus strains, designated Baikal and Siberia, represented genetic variants of HOKV Previously unknown genetic variant designated Siberia was identified in M. rufocanus captured in Olhon region. Second genetic variant from Tunka region, designated Baikal, was closely related to previously described hantavirus strain from the same region. Alignment and comparison of the nucleotide and amino acid sequences showed intra-strain differences of 18,4 % and 5,3 % for the L segment and 17,4 % and 3,5 % for the S segment, respectively. Sequence divergence from geographically distant HOKV strains were 17,4-21,5 % and 3,9-6,8 % for the L segment and 15,2-17,0 % and 3,3-4,0 % for the S segment, respectively. Phylogenetic analysis, based on a 346-nucleotide region of the L segment, revealed four lineages represented by previously reported variants from Japan and Sakhalin (strains Kitahiyama128L/2008, Tobetsu35L/2010 and Sakhalin99L/1998), Shkotovo in Far-Eastern Russia (strain Khekhtsir37L/2002) and the new variants from Baikal Lake. Analysis of the N protein, coding by the S segment, identified specific amino acid signatures for YJRV of Lys₅, Arg₂₆, Val/Ile₆₈, Val/Ala₉ He₂₆₂, Pro₂₈₃. Conclusions: HOKV is widespread across the geographic range of its arvicolid rodent reservoir host.

This review describe some possible links of epidemiology and progress diseases with people ethnicity and race. Cultural, socioeconomic, genetic and environmental factors play significant roles in these links. It was shown some ethnic differences in development of a number of pathological conditions in aboriginal and indigenous minorities of the North and Siberia. It was found increasing of the incidence of disease among individual classes of peoples in Siberia. The ethnic factor should be taken in accounts in explanation of pathogenesis of pathological processes, development of evidence-based, differentiated treatment programs and therapeutic approaches in multinational regions of our country.

An analysis of the researches showed that the indigenous ethnic group of Baikal region has high level of adaptation to a place of residence in comparison with migrant. Rate and clinical manifestations of diseases in the Buryat ethnic group have significant differences from the Russian (moderate type 1 diabetes, severe reproductive disorders). Also, there are some differences of redox protection state in indigenous ethnic group of Baikal region that could be an additional biochemical marker of disease severity.

Oxidative stress plays an important role in the pathogenesis a most of diseases. Important components of protecting cells from oxidative stress are antioxidant enzymes, whose activity is genetically determined, due to the presence in the structure of the alleles of genes. Antioxidant enzymes are characterized by population and individual differences in enzyme activity. The study of genetic variation in the population of the world and the history of the formation of its gene pool is one of the promising areas of modern population genetics. Genetic variability of antioxidant enzymes in the body has recently become the most attractive destination in the pathogenesis of many diseases. Due to the involvement of enzymes in the pathogenesis of antioxidant enzymes social diseases is an important implementation. Comprehensive study of the genetic polymorphisms of genes contributes to the formation of human disease susceptibility. The antioxidant system is of the person a system that blocks the formation of free radicals, highly active oxygen. Under normal physiological conditions, a small amount of oxygen is constantly converted to superoxide anions, hydrogen peroxide and hydroxyl radicals. Excessive production of these radicals is a factor of injury; compensatory mechanism is the antioxidant system. The main component of this system is a network of antioxidant enzymes (AOP): superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) and paraoxonase (PON). In this case, the activity of enzymes evolutionarily and genetically programmed to optimize the balance of oxidative processes and the activity of antioxidant defense systems. The purpose of the review is to summarize and discuss the current data on genetic polymorphisms of antioxidant enzymes in certain pathologies, the development of which plays the role of oxidative stress.

We analyzed and summarized research data concerning considerable deterioration of reproductive function in men form different ethnic groups during the last decades. These changes are expressed not only in deterioration of spermatogenesis, but also in appearance of an oxidative stress signs in blood serum and ejaculate in men of reproductive age. The analysis of domestic and foreign publications indicates that oxidative stress is accompanying and/or plays one of pathogenic role in development of many types of reproductive disorders in men of various ethnic groups. The state of health of the male population affected by factors related to lifestyle, environment, population genotype. Frequency and clinical manifestations of pathology of the male reproductive system depend on the combinatorial impact of the environment influences exerted more often during the growing effect. A combination of several, even the weakest, but unidirectionally influencing factors, makes the risk of the development of the male reproductive pathology very high.