We researched, polymorphism, of interleukin IL-8 gene at Helicobacter pylori-associated diseases: ulcers and chronic gastritis in native and visitant population of the Republic of Khakassia by the method, of restriction enzyme digest analysis. Prevalence of subtypes VacA+ and CagA+ of Helicobacter pylori was realized, by the method, of polymerase chain reaction. We revealed, the most widespread allelic variants of genes of cytokines among Khakas. The expediency of determination, of population, risk and. protective genotypes of Helicobacter pylori that promote development of ulcer desease in Khakas.

The different forms and the degree of expression of the immune responses of the employees to the exposure to the neurotoxicants of different chemical nature (metallic mercury vapours, vinyl chloride and dichloroethane, epichlorohydrin and. allyl chloride), stipulated, mainly by the specific character of chemical factor, were revealed. The role of pro- and. anti-inflammatory cytokines in the immune regulation, processes was indicated to be in the exposure to the neurotoxicants. The pro- inflammatory trend, of the responses of different intensity without the dependence on the exposure factor was considered, as the common change regularity of the cytokine profile in the persons of the "risk group". The peculiarities of the immunoresponsiveness changes in dependence on the working period, duration (record of service) under the harmful working conditions displaying the different immune mechanisms in exposure to the harmful production, substances (metallic mercury vapours, vinyl chloride and. dichloroethane, epichlorohydrin. and. allyl chloride) were revealed.

The results of bacteriological research of scatological material from children with allergic diseases (atopic dermatitis, bronchia! asthma combined, with allergic rhinitis, dermal and respiratory syndrome, allergic rhinitis) in Irkutsk are presented, in the article. 62 patients from 1 year to 17 years were examined, and. significant deviations from the scatological norm, were revealed: in lactic acid, bacteria — 75,8 % while the number of bifidobacteria was reduced, in 58 % of patients. The most frequently identified, bacteria were S. aureus (24,2 %) and. K. pneumoniae (14,5 %).

Decrease of estriol and estradiol concentration, was found, at herpes-viral infection exacerbation, in placenta of pregnant at early stages of gestations. Revealed, change was shown by result of defect of base steroid. — cholesterol content, as well as distribution, of the steroid, hormone syntheses process: low activity of placental 17β-hydroxysteroid dehydrogenase and. inadequacy steroidogenesis regulating mechanism..

We realized, the definition, of polymorphic variants of genes of folate cycle (C677T, A1298C, A66G) in children with, essential hypertension, having the burdened, and not burdened, hereditary anamnesis of thrombosis. Frequency of the incidence of low functional allele polymorphisms C677T and. A1298C didn't exceed, ubiquitous in the general population, and. in agreement with, those obtained, in other studies, with, an unfavorable genotype GG A66G gene was more frequent than in the population. In all groups of children studied, most often occurred in the carriage of any one of the polymorphic genes, but the combination, of two or even three adverse alleles also met with, relatively high, frequency. No statistically significant differences in the distribution, of genotypes between groups were found.

As a result of improving the working condition for the employees of chemical productions undergoing to the exposure to the neurotoxicants the clinical picture of the neurotoxications was considerably found to change. The oligosymptomatic forms of the occupational pathology which, may make difficult the differential diagnostics along with, the other diseases of the central nervous system, which, proceed with, the asthenic-vegetative syndrome were revealed, to prevail. The methods of performing the psychological and. vegetative tests which allow to suggest the early manifestations of the occupational intoxication, as well as to form the risk groups have been first introduced, in this paper. The analysis of the findings has allowed, to reveal the cognitive deficiency in the employees with a long-term, working period, in the combination, with the emotional-willing disorders, the polysystemic vegetative dysfunction, of the sympathetic trend, on the background, of the rapidly expressed, disorders in the neurological status. The need, of introducing the approach to performing the periodical medical examinations at the productions of chemical industry is indicated in this paper.

The article presents the results of the study of psychological status, centra! and peripheral nervous systems, neuromuscular apparatus in patients with vibration-induced, disease and sensorineural deafness of occupational genesis. The dynamics of forming of changes in these systems with the increase of vibration and. noise doses in the experiment on laboratory animals is showed. The results allowed, to supplement and. extend, the ideas about the conception of «sensory conflict».

We realized, prospective study, including staging clinicolaboratory and specialized neurological research during 12 months after the operation, to estimate the course of disseminated, sclerosis after Cesarean section at the neuroaxial blockades with use of modern local anesthetics. We observed 17 patients of 26—30 years with disseminated, sclerosis. It is showed, that neuroaxial anesthesia techniques with modern local anesthetics at the operative delivery don't worsen the prognosis of underlying disease.

The article presents the results of correlation analysis between the indices of lipid, peroxidation. — antioxidant defense (LPO — AOD) and. the level of hormones in 30 fertile women and. 71 patient with, endocrine sterility. Patients with, infertility were divided into 4 groups depending on the form of the disease: with, polycystic ovary syndrome (PCOS), with, gipergonadotropnym hypogonadism., with, adrenal hyperandrogenism, with, hyperprolactinemia. In the correlation analysis the changes in the structure of relationships between the hormonal and. metabolic parameters in patients with infertility were determined.

The article shows the role of mothers' adverse pregnancy and birth, in the formation of pathology of the reproductive system, for the girls with, connective tissue dysplasia. The most significant risk factors were revealed: the threat of premature termination, of pregnancy, preeclampsia, preterm, birth, and. also basic phenotypic features of connective tissue dysplasia syndrome were determined. Menstrual function disorders in adolescent girls are characterized by early menarche, hypomenstrual syndrome, uterine bleeding of puberty.

The article presents a case of Q-wave myocardial infarction, in a young woman of 35 years old. The patient complained. of pains not typical for angina pectoris. Therefore, the initial diagnosis was incorrect. After 3 months myocardial infarction, of cicatrization, stage was diagnosed. For definition, of further tactics of treatment we used, coronary angiography and recommended, stenting of critical stenosis on left anterior descending artery. For prophylactics of this case electrocardiography should, be routinely used, in all the cases of pain in the neck and. thorax in young women.

The article presents original methods of mathematical prediction of development of dyscirculatory encephalopathy in women with SLE without clinical manifestations of cerebrovascular pathology. Tactics of dispensary system, depending on the results of prediction was proposed, and. approximate list of preventive measures based. on the use of systems of individual prediction is presented in the article.

The article presents the results of a study of levels of hormones of hypophysial-thyroid, system, in women with parenteral chronic viral hepatitis B and C in the light menstrua! disorders. We examined. 77 women of reproductive age: 42 patients with, chronic viral hepatitis and 35 healthy controls. We determined, the concentration of thyroid-stimulating hormone, triiodothyronine, thyroxine, free triiodothyronine and. free thyroxine. We identified. some differences in the concentrations of the studied, hormones in patients with, viral hepatitis depending on the nature of the menstrual cycle.

The aim. of the work was to estimate the degree of intensity of interhemispheric interaction with use of complex neurophysiological (electroneuromyography, electroencephalography) testing of 163 patients of 12—74 years in residual period, of ischemic (n = 108) and hemorrhagic (n = 22) hemispheric stroke and. severe craniocerebral injury with brain contusion (n = 33). Obtained, data testifies to the distinct negative influence of postinsult/ posttraumatic cerebral defect on functional characteristica of counter-lateral ("intact") hemisphere that is reflected in proportional changes of all the spectrum, of analyzed, neurophysiological signs. These changes affects all the tested, modules of neuromotor system, and. can be observed over a long period, after the stroke or craniocerebral injury.

The article reviews the problems of prevalence of diphyllobothriasis in Perm. Krai. The territories of risk on the diphyllobothriasis morbidity are revealed.

The article sums up long-term, researches of studying of species and genetic variety of tick infections pathogens in combined, natural focuses of the Eastern Siberia. The results of the research testify to the high genetic variety of regional population, of tick-borne encephalitis virus that is represented, by the strains of Far-Eastern, West, Ural-Siberian genotypes, the strains of the group 886 and. 178-79. Infection of Ixodidae by the next pathogens: B. garinii, B. afzelii, R. sibirica, R. raoultii (генотипы. R. sp. DnS14, R. sp. DnS28), E. muris, A. phagocytophilum и Candidatus «Neoehrlichia mikurensis» was determined.

As a result of questioning of high school and student girls of Irkutsk region we got data on the adequacy and. condition of their nutrition. The nutrition of most of high, school and. student girls is unsatisfactory according to the indices of structural and. biological value of food.

We revealed, the peculiarities of health, disorders in the employees of modern, chemical enterprises in the dynamics of medical examinations and quantitative risk assessment of the basic pathological syndromes. It was determined, that significant growth, of cases of medium, and. high, risk of functional disorders of cardiovascular system, boundary psychical disorders, gastrointestinal tract and. liver was observed in dynamics. We registered the increase of levels of morbidity of circulatory system, nervous system, and. psychiatric disorders. Reliable increase of risk levels associated, with, exposure toxic load, in workers of the basic professions in caustic soda and. polyvinyl chloride productions was detected.

Complex researches on the evaluation, of common resistance of organism, of senior classes schoolchildren. living in the urbanized, territories was performed. The analysis of the results of microbiological and immunological studies of upper respiratory ways (URW) in schoolchildren is presented, in this paper. The changes in the mi-croecological status of respiratory ways, the decrease in the local immunity of the URW and. common organism resistance that may later promote the development of clinically expressed, pathology or the aggravation, of the diseases of the respiratory organs were revealed. The need, of performing of the correction measures for the teenagers examined, with aim. to prevent the diseases of the respiratory organs was grounded.

The article reviews the main problem, of environmental hygiene and medical ecology — the absence of unity of methodological approaches to the detection of environmental health, disorders (EHD).

The results of the analysis of the incidence of professional dermatosis in the Irkutsk region for the period, from 2006 to 2010. The features of the clinical course of disease of the skin and the most important etiological factors in various occupational groups. Prevalence of allergic occupational structure in the skin lesions. Analysis of the frequency distribution, of the surveyed, persons by industry allowed, to ascertain the highest prevalence of allergic diseases among health, care workers — 46, 2%. In the chemical industry, the formation of pathological skin against toxic lesions of the respiratory system., in mechanical engineering and. metallurgy — the tendency to torpid, course of skin process.

The structure of gynecologic disease for the reasons of hospitalization, of590 female students is studied. The leading place in students gynecologic disease structure was occupied, the spontaneous and not specified abortions in I—II trimesters of gestation (21,53 %), threats of interruption, of pregnancy till 26 weeks of gestation (20,00 %), artificial abortions (18,14 %) and. complications of abortions (12,03 %). Conclusion: a gynecologic pathology of students is associated, to gender risk behavior and. low level of reproductive and. contraceptive knowledge.

Intensity of immunity to the diphtheria is analyzed, in the article according to the levels of antitoxic antibodies in blood serum, of healthy adults from 20 to 51 years and older who live in England, Italy, Latvia, Lithuania, Russia and. Finland. In Russia displacement of morbidity during the epidemic of 1993—1996 to the older age groups caused, inclusion of compulsory revaccination of adults every 10 years after the latest vaccination, of teenagers in 14 years in National calendar of o prophylactic vaccination, in 1998. Chosen tactics of vaccinal prevention, wasn't included, in National calendars of o prophylactic vaccination, of other countries including European except for Finland. On the basis of the analysis for the optimization, of vaccinal prevention, of diphtheria the authors propose: to transfer revaccination of children from the age of 18 months to the age of 3—6 years (like in Italy, England, and. Finland), to realize vaccination, of adults individually taking into account the content of antitoxic antibodies in blood serum.. Key words: diphtheria, vaccinal prevention, antitoxic antibodies

In article the results of investigating the phenol migration from polyvinyl chloride medical infusion set into contacting water solution were presented. The perfusion of ozonized, physiologic solutions through the medical infusion set extended, in clinical practice can be accompanied, by migration of phenol from a polymeric material with concentration up to 1 mg/l.

Efficient synthetic approaches to novel organotellurium. compounds with potential biologically activity were elaborated, based, on acetylenes and tellurium, tetrahalid.es.

In the materials there are presented, results of the synthesis and biological testing of the new nanocomposite which, contains silver nanoparticles incapsulated. in the synthetic polymer poly-1-vinyl-1,2,4-triazole. The synthesis method, of silvercontaining polymere nanocomposite is shown. With the use of modern equipment evidence of the nanocomposite with the size of 2-10 nm silver production, are substinated. It was revealed, that the new nanocomposite causes slight changes in the tissue structure of experimental animals internal organs and biochemical shift that is characteristic for the compensatory-adaptive reactions development. There are presented, the results of the silver nanoparticles distribution, mainly in the kidney and. liver tissue.

The article presents the results of the study of health, status of the children population of Transbaikalia region. The prevalence of individual nosologic forms of chronic pathology depending on the age and place of residence was shown. Also we revealed, the reasons of the formation of a pathology.

Coxarthorosis is a degenerative-dystrophic disorder affecting all layers of population with increasing sickness rate among adult people. Coxarthoris is characterized by steadily progressive course leading patients to disability without ability of self-service. Closer attention of all kinds of medical workers is necessary in diagnostics and. rendering of all kinds of assistance available for this category of patients: not only qualified, medical attention, but also help in social rehabilitation.

We carried out the analysis of morbidity of children of 0—14 years by malignant tumors among the children living in Transbaikalia region during 1996—2010 years. The basis of the research, was regional register of cases malignant tumors. Ling-term, dynamics of malignant tumors morbidity in different age and sex groups was studied. The prognosis of morbidity of children with malignant tumors till 2014 was realized, with help of obtained, frequency characteristics.

Diagnosis of urogenital tuberculosis presents great difficulties. The article shows the main methods of diagnosing disease in modern conditions. For the early and timely detection of tuberculosis of female genital mutilation it is necessary to restore the interaction, of TB doctors and. gynecologists.

The article is devoted, to the history of studying of a problem, of stress fractures. The article raised, questions of terminology and statistics of stress fracture at different times by different authors and. the stage-by-stage scientific accumulation of information on this topic is shown.

This article provides an overview of data on health, status depending on ethnicity and race. The influence of genetic, geographic, socioeconomic and. cultural factors. In recent years there has been deterioration in the quality of life of indigenous peoples living in the North and. Siberia. For members of the Buryat population, in comparison, with. Russian favorable characteristic for diabetes, cardiovascular disease, hypertension, more severe reproductive disorders. Consideration of ethnic and. racial factors in evaluating the course and. outcomes of many diseases is necessary for understanding the mechanisms of the pathogenesis of pathological processes, the development of science-based, differentiated, treatment programs and. therapeutic activities for members of different populations.

An. analysis the results were obtained in the laboratory of pathophysiology of reproduction, of Scientific Centre of Family Health, and Human Reproduction. Problems, SB RAMS clearly indicate that oxidative stress accompanies and. / or appears like a key pathogenetic link in the development of many types of reproductive disorders. We dedicate, that further researches of the roles of the system, «lipid, peroxidation. — antioxidant protection.» are needed. Moreover, there are good reasons for using of different antioxidants, but it should, be prescribed individually, taking into account of nature of oxidative imbalance.

In a review of the literature shows the data from studies of changes of lipid peroxidation and antioxidant protection, in blood and semen of men of reproductive age in various pathological conditions. The analysis of survey data of men with various disorders of the reproductive system, indicates a change in the indices of lipid, peroxidation, antioxidant protection, indicating that the development of their oxidative stress.

The level of awareness on reproductive health, and safety of sexual relations of the modern teenagers is low and. not corresponding to the modern requirements and. to their lifestyle. The presented, facts of the literature review prove good, timing and. the need, for implementation, of youth, reproductive education programs aimed, at raising awareness on reproductive health, issues and. the skills to save it.

The article contains the review of literature data of domestic and foreign researchers concerning the issues of climacteric period, in women.

On the first line of defense against reactive oxygen species in cells of all organisms are low molecular weight compounds such as ascorbic acid, glutathione, tocopherols, carotenoids, etc. Particular attention is attracted, by including tripeptide glutathione, which is contained in cells in milimolyarnyh concentrations, and is localized. in almost all cellular compartments. He participates in many enzymatic and. non-enzymatic antioxidant protection, paths.

Gallstone disease and chronic calculous cholecystitis are the most prevalent gastroenterological diseases which require a surgical treatment. The quantity of patients with, gallstone disease or chronic calculous cholecystitis constantly is increased with, raise in age. Accordingly, the quantity of patients after cholecystectomy grows. The cholesterol gallstones and. mixed, gallstones in the gallbladder can make up from 60 % up to 80 %. Now cholesterol cholecystolithiasis is considered, as a complex of metabolic disorders in a liver and. a gallbladder. The mechanism of formation of cholesterol gallstones unites set of some conditions: cholesterol supersaturation of gallbladder bile and. precipitation, of cholesterol monohydrate crystals, hypersecretion, of glycoprotein, mucins and. gallbladder hypomotility. Treatment of gallstone disease and chronic calculous cholecystitis includes the ordinary opened, cholecystectomy and. laparoscopic cholecystectomy, sometimes cholecystolithotomy. Organ preservation, methods are applied only for the treatment of cholesterol gallstones: extracorporeal shock-wave lithotripsy of gallstones, local contact chemical litholysis with. MTBE and. systemic litholysis with, bile acids (CDCA and. UDCA).