The article describes the results of investigation of the influence of tranexamic acid, on hemostasis system, at the revision hip replacement surgery. Correlation of changes in hemostasis system, and hemorrhage in intra-and postoperative periods, frequency of hemotransfusion, at the stages of the operation and in postoperative period, were evaluated. Use of tranexamic acid, at the revision hip replacement surgeries reduces perioperative hemorrhage.

The aim of the study was to carry out the analysis of food rations in order to study provision of patients with arterial hypertension with basic macronutrients. Analysis of nutrition condition was carried out by using the computer program. «The Analysis of the person's condition» (version 1.2, Scientific Research. Institute of Nutrition RAMS, 2003—2005), based, on the frequency of food substances consumption. The analysis of basic macronutrients showed that the content of proteins is below physiological norm on the whole, the content of carbohydrates and. fats was considerably higher than the physiological norm.. The results of the analysis of nutrition condition of patients with arterial hypertension, revealed, disorder of balanced, ration principles that require correction of a ration.

According to the research possible interrelation of uric system deceases and gastrointestinal tract organs in children is showed. During the research, we determined, the structure of combined, pathology of uric system, and gastrointestinal tract organs in children. 79 % of examined, patients had. combined, pathology of kidneys and. digestive organs. In clinical finding dyspepsic and. abdominal syndromes were marked. Clinical manifestations were absent in 18 % of cases. Patients with metabolic urolithiasis have prevailing functional pathology of digestive organs and. children with dysmetabolic tubulointerstitial nephritis have inflammatory diseases of gastrointestinal tract.

We studied the changes in content of the autoantibodies to the antigens from nervous tissue was performed in the employees contacting with, metallic mercury, in the patients with, the mercury intoxication, at the different stages of the pathological process. It was found that small increase of concentrations of the autoantibodies to the protein S-100 in the "practically" healthy employees may be considered, as the protective physiological mechanism.. Influence of the mercury on the employees' organisms promotes the change of autoimmune reactions that are characterized by the increase of content of antibodies to the brain-specific proteins in blood serum.. The decrease of the antibody levels in patients with chronic mercury intoxication, in remote period and the increase of severity of pathological process testifies to the dysregulation in the immune system.. It was determined, that the increase of autoantibodies to MAG was typical only for the patients with chronic mercury intoxication. (CMI), thereby, higher levels of autoantibodies were observed in the patients with more dominated cognitive disorders in comparison with the patients with more dominated asthenic disorders. In healthy employees and the ones of "risk group" concentrations of autoantibodies to MAG were at the level of control. Increased, levels of autoantibodies to MAG testify to the formation of neurodegenerative changes and. are one of the diagnostic criteria.

We analyzed the results of radiation treatment of 728 patients with acute spinal and spinal cord traumas who were treated in Omsk Municipal Clinical Emergency Hospital N1 during 2008—2011 years. The traumas were mainly caused, by catatrauma (68,7 %), car accidents (22,3 %) and the others (9 %). About 46,2 % of cases of spinal traumas were multifocal. Diagnostic algorithm, of instrumental researches in acute period, of spinal trauma was carried out in the following sequence: spondylograms in two projections (77 %), spondylograms in special positions (3 %), multispiral computer tomography (75 %) and MRI (22 %). MCT was a primary method of diagnostic of spinal fractures in patients with polytrauma and high probability of vertebral injury, without preliminary X-ray.

With the purpose of studying of bone tissue state at the degenerative dystrophic changes of musculoskeletal system, of the 3—4^th degree densitometry with use of ultrasonic densitometer Sunlight Omnisens was carried out in preoperative period, in patients in the age from 50 to 72 years. These patients had. diskogenic lumbosacral radiculitis, one-sided. L—S_t radiculoneuritis, one-sided, degenerative coxarthrosis of the III degree and one-sided deforming gonarthrosis of the III degree. As the results in examined, groups of patients high percent of osteoporosis and ostheopenia was revealed. It was registered that intensity of osteoporotic changes on diseased. and. healthy extremities was different and. to a greater extent they showed, up on a diseased, extremity. This data confirmed, opportunities of ultrasonic densitometer Sunlight Omnisens to diagnose of ostheoporosis at earlier stages.

Our research, showed, that stress-induced, alteration, of liver that forewent poisoning and. toxic stress, that accompanied. poisoning and. had. lingering nature intensify lesion of organ causing considerable injury of its parenchyma and stroma.

There are direct and invert correlations between the indices of the electroencephalography and. electroneuromyography in the groups of patient with vibration-induced, diseases and. occupational neurosensoric dullness of hearing. Despite the fact that coincidence of correlation indices was observed in one case only, this fact may testify to the similar influence of physical factors (local vibration and. noise) on the employees' organisms and. it may confirm that the changes may be observed both in central and peripheral nervous system, that is, the whole neurosensoric complex is activated.

The article presents the data on the prevalence and clinical and. morphological characteristics of gastritis in Evenkia children. We examined. 299 native children — the Evenks (the Mongoloids) and. 1204 alien children (the Caucasians) of 7—17 years. We found, the increase of gastritis prevalence and. its progressive course in the Caucasians. In both ethnic populations we marked, the association, of gastritis with. Helicobacter fylori. At the same time erosive-ulcer lesions of mucous tunic in gastroduodenal area was diagnosed, in the Evenks two times less frequent than in the Caucasians. Besides, the infection in the Evenks was accompanied, by weaker stage of gastritis activity.

The main aim of this research was to identify species ratio and compatibility in children with functional disorders of gastrointestinal tract (GIT) using PCR method, with, species-specific primers for bifidobacteria. The assessment of intestinal microbiota symbionts composition, was made simultaneously. Dysbiosis changes of I—II degree in large intestine microbiocenosis in 86 children examined, were detected. The definition, of bifidobacteria species profile with, the dominance of B. longum, B. catenulatum. and B. bifidum. will allow to optimize the treatment of this pathology.

During one year after the abortion complications such as purulo-septic diseases, disorders of menstrual cycle develop in teenage girls. The basis for these complications are the changes in state of immunological reactivity. The state of local protection, system, varies greatly after the abortion than in the control group. Individual analysis of immunological parameters allows to evaluate them, more accurately and enhances the diagnosis of local defense. Teenage girls after the abortion had. prevalence of increased rates. On the basis of limits of studied, indices their reference values and. criteria for diagnosis of local defense system, with, a 95% probability of accuracy are designed.

We performed the research of thyroidal status in children with endemic goiter who live in ecologically unfavorable area of Transbaikalia. Frequency distribution of endemic goiter was analyzed, depending on a sex and age

The article reviews the indices of cardiorespiratory system adaptation, obtained, at the performing the test with, graduated, physical exercise in pregnant women with. high, obstetrical risk, that can be used, as prognostic criteria of development of pregnancy course complications.

For the first time the results of the study of 1399 blood serum, samples from people bitten by Ixodid ticks in Predbaykalye region (East Siberia, Russia) and asking for medical care in the Center for prophylaxis of tick-borne diseases of Scientific Center of Family Health. Problems and. Human Reproduction. SB RAMS. The study showed, high, (up to 99,93 %) efficacy of early antibiotic course in preventing the Lyme disease in bitten people

Blood, enzymes and phospholipids are one of the objective criteria for diagnostics of abortion threat that allow to carry out an adequate monitoring of therapy effectiveness. c-AMP and. c-GMP in blood plasma of women with, threatening premature birth, and. phospholipid, composition, in serum, and. erythrocyte membranes of the mother's blood were studied, to clarify their role in the pathogenesis of abortion as well as their possible use in diagnostics of this pathology and. evaluation, of its treatment effectiveness. Our results showed, that c-AMP, c-GMP and. phospholipids played, an important role in the pathogenesis of premature birth, threat. Determination of studied, parameters in blood plasma of women with, this pathology can be classified, as informative methods of evaluation, of pregnancy course.

The article presents the results of long-term, researches of state of health, of children and adolescents of Angarsk on the basic parameters that characterize health: infant morbidity; level of prevalence of different types of pathology among children and. adolescents; levels of infant, children's and. adolescent mortality. The article presents the results of profound, researches of estimation, of health state and. influence of different factors on the health state of children and. adolescents.

Due to examination of animal breeding workers at the Irkutsk Region a case of human leptospirosis was identified. at the cattle farm of Tugutuy settlement. Due to epizootological-epidemiological study a mixed, leptospirosis focus in Ekhirit-Bulagat district was established, the agent circulation among commensal and wild, small mammals was demonstrated. Continuous pathogenic Leptospira DNA detection during the second, half of 2011, as well as the positive tularemia laboratory results require further study of the focus.

Epizootological and epidemiological anthrax situation in Siberia in 2000—2011 was analyzed. On the basis of the situation evaluation and. geographical demarcation of Siberia territory the anthrax morbidity was prognosed

The article presents the results of examination, of teenagers schoolchildren, of 14—16 years old. who live in a town of Eastern. Siberia (by the example of Sayansk). According to the findings, 75,3 % of the teenagers have enough, adaptive capabilities. Performed, test for the responsiveness of the cardiovascular system, showed, that physiological response to the physical activity was observed, in most of examined, teenagers. The vascular type of the self-regulation of circulation of the blood that can testify to the circulation economization, was found, to be in 14,2 % of the teenagers.

We realized, the analysis of 134 cases of first-revealed tuberculosis of respiratory apparatus in women of Tuva Republic. We detected, prevalence of disseminate affections, high, frequency of dissociation, and bacterioexcre-tion (in 86,9 % of cases — excretion of drug-resistant bacteria, half of them, has plural drug resistance and. one third, has high, vitality, that proves high, epidemiologic risk of ill people). We marked, out factors of risk of tuberculosis morbidity in women and. determined, their significance in development of specific process. It was shown that disease in every fourth, woman is connected, with, pregnancy and. birth. We concluded, necessity of obligatory checking fluoroscopy for all women in puerperal period, during their stay in maternity hospital.

The results of the object exercise of the Specialized Anti-Epidemic Formation (SAEF) of Irkutsk Antiplague Research Institute performed in July 2011 are summarized. According to the exercise plan, SAEF subdivisions carried out tasks on monitoring of surface waters in conditions of an imported, cholera focus. GIS (Geo-Informational Systems)-technologies and. GPS-navigation were used, for optimization, the SAEF actions. Algorithm of measures on the basis of the epidemic significance of vibrios isolated, from surface waters was developed.

Changes of birth, rate level in Siberian federal district during 1990—2000s testify to the abrupt decrease in the reproduction of population. The main factor of birth rate declination is complexities of an adaptation, of significant part of families to the changing conditions of vital activity. More evident changes of birth rate index (decrease) were found, in the group of women of 15—19 years old. as well as in the group of women of20—24 years old. that has important contribution, to the total birth, rate. Main reasons of negative changes of age-specific model are the transformation of marriage behavior among the young people, later marriage, delay or refuse to register the marriage, reproductive intentions. Basic principles and. measures for increase of birth, rate and. negotiation, of the intentions not to have many children were formulated.

Irkutsk residents are infected, with, tick-borne encephalitis (TBE) mainly in Pribaykalie (Irkutsk region and Buryat Republic). TBE foci are rather various on this territory. Differences in some parameters of morbidity structure at the infection in different areas of this territory are reviewed, in this article.

The functional state of respiratory system, was studied in the employees of sulfate cellulose production, exposed, to the harmful chemical substances — methylsulfuric compounds (MSC), chlorine and chlorodioxide, the lime dust and. the alkaline aerosol. It was found, that the significant disorder prevalence of the external breathing function increasing as the occupational work length, increases and. manifestating as the moderate decrease in the main indices of the pulmonary ventilation, was observed to be in the practically healthy employees exposed, to a chemical factor. The significant influence on the functional state of respiratory system, may exert the smoking effect factor exaggerating the influence of a chemical factor.

Influence of a cobalt-containing nanobiocomposite on basis of arabinogalactane on morphological changes in immunocompetent organs of the experimental animals at peroral and parenteral introduction was studied, by a computer program. «Morphometry». Comparative estimation, of morphological and. histological changes in spleen and. regional lymph, nodes of the outbred. white mice was performed.

Improving of methodical approaches to gas chromatography methodologies of determination, of chlorohydrocarbons — vinyl chloride, 1,2-dichloroethane — and their metabolites — chloroethanol, monochloroacetic acid, and. thiodiglycolic acid. — in biological matrixes (blood and. urine) is reviewed. Metrological characteristics were determined. Content of these chemical compounds and. their metabolites in biological matrixes of workers contacting with chlorohydrocarbons was studied.

Hepatoprotective activity of herbal remedy at the experimental hepatitis was established. The herbal remedy digda-shi-tan decreases the content of TBA-active products in blood and tissues, increases activity of disintoxication function of liver and stimulates reparative processes in liver.

The immunomodulating activity of dry extract «Arkositel» was established, in experiments on the СВА and F (СВАхС57В1/6) mice. The extract in experimental-therapeutic dose of200 mg/kg is capable to decrease suppressive action of cytostatic azatioprin on antibody genesis, cellular-indirect immune reaction of hypersensitivity of slow type, that is expressed, by increasing of immune indices.

Comparative evaluation, of bacteriological, serological and PCR diagnostic methods was resulted, at experimental brucellosis in guinea pigs infected, with. S- and. L-forms of the causative agent in different periods of the infection. It was shown that Brucella S-forms were isolated, during six months, L-forms - about one month, by a bacteriological method. Positive PCR results were observed about six months after S- and. L-form infection in animals. Positive slide agglutination, of guinea pig blood sera was revealed, till 12 months by a corpuscular diagnosticum with. S- and. L-forms of Brucella. Complex use of bacteriological, PCR and. serological methods for laboratory diagnostics of atypical brucellosis caused, by Brucella L-form allows to obtain more reliable information, about epizootological-epidemiological situation in non-manifested (non-clinical) infection foci.

Cultural-morphological properties of Brucella are studied, during L-transformation on solid, nutrient media with increasing antibiotic concentration and visualization of morphology features of cells with various passages is presented, by light phase-contrast microscopy. Differences of cultural-morphological properties of Brucella L- and S-forms are shown.

The article represents main results of the approach to development of information system, for supporting of clinical diagnostic process of occupational neurointoxications identification. The key features and capabilities of the system, are reviewed, and the original algorithmic base of its expert-analytical functions is shown. The directions of further development of the system, and. the ways of its prospective scientific use are revealed.

The targets of application of antiaggregant therapy by clopidogrel and the factors that influence its outcome were presented, in this review. Special attention was given to the application of personalized, approach for the optimization of clopidogrel therapy. The data of clinical investigations were discussed.

There are two sources of cholesterol: endogenous (biliary) and exogenous (dietary) in human organism. Biliary cholesterol arrives with cyctic and. hepatic bile in small intestine and. is mixed, with dietary cholesterol. The pool of absorbed cholesterol in the ileum, contains 1/3 of dietary and. 2/3 of biliary cholesterol. Cholesterol concentration, in blood serum, depends on: 1) absorption, of dietary and. biliary cholesterol in the ileum; 2) absorption, of biliary cholesterol in the gallbladder; 3) activity of biosynthesis of cholesterol in the liver and the small intestine; 4) biosynthesis of bile acids in the liver; 5) speed, of elimination, of cholesterol from blood by liver; 6) rate of excretion of biliary cholesterol with, hepatic and. cystic bile into duodenum. Together with, enterohepatic circulation, of bile acids in human organism, there is enterohepatic circulation, of biliary cholesterol. It was proposed, that regulation, of concentration, of biliary cholesterol that participates in enterohepatic circulation, can influence a level of cholesterol in blood.

Modern data concerning functional regularities of the secondary signal systems of cyclic nucleotides (CN) in immune and. pathological reactions of a macroorganism, are analyzed, in this review. Intracellular regulatory mechanisms controlling CN system, and. its interaction with other signal systems are described. Influence of endogenic and. exogenic factors on activity of CN system, components and. its use as means or «targets» of special exposure to immune and. pathological reactions of a macroorganism, are examined.