THE DEPOSIT OF ANTIBODY’S PROLIFERATIVE ACTIVITY IN THE IMMUNE RESPONSE AND ITS RESISTANCE TO INHIBITORS OF PROLIFERATION
Abstract
The effect of hyperstimulation of the primary immune response was showed by additional introducing of antigen in the late log-phase of the primary IgM-response. The multiple increase of IgM-and IgG-antibody productive cells (АРС) in the spleen during the primary response was accompanied by suppression of anamnestic response. The injection of hydroxyurea (an inhibitor of DNA synthesis) together with the additional introduction of the antigen at the late log-phase of the primary IgM-response reduces the rise of IgM-APC, but does not abolish the stimulation of the primary and secondary IgG-APC formation. This fact indicates that proliferative processes play an important role in the stimulation of IgM-response induced by reinjection of the antigen. The stimulation of proliferation of B-lymphocytes which differentiate into antibody productive cells significantly reduces the pool of memory cells and consequently, suppresses secondary immune response.
About the Authors
E. D. Gavrilova
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
O. T. Kudayeva
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
O. P. Kolesnikova
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
V. A. Kozlov
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
References
1. Гаврилова Е.Д., Кудаева О.Т., Колесникова О.П. Регуляторные взаимодействия между клеточным и гуморальным ответом при формировании иммунной памяти // Вестн. Уральской мед. акад. науки. — 2006. — № 3—1. — С. 32 — 35.
2. Гаврилова Е.Д., Кудаева О.Т., Колесникова О.П. Антиген как фактор регуляции синтеза антител в продуктивную фазу иммунного ответа // Омский науч. вестн. — 2007. — Т. 61, № 3. — С. 17 — 18.
3. Гурвич А.Г. Динамика антителообразования // Иммуногенез и клеточная дифференцировка. — М., 1978. — C. 128—158.
4. Ahmed R., Gray D. Immunological memory and protective immunity: understanding their relation // Science. — 1996. — Vol. 272. — P. 54 — 60.
5. Batista F.D., Harwood N.E. The who, how and where of antigen presentation to B cells. Nature Reviews // Immunology. — 2009. — Vol. 9. — P. 15 — 27.
6. Crowley J.E., Scholz J.L., Quinn W.J. 3rd, Stadanlick J.E. et al. Homeostatic control of B lymphocyte subsets // Immunol. Res. — 2008. — Vol. 42. — P. 75 — 83.
7. Dooms H., Abbas A. Control of CD4+ T-cell memory by cytokines and costimulators // Immunological Reviews. — 2006. — Vol. 211. — P. 23 — 38.
8. Gudat F.G., Harris T.N., Harris S. Studies on antibody-producing cells. 3. Identification of young plaque-forming cells by thymidine-3 H labeling // J. Exp. Med. — 1971. — Vol. 134. — P. 1155—1169.
9. Hay J.B., Murphy M.J., Morris B. Quantitative studies on the proliferation and differentiation of antibody-forming cells in lymph // Am. J. Pathol. — 1972. — Vol. 6. — P. 1—24.
10. Henry C., Jerne N.K. Competition of 19S and 7S antigen receptors in the regulation of the primary immune response // J. Exp. Med. 1968. — Vol. 128. — P. 133—152.
11. Hjelm F., Carlsson F., Getahun A., Heyman B. Antibody-mediated regulation of the immune response // Scand. J. Immunol. — 2006. — Vol. 64. — P. 177—184.
12. Morse B.S., Rencricca N.J., Stohlman F. The effect of hydroxyurea on differentiated marrow erythroid precursors // Proc. Soc. Exp. Biol. Med. — 1969. — Vol. 130, N 3. — P. 986 — 989.
13. Tangye S.G., Hodgkin P.D. Divide and conquer: the importance of cell division in regulating B-cell responses // Immunol. — 2004. — Vol. 112. — P. 509 — 520.
14. Tarlinton D., Radbruch A., Hiepe F., Dorner T. Plasma cell differentiation and survival // Current Opinion in Immunology. — 2008. — Vol. 20. — P. 162—169.
15. Zinkernagel R.M., Ehl S., Aichele P., Oehen S. et al. Ahtigen localization regulates immune responses in s dose- and time-dependent fashion: a geographical view of immune reactivity // Immunol.Rev. — 1997. — Vol. 156. — P. 199 — 209.
Review
For citations:
Gavrilova E.D., Kudayeva O.T., Kolesnikova O.P., Kozlov V.A. THE DEPOSIT OF ANTIBODY’S PROLIFERATIVE ACTIVITY IN THE IMMUNE RESPONSE AND ITS RESISTANCE TO INHIBITORS OF PROLIFERATION. Acta Biomedica Scientifica. 2012;(3(2)):260-263. (In Russ.)
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