THE DEPOSIT OF ANTIBODY’S PROLIFERATIVE ACTIVITY IN THE IMMUNE RESPONSE AND ITS RESISTANCE TO INHIBITORS OF PROLIFERATION
Abstract
The effect of hyperstimulation of the primary immune response was showed by additional introducing of antigen in the late log-phase of the primary IgM-response. The multiple increase of IgM-and IgG-antibody productive cells (АРС) in the spleen during the primary response was accompanied by suppression of anamnestic response. The injection of hydroxyurea (an inhibitor of DNA synthesis) together with the additional introduction of the antigen at the late log-phase of the primary IgM-response reduces the rise of IgM-APC, but does not abolish the stimulation of the primary and secondary IgG-APC formation. This fact indicates that proliferative processes play an important role in the stimulation of IgM-response induced by reinjection of the antigen. The stimulation of proliferation of B-lymphocytes which differentiate into antibody productive cells significantly reduces the pool of memory cells and consequently, suppresses secondary immune response.
About the Authors
E. D. Gavrilova
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
O. T. Kudayeva
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
O. P. Kolesnikova
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
V. A. Kozlov
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
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Review
For citations:
Gavrilova E.D., Kudayeva O.T., Kolesnikova O.P., Kozlov V.A. THE DEPOSIT OF ANTIBODY’S PROLIFERATIVE ACTIVITY IN THE IMMUNE RESPONSE AND ITS RESISTANCE TO INHIBITORS OF PROLIFERATION. Acta Biomedica Scientifica. 2012;(3(2)):260-263. (In Russ.)
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