FEATURES OF CELLULAR AND HUMORAL IMMUNITY IN ACUTE AND CHRONIC VIRAL HEPATITIS В
Abstract
We investigated immunological paгameters in patients with acute (AVHB) and chronic hepatitis B. It is established that changing the values of immunological parameters can determine the nature of the infection couse in chronic viral hepatitis B and select at least two types of immune response. The first type (hyperergic) is characterized by high values of immunological indicator, determined by increasing the content of CD3+-lymphocytes with a dysregulation in the subpopulation of T-cells and an increase in humoral immunity. The second (hypoergic) — decrease in the number of T-cells, CD4+- and CD8+-lymphocytes, and various types of immunoglobulins. When AVHB development of acute infection is associated with a reduction in the number of T-lymphocytes, mainly due to the population of CD4+-lymphocytes, increased concentration of immunoglobulins and the CIC, which also indicates the hypoergic type of immune response in acute viral infection.
About the Authors
A. G. Borisov
Research Institute of Medical Problems of the North SB RAMS
Russian Federation
Russian Federation
A. A. Savchenko
Research Institute of Medical Problems of the North SB RAMS
Russian Federation
Russian Federation
References
1. Болезни печени и желчевыводящих путей: руководство для врачей / под ред. В.Т. Ивашкина. — М.: ООО Издат. дом М-Вести, 2002. — 416 с.
2. Земсков А.М., Земсков В.М. Дополнительные методы оценки иммунного статуса // Клин. лаб. диагностика. — 1994. — № 3. — С. 34 — 35.
3. Практические аспекты диагностики и лечения иммунных нарушений: рук. для врачей / под ред. В.А. Козлова. — Новосибирск: Наука, 2009. - 274 с.
4. Araujo N.M., Vianna C.O., Moraes M.T., Gomes S.A. Expression of Hepatitis B virus surface antigen (HBsAg) from genotypes A, D and F and influence of amino acid variations related or not to genotypes on HBsAg detection // Braz. J. Infect. Dis. - 2009. - Vol. 13, N 4. - P. 266-271.
5. Chen C.J., Yang H.I., Su J. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level // JAMA. - 2006. - Vol. 295, N 1. - P. 65-73.
6. Iloeje U.H., Yangm J., Su J. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load // Gastroenterology. - 2006. - Vol. 130, N 3. -P. 678-686.
7. Kallenberg C.G., Tadema H. Vasculitis and infections: contribution to the issue of autoimmunity reviews devoted to «autoimmunity and infection» // Autoimmun. Rev. - 2008. - Vol. 8, N 1. - P. 29-32.
8. Liu H., Shi W., Luan F. Hepatitis B virus X protein upregulates transcriptional activation of human telomerase reverse transcriptase // Virus Genes. - 2010. - Vol. 40, N 2. - P. 174-182.
9. Longhi M.S., Ma Y., Mieli-Vergani G., Vergani D. Aetiopathogenesis of autoimmune hepatitis // J. Autoimmun. - 2010. - Vol. 34, N 1. - P. 7-14.
10. Mancini G., Carbonaro A.O., Haremans J.F. Immunochemical quantitation of antigens by single radial diffusion // Immunochemistry. - 1965. - Vol. 2, N 3. - P. 235-255.
11. Nan X.P., Zhang Y., Yu H.T. Circulating CD4 + CD25high regulatory T-cells and expression of PD-1 and BTLA on CD4+ T cells in patients with chronic hepatitis B virus infection // Viral. Immunol. - 2010. - Vol. 23, N 1. - P. 63-70.
12. Qu Z., Liang X., Liu Y. Hepatitis B virus sensitizes hepatocytes to complement-dependent cytotoxicity through downregulating CD59 // Mol. Immunol. - 2009. - Vol. 47, N 2-3. - P. 283-289.
13. Sir D., Tian Y., Chen W.L. The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication // Proc. Natl. Acad. Sci. USA. - 2010. - Vol. 107, N 9. - P. 4383-4388.
14. Te H.S., Jensen D.M. Epidemiology of hepatitis B and C viruses: a global overview // Clin. Liver Dis. - 2010. - Vol. 14, N 1. - P. 1-21.
15. Watts N.R., Cardone G., Vethanayagam J.G. Non-canonical binding of an antibody resembling a naïve B cell receptor immunoglobulin to hepatitis B virus capsids // J. Mol. Biol. - 2008. - Vol. 379, N 5. - P. 1119-1129.
Review
For citations:
Borisov A.G., Savchenko A.A. FEATURES OF CELLULAR AND HUMORAL IMMUNITY IN ACUTE AND CHRONIC VIRAL HEPATITIS В. Acta Biomedica Scientifica. 2012;(3(2)):53-57. (In Russ.)
Views:
372
Email this article 
