DISTRIBUTION OF BIOCHEMICAL AND MOLECULAR-GENETIC MARKERS OF GENES IN WORKERS OF COAL MINING ENTERPRISES OF KUZBASS REGION SUFFERING FROM CHRONIC DUST BRONCHITIS
Abstract
Distribution of genotypes of biochemical markers of HP, GC, EsD, АсР genes, genotypes on polymorphic variants of the genes coding enzymes of biotransformation GSTT1 (GST-ɵ1) and GSTM1 (GST-μ1) and NOS3 (VNTR4 polymorphism) in the miners with chronic mechanic bronchitis, and in persons without this occupational pathology is investigated. It is shown that the owners of EsD 1-2, АсР bb genotypes are most subject to development of chronic mechanic bronchitis. Endogen factors of resistance to this disease are GC 1-1, EsD 1-1, АсР bc genotypes.
About the Authors
V. V. Zakharenkov
Scientific Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS, Novokuznetsk
Russian Federation
Russian Federation
N. I. Gafarov
Scientific Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS, Novokuznetsk
Russian Federation
Russian Federation
N. I. Panev
Scientific Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS, Novokuznetsk
Russian Federation
Russian Federation
A. N. Kucher
Scientific Research Institute of Medical Genetics of Tomsk Scientific Center SB RAMS
Russian Federation
Russian Federation
M. B. Freydin
Scientific Research Institute of Medical Genetics of Tomsk Scientific Center SB RAMS
Russian Federation
Russian Federation
A. A. Rudko
Scientific Research Institute of Medical Genetics of Tomsk Scientific Center SB RAMS
Russian Federation
Russian Federation
T. K. Yadikina
Scientific Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS, Novokuznetsk
Russian Federation
Russian Federation
A. S. Kazitskaya
Scientific Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS, Novokuznetsk
Russian Federation
Russian Federation
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Review
For citations:
Zakharenkov V.V., Gafarov N.I., Panev N.I., Kucher A.N., Freydin M.B., Rudko A.A., Yadikina T.K., Kazitskaya A.S. DISTRIBUTION OF BIOCHEMICAL AND MOLECULAR-GENETIC MARKERS OF GENES IN WORKERS OF COAL MINING ENTERPRISES OF KUZBASS REGION SUFFERING FROM CHRONIC DUST BRONCHITIS. Acta Biomedica Scientifica. 2012;(1):93-97. (In Russ.)
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