FREQUENCY OF HUMAN PAPILLOMA VIRUS IN IRKUTSK POPULATION
https://doi.org/10.29413/ABS.2018-3.5.21
Abstract
Background. In the regions of the Russian Federation (RF), papillomavirus infection in women of reproductive age is characterized by different frequency of occurrence from 13 to 68.4 %. Aims: to establish the frequency of detection of human papilloma virus in Irkutsk, according to the data of circulation.
Materials and methods. The article presents the results of the medical examination of residents of Irkutsk on the presence DNA of human papilloma virus. We analyzed the results of laboratory studies of patients who from 2014 to 2016 turned to the medical institution for the diagnosis of human papilloma virus. For the period surveyed was 13 090 man, age from 18 to 67 years, including 11 174 women and 1 916 male. The diagnosis of HPV was carried out by polymerase chain reaction (PCR).
Results. It was found the frequency of HPV in Irkutsk in the general population is 21.1 %, among women – 21.9 %, among male – 16.4 %. It was shown that the frequency of detection of papillomavirus infection in the sample of women was significantly higher than in the sample of men (p < 0.001).
Conclusions: It was shown that the frequency of HPV is 21.1 % the frequency of detection of the pathogen of papillomavirus infection in the sample of women was significantly higher (p < 0.001) than in the sample of male.
About the Authors
E. V. Belyaeva
Scientific Сentre for Family Health and Human Reproduction Problems.
Russian Federation
Russian Federation
ul. Timiryazeva 16, Irkutsk 664003.
Candidate of Biological Sciences, Research Officer at the Laboratory of Personalized Medicine.
O. A. Tokarskaya
Irkutsk State University.
Russian Federation
Russian Federation
ul. Karla Marksa 1, Irkutsk 664003.
Master’s Degree Student.
T. S. Belokhvostikova
Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education.
Russian Federation
Russian Federation
Yubileyniy 100, Irkutsk 664049.
Doctor of Medical Sciences, Head of the Department of Clinical Laboratory Diagnostics.
Т. A. Bairova
Scientific Сentre for Family Health and Human Reproduction Problems.
Russian Federation
Russian Federation
ul. Timiryazeva 16, Irkutsk 664003.
Doctor of Medical Sciences, Head of the Laboratory of Personalized Medicine.
References
1. Abramovskikh OS, Letyaeva OI. (2011). Age aspects of papillomavirus infection in women of reproductive age in the Chelyabinsk region [Vozrastnye aspekty papillomavirusnoy infektsii u zhenshchin reproduktivnogo vozrasta v Chelyabinskoy oblasti]. Vestnik Yuzhno-Ural’skogo gosudarstvennogo universiteta. Seriya: Obrazovanie, zdravookhranenie, fizicheskaya kul’tura, (20), 131-134.
2. Belyaeva EV, Pervushina OA. (2013). Frequency of human papilloma virus in girls and women in different age groups living in Irkutsk [Chastota vstrechaemosti virusa papillomy cheloveka u devushek i zhenshchin v raznykh vozrastnykh gruppakh, prozhivayushchikh v g. Irkutske]. Infektsionnye bolezni, 11 (S1), 52-53.
3. Belyaeva EV, Tokarskaya OA, Bairova TA. (2018). Features of human papillomavirus infection frequency in different regions of the Russian Federation (literature review) [Osobennosti rasprostraneniya papillomavirusnoy infektsii v razlichnykh regionakh Rossiyskoy Federatsii (obzor literatury)]. Acta Biomedica Scientifica, 3 (3), 127-135.
4. Vidyaeva IG, Urazova LN, Nikitina EG, Agarkova LA, Gabitova NA, Reznikova OV, Shipulina OYu. (2008). Prevalence of human papillomavirus with increased cancer risk in reproductive-aged women of the Tomsk region [Chastota vyyavleniya virusa papillomy cheloveka vysokogo onkogennogo riska u zhenshchin reproduktivnogo vozrasta Tomskoy oblasti]. Sibirskiy meditsinskiy zhurnal (g. Tomsk), 23 (4-1), 56-57.
5. Vidyaeva IG, Urazova LN, Pisareva LF, Nikitina EG, Mansurova GN, Shivit-Ool AA, Makarova NN. (2010). Detection and quantitative determination of wide HPV variety in reproductive women of Siberia [Vyyavlenie i kolichestvennoe opredelenie shirokogo spektra VPCh u zhenshchin reproduktivnogo vozrasta regiona Sibiri]. Problemy zdorov’ya i ekologii, (S), 17-19.
6. Goncharevskaya ZL, Lapochkina NP, Nekrasov PI, Badalova LA, Terebnyova LA, Rogovskaya SI. (2014). Clinical and economic effectiveness of HPV test and current screening methods for cervical cancer [Sovremennye metody skrininga raka sheyki matki i VPCh-test: kliniko-ekonomicheskaya effektivnost’]. Doktor.Ru, S1 (5), 11-16.
7. Goncharevskaya ZL, Shipulina OYu, Mikheeva IV, Rogovskaya SI, Romanyuk TN, Shipulin GA, Radzinskiy VE. (2011). Using HPV test in cervical screening [Opyt is pol’zovaniya VPCH-testa v tservikal’nom skrininge]. Mat’ i ditya: Materialy XII Vserossiyskogo nauchnogo foruma. Moskva, 286.
8. Zotovа MA, Abramovskikh OS. (2011). Human papillomavirus infection in women in normal cytology and cervical ectopia [Papillomavirusnaya infektsiya u zhenshchin pri tsitologicheskoy norme i tservikal’noy ektopii]. Vestnik Novosibirskogo gosudarstvennogo universiteta. Seriya: Biologiya, klinicheskaya meditsina, 9 (2), 48-52.
9. Kubanov AA. (2005). Results of human papilloma virus gene typing from a screening study in Moscow region [Rezul’taty genotipirovaniya virusa papillomy cheloveka pri skriningovom issledovanii v Moskovskom regione]. Vestnik dermatologii i venerologii, (2), 51-55.
10. Leshchenko OYa. (2010). Prevalence of diseases having essential influence on reproductive potential of Irkutsk region population [ Rasprostranennost’ zabolevaniy, sushchestvenno vliyayushchikh na reproduktivnyy potentsial naseleniya Irkutskoy oblasti]. Acta Biomedica Scientifica, (6-2), 121-125.
11. Mashkina EV, Kovalenko KA, Saraev KN, Lysenko OV, Shkurat TP. (2009). Gene diagnostics of papilloma virus infection in Rostov region [Genodiagnostika papillomavirusnoy infektsii u zhiteley Rostovskoy oblasti]. Valeologiya, (3), 21-28.
12. Mishina SV, Yatsuk IG, Medzhidova KhM. (2009). Analysis of the frequency of human papillomavirus in women of reproductive age living in the Kamchatka region [Analiz chastoty vyyavleniya virusa papillomy cheloveka u zhenshchin reproduktivnogo vozrasta, prozhivayushchikh v Kamchatskom krae]. Zdorov’e. Meditsinskaya ekologiya. Nauka, 37 (2), 27-31.
13. Miktadova AV, Saraev KN, Lebedev VV, Poltavskiy MA, Popova ZG, Kovalenko KA. (2014). Analysis of the level of infection with the human papillomavirus in Rostov-onDon [Analiz urovnya infitsirovannosti virusom papillomy cheloveka naseleniya Rostova-na-Donu]. Zhivye i biRogovskaya SI, Mikheeva IV, Shipulina OYu, Minkina GN, Podzolkova NM, Radzinsky VE, Shipulin GA. (2012). Prevalence of human papillomavirus infection in Russia [Rasprostranennost’ papillomavirusnoy infektsii v Rossii]. Epidemiologiya i vaktsinoprofilaktika, (1), 25-33.
14. Roik EE, Baranov AV, Treshcheva ND. (2015). Epidemiological features of human papilloma virus infection [Epidemiologicheskie osobennosti papillomovirusnoy infektsii]. Ekologiya cheloveka, (5), 21-26.
15. Urazova LN, Merzlyakova MK, Nikitina EG, Pisareva LF, Kolomiets LA, Churuksaeva ON, Shivit-Ool AA. (2012). Comparative study of incidence of high-risk human papillomavirus infection in females of the Tyva Republic [Sravnitel’noe izuchenie urovnya infitsirovannosti virusom papillomy cheloveka vysokogo onkogennogo riska zhenskogo naseleniya Tomskoy oblasti i respubliki Tyva]. Epidemiologiya i vaktsinoprofilaktika, (6), 15-20.
16. Kharaeva ZF, Shevchenko AA, Sizhazheva OA, Tekueva MM, Samoylik NI. (2012). Epidemiological features of the incidence of papillomavirus infection in women [Epidemiologicheskie osobennosti rasprostraneniya papillomavirusnoy infektsii u zhenshchin]. Izvestiya KabardinoBalkarskogo nauchnogo tsentra RAN, (3), 243-246.
17. Shipulina OYu, Maksimova EG. (2014). Incidence of HPV infection of high oncogenic risk among men and women living in Moscow and Irkutsk [Rasprostranennost’ VPCH-infektsii vysokogo onkogennogo riska sredi muzhchin i zhenshchin gorodov Moskvy i Irkutska]. Molekulyarnaya diagnostika – 2014: Sbornik trudov VIII Vserossiyskoy nauchno-prakticheskoy konferentsii s mezhdunarodnym uchastiem. Moskva, 198-200.
18. Shipulina OYu, Silveistrova OYu, Tvorogova MG. (2011). The first Russian panel for quality control of detection of human papilloma virus of high carcinogenic risk by nucleic acid amplification methods [Pervaya rossiyskaya panel’ dlya kontrolya kachestva vyyavleniya virusa papillomy cheloveka vysokogo kantserogennogo riska metodami amplifikatsii nukleinovykh kislot]. Spravochnik zaveduyushchego KDL, (5), 35-44.
19. Arbyn M, Xu L, Simoens C, Martin-Hirsch PP. (2018). Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors. Cochrane Database Syst Rev, 9, 5, CD009069. DOI: 10.1002/14651858.CD009069.pub3
20. Bosch FX, de Sanjose S. (2007). The epidemiology of human papillomavirus infection and cervical cancer. Dis Markers, 23 (4), 213-227.
21. Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, Vignat J, Ferlay J, Bray F, Plummer M, Franceschi S. (2012). Global burden of human papillomavirus and related diseases. Vaccine, 30 (Suppl 5), 12-23. DOI: 10.1016/j.vaccine.2012.07.055
22. Franco EL, Duarte-Franco E, Ferenczy A. (2001). Cervical cancer: epidemiology, prevention and the role of human papillomavirus infection. CMAJ, 164 (7), 10171025.
23. Gamaoun R. (2018). Awareness and knowledge about cervical cancer prevention methods among Tunisian women. J Prev Med Hyg, 59 (1), 30-35. DOI: 10.15167/2421-4248/jpmh2018.59.1.709
24. Guo F, Hirth JM, Berenson AB. (2015).Comparison of HPV prevalence between HPV-vaccinated and non-vaccinated young adult women (20-26 years). Hum Vaccin Immunother, 11 (10), 2337-2344. DOI: 10.1080/21645515.2015.1066948
25. International Human Papillomavirus (HPV). Available at : http://www.nordicehealth.se/hpvcenter.
26. Leshchenko O, Belyaeva E, Yershova O, Atalyan A, Timofeeva E. (2017). The frequency of human papilloma virus in women of reproductive age with infection. J Low Genit Tract Dis, 21 (2 S1), S39-S40.
27. Li TY, Wu ZN, Jiang MY, Cui JF, Liu B, Chen F, Chen W. (2018). Association between high risk human papillomavirus DNA load and cervical lesions in different infection status. Zhonghua Zhong Liu Za Zhi, 40 (6), 475480. DOI: 10.3760/cma.j.issn.0253-3766.2018.06.015
28. Mattoscio D, Medda A, Chiocca S. (2018). Human papilloma virus and autophagy. Int J Mol Sc, 19 (6). PII: E1775. DOI: 10.3390/ijms19061775
29. Mesher D, Panwar K, Thomas SL, Edmundson C, Choi YH, Beddows S, Soldan K. (2018). The impact of the national HPV vaccination program in England using the bivalent HPV vaccine: surveillance of type-specific HPV in young females, 2010-2016. J Infect Dis. DOI: 10.1093/ infdis/jiy249
30. Middleton K, Peh W, Southern S, Griffin H, Sotlar K, Nakahara T, El-Sherif A, Morris L, Seth R, Hibma M, Jenkins D, Lambert P, Coleman N, Doorbar J. (2003). Organization of human papillomavirus productive cycle during neoplastic progression provides a basis for selection of diagnostic markers. J Virol, 77 (19), 10186-10201.
31. Myers KO, Ahmed NU. (2018). The role of HIV in the progression through the stages of the human papillomavirus to cervical cancer pathway. AIDS Rev, 20 (2), 94-1043.
32. Tam S, Fu S, Xu L, Krause KJ, Lairson DR, Miao H, Sturgis EM, Dahlstrom KR. (2018). The epidemiology of oral human papillomavirus infection in healthy populations: A systematic review and meta-analysis. Oral Oncol, 82, 91-99. DOI: 10.1016/j.oraloncology.2018.04.005
33. Van Doorslaer K, Chen Z, Bernard HU, Chan PKS, DeSalle R, Dillner J, Forslund O, Haga T, McBride AA, Villa LL, Burk RD, Ictv Report Consortium. (2018). ICTV virus taxonomy profile: Papillomaviridae. J Gen Virol, 99 (8), 989-990. DOI: 10.1099/jgv.0.001105
34. Zur Hausen H. (2002). Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer, 2 (5), 342-350. DOI: 10.1038/nrc798.
Review
For citations:
Belyaeva E.V., Tokarskaya O.A., Belokhvostikova T.S., Bairova Т.A. FREQUENCY OF HUMAN PAPILLOMA VIRUS IN IRKUTSK POPULATION. Acta Biomedica Scientifica. 2018;3(5):141-147. (In Russ.) https://doi.org/10.29413/ABS.2018-3.5.21
Views:
972
.png)
Email this article 
