NEURAL NETWORK MODELING OF THE INFLUENCE OF SPORT ACTIVITY FACTORS ON THE FUNCTIONAL ACTIVITY OF NEUTROPHILIC LEUKOCYTES
https://doi.org/10.12737/article_59a614fbc56b10.09341112
Abstract
The high exercise stress in sport causes decrease in immune cells reactivity. Changes of intensity of neutrophilic granulocytes «respiratory burst» due to the main operating factors of sports activity have not yet been investigated. The study included 96 male athletes (24.34 ± 3.54 y.o.), 59 female athletes (23.12 ± 2.3y.o.) and 53 healthy male non-athletes (23.17 ± 2.54 y.o.); 48 healthy female non-athletes (22.12 ± 3.01 y.o.) participated as control group. Two neural network predictor models for neutrophilic granulocytes functional activity were created. The average error of approximation was 2.77 % and 2.98 % for male and female respectively. In a series of virtual experiments, the effect of different approaches to the organization of training-competitive process was studied. We have found the conditions that should allow to avoid decompensation in the immune system in the end of the competition period.
About the Authors
K. P. Bazarin
Krasnoyarsk Regional Institute for Advanced Training of Physical Training and Sports Professionals; Research Institute for Medical Problems of the North
Russian Federation
Russian Federation
A. A. Savchenko
Research Institute for Medical Problems of the North; Siberian Federal University
Russian Federation
Russian Federation
V. N. Kovalev
Krasnoyarsk Regional Institute for Advanced Training of Physical Training and Sports Professionals
Russian Federation
Russian Federation
N. A. Lazarenko
Krasnoyarsk Regional Institute for Advanced Training of Physical Training and Sports Professionals
Russian Federation
Russian Federation
A. V. Landyonok
Krasnoyarsk Regional Institute for Advanced Training of Physical Training and Sports Professionals
Russian Federation
Russian Federation
References
1. Базарин К.П., Савченко А.А., Александрова Л.И. Изменение функциональной активности нейтрофильных гранулоцитов крови у квалифицированных спортсменов // Бюл. ВСНЦ СО РАМН. - 2013. - № 6. -С. 16-18
2. Базарин К.П., Савченко А.А., Особенности метаболической активности нейтрофильных гранулоцитов у спортсменов в динамике тренировочного цикла // Спортивная медицина: наука и практика. -2013. - № 1. - С. 246-247
3. Савченко А.А. Определение активности NAD (P)-зависимых дегидрогеназ в нейтрофильных гранулоцитах биолюминесцентным методом // Бюллетень экспериментальной биологии и медицины. -2015. - Т. 159, № 5. - С. 656-660
4. Савченко А.А., Базарин К.П. Состояние активности НАД- и НАДФ-зависимых дегидрогеназ в нейтрофильных гранулоцитах у спортсменов в динамике тренировочного цикла // Журнал Сибирского федерального университета. Биология. - 2013. - № 6. -С. 151-162
5. Савченко А.А., Борисов А.Г. Основы клинической иммунометаболомики. - Новосибирск: Наука, 2012. - 263 с
6. Савченко А.А., Смирнова С.В., Борисов А.Г. Содержание АТФиактивность НАД(Ф)-зависимых дегидрогеназ в лимфоцитах при иммунодефицит-ассоциированных заболеваниях у пришлых жителей Эвенкии // Бюллетень СО РАМН. - 2010. - № 3. - С. 33-38
7. Тишакин Д.И., Джафарова О.А., Гребнева О.Л. Анализ психофизиологических реакций при стресс-тестировании курсантов военных вузов // Бюллетень сибирской медицины. - 2010. - № 2. - С. 73-78
8. Hackney A.C., Koltun K.J. (2012). The immune system and overtraining in athletes: clinical implications. Acta Clin. Croat., 51 (4), 633-637.
9. Kakanis M.W., Peake J., Brenu E.W., Simmonds M., Gray B., Hooper S.L., Marshall-Gradisnik S.M. (2010). The open window of susceptibility to infection after acute exercise in healthy young male elite athletes. Exerc. Immunol. Rev., 16, 119-137.
10. Kolaczkowska E., Kubes P. (2013). Neutrophil recruitment and function in health and inflammation. Nat. Rev. Immunol., 13 (3), 159-175.
11. Levada-Pires A.C., Fonseca C.E., Hatanaka E. (2010). The effect of an adventure race on lymphocyte and neutrophil death. Eur. J. Appl. Physiol., 109 (3), 447-465.
12. Seiler S. (1997). XC endurance training theory -Norwegian style. Kristiansand, 16 p.
Review
For citations:
Bazarin K.P., Savchenko A.A., Kovalev V.N., Lazarenko N.A., Landyonok A.V. NEURAL NETWORK MODELING OF THE INFLUENCE OF SPORT ACTIVITY FACTORS ON THE FUNCTIONAL ACTIVITY OF NEUTROPHILIC LEUKOCYTES. Acta Biomedica Scientifica. 2017;2(2):62-68. (In Russ.) https://doi.org/10.12737/article_59a614fbc56b10.09341112
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