Rationale for the use of low-intensity photodynamic therapy in stage I basal cell skin carcinoma

Background. The paper describes a method of low intensity photodynamic therapy (LIPDT) for the treatment of superficial basal cell skin cancer (SBCSC) stage I using topical application of the photosensitizer Photoditazine gel® or intravenous Photoditazine® solution. LIPDT is the treatment of choice in medical organizations lacking laser equipment, specialized facilities, or for remote use (in distant areas). It can also be used as an adjunct to other treatment methods.

Aim. To provide a theoretical rationale for the use of a LIPDT device with Photoditazine® and Photoditazine gel® for the treatment of SBCSC.

Materials and methods. The developed device consists of the following elements: a battery, a control board, a DC-DC voltage converter, a microcontroller, a driver, and an LED matrix. The mechanism of the device is based on the classical PDT method but has several key differences: automatic mode (eliminating the need for manual adjustment), low output radiation power (which prevents oxygen depletion in tumor tissue), and the ability to function under conditions unsuitable for standard PDT.

Conclusion. The proposed LIPDT method for treating stage I SBCSC will reduce treatment costs while maintaining the effectiveness of the existing standard PDT method.

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