The link between inflammation and hemostasis in patients with schizotypic disorder

Background. A current research on mental disorders ethiopathology is about to attract a special attention towards a possible role of inflammation/neuroinflammation related metabolic pathways. It has been shown that there is a close link between immunoinflammation and hemostasis. It might be assumed that the interrelated processes of inflammation and blood coagulation are the important elements in pathogenesis of psychiatric diseases. However; this problem remains rather obscure so far.

The aim. Identification of significant parameters characterizing the hemostasis system and markers of systemic inflammation; as well as an assessment of their possible relationship in patients with schizotypal disorder.

Materials and Methods. Eighteen female patients; aged 16–41 (median age [Q1;Q2] – 20 years [17.0; 26.0]); were hospitalized to the Mental Health Research Center (MHRC) clinic; all in clinically acute conditions. The blood plasma analysis based on evaluation of immune status was performed according to a special «Neuroimmunotest» technology developed and proposed earlier by the above mentioned research center (MHRC). A «Fibrinodynamics» technique was employed to elucidate the hemostasis system functioning in vivo simulating; method is also a product of our research team.

Results. It has been shown that the inborn immunity patters (leucocyte elastase catalytic activity and its specific inhibitor – which is an acute phase alfa-1 protein – functional activity) are significantly increased in patients studied. Indicators of acquired immunity (S100B and the basic myelin protein antibodies level values); do not differ from the reference values. A number of «Fibrinodynamics» detected parameters were found of being significantly higher as compared to the referent values. Thus; the values of potentials of coagulation; fibrinolysis and hemostasis are essentially increased; while the hemostasis system equilibrity patterns are the same in patients as in controls. A correlation analysis results are in a favor to the existence of a link between inflammation and hemostasis parameters.

Conclusion. The results of a present study reflect an interdependence between immu- noinflammatory and hemostatic systems in schizotypal disorder.

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