Indicators of the Immune Status in Children after a New Coronavirus Infection
https://doi.org/10.29413/ABS.2021-6.2.6
Abstract
Background. The mechanism of the immune response in patients with COVID-19 is still poorly understood and differs from other respiratory infections. Immunodeficiencies and age-related characteristics of immunity can be regarded as factors influencing reinfection and a predisposition to prolonged persistence of SARS-CoV-2. Most of the studies report about post-infection immunity to SARS-CoV-2 for adults and less for children. However, understanding the dynamics of antibody production to SARS-CoV-2 among children as well as other unique features of immune response is extremely important, because this provides to avoid possible complications and long-term outcomes of COVID-19, and predict the epidemic spread of the new coronavirus in the organized groups of children such as kindergartens, schools, study groups and clubs.
Aim: to evaluate the humoral and cellular immunity after SARS-CoV-2 infection in children.
Materials and methods. We reported data of the first phase prospective cohort study of immunity among 60 children living in Irkutsk, Russia within a month after SARS-CoV-2 infection, which took place in October and November 2020.
Results. Immunity of children one month after SARS-Cov-2 infection was characterized by suppressed cell-mediated and humoral immunity, and phagocytosis dysfunction. Reduced phagocytosis by neutrophils was noted for 61.6 % of individuals.
Conclusions. Children after COVID-19 had impaired immunity to SARS-CoV-2, which may be a predictor of chronic infection and other long-term outcomes of COVID-19.
About the Authors
E. V. Moskaleva
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Cand. Sc. (Med.), Research Officer at the Laboratory of Infectology and Immunoprophylaxis,
Timiryazeva str. 16, Irkutsk 664003
A. G. Petrova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Dr. Sc. (Med.), Professor, Head of the Laboratory of Infectology and Immunoprophylaxis,
Timiryazeva str. 16, Irkutsk 664003
L. V. Rychkova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Corresponding Member of the Russian Academy of Sciences, Director,
Timiryazeva str. 16, Irkutsk 664003
E. A. Novikova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Junior Research Officer at the Laboratory of Infectology and Immunoprophylaxis,
Timiryazeva str. 16, Irkutsk 664003
A. S. Vanyarkinа
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Cand. Sc. (Med.), Research Officer at the Laboratory of Infectology and Immunoprophylaxis,
Timiryazeva str. 16, Irkutsk 664003
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Review
For citations:
Moskaleva E.V., Petrova A.G., Rychkova L.V., Novikova E.A., Vanyarkinа A.S. Indicators of the Immune Status in Children after a New Coronavirus Infection. Acta Biomedica Scientifica. 2021;6(2):58-62. (In Russ.) https://doi.org/10.29413/ABS.2021-6.2.6
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