Dynamics of the Level of Myeloperoxidase and Serum Calprotectin in Local Cold Injury
https://doi.org/10.29413/ABS.2020-5.3.3
Abstract
Relevance. Cold injury is defined as a complex of pathophysiological and pathomorphological changes arising as a result of local or general cooling of the human body. Endothelial dysfunction provokes a powerful cascade of cellular interactions with expressed excretory activity, which ultimately leads to a pronounced remodeling of microcirculation and a protracted process of inflammation in the focus of alterations.
Aim of the study. To establish the dynamics of the level of myeloperoxidase and calprotectin in the serum of patients with local cold injury.
Materials and methods. The study included 80 patients with III–IV degree lesions in the late reactive period and the period of granulation and epithelialization. The average age of patients was 38 ± 8 years. The myeloperoxidase level was measured on the 5th and 30th days from the moment of cryopreservation using multiplex analysis of blood serum.
Results. The level of myeloperoxidase and serum calprotectin increases. In late reactive period (day 5), MPO level in patients with frostbite is 7.25 times higher in comparison with control values, in the period of granulation and epithelialization (day 30), it remains elevated, but only 3.63 times higher than in the control group. In the late reactive period, the level of calprotectin in the blood serum of patients with local cold injury was 4.6 times higher in comparison with control values, and on the 30th day of cryopreservation, the value of calprotectin was 4.5 times higher than in the control group. Changes in the level of myeloperoxidase and serum calprotectin reflect the flow of destructive and reparative mechanisms in tissues during local cold trauma and can be used in predicting an unfavorable prolonged course of the wound process.
About the Authors
M. I. Mikhailichenko
Chita State Medical Academy
Russian Federation
Russian Federation
Maksim I. Mikhailichenko – Cand. Sc. (Med.), Teaching Assistant at the Department of Intermediate Level Surgery with the Course of Urology
Gorky str. 39A, Chita 672000
K. G. Shapovalov
Chita State Medical Academy
Russian Federation
Russian Federation
Konstantin G. Shapovalov – Dr. Sc. (Med.), Professor, Head of the Department of Anesthesiology and Intensive Care
Gorky str. 39A, Chita 672000
V. A. Mudrov
Chita State Medical Academy
Russian Federation
Russian Federation
Viktor A. Mudrov – Cand. Sc. (Med.), Associate Professor at the Department of Obstetrics and Gynecology of the Faculty of Medicine and Dentistry
Gorky str. 39A, Chita 672000
O. S. Gruzdeva
Chita State Medical Academy
Russian Federation
Russian Federation
Olga S. Gruzdeva – Head of the Department of Pathological Anatomy
Gorky str. 39A, Chita 672000
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Review
For citations:
Mikhailichenko M.I., Shapovalov K.G., Mudrov V.A., Gruzdeva O.S. Dynamics of the Level of Myeloperoxidase and Serum Calprotectin in Local Cold Injury. Acta Biomedica Scientifica. 2020;5(3):24-28. (In Russ.) https://doi.org/10.29413/ABS.2020-5.3.3
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