EVALUATION OF HISTOLOGICAL PARAMETERS IN PATIENTS WITH CLINICAL REMISSION OF ULCERATIVE COLITIS
Abstract
Goal of the study: to examine histological changes in the mucosa of patients with clinical remission of ulcerative colitis and compare these changes with endoscopic parameters. Methods: 25 patients with clinical remission of ulcerative colitis underwent fibrocolonoscopy with biopsy and histological assessment of disease activity on the Gebos scale. Due to limited number of observations, it was possible to identify comparable study and control groups only for two parameters: increased eosinophil count and increased density of infiltrate in the mucosa. Results of the study: erosions, cryptitis, hyperplasia of lymphoid structures and infiltration of the intestinal mucosa with neutrophilic leukocyte often observed in the presence of increased eosinophil count in the mucosa and/or increased density of the cellular infiltrate. Conclusion: increased eosinophil count and/or increased density of the cellular infiltrate in the mucosa often accompanied by other signs of lack of the mucosa healing. Confirmation of complete remission of the disease requires histological control for exclusion of the inflammation signs.
About the Authors
O. B. Shchukina
Mechnikov North-Western State University
Russian Federation
Russian Federation
E. A. Kondrashina
Mechnikov North-Western State University
Russian Federation
Russian Federation
A. M. Kharitidis
City Center of Diagnostics and Treatment of Colon Inflammatory Disorders at City Clinical Hospital N 31
Russian Federation
Russian Federation
A. V. Botina
First St. Petersburg State Medical University
Russian Federation
Russian Federation
E. A. Markova
City Clinical Hospital N 31
Russian Federation
Russian Federation
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Review
For citations:
Shchukina O.B., Kondrashina E.A., Kharitidis A.M., Botina A.V., Markova E.A. EVALUATION OF HISTOLOGICAL PARAMETERS IN PATIENTS WITH CLINICAL REMISSION OF ULCERATIVE COLITIS. Acta Biomedica Scientifica. 2014;(6):39-43. (In Russ.)
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