actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problemsactabiomedica-1832Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEОЦЕНКА ГИСТОЛОГИЧЕСКИХ ПОКАЗАТЕЛЕЙ У БОЛЬНЫХ С КЛИНИЧЕСКОЙ РЕМИССИЕЙ ЯЗВЕННОГО КОЛИТАEVALUATION OF HISTOLOGICAL PARAMETERS IN PATIENTS WITH CLINICAL REMISSION OF ULCERATIVE COLITISЩукинаО. Б.ShchukinaO. B.burmao@gmail.comКондрашинаЭ. А.KondrashinaE. A.elalkon@rambler.ruХаритидисА. М.KharitidisA. M.akharitidis@gmail.comБотинаА. В.BotinaA. V.botinaanna@mail.ruМарковаЕ. А.MarkovaE. A.markova2408@mail.ruСеверо-Западный государственный университет имени И.И. МечниковаMechnikov North-Western State UniversityГородский центр диагностики и лечения ВЗК Городской клинической больницы № 31City Center of Diagnostics and Treatment of Colon Inflammatory Disorders at City Clinical Hospital N 31Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. ПавловаFirst St. Petersburg State Medical UniversityГородская клиническая больница № 31City Clinical Hospital N 31201428112014063943Copyright © Щукина О.Б., Кондрашина Э.А., Харитидис А.М., Ботина А.В., Маркова Е.А., 20142014Щукина О.Б., Кондрашина Э.А., Харитидис А.М., Ботина А.В., Маркова Е.А.Shchukina O.B., Kondrashina E.A., Kharitidis A.M., Botina A.V., Markova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/1832

Изучение гистологических изменений в слизистой оболочке у пациентов с клинической ремиссией язвенного колита и сопоставление этих изменений с эндоскопическими показателями показало, что повышение количества эозинофилов и/или повышение плотности клеточного инфильтрата в слизистой оболочке чаще сопровождалось другими признаками отсутствия заживления слизистой: эрозиями, криптами, гиперплазиями лимфоидных структур и инфильтрацией слизистой оболочки кишки нейтрофильными лейкоцитами. Для подтверждения полной ремиссии заболевания необходим гистологический контроль для исключения признаков воспаления.

Goal of the study: to examine histological changes in the mucosa of patients with clinical remission of ulcerative colitis and compare these changes with endoscopic parameters. Methods: 25 patients with clinical remission of ulcerative colitis underwent fibrocolonoscopy with biopsy and histological assessment of disease activity on the Gebos scale. Due to limited number of observations, it was possible to identify comparable study and control groups only for two parameters: increased eosinophil count and increased density of infiltrate in the mucosa. Results of the study: erosions, cryptitis, hyperplasia of lymphoid structures and infiltration of the intestinal mucosa with neutrophilic leukocyte often observed in the presence of increased eosinophil count in the mucosa and/or increased density of the cellular infiltrate. Conclusion: increased eosinophil count and/or increased density of the cellular infiltrate in the mucosa often accompanied by other signs of lack of the mucosa healing. Confirmation of complete remission of the disease requires histological control for exclusion of the inflammation signs.

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The authors declare that there are no conflicts of interest present.