Energy metabolism at experimental polytrauma: changes at the prescription of adrenaline and dexamethasone

Abstract

The aim of the research was to study influence of dexamethasone and adrenaline on the concentration of energy metabolism substrates in blood of Chinchilla rabbits under the conditions of multiple skeletal trauma. We performed stabilization of the bones of right forearm and left shin in 35 animals by wire external fixation device with further osteotomy of bones of corresponding segments. We observed the decrease of activity of metabolism in rabbits on the background of standard treatment. Maintenance of normal activity of metabolism by prescription of adrenaline and dexamethasone caused more intensive use of energy resources of an organism. Imitation of hyperergic reaction of stress-realizing systems in rabbits caused the increase of concentration of glucose in blood and the decrease of concentration of triglycerides. High consumption of energy substrates was provided by more expressed catabolic reaction. The result of hypercatabolism was development of hypoproteinemia, hypoalbuminemia and increase of the risk of fluid shift from bloodstream into the tissues with formation of organ insufficiency.