Differentiated approach to cell correction of acute hepatic failure at the acute toxic injury. Morphological basis of choosing the way of treatment
Abstract
The article is devoted to the estimation of morphological changes in liver of experimental animals with acute hepatic failure caused by toxic injury of liver under the influence of xenotransplantation of culture of cryopreserved cells of liver and isolated cryopreserved neonatal hepatocytes. It was determined that undamaged hepatocytes with simultaneous decrease of number of vacuolated cells, preservation. of beam structure, decrease of fat insertions prevailed in the liver of animals with xenotransplantation of culture of cryopreserved cells of liver to the 6th day. At the transplantation of isolated neonatal hepatocytes number of hepatocytes with undamaged structure decreased and number of damaged hepatocytes increased. Thus, cultivated cryopreserved cells of liver are the cells of choice of correction of acute toxic liver injury.
About the Authors
S. A. Lepekhova
ФГБУ «Научный центр реконструктивной и восстановительной хирургии» СО РАМН; ГБОУ ВПО «Иркутский государственный медицинский университет» Минздрава России; ФГБУН «Иркутский научный центр» СО РАН
Russian Federation
Russian Federation
O. A. Goldberg
ФГБУ «Научный центр реконструктивной и восстановительной хирургии» СО РАМН
Russian Federation
Russian Federation
K. A. Apartsin
ФГБУ «Научный центр реконструктивной и восстановительной хирургии» СО РАМН; ГБОУ ВПО «Иркутский государственный медицинский университет» Минздрава России; ФГБУН «Иркутский научный центр» СО РАН
Russian Federation
Russian Federation
M. V. Prokopyev
ФГБУ «Научный центр реконструктивной и восстановительной хирургии» СО РАМН; ГБУЗ «Иркутская ордена «Знак почета» областная клиническая больница»
Russian Federation
Russian Federation
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Review
For citations:
Lepekhova S.A., Goldberg O.A., Apartsin K.A., Prokopyev M.V. Differentiated approach to cell correction of acute hepatic failure at the acute toxic injury. Morphological basis of choosing the way of treatment. Acta Biomedica Scientifica. 2013;(2(1)):128-132. (In Russ.)
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