Results of the study of the immunogenic activity of cell envelopes of Francisella tularensis different subspicies (Report 2)
Abstract
The effect of cell envelopes preparations of four subspecies of Francisella tularensis, derived from urea lysates of tularemia microbe on cytokine production by immunocompetent cells of experimental animals has been studied. Stimulating influence of F. tularensis cell envelopes preparations on cytokine synthesis on the 7th day after inoculation was shown. The results showed that the cell envelopes of different subspecies F. tularensis have different stimulatory effect on the production of proinflammatory cytokines and growth factors GM-CSF and G-CSF, further defining the immune system of host.The results allow to consider cell envelopes preparations of F. tularensis as constituent component in the development of subunit vaccines.
About the Authors
A. V. Korneva
Irkutsk Antiplague Research Institute of Rospotrebnadzor
Russian Federation
Russian Federation
V. B. Nikolaev
Irkutsk Antiplague Research Institute of Rospotrebnadzor
Russian Federation
Russian Federation
K. Yu. Yastremskaya
Irkutsk Antiplague Research Institute of Rospotrebnadzor
Russian Federation
Russian Federation
E. Yu. Markov
Irkutsk Antiplague Research Institute of Rospotrebnadzor
Russian Federation
Russian Federation
V. V. Voytkova
Irkutsk Antiplague Research Institute of Rospotrebnadzor
Russian Federation
Russian Federation
S. Yu. Solovyov
Irkutsk Antiplague Research Institute of Rospotrebnadzor
Russian Federation
Russian Federation
Yu. O. Popova
Irkutsk Antiplague Research Institute of Rospotrebnadzor
Russian Federation
Russian Federation
A. V. Mazepa
Irkutsk Antiplague Research Institute of Rospotrebnadzor
Russian Federation
Russian Federation
T. A. Ivanova
Irkutsk Antiplague Research Institute of Rospotrebnadzor
Russian Federation
Russian Federation
V. S. Polovinkina
Irkutsk Antiplague Research Institute of Rospotrebnadzor
Russian Federation
Russian Federation
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Review
For citations:
Korneva A.V., Nikolaev V.B., Yastremskaya K.Yu., Markov E.Yu., Voytkova V.V., Solovyov S.Yu., Popova Yu.O., Mazepa A.V., Ivanova T.A., Polovinkina V.S. Results of the study of the immunogenic activity of cell envelopes of Francisella tularensis different subspicies (Report 2). Acta Biomedica Scientifica. 2015;(1):63-66. (In Russ.)
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