Antioxidant activity of oleic acid in pregnant women with herpes-virus infection

Abstract

The research by gas-fluid chromatography of content of monounsaturated oleic acid in peripheral blood (plasma, membranes of erythrocytes) of pregnant women who had. worsening of chronic herpes-virus infection with IgG antibodies titre to herpes simplex virus of the 1^st type 1 : 12800 was realized to study antioxidant activity of this compound. As the result it was determined that worsening of herpes-virus infection with high-intensive course (IgG antibodies titre to herpes simplex virus of the 1^st type 1: 12800) was accompanied, by the decrease of concentration of the acid both in plasma (1^st trimester — 15 % 2^nd trimester — 9 %, 3^rd trimester — 20 % in compariso, with control values) and in the membranes of erythrocytes (1^st trimester — 12 %, 2^nd trimester — 10 %, 3^rd trimester — 17 % in comparison with control values) and. is compensatory mechanism, aimed at the decrease of damaging action of products formed as the result of activation of lipid peroxidation processes. Therefore pregnant women with worsening of herpes-virus infection (IgG antibodies titre to herpes simplex virus of the 1^st type 1: 12800) have disorders in antioxidant activity caused by low level of oleic acid that leads to the changes of inhibition and. aggravation of processes of radical-production that have damaging action on structural components of the membranes of erythrocytes by their destruction. Consequently we can suppose that monounsaturated oleic acid has great contribution in antioxidant activity of blood and. can be endogenous biologic antioxidant and. reactive oxygen species invader in conditions of aggravation of chronic herpes-virus infection at the activation of lipid peroxidation processes and. low concentration of α-tocopherol. That's why the treatment of pregnant women with this pathology will be more successful if antioxidants are included in complex of drug therapy together with drugs normalizing lipid exchange that promote favorable outcome of pregnancy and. delivery