The aim of the research was to compare incidence of small complications after carotid endarterectomy (CEA) versus carotid artery stenting, as well as to evaluate its application in specific clinical situations. The outcomes of1826 patients who underwent surgery for stenosis of the internal carotid artery (ICA) were analyzed. There were two groups: 1018 patients who underwent CEA and 808 patients who carried the stenting. Age of patients was greater and coronary heart disease, diabetes, chronic obstructive pulmonary disease occurs more often in group with endovascular treatment, and they had rife stroke anamnesis. The mortality rate, uncontrolled hypertension and transient ischemic attacks were similar in early postoperative period. Stroke frequency was higher in patients with carotid artery stenting (35 (4,3 %) versus 27 patients (2,6 %) with CEA (p = 0,02)), and myocardial infarction took place more often after CEA (38 (3,7 %) versus 13 (1,6 %) patients with endovascular treatment (p = 0,008)). There was no statistically significant difference in security between CEA and stenting. However, treatment of carotid stenosis should be chosen according to individual characteristics, including individual anatomy.

In the known classifications, there is no terminological wording as asymmetrical sagittal occlusion of segments of dentition in lateral areas. The work complemented classification of sagittal occlusion anomalies in the lateral areas of dentition of following types of asymmetric occlusion: Type I of asymmetrical sagittal occlusion: correct (neutral - class 1] ratio of lateral teeth on one side and distal (class 2) ratio on the other side. Type II of asymmetrical sagittal occlusion: correct (neutral - class 1] ratio of lateral teeth on one side and mesial (class 3) ratio on the other side. Type III of asymmetrical sagittal occlusion: distal (class 2] ratio of lateral teeth on one side and mesial (class 3) ratio on the other side. Type of asymmetrical sagittal occlusion is not the basis for the establishment of gravity anomalies.

At the present moment periodontium tissues diseases are often registered in the population of children and teenagers. The article shows the interrelation of progress of periodontium tissues diseases with hygienic state of oral cavity. In this article we showed thatfirst evident manifestations of periodontium tissues diseases are revealed in thisgroup of patients at the age of eight. Number of diseases increases (up to 13,61 ± 2,48 %] and their severity grows with the increase of years. Th is is related to the h igh level (up to 45,45 %) of unsatisfactory hygienic state of oral cavity of examined children and teenagers.

The aim of the work was to evaluate the perioperative management of aged patients after elective surgical cerebral revascularization. We analyzed the outcomes of 813 patients of 70 years and older who had surgery for stenosis of the internal carotid artery [ІСА]. There were two groups: 392 patients who had carotid endarterectomy [CEA] and 421 patients who had the stenting. Age of the patients, severity of disease and comorbidity were similar in both groups In aged patients, the incidence of acute disorders of cerebral circulation (stroke] after CEA was significantly lower than the one after stenting (p = 0,04]. Frequency of perioperative myocardial infarction [MI] was 3 times higher in cases with CEA (p = 0,03]. in patients of 70 years and older, CEA shown lower incidence of stroke, however, there is increase of perioperative MI while using this method. Endovascular treatment could be chosen in patients with severe cardiac disease according to atherosclerotic plaques with no risk of embolism. In addition, the individual approach and assessment of social aspect are necessary.

At Hie present time, studying psychophysiological condition of levels of mental adaptation by means of objective indices is especially actual. Therefore, the identification and assessment of the indices characterizing the functional condition of an organism will allow the expert to decide on the level of mental adaptation. We examined 75 respondents which were divided into groups in correspondence with V.Y. Semke's concept. Primary diagnostic measures included clinical and psychological methods, the assessment of the functional condition of nervous system, short record of variability of cardiac rhythm. Features of psychophysiological condition of processes of regulation and functioning of ground levels of mental health in persons of hazardous occupation are studied. /Is a result of the conducted research, we revealed the reliable changes in the psychoadaptation and psychodisadaptation state in vegetative system of supporting of the processes of regulation of an organism in group (p < 0,05) (according to the indices of spectral analysis of cardiac rhythm and variation ofpulsometry according to R.M. Bayevsky). The tension index increased from 45,92 ± 31,81 to 347,94 ± 434,01 (p < 0,05). Reliable negative dynamics of change of clinical, psychological and psychophysiological indexes is shown upon transition from the first to the third level of mental health (p < 0,05).

The article presents the methods of mathematical analysis of the impactof alcohol on pregnancy, childbirth, postpartum and the state of health of newborn state. With the help of this analysis we revealed informative diagnostic features that let determine the effect of alcohol on pregnancy, childbirth, postpartum and newborn state: the use of alcohol before pregnancy once per month; alcohol consumption before pregnancy 2-4 times per month; smoking during pregnancy; abortion history; anemia during pregnancy; congenital heart disease on the third ultrasound screening; abnormal birth activity; subinvolution of uterus in the postpartum period; newborn gender; gestational age; prematurity and generally heavy state of a newborn. Linear classification function can be calculated by the formula 1.2. Canonical linear discriminant function can be calculated from equation [formula 3]. Diagnostic accuracy of decision rules in the middle is quite high - 76,69 %, in the first group - 75,7 %, in the second group - 77,6 %.

Individual variation in the clinical trajectories of affective disorder may have prognostic and therapeutic implications. We aimed to describe the long-term clinical course and outcome of non-psychotic affective disorder based on 5-year catamnesis. Medical records of 47 patients were studied (12 men, 35 women). The studied cases are characterized by polymorphism of symptoms and high levels of somatization and comorbid disorders. At first hospitalization only 46,8 % of cases diagnosed matched category F3 (ICD-10), a high level of double diagnosis has been described (14 cases - 29,8 %). Subsequent hospitalizations increased frequency of diagnosis of bipolar disorder type 2 (DSM-IV) - from 6,4 % to 33,3 % (p < 0,005). The problem of early recognition of non-psychotic affective disorders was discussed.

To estimate an accuracy of methods of myocardial infarction diagnostics (ECC, echocardiography, biomarkers) 41 case history reports of patients with Q(+) and Q(-) myocardial infarction and lethal outcome were analyzed. ECG and echocardiography were proved to be most accurate in case of anterior (67 % and 67 %), lateral (71 % and 67 %) and inferior (46 % and 79%) localizations of myocardial infarction. Interventricular septum and posterior localizations were not detected on ECG (0%). Complete coincidence of ECG and echocardiography with autopsy results was detected only in 4 %. CPC and CPC-МВ levels were elevated in 97%, troponins were positive in 70 %. Risk factors of lethal outcome in case of myocardial infarction include sex (male), comorbid pathology (arterial hypertension, cerebrovascular disease, diabetes mellitus type 2), complications (rhythm disorders, cardiogenic shock, congestive heart failure), absence of thrombolytic therapy and its inefficacy. Myocardial infarction hypo- and hyperdiagnosis were detected.

One of the frequent conditions which accompany bronchial asthma is essential hypertension. The authors compared the functional characteristics of patients with isolated asthma and bronchial asthma combined with essential hypertension. As a result the parameters of spirometry in group ofcomorbid disorders are significantly more decreased than in the group of isolated bronchial asthma: FEV1 [% predicted) before the testwith bronchodilator84,3 ± 1,28 and 85,7 ±2,63 (p < 0,05); the percent of increase in FEV1 after bronchodilator testis 6,5 ± 0,8 and 7,45 ± 0,3 (p < 0,05); fraction of exhaled nitric oxide (ppb) is 24,6 ± 1,15 and 27,6 ± 1,8. Exhaled NO level is higher in patients with bronchial asthma and arterial hypertension and in patients with atopy.

We conducted regionalization of Zabaykalsky Krai by the quantity of epidemic manifestations of tick-borne viral encephalitis over a period of 10years. The most adverse territories in the context of tick-borne viral encephalitis were determined. Maximum duration of seasonal incidence rate was 112 days -from the end of April to the mid-August. The categories of population included in infection contamination risk group were revealed. The researches promote forehanded development of the complex of preventive measures aimed at the decrease of tick- borne viral encephalitis incidence rate in Zabaykalsky Krai.

Influenza A virus (IAV) is a worldwide pathogen of humans and animals. In nature IAV is associated with aquatic birds. The regular survey of natural populations of aquatic birds is important to describe the diversity of IAV, evaluate pathogenic potential of circulating strains for human and domestic animals and reveal possible routes of virus spread during seasonal migrations of wild birds. In this paper the results of annual ecological and viroiogicai survey among wild birds of Eastern Siberia performed between 2005 and 2012 are presented. The cloacal swabs and tissue samples from 901 wild birds were analyzed for presence of IAV using virus isolation in chicken embryos and/or PCR assay. The subtype of IAV was established using haemaggiutintion inhibition assay and genome sequencing. Seventeen subtypes of IAV were discovered including H1N1, H5N1, HswNl, H0N1, H1N4, HlNlsw, H2N2, H3N2, H3N5, H3N6, H3N8, H4N6, H7N1, H7N8, H10N7, H13N6, H13N8. Highest prevalence of infection was detected among wild ducks Anas crecca (18.3 %), A. platyrhynchos (13.8 %) and herring gull Larus argentatus (6.5 %). The most diverse virus population was revealed in Irkutsk Region among L. argentatus that hosted subtypes H3, H6N1 and H9. In the Republic of Tuva and Krasnoyarsk territory H3N8, H5N1 and H7 subtypes were detected. The wild birds from Republic of Khakassia were shown to hostH4 subtype, whereas in Republic of Buryatia subtypes H3 and H4 were detected in wild ducks and herring gulls. Possible routes of IAV spread and epidemiological implications are discussed.

The study involved using morphometry in quantitative and qualitative evaluation of reconstruction of rabbit forelimb distracted bone graft. The dynamics of bone graft remodeling process revealed during the experiment showed that relative vascular volume in the bone graft was 70 % increased, cell number was 60 % higher, meanwhile relative volume of tissue structures in the bone graft was lower than in the noninvolved bone. All those parameters can indicate that there is an ongoing process of osteogenesis in the graft. 

During our experimental study, we researched peculiarities of formation and remodeling of distraction forelimb bone graft in rabbits at insertion of transosseous elements through acupuncture points (stimulation of biologically active points). One of the forelimbs was lengthened on 10 mm by Ilizarov method. Using morphoscopy and morphometry we studied morphofunctional changes in the bone regenerate at different stages of experiment during stimulation of biologically active points and compared these quantitative characteristics with parameters of the intact bone.

Cichorium intybus L., a perennial herbaceous plant of Asteraceae family, is widely distributed in the flora of Russia. Aboveground and underground parts of this plant are used in scientific and traditional medicine as hypoglycemic, antioxidant, hepatoprotective remedy. In this experiment lipophilic fractions of the herb and roots of chicory by method of gas chromatography with mass spectrometry detection was investigated. 4s a result of the research in the grass we revealed the presence of 14 compounds: derivatives of higher fatty alcohols, vital, isophytol, 3,7,11,15-tetrameth- yl-l,6,10,14-hexametre-3-ol, heneicosane, polien, first identifiedD-Iimonene. In the roots of chicory ordinary identified 12 substances - derivatives oflinoleic acid, first identified a-gorunen, (1-veteranen, a-amyrin and betulin.

In the Republic of Kazakhstan, there a re the natural plague foci. For the analysis, the passport data of plague epizooty activity in the PreAral-Qaraqym plague focus of Qyzylorda Province were collected. The data were received in the spring and summer seasons of2013. For the research of plague epizooty, the places ofstucfy were determined. The selection of places was based on the parameters as a presence of settlements, annual data of plague epizooty activity in the focus. Then the places were studied by serological and bacteriological methods; and the plague epizooty was found in some of them. During spring and summer seasons the plague strains were isolatedfrom the plague hostRhombomys opimus and plague vectors X. skrjabini, H. asiaticum, N. laeviceps, Cit. tesguorum, E. oshanini. For spatial and temporal analysis, the received positive data were processed by ArcGIS 10 program. The tasks of the analysis were definition of the plague epizooty center for plague risk zoning of the area; definition of direction of the plague epizooty for calculation of possibility of the plague epizooty increasing; calculation of plague epizooty radius for conducting of plague prophylaxis measures; definition of zones where the possibility to be infected with plague is high for population. The plague epizooty model of PreAral-Qaraqym plague focus was created, in the framework of plague epidemiological surveillance system, application the modeling in program ArcGIS 10 is useful instrument for detection of plague risk areas, and conduction of plague prophylaxis measures for protection of local population form the plague.

Lectin systems of industrial strains of probiotic bacteria of human origin were investigated. Lectin systems were observed as ceil surface and extracellular; solubilized in mild and firm conditions; solid phased fluorescent and chemiluminescent; anionic/acidic, neutral and cationic/alkaline; masked/biocked/encapsuiated with exopoiymeric substances of non-protein origin (localized together] and non-encapsuiated;genus/strain/consortia-specific and typing; specific to soluble artificial polymeric polyvalent glycoconjugates imitating exposed clusters of mucin-type glycans and possessing exposed multiple carbohydrate residues such asGalNAc-alpha- or Man-alpha- as side short branches of polyacrylamide linear chain). Results indicate prospects of glycoconjugates-binding lectin systems in glycobiology, molecularglyco- medicine and bio(nano)giycotechnoiogy.

A total of 452 blood samples of cattle, sheep and goat collected in different regions of Altai Republic, Altai region, Novosibirsk and Irkutsk regions were examined on the presence of Anaplasma DNA using nested PCR with subsequent sequencing of PCR fragments. Anaplasma DNA was found in all examined blood samples of goat, 75.2 % samples of sheep, and 49.3 % samples of cattle. A molecular genetic analysis has demonstrated that intraerythrocytic Anaplasma ovis circulates in goat and sheep blood, while an intraerythrocytic Anaplasma sp. Omsk and a new intraerythrocytic Anaplasma sp. Sibl22, which cannot be attributed to any known species, circulate in cattle blood. In addition to intraerythrocytic Anaplasma, DNA of monocytic Anaplasma bovis was found in one blood sample of cattle.

Results on visual patterns of subisotypes of patient sera complement component C4 complexes separated by isoelectric focusing in polyacrylamide gel and eiectrobiotting are presented. Method of visual controlled desialylation of sera using iso types C4A and C4B as internal biomarkers is described. Method was applied to investigation C4 isotyping and subisotyping patient sera. Sera of patients were classified into groups differing in subisotyping. The number of established groups of system component C4 was higher compared to groups detecting by other methods (for example, detecting using microplate functional assay of isotypes C4A and С4В]. Results open new prospects in diagnostics of autoimmune and infectious diseases using detection of pathological blood biomarkers complexed to C4 isotypes.

Frequencies of genotypes and alleles for 26 polymorphic variants of23 genes were statistically analyzed in 330patients with Ischemic stroke and 200 healthy subjects, matched for age and gender (p > 0,05) after genetic analysis (PCR-Ehf andPCR-Rt). SELP-1087A (OR = 1,6), SELP-1087GA (OR = l,96),SELE-128Pro (OR=2,66),SELE-128SerPro (OR=3,92), ApoC3-3238G (OR = 1,63), ApoC3-3238CG (OR = 1,95) alleles and genotypes were revealed to be associated with the disease independently (p < 0,05). MDR-method showed 2-6 components combinations of genotypes associated with the (non) development of lacunar ischemic stroke (prediction complexes: SELE-128Ser/ProxNOS3-786C/C (OR = 1,6) and PAI-1675/5G/4GxNOS3-786T/T*NOSl-84G/AxVEGF-A-2578A/C (OR = 6,0); protection complex: SELE-128Ser/ SerxNOS3-786C/T, OR=0,09) and atherothrombotic ischemic stroke (prediction complexes: NOSl-84A/AxApoC3- 3238C/C (OR = 3,0) and SELE-128Ser/ProxFRb-455G/AxNOSl-84G/A (OR = 10,0); protection complex: NOS1-84G/ GxApoC3-3238C/C (OR = 0,31)).

Polymorphisms of gene-candidates of hemostasis disorder (F2:20210 G>A, F5:1691 G>A, F7:10976 G>A, F13:103 G>T, FGB:455 G>A, ITGA2:807 C>T, ITGB3:1565 T>C, PAI-1:675 5G>4G) and frequency of 14 groups of alleles of the HLA-DRB1 locus were study in women, suffered from flu А(H1N1)pdm09 during pregnancy. Significant association between heterozygotes genotype F7: 0976G/A and complicated forms of influenza was found (OR = 1,5). Mutant homozygotes with PAI-1:675 4G/4G genotype also had high risk of severe complicated influenza A(H1N1) (OR = 1,5). Genotypes HLA DRB1*07*15 and DRB1*16*16 were associated with complicated influenza. We assume, that сombined F7:0976GA, PAI-1:6754G4G and HLA DRB1*07*15, *16*16, DRB1*01*01 genotypes may be genetic predictor of severe complicated flu А(H1N1)pdm09 in pregnancy.

According to different authors, cicatricial changes due to chemical bums of a gullet fluctuate in the big range from 3 to 74 %. Chemical esophagus burn of III degree leads to post-bum scar stricture of the esophagus in 15-70 % of cases. Bougienage, stenting, balloon dilatation are the most effective and safe in 70-96 % of patients. Bougienage is a leading method today. Developing promising direction - stenting with the use of new technologies. Despite the success of minimally invasive surgery in the treatment of stricture, 10-50 % of patients require surgical treatment. For the moment, despite high traumatic and high percent ofstricture relapse (15-40 %), and also exitus letalis coming up to 10%, bougienage is the basic and most effective method of treatment.

Results on cofunctioning innate mucosal immunity (MI) and human complement system (HCS) pathways at steps of HCS initiation, amplification and termination were summarized. Receptor participants and pattern recognizing molecules (oligomeric lectins, multifunctional-site mucins and glycoproteins) of HCS and MI are taking into consideration. The ways of antipathogen cofunctioning MI and HCS are shown. The cases of viral, bacterial and fungal pathogens which use components, agent ingredients and reactions of HCS and Ml in pathogen strategies of invasion and survival in organism are represented. Prospects of cofunctioning MI and HCS, strategic directions of MI and HCS combinative using in development of medical aspects, constructing drugs and compositions of medical biotechnology significance are suggested and argued.

The article presents review of literature data concerning modern vision of concomitant deformities and disorders of the spine and pelvis in terms of age aspect, covering the causes of development of locomotor system functional disorders in children and teenagers and considering information on concomitant orthopedic pathology. The authors analyse new approaches to health evaluation in various age groups of population. The conclusion has been made, that despite certain success obtained in studying separate degenerative-dystrophic disorders of locomotor system, there is no unique solution to the problem of concomitant deformities and disorders of the spine and pelvis and their mutual interaction.

Biographical sketch about V.Yu. Lebedinsky, Doctor of Medical Sciences, Professor: main research areas in the morphology, scientific works, dissertationists, scientific schools.