The article describes the results of dynamics of impaired cognitive functions of patients with alcohol dependence who received treatment with antipsychotics. Cognitive functions improve significantly faster in patients of the main group whose treatment included Risperidone, an atypical antipsychotic. There is insignificant positive dynamics of impaired cognitive functions in the group of patients who received Haloperidol as antipsychotic. The patients who received Risperidone have shown improved compliance, lack of negative attitude to the therapy provided as compared with the control group patients. Risperidone's most significant effects include improvement of disorganized psychic activity, recovery of active attention, dynamic and tempo parameters of activity, recovery of the capacity for unconditioned regulation of thinking and behavior, critical assessment.

This article presents results of comparative research of the functional activity of neutrophilic granulocytes, expressed through a calculated index of activation, in sportsmen going in for orienteering at the end of competitive period and the control group, consisting mostly of healthy people, who do not expose to high physical load. We detected a reliable decrease of the activation index of neutrophils of sportsmen in more than 2 times in comparison to the control group.

The article describes participation of immune system in pathogenesis of varicose vein of pelvis minor. The study revealed elevation of proinflammatory cytokines, discovered disturbances in cellular and humoral units of immunity. Indicated changes are evidence for inflammatory character of changes in venous vascular wall, causing its destruction and varicose dilatation.

In the article the complex therapy of varicose vein disease of pelvis minor in women is suggested; it includes phlebotropic, metabolic and immunotropic drugs. Indicated scheme of treatment lead to improvement of hemodynamic parameters of venous system of pelvis minor. Positive changes of parameters of cytokine, cellular and humoral units of immune system are evidence for decrease of inflammatory response of venous vascular wall.

At labile and stable hypertension (AH) practically we revealed equal number of patients with decreased activity of protein C system (PS), antithrombin-IH (AT-ПІ), protein C (PS), Leiden anomaly. With stable hypertension decreased activity of PS was more pronounced. Reduced activity of PS was found only in children with stable hypertension. Significantly greater number of patients with decreased activity PS were revealed at stable hypertension. Comprehensive study of hemostasis is advisable in children with AH.

The results of research of occurrence of genotypes of a polymorphic marker of a gene of interleukin-17 (IL-17А G-197A, IL-17F His161Arg) in 141 children at a influenza are presented in the article. It is established, that genotypes G/A of gene IL-17А G-197A and His/Arg gene IL-17F His161Arg act as factors of protection in children at a seasonal influenza. And at a influenza A H1N1/v genotypes G/A of gene IL-17А G-197A and His/Arg gene IL-17F His161Arg are associated with risk of occurrence of a disease. Serious forms of a pandemic influenza are accompanied by frequent revealing of allele Arg and more rare - of His gene IL-17F His161Arg in comparison with not serious forms of a influenza A H1N1/v.

The aim of the work was to study the peculiarities of the influence of bloodfactors on the development of spherocytosis in patients with coronary disease and arterial hypertension. The study involved 30 patients with coronary disease and 24 patients arterial hypertension with the study of their clinical status and biochemical parameters of blood, hemostasis, blood cell analysis. It was found that the increase in the pool spherocytic cells in patients with arterial hypertension were associated with increased nitric oxide production, while in patients with coronary disease spherocytosis was due to an increase in the concentration of reactive oxygen metabolites.

The problem of studying myopia as multifactorial disease remains relevant due to the increase and morbidity of the disease, particularly in childhood. One of the factors of progressing myopia among children - orthopedic pathology which progresses simultaneously with myopia - is discussed in the article. The aim of the work was to reveal dependance between orthopedic pathology and progression of myopia. A retrospective analysis of the restuls of prophylactic examination of children of decreed ages in 2007-2012 years was realized. The analysis of the results of medical examinations showed that myopia and accomodation spasm come to 80 % of cases in the structure of revealed ophthalmic pathology. It was revealed that orthopedic pathology accompanies and often provides development and progression of myopia. The increase of morbidity with refraction disorder is registered during 5years. Direct dependance between orthopedic pathology and progression of myopia was revealed.

The article is devoted to some features of revision hip arthroplasty, especially to the prolapse of the acetabular component into the pelvis cavity. International literature review is presented, in which the authors warn surgeons about some possible complications during the removal of the components using retroperitoneal and external approach. In case of contact of acetabular component with neurovascular bundle in pelvis, foreign authors recommend retroperitoneal approach.

This article is devoted to investigation of emotional symptoms and social anhedonia in clinical context. The article describes the most important theories of emotion including modern concept of «emotional intelligence». Growing attention is paid to investigate the emotional experience in laboratory settings, and the study is continued this tradition. Schizophrenia subjects experienced more intense and more variable negative emotions than controls. Our findings suggest that patients with schizophrenia have social cognitive deficits, difficulties in perception of emotions and high level blocking of emotions. Finally, analyses of results suggested the possibility of a shift in the structure of emotional diseases in schizophrenia.

Allele and genotype frequencies of 5 polymorphisms were studied in healthy population in Transbaikalian region. High percent of spontaneous and inductive aggregation were observed in subjects with three or more mutant allele (р < 0,05). These subjects developed maximum radius of aggregates only in spontaneous -1,7 ± 0,4 opt.un. (р < 0,05) and collagen-induced aggregation - 7,6 ± 2,5 opt.un. (р < 0,05).

Preeclampsia is one of the most common obstetric pathologies affecting the level of maternal and perinatal loss. It is manifested through polyorganic dysadaptation state at pregnancy, and depends on the climatic conditions predetermined by fluctuations of temperature and atmospheric pressure. The objective of the work was to identify the frequency of severe preeclampsia in the Far North and the determination of the most sensitive markers of the state of preeclampsia of ulterior degree. Incidence rate of preeclampsia in the Northern areas of Irkutsk region is higher than in its Southern parts. The frequency of severe preeclampsia in these regions did not differ. The most sensitive markers of the state of maladjustment pregnant as a mild form of preeclampsia are the concentration ratios dienes and cortisol.

The aim of the research is to determine of the efficiency of developed uniplex, duplex, and multiplex variants of PCR test systems for the epizootic research of the plague natural foci. The research was carried out on the model of plague and its relative strains, and with the suspension of fleas and ticks. Selection of the primers used for detection of the genes cafl, pla and yopE is carried out by the program software Primer 3 and the complex of online program BLAST® (Basic Local Alignment Search Tool. Synthesis of primers is carried out by the traditional phosphoramidite method on the automatic synthesizer DNA/RNA H6 (K&A, Germany). Purification of the received solutions of primers is carried out by the gel filtration method on Centri-Pure N10 columns (emp Biotech GmbH, Germany). Extraction of genomic DNA of Y. pestis, Y. pseudotuberculosis and Y. enterocolitica is done by QIAamp DNA Mini Kit (QIAGEN, Germany). Testing of specific primers and test system was carried out by the standard PCR. Analysis of amplification's results is conducted by standard method of horizontal agarose gel electrophoresis. In the research, Y.pestis strains from the Alive cultures museum of M. Aikimbayev's Kazakh Scientific Center for Quarantine and Zoonotic Diseases, and suspensions of ticks and fleas collected from the Central Asian Desert Plague Focus were used. For the first time in Kazakhstan, for production, PCR test systems have been developed for detection of the plague microbe in the field and laboratory conditions. The PCR test systems developed on the base of specific primers to plague microbe's genes yopE, cafl and pla helped to detect the circulation of plague microbe without Fl (without fraction). Research of suspensions of fleas and ticks collected during the plague epizooty confirmed the specificity and high sensitivity of the developed test systems.

A review of international and national standards was realized and it was showed that the residue of presbycusis was valid only if the employer wants for comparison of the audiogram taken in different years. It was proved that the development of a significant degree of professional hearing loss in older age groups depended on the length of service in terms of noise.

The article presents comparative analysis of the results of complex long-term examination of occupational male patients of three types of economic activity: civil aviation, engineering and coal mining industry with determined diagnosis of sensorineural hearing loss.

It is established that in long-term dynamics in the Republic of Sakha (Yakutia), it was characterized by statistically significant growth, as pollution of atmospheric air, incidence growth on the main classes of diseases of MKB - 10. Studying of correlation communications between incidence indicators on separate classes of diseases and technogenic pollution of atmospheric air allowed to establish that from 304 calculated coefficients of correlation 129 (42,4 %) were statistically significant (р < 0,05 or р < 0,01). The carried-out regression analysis between total incidence and total of the emissions arriving in the atmosphere of the studied territory, revealed that one ton of emissions getting to atmospheric air initiates emergence of diseases of a various etiology of 10,1⁰/₀₀ and 41,8⁰/₀₀ cases among adults and children respectively.

In the article results of sanitary epidemiological characteristics of water of the Lena River, including on indicators of parasitic safety and physiological full value are analysed. It is established that the adverse effect of water of a water source on health of the population is connected with its physiological inferiority which is caused by the low maintenance of a number of biologically active elements. The received value of factor of "utility of water» in 47 times below recommended value.

The problem of contamination of the lower layer of the atmosphere in Western Siberia remains relevant more than half a century. The territory of the city of Kemerovo, a major industrial center with well-developed coal-chemical complex is an obvious example of antropotechnogenous burden on the environment and the health of the population with its climatic and geographical, weather and economic features. The aim of the study was to evaluate the structure of chemical contamination during 2005-2011 years, their interaction and the allocation of the factors that determine the ecological zoning on the example of the city of Kemerovo to identify the role of chemical pollution on the health of the population. Factor analysis revealed two latentfactors that determine the structuring of chemical pollution of the city of Kemerovo, in accordance with the wind rose and the chemical nature of the contaminants. The research shows the negative influence of chemical pollution on the health of the population of the city of Kemerovo.

The article briefly describes the history of the biochemistry laboratory of the Federal State Organization "Scientific Center of Reconstructive and Restorative Surgery" SB RAMS - from organizing VI. Astafev Siberian Branch of the All-Union Scientific Center of Surgery RAMS, and create groups: 1) biochemistry (head A.L. Tarabrin) and 2) express diagnosis and drug therapy (head E.E.Kuznetsova). The main areas of research have been associated with the study of mechanisms, assessment of severity of the correction and effectiveness in the clinic and in the experiment with coronary heart disease, acute myocardial infarction, toxic hepatitis, hypercholesterolemia, hypertension, inflammatory bowel diseases, injuries. We investigated the efficacy and mechanisms: the thrombolysis in AMI, actions imozimaza in purulent processes, new antibiotics, anti-cytokine therapy in IBD, stem cell therapy in various pathologies. Results of some studies.

The algorithm of classification of municipal unions (MU is based on definition of a confidential interval of average long-term tick-borne encephalitis virus (TBE) sickness rate, as a quantitative integrated indicator of an epidemiological situation at the territory. It is proved that a decade is a sufficient period to reveal the patters that can be transferred to general totality and facilitate realization of MU classification. Distribution by MU groups is a steady characteristic of TBE morbidity at MU territories by decades in 95 % a confidential interval.

Main principles of the organization of sanitary protection of territory in a network of the Russian Federation railways, peculiarities of interaction of sanitary-epidemiological services of railway administrations of the states-CIS participants in the field of sanitary-epidemiological well-being maintenance are considered. These measures will permit to reduce the probability of importation to the State territory and further distribution of the infectious diseases dangerous for humans, dangerous cargoes and the goods and also to minimize expenses for liquidation of its importation consequences.

Influence of Francisella tularensis lipopolysaccharide preparations on morphological changes in immunocompetent experimental animals was studied by subcutaneous introduction using survey microscopy and morphometric methods. Low expressed activation of B- and T-dependent bands in immunocompetent organs was determined. Proliferation of antigen-presented cells at early stages of investigation indicates the cell immunity activation. Pathomorphological alterations caused by lipopolysaccharide inoculation are homogeneous and benignant.

There were atoxigenic Vibrio cholerae strains housekeeping genes analyzed. There were studied 20 isolates, in which nine sequence types have determined and five of which have described as unique. There were clustersformed as belonging to serogroup: first cluster includes RO-variantstrains and one O139 serogroup strain of V. cholerae, second - all O1 serogroup V. cholerae strains. There are sequence types associated with place and time isolation strains in some cases, although differentiation of the strains, which are formed the dominant sequence type strains group have no spatial and temporal characteristics associated.

Data of Yersinia pestis plasmid structure influence on its adhesive properties and phagocytic activity of peritoneal macrophages in vitro are represented. It is shown that Y. pestis strains of diverse subspecies differing by a plasmid profile, particularly by one of the plasmids (pYP, pYV) lacking, possess low adhesive activity and promote the increase of laboratory animal phagocyte absorbing capacity.

The result presents in the article of the morphological and histochemical studies of the liver on the model of experiment toxic hepatitis CCl₄ on rats and this correction nanopreparation of selenium. It has been shown that the drag of nanoselenium in the arabinogalactan matrix has hepetoprotective property. This is manifests in the protective effect of hepatocyte damage from the toxic carbon tetrachloride. On the seventh day of experiment ascertained atomized fatty degeneration, it will has disappear by fourteenth day of experiment, then hepatocytes has monomorphic sizes and well-marked nucleus and evenly distributed chromatin. The activity of enzymes and glycogen preserves, the lipid content reduce. The nanocomposite preparation of selenium reduces poisonous action to hepatocytes.

With the use of diffusion test in substrate agarose gel in sterile subcellular fractions of Vibrio cholerae 01 and 0139 serogroups, got from by the lysis urea of living microbial cells, found out a ability for the proteolysis of rabbit and human immunoglobulins of class G. Substrate electrophoresis detected polypeptides with IgG-protease activity both in water-soluble and membrane fractions of the strains with different molecular masses. Differences in IgG-protease activity of subcellular fractions of V. cholerae ompT⁺ and ompT^-strains were determined.

Proposed approaches to the monitoring early biofilm forming by microbial strains and their mixtures can be used for evaluation of healthy status of human biotope microbiocenoses as well as for choice of new sources for cellular and molecular therapy (antibiofilm, antipathogen, alternative to antibiotics, immunovodulator, enzyme, cytokine or combinative type).

It is established, that ethanol in the dose of 12 g/kg at experimental animals (white noninbred male rats) has the pronounced damaging effect on the liver, which is manifested in the dynamics of the aggregate biochemical, histological and histochemical indicators.

The article provides information on the efficiency of thermal injury healing in animals (rabbits) under light therapy with «Bioptron», «Ricta», «Azor», 0KN-11M, BOP-4. An analysis has been done of the results of the morphological and planimetric research within 5-15 days after wounding. The factual data received have led to the conclusion that it is advisable to combine different physiotherapeutic practices in wound treatment. Synchronization of processes of an epitelization and maturing of granulyatsionny fabric allowed to recommend for appointment different lengths of waves of optical range in a certain sequence, beginning from ultra-violet beams of short, average range, then laser radiation of an infrared, red range, and also their combination, then to continue influence by the polarized light through standard periods (courses).

The complex study of a number of humic substances was conducted with help of bioassay methods using invertebrates (Daphnia, paramecium, earthworms), terrestrial (wheat seeds) and aquatic plants (elodea, duckweed) and algae (Scenedesmus quadricauda). The ranges of concentrations of humates that have a negative and a stimulating effect on biological objects were identified. The efficiency of biological testing methods to evaluate the effect of humic substances on biological objects is shown.

This review of literature describes a role of chronic stress in the development of substance dependence including alcohol dependence. It is focused on neurochemical mechanisms of this dependence and approaches to its treatment in people with mental adaptation disorders.

Review of the literature in problems of diagnosis of chronic obstructive pulmonary disease (COPD) exacerbation and the main radiological techniques of COPD exacerbation were presented. Diagnostic possibilities of screen-film radiography, functional low-dose digital fluorography (LDDR), high-resolution computed tomography (HRCT), inspiration-expiration HRCT, ventilation-perfusion pulmoscintigraphy and magnetic resonance tomography in patients with COPD exacerbation were described. The advantages offunctional LDDR in patients with COPD exacerbation were shown.

In a review of the scientific literature describes the current understanding of the problem of the teratogenic effects of alcohol on the fetus, and pregnancy outcome. Attention is paid to the occurrence, clinical manifestations of fetal alcohol syndrome and fetal alcohol spectrum disorders. It is shown that in Russia accurate epidemiological data on the incidence of fetal alcohol syndrome and fetal alcohol spectrum disorders are not available. It is noted that the use of alcohol by women is associated with adverse pregnancy outcome. May manifest clinically delayed fetal development, risk of miscarriage and low birth weight. In reviewing the domestic and foreign literature revealed that in Russia the problem is insufficiently known, relevant. Therefore, the study of this problem will be of great theoretical and practical significance.