The article shows the opportunity of use of biomonitoring in patients with exogenous toxic encephalopathy in the remote period of chronic mercury intoxication. (CMI) and with, vibration disease caused by local vibration. The efficiency of the biofeedback method was assessed on the basis of the data of electroencephalography, auditory, visual and somatosensoric generated potentials, electroneuromyography, thermometry, dosed cold test and. rheography. Biofeedback training in people with. CMI caused decrease of total brain changes in EEG, improvement of amplitude indices at of the brain generated potentials, in people with vibration disease it caused decrease of manifestation of angiodistonic syndrome and. restoration of neuromuscular conductivity.

Frequency of detection of pathology of respiratory organs in employees of SUAL Public corporation, the branch, of IrkAZ-SUAL, and clilicofunctional peculiarities of course of bronchopulmonary pathology in patients with toxicodust bronchitis, former employees of this enterprise, were studied. Conditions of work of electrolysis and. anode employees corresponded to the class 3.2, of smelter — to the class 3.1. It was determined that medium grave and grave course of chronic obstructive lungs disease and. chronic non-obstructive bronchitis in patients with toxicodust bronchitis, former employees of Irkutsk aluminium factory happened more often in employees of general occupations.

We carried out comparative estimation of treatment of polyneuropathy of extremities caused by exposure of general vibration and physical activity with use of travelling magnetic field on the extremity and. organ-mineral napkins on the basis of "extraction" of sludge dirt rich with mineral salts and. wide complex of microelements. As the result of performed therapy we registered regress of main symptoms and. improvement of electrophysiological indices.

The article presents the results of complex treatment of erectile dysfunction of 38 patients with vibration disease of II degree. The diagnosis of erectile dysfunction was proved by clinical and instrumental data, besides we carried out survey with determination of international index of erectile dysfunction. Treatment complex included homeopathic remedies, vasodilating ointment for local application and physiotherapeutic procedures. Improvement of the indices of phallography and. the index of erectile dysfunction was registered on the basis of treatments. Total effectiveness of the therapy was 89,9 %.

Associated cardiovascular pathology (ischemic heart disease and arterial hypertension.) in miners with chronic obstructive pulmonary disease increases the degree of hypertrophy of myocardium of right ventricle of heart and worsens its systolic and diastolic functions.

The article presents the results of content of nitric oxide in blood of workers exposed by mercury and vinyl chloride, and in people in the remote period of mercury intoxication. Reduced levels of nitric oxide are considered as one of the mechanisms development and. progressing of basic and. concomitant pathology in examined. people.

As a result of the performed researches we studied the features of vegetative regulation and cerebral circulation in patients with musculotonic syndromes of the cervical level of professional origin. On the basis of this study we worked out individualized differentiated rehabilitation programs of laser and. EHF-therapy, that showed higher effectiveness in comparison with common treatment.

The article shows peculiarities of regional circulation of the blood in patients with acute pancreatitis during conservative treatment. Obtained data allows to estimate state of pancreas objectively and also to control adequacy of the treatment.

The article presents the experience of medicosanitary department of the factory of titanium alloys production. on the organization of stage medical aid for employees at the acute occupational poisoning with hydrogen fluoride and nitrogen dioxide. The article also presents data of clinical examination of people suffered in different terms of post-intoxicational period and the effectiveness of the complex of measures.

Item. 4.2.2.6 "bauxite pneumotoxicosis (influence of bauxite dust)" is included, in the "List of occupational diseases" (code Х J 63.1), that requires elaboration of standards of its diagnostics, treatment and rehabilitation of patients. The article presents the results of clinicohygienic researches of the evaluation of influence of bauxite dust on the condition of bronchopulmonary system of the employees. It was shown than influence of low-fibrinogenous dust at the extraction of bauxite ore leads to the development of pneumotoxicosis, that shows itself as significant convection and. hemodynamic disorders that limit patients' earning capacity.

The article presents individual features of metabolism of connective tissue in patients with, different terms of formation of vibration disease. The assessment of metabolic disorders in connective tissue of patients with vibration disease for prediction of its course in post-contact period was carried out.

We determined higher effectiveness of rehabilitation in comparison with control group by subjective and objective indices (biochemical, immunological and. clinical); increase of life quality on 60 % of patients with occupational chronic bronchitis at the including of natural concentrated food substances with increased content of biologically active substances with apparent antioxidative characteristics in complex.

Clinical manifestations of vibration pathology with different degree of pathological process intensity were studied in 288 vibration exposured miners. Peculiarities of formation of vibration pathology in Kuzbass miners are connected with the development of angiodystonic syndrome (97—100 %) with acrospasm attacks. Formation. of vibration pathology is associated with the increase of arterial hypertension incidence — up to 28,3 % at stage I and up to 34,1 % at stage II, that is possibly caused by the increase of endothelia system dysfunction. There is progressive disease course both in the persons continuing contact with vibration and in those who stopped it.

We carried out clinical-psychological examination of 504 children of 12—17 years old. According to the comparative analysis of indices of children in main (with arterial hypertension — AH) and control (without AH) groups we resealed frequency, age and. sex structure, factors of risk of arterial hypertension. We analyzed, psychosocial (acute and chronic psychologic traumatic experience) and sociocultural factors (medico-demographic and social-economic family status), studied individual and. typological features of the person, structure of temperament, psychic conditions, peculiarities of interpersonal attitudes (in family and. in school). We studied interactions and determined diagnostic significance of studied indices as the factors of risk of development of hypertension with estimation of their quantitative characteristics by the index of chances ratio and. its confidence intervals.

The data base on occupational illness in Rostov region in 2002—2011 has been formed. Branch and occupational structure and. dynamics of relative indices of occupational illness with the economics branch consideration have been analysed. The tendency of reducing occupational illness indices in Rostov region has been revealed, it being caused by incomplete revealing the patients with occupational illness. Coal mining industry, in which the high level of occupational illness is caused by the extremely unfavourable conditions of labor, is an exception. It is necessary to increase the efficiency of periodical medical examinations, especially for agricultural workers, in order to reveal the real level of occupational illness.

The paper deals with the approaches to revealing the problems of communities' health, functioning public health services against social and economic reforms (at the example of the Siberian Federal District). The main basis is presented and. the basic components of determining the requirement for medical and. recovery aid. of the patients with occupational diseases included as an element into the complex target programs directed to the improvement of demographic situation, the prevention of occupational diseases and. maintenance of labor population potential are systematized.

The results of long-term dispensary supervision (14 years) of 284 silicosis patients (including 54 silicotuberculosis patients) worked at Kuznetsk Metallurgical Plant have shown that high concentration of dust in air with 5% content of free silicon dioxide promotes the development of non-complicated silicosis as well as silicotuberculosis. This dispensary supervision, has been conducted by the physicians of scientific and consultative department of FSBI "RI CPHOD" SB RAMS in Novokuznetsk. Fast development of silicosis is risk factor for silicotuberculosis (р < 0,05). Slow development of silicosis is much rarely associated by tuberculosis infection. The patients with non-complicated. silicosis and. silicotuberculosis have the signs of pneumonia (oftener in non-complicated silicosis) and. chronic obstructive pulmonary disease (oftener in silicotuberculosis) according to the results of chest radiography.

Questionnaire of 285 teachers of comprehensive schools estimated subjective fatigue and possibilities of restoration of working capacity depending on a number of biological and. social factors. From among studied factors the greatest contribution to efficiency of workers of brainwork is brought by indicators of a state of health, in particular chronic incidence, frequency of diseases in a year and. value judgment of health. The age of the worker and. level of satisfaction of the general and. professional requirements have a certain value.

The estimation of risk for development of diseases due to whole body vibration exposure on the basis of spectral characteristics at the workplaces in turbine shops of thermal power stations was carried out. The highest average equivalent levels of whole-body vibration by speeding up of vibration and. vibration velocity were observed at the workplaces of turbine machinists of Kuznetsk Thermal Power Station and. the Western-Siberian Thermal Power Station; in the machinists-inspectors of turbine equipment the indicators were a little bit lower. At the workplaces of turbine machinists the highest levels of risk for backache in the lower part and autonomic sensory polyneuropathy syndromes development were registered at the Western-Siberian Thermal Power Station and the Southern-Kuzbass Thermal Power Station, little smaller indicators were observed at Tom-Usinsk Thermal Power Station and Kuznetsk Thermal Power Station.

Analysis of dynamic rows of indices of occupational patients mortality in coal mining industry for the period from 1950 till 2009 (8078 cases) has been carried out. Essential increase of age and the length of service of workers taken into registration for the first time in the Centre of Occupational Pathology as well as the reduction in seven times of the period of living of occupational patients from the moment of establishing the diagnose of an occupational disease till death have been revealed. It has been shown that the urgent working out and realization. of the complex system of medical rehabilitation of workers with initial indications of influence of harmful factors of working environment to the organism as well as with initial symptoms of occupational diseases are demanded in the country.

Resonance frequencies of chemical elements of periodic table were obtained for the first time, exact limits of electroencephalogram rhythms were determined, correspondence of ranges (677 — 0,02 Hz) of resonance frequencies of chemical elements with rhythms of brain, heart, breathing and intestines work and. their octaves with limits of frequencies that are resonance with frequency of hydrogen atom radiation was revealed.

We studied influence of silver-containing nanocomposites — galactomannan and poly-1-vinyl-1,2,4-triazole — on cell structure of peripheral blood and red marrow of white mice. The results obtained after the experiments testify that these nanocomposites aren't toxic, the changes caused by their introduction are productive and. part of them points at the activization of immune system of macroorganizm.

Morphological changes in tissues and organs at subchronic intoxication of white rats with 1,4-benzodiazepines synthetic medications (alprazolame, mezapame, diazepame, and nozepame) are studied in an experiment. Pathomorphological changes in tissues of liver, kidneys, brain and reproductive system that can lead to the development of industrially caused diseases in the employees of benzodiazepines production are revealed.

Early stages of coal-dust exposure on laboratory animals do not cause morphological changes in heart muscle. Later periods (6—9 weeks of experiment) are accompanied on the one hand expressed compensatory-adaptive processes, on the other hand. - selective accumulation of lipofuscin in cardiomyocytes. Accumulation of lipofuscin is directly dependent on the duration of the adverse effects of the dust factor and. may be one of the main morphological markers of deep damage and cell death with prolonged exposure to coal and rock dust.

Experimental models of anthracosilicosis (AS) and fluoride intoxication. (FI) show that the inhalation of coal and. rock dust (CRD) results in an early anti-inflammatory cytokine response (IL-4, IL-10) and. activation of humoral immunity on the background of lower level of proinflammatory cytokines. Later stages of the CRD activity are characterized by inflammation and. immunodeficiency. FI start is accompanied, by an increase of proinflammatory cytokines (IL-8, TNF-α). Anti-inflammatory protection is seen on the later stages (IL-10), immunoglobulin levels did. not change during 6 weeks of FI. Recommendations for the prevention of the anthracosilicosis and. fluoride intoxication given.

In an experimental model of long bone fractures studied osteoclastic activity in the fracture zone. We used histological staining methods and histochemical staining with antibodies to carbonic anhydrase type II. It is shown that the use of histochemical staining to carbonic anhydrase type II cells is promising for the evaluation of osteoclastic activity in bone tissue. Application of this technique significantly simplifies the morphological study, allows a clear differentiation of osteoclastic cells.

It is necessary to create the low of RF (the Decree of the government of RF) which will clearly define the order of organization and carrying out medical examinations of workers of harmful occupations and. their financing. For the organizations of prevention of occupational diseases and. medical rehabilitation of patients with occupational diseases during working out the order of financial security of preventive measures for reducing occupational diseases. It is necessary: to include into the list of preventive measures profound medical examinations of workers in the centres of occupational pathology, rehabilitation treatment of workers from the group of "risk" and patients with initial displays of occupational diseases in the centres of occupational pathology (rehabilitation centres); to insert the changes into the Federal Law no 125-03, supplementing the list of kinds of financial security for insurance of medical rehabilitation of the insured patients in the centres of occupational pathology (the centres of rehabilitation); to include into the Federal programme of compulsory medical insurance occupational pathology help.

The article discusses the problems of grounding for additional documentation in the preliminary examination of a candidate to shift work in the Arctic shelf, of choosing the variant of preliminary and. periodic medical examinations in order to increase the effectiveness of medical support during the manufacturing process of medical screening, improving the effectiveness of periodic inspection, when combining it with the dispensary inspection.

The expediency of introducing the system of movable clinical diagnostic laboratories for well-timed medical service of high quality for workers with high level of occupational risk has been grounded in this work, the efficiency of their activity in carrying out obligatory medical examinations of workers of harmful occupations in the period of making the home system of obligatory insurance against accidents in industry and occupational disease has been proved.

Bone tissue preserves high metabolic activity during all time of its life. Homeostasis of bone tissue is provided by fine balance between its formation by osteoblasts and its resorption by osteoclasts. There are complex regulatory interrelations between cells of bone differon and. system of interferons, the peculiarities of production of which mediate disturbances of osteoformating and. resorptive components of osteo metabolism at various pathological conditions. The review presents literature data on the role of interferons in regulation of osteogenous and. osteoresorptive processes which opens up the prospective of aimed application of interferons preparations with the purpose of restoration of immunologic imbalance and. bone tissue homeostasis.

On the main scientific directions of "RI CPHOD" SB RAMS connected with the study on the bases of human reproductive health formation estimation, and prediction of population reproduction and. losses of health in the regions of Siberia, the Far East and. the Far North; the hygienic estimation of social, ecological and. industrial conditions in the territories of Siberia with the elaboration of effective methods for prevention, treatment and. rehabilitation of occupational diseases, industrially caused diseases and. common somatic diseases in the working communities; the study on the problems of management and. organization of public health care systems, elaboration of methodological bases and. techniques for formation of strategy and. technology for realization of health improving programs, territorial public health services, medical services and. organizations the scientific review of the results of the researches of the influence of environmental and. genetic factors on the development, course and. outcomes of occupational diseases is carried out.

Matrix metalloproteinases are main proteolytic enzymes breaking down most components of extracellular matrix of various tissues. In the review shows role of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases during implantation, morphogenesis, and. delivery.

Acute hepatic failure is a cause of a significant amount of liver diseases. In a basis of pathogenesis of acute hepatic failure lie necrotic processes, apoptosis and necroapoptosis of hepatocytes. In this review modern information on a question of acute hepatic failure is analysed and generalized, and. therefore problem questions on pathogenesis, diagnostics and. treatment of this severe complication are revealed. In the world there are plenty prognostic tests of acute hepatic failure outcomes, however they not always can predict current of disease and. have the limited value.

This article presents a review of the scientific literature on the early diagnosis and treatment of rheumatic diseases. Separate issues of early arthritis, which due to the paucity of clinical symptoms, often incorrectly considered doctors. Describes the diagnostic difficulties with rheumatic heart disease, systemic lupus erythematosus, Behcet's disease, ankylosing spondylitis, it focuses on the diagnosis of gout.