The aim. of the research was to prove and develop methodology of use of dynamic segmental diagnostics as the way of testing of skin sympathetic reactions during complex examination of patients with dorsopathies. We examined, patients with injuries of intervertebral discs of cervical, thoracic and. lumbar segments of spine, with dorsalgies on the background, of neurological manifestations of spinal osteochondrosis: 151 male and. 165 females (from 17 to 62 years) and 67 healthy people (27 males and 40 females (from 14 to 29 years). We summarized data of the intensity of skin sympathetic reactions in paravertebral segmental zones of different segments of spine and showed dependence of these reactions' intensity on the character of injury of vertebromotor segments at the dorsopathies.

The aim. of the study was to form a certain conception on the basis of evidence obtained by dynamic segmentary diagnostics of patients with pathology of various systems of an organism. Patients with diseases of cardiovascular, pulmonary, genitourinary and. digestive systems (280 patients: 142 males and. 138 females, aged from 14 to 67) and. healthy people (46 people: 22 males and. 24 females, aged from 18 to 25) were examined. According to study 12 pairs of skin segments of vegetative provision on the human body have been allocated. The concept of vegetotome as a part of the embryonic element of the autonomic nervous system, forming a united autonomic innervation of individual sections of meso-, entho- and. ectoderm has been offered.

We researched hormonal function of fetoplacental complex (FPC) in 180 pregnant women with threatening premature birth and chronic fetoplacental insufficiency including 90 patients who received ozone therapy in combination with Utrozhestan, 90 pregnant women who received traditional therapy, and 51 woman with an uncomplicated pregnancy (control group). Corrective and. stimulating effect of ozone therapy and. Utrozhestan. on hormonal function fetoplacental complex was revealed.

The paper presents the results of studying of 44 families of patients with diseases of upper segment of respiratory tract, associated with Chlamydia infection. Control group included. 43 families of ENT-patients without Chlamydia infection. Diagnostics of Chlamydia infection was provided by using the complex of laboratory methods (direct fluorescence immunoassay and immune-enzyme analysis, polymerase-chain reaction). The presence of a patient with respiratory chlamydiosis in a family promotes infecting of other members of the family with Chlamydia.

We examined the patients with encephalopathy of different genesis (vascular from the exposure of mercury and alcohol). Besides the comparison of clinical picture of disease the comparative analysis of psychological and neuropsychological indices was performed. The disorders of higher psychical functions revealed in patients with encephalopathy from different etiological factor may testify the dysfunction of subcortical-frontal systems that take part in the regulation of cognitive functions.

The examination of 130 men including neurological examination and. computer electroencephalography with determining of equivalent dipolar sources of pathological activity was performed. Three main groups included employees with a long-term working period exposed by a complex of unfavourable production factors (the local, the whole body vibration, supercooling, physical stress), the patients with occupational polyneuropathy after exposure by a complex of unfavourable factors and. the patients with the vibration-induced diseases due to the local vibration. The study results showed the common signs of the change in bioelectrical brain activity which were found to be characteristic for studied groups compared with clinical symptomatic complex as well as distinguishing features.

The results of the examination of employees realizing the exploitation of the Severomuiski distance of railway in serving of the tunnels of the East-Siberian railway concerning studying the state of mineral bone tissue density are presented in this paper. Examined patients (66 men) were divided into two age groups — up to 50 years old. and. older than 50 years old. The double-energetic x-ray absorptiometry (osteodensitometry) was performed. The reduction in the mineral bone tissue density was found to be in both studied groups.

The aim. of the study was to improve organ-preserving pancreatic head resection in patients with chronic pancreatitis due to application of developed methods that eliminate the pain, common bile duct obstruction, duodenal stenosis, and involvement of major retropancreatic intestinal vessels that prevent the development of inflammatory, infiltrative and septic complications of abdominal cavity. With the use of developed techniques we operated 30 patients. The results of clinical studies and additional tool researches confirmed the effectiveness of methods for addressing the underlying symptoms, clinical manifestations of chronic pancreatitis and prevention of inflammatory, infiltrative and disseminated septic complications of abdominal cavity.

N the study of NAD(P)-dependent dehydrogenases activity in blood lymphocytes in children with dysfunctional disorders of the biliary tract (DDBT) and. DDBT in association with giardiasis detected significant changes in the intracellular metabolism. In children with DDBT in blood lymphocytes the levels of substrate flow decreased at the terminal reactions of glycolysis and. the tricarboxylic acid cycle, which determines the inhibition, respectively, anaerobic and aerobic cellular respiration. It's been established that in blood lymphocytes of children with DDBT, associated with giardiasis, the activity of enzymes determining the state of aerobic respiration is reduced, while maintaining the normal level of intensity of the terminal reactions of anaerobic glycolysis. Regardless of the presence or absence of giardiasis in children with DDBT the activity of pentose phosphate cycle is reduced which characterizes the inhibition of the reactions of macromolecular synthesis.

In the article the results of complex treatment of acute pleural empyema in 123 patients are presented. In all cases we observed pleural empyema of nontraumatic character. Positive results of treatment of patients with this pathology are marked in patients whose complex of treatment included laser therapy.

One of the important problems with patients with Hodgkin's lymphoma is lung injury, caused both by a tumor effect and the influence of chemoradiotherapy. Before the treatment an obstructive lung function pattern connected with tumor substrate has been revealed in 38% of cases. After chemoradiotherapy the restrictive lung pattern was shown in 14% of the patients and mixed lung pattern was seen in 12% of the cases, which were caused by the development of pneumosclerosis and emphysema.

Laser tunneling of pancreas for stimulation of neoangiogenesis, regeneration and reverse of sclerotic changes was performed in 23 patients with fibrosclerotic pancreatitis. Twelve of them were men and eleven were women. The age of patients ranged from 23 to 71 years. All the patients had persistent pain and dyspeptic syndromes, with negligible effect on antispasmodics. Medical history of the disease was from 6 months to 15 years, the frequency of severe attacks requiring hospitalization was from 2 to 6 per year. The results of clinical trial testify for possibility of safe and. effective application of laser tunneling of pancreas in patients with chronic pancreatitis. One of the significant features of the operation was the pain relief and. life quality improvement in those patients.

The article describes the evaluation of efficiency of the temperature-myographic training in the patients with vibration-induced disease after the local vibration exposure based on the data of the thermometry, the dosed cold sample, the rheography of the upper extremities, the algesimetry, the pallaesthesimetry, the psychological examination to control the changes in the neuropathic pain, the electroneuromyography. It was shown that the training effectively influenced the manifestations of the angiodystonic syndrome as well as to restore the nervous-muscular conducti-vity at the upper and. the lower extremities.

Indices of energy metabolism in blood serum and partial oxygen and. carbon dioxide pressure in the injured limb tissues were studied in dynamics in 32 patients with open leg fractures (Kaplan-Markova type I-II B, C) during their treatment with the Ilizarov method. It was revealed that circulatory hypoxia, complicated by hemic hypoxia and followed by tissue hypoxia developed sequentially in the tissues of the injured limb segment in the posttraumatic period.

The aim. of the present research was studying of parameters of lipid peroxidation and antioxidant blood status components during different periods of psoriasis, depending on duration of disease. Summarizing the obtained data, it is possible to ascertain that psoriatic disease proceeds in the conditions of antioxidant protection factors deficiency, which is mostly expressed in an aggravation of pathological process, and especially in the disease of the patients, suffering more than 5 years. The "lipid peroxidation — antioxidant" misbalance is defined by the duration of pathological process. The great progress in the studied system, occurs, if the duration of disease is less, than 5 years.

The author has carried out mathematical analysis which revealed the most significant risk factors of disease development in contact persons from nidi of tuberculosis infection, helped to define the degree of their influence on indices of nidal morbidity and to forecast development of epidemic process in epidemic nidi. The forecast table of morbidity in TB nidi was worked out and introduced. The use of this table will provide phthisiatricians and epidemiologists with the opportunity to carry out more qualitative antiepidemic measurements on the territory.

On the territory in Omsk region for 20 years has been an active epidemiological surveillance of tuberculosis infection. The author presents data of epidemiological surveillance of tuberculosis infection in the region.

Distribution of genotypes of biochemical markers of HP, GC, EsD, АсР genes, genotypes on polymorphic variants of the genes coding enzymes of biotransformation GSTT1 (GST-ɵ1) and GSTM1 (GST-μ1) and NOS3 (VNTR4 polymorphism) in the miners with chronic mechanic bronchitis, and in persons without this occupational pathology is investigated. It is shown that the owners of EsD 1-2, АсР bb genotypes are most subject to development of chronic mechanic bronchitis. Endogen factors of resistance to this disease are GC 1-1, EsD 1-1, АсР bc genotypes.

The publication presents to analysis of morbidity of malignant tumors in children at the age of 0—14 years living in Transbaikalia region from 1996 to 2010 years. The data about patients were congregated in regional cancer register. Cancer morbidity in children of region has been assessed among different subcohorts. Using medical statistic data received from cancer register the prognosis for morbidity of malignant tumors among children of region till 2014 year was modeled.

The materials of the long-studies among the employees working in the aircraft industry, of both the patients with occupational diseases and the practically healthy persons are discussed in the paper. Using the method of the biological feedback for the vibration-induced disease prevention has been grounded. The preliminary results of the experimental studies using the animals are presented in this paper.

Hypothyreosis, caused by introduction of mercazolil, leads to reduction of production of thyroid hormones, destabilization of membranes and. acceleration of erythrocytes destruction, activation of erythropoiesis, development of macroerythrocytosis in blood. In 28 days after cancelling of mercazolil reserves of red bone marrow are exhausted, in blood microerythrocytosis accrues. The stress in animals with hypothyreosis does not change the composition of blood erythrocytes and activity of erythrocytopoiesis, but promotes preservation of a marrowy reserve of erythrocytes and increases a level of thyroid hormones.

The data on the expressed toxic effect of ethanol in dose DL₅₀ (12 g/kg) on experimental rats were received. The toxic effect was expressed in significant stimulation of processes of lipid peroxidation against the background of antioxidant system suppression. While evaluating the results of statistic analysis it was proved, that new chelate zinc (2,8,9-trihydrozincatrane) in the protective dose of 4 mg/kg under conditions of the acute ethanol poisoning reduces the severity of oxidative stress and normalizes indicators of antioxidant system.

It has been experimentally proved that alcoholic and polysaccharide extracts of Viola uniflora L. have the gastroprotective characteristics. These characteristics are more proper for alcoholic extract. Its anti-ulcer effect is 1,9 times higher as compared to polysaccharide extract.

The experiment was performed on 10 adult dogs underwent tibial lengthening by 14—18 % from the initial length using a "fan" technique interchanging weekly active periods of dosed lengthening on various muscle groups and. their weekly rest. This effect created sufficiently favourable conditions for bone distraction regenerate formation and functioning of the first sensitive neurons of the motor analyzer.

The dynamic contractile activity of duodenal and jejuna was studied during daily chronic one-hour stress in experiment on the dogs. It was revealed, that the stress leads to the increasing index of the contractile activity of experimental areas, which is preserved even on the 7^th day of immobilized stress.

Reconstruction of fenestrated tracheal defect using free revascularized flap combined with titanium nikelide implant has been developed. The experimental study was performed on 8 mongrels, on which defect or tracheostomy was created. The tracheal defect reconstruction was completed using free fasciocutaneous inguinal flap. Efficacy of the method was tested using clinical, radiological, macro- and microscopic examination. It is ascertained, that the technique permits to reconstruct fenestrated tracheal defect with minimal injury of donor zone, to simplify and shorten the operation.

Key competences required for any graduated specialist in the manufacture of medicines include understanding of GMP principles, good knowledge of production processes and. managerial skills. In the present day Russian Pharma Industry there is a shortage of experts in Pharmaceutical Engineering, QC and GMP auditors. Notions of "Industrial Pharmacy" and of "industrial pharmacist" are not yet introduced into students syllabus and postgraduate curricula.

The article presents the characteristics of the tantalum, one of the rare metals which is used in an aviationspace technology, motor electronics, and medicine and. communications electronics. The view of the main world tantalum productions has been showed in the article. The production of tantalum in the East Kazakhstan is one of the largest in the world, where the new technology of high capacity tantalum powder has been opened.

Muramyl dipeptide (MDP) is a minimal peptidoglycan motif common to Gram-negative and Gram-positive bacteria, activate both innate and. adaptive immunity. MDP are recognized by Nod2-like-receptor that triggers of cell signaling pathways induction, activates of proinflammatory cytokine synthesis. In present review we consider structure, functions, adjuvanticity, immune properties and. clinical usage perspectives of MDP and. other muropeptides.