INTERRELATION BETWEEN LUNGS FUNCTiONAL PARAMETERS AND CONDiTiON OF BONE TISSUE AT THE TERMINAL PULMONARY PATHOLOGY
Abstract
The aim of this study was to evaluate the condition of mineral density of bone tissue at the terminal pulmonary pathology, to determine correlations between lungs functional parameters and. pre-transplantation bone mass. Materials and methods: we realized retrospective analysis of 74 case histories of patients with terminal pulmonary pathology, waiting for lung transplantation. MDBT in lumbar segment of spine (L2—L4) and. femoral neck (FN) was evaluated, with help of double-energy X-ray absorptiometry (Hologic). Function of external respiration was researched, gasometry and 6-minutes walking test were realized, in all the patients. Results: osteopenic syndrome in any zone of interest was registered in 69 % of patients. Normal indices of MDBT both in L2—L4 and. in FN were registered only in 11 % of patients. On our data the indices of T-criterion (both, in L2—L4 and. in FN) had. direct relation with, body weight index (BWI) and. total fatty mass. Direct correlation between MDBT, volume of forced expiration for 1 second. (FEV) (r = 0,49, p < 0,05 in L2—L4 and. r = 0,52, p < 0,05 in FN) and. indirect correlation with, total lungs capacity (TLC) (r = —0,53, p < 0,01) with residual lungs volume (RV) (r = —0,48, p < 0,05) only in FN. We revealed, reliable negative interrelation, of MDBT only with pCO2 of arterial blood (r = —0,54, p < 0,01 in L2—L4 and r = —0,48, p < 0,05 in FN). There were no reliable correlation between DLCO, 6-minutes walking test and. MDBT both in L2—L4 and. in FN. 11% of patients had. atraumatic fractures of different localization. Conclusion: thus, osteoporosis is sufficiently frequent system, manifestation, in patients with, different terminal pulmonary pathology in pre-transplantation period. Worsening of lungs functional parameters, low BWI and. decrease of total fatty mass can be strong predictors of osteoporosis at the serious respiratory pathology.
About the Authors
L. G. Ugay
Vladivostok State Medical University
Russian Federation
Russian Federation
E. A. Kochetkova
Vladivostok State Medical University
Russian Federation
Russian Federation
K. A. Burya
Vladivostok State Medical University
Russian Federation
Russian Federation
S. A. Albavichus
Vladivostok State Medical University
Russian Federation
Russian Federation
References
1. Aris R., Lester G., Ontjes D. Treatment of bone disease in cystic fibrosis // Curr. Opin. Pulmon. Med. - 2004. - N 10. - P. 524-530.
2. Body mass index as a predictor of fracture risk: a meta-analysis / C. de Laet, J.A. Kanis, A. Odén [et al.] // Osteoporosis Int. - 2005. - Vol. 16. -P. 1330-1338.
3. Bone loss in patients with untreated chronic obstructive pulmonary disease is mediated by an increase in bone resorption associated with hypercapnia / H.P. Dimai, W. Domej, G. Leb [et al.] // J. Bone Miner. Res. - 2001. - Vol. 16. - P. 2132-2141.
4. Bone mineral density in patients with chronic obstructive pulmonary disease who are candidates for lung transplant / J.M. Vaquero-Barrios, M.S. Arenasde Larriva, J. Redel-Montero [et al.] // Transplantation Proceedings. - 2010. - Vol. 42. - P. 3020-3022.
5. Functional status and quality of life in patients surviving 10 years after lung transplantation / R.M. Rutherford, A.J. Fisher, C. Hilton [et al.] // Amer. J. Transplant. - 2005. - N 5. - P. 1099-1104.
6. Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass / A. Vrieze, H.M. de Greef, P.J. Wykstra, J.B. Wempe // Osteoporosis Int. - 2007. - Vol. 18. -P. 1197-1202.
7. Osteoporosis and lung transplantation: a prospective study / A. Spira, C. Gutierrez, C. Chaparro [et al.] // Chest. - 2000. - Vol. 117. - P. 476-481.
8. Osteoporosis before lung transplantation: association with low body mass index, but not with underlying disease / O. Tschopp, A. Boehler, R. Speich [et al.] // Am. J. Transplant. - 2002. - N 2. -P. 167-172.
9. Osteoporosis in diffuse parenchymal lung disease / C.E. Caplan-Shaw, S.M. Arcasoy, E. Shawe [et al.] // Chest. - 2006. - N 129. - P. 140-146.
10. Osteoporosis in lung transplant candidates compared to matched healthy controls / W.C. Lakey, S. Spratt, E.N. Vinson [et al.] // Clin. Transplant. -2011. - Vol. 25. - P. 426-435.
11. Predictors of low bone mineral density in elderly males with chronic obstructive pulmonary disease: the role of body mass index / A. Coin, G. Sergi, S. Marin [et al.] // Aging Male. - 2010. - Vol. 13, N 2. - P. 142-147.
12. Severe osteoporosis before and after lung transplantation / R. Aris, I. Neuringer, M. Weiner, D. Ontjes // Chest. - 1996. - N 109. - P. 1176-1183.
13. The prevalence of osteoporosis in patients with chronic obstructive pulmonary disease. A crosssectional study / N.R. Jorgensen, P. Schwarz, I. Holme [et al.] // Respir. Med. - 2006. - N 4. - P. 34-38.
14. The Registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult lung and heart-lung transplantation report -2010 / J.D. Christie, L.B. Edwards, A.Y. Kucheryavaya [et al.] // J. Heart. Lung. Transplant. - 2010. -N 29. - P. 1104-1118.
Review
For citations:
Ugay L.G., Kochetkova E.A., Burya K.A., Albavichus S.A. INTERRELATION BETWEEN LUNGS FUNCTiONAL PARAMETERS AND CONDiTiON OF BONE TISSUE AT THE TERMINAL PULMONARY PATHOLOGY. Acta Biomedica Scientifica. 2012;(4(1)):122-125. (In Russ.)
Views:
371
Email this article 
