IMMUNOMODULATORY EFFECT OF SOTALOL HYDROHLORIDE UNDER ACUTE STRESS
Abstract
It was established that acute stress in period induction of the local and systemic immune response to thymus-dependent antigen caused an inhibition of expression of delayed-type hypersensitivity reactions, did not effect on antibody production in the regional lymph node under the local response and suppressed of antibody production in the spleen under the systemic immune response. Administration of sotalol hydrochloride (antagonist of beta-adrenoceptors with peripheral action) canceled these changes, that points to participate in their implementation of immunosuppressive signals from the peripheral beta-adrenergic receptors.
About the Authors
D. Ju. Shilov
Perm State Medical Academy named after acad. E.A. Wagner
Russian Federation
Russian Federation
Ju. I. Shilov
Institute of Ecology and Genetics of Microorganisms UB RAS; Perm State Medical Academy named after acad. E.A. Wagner
Russian Federation
Russian Federation
References
1. Besedovsky H.O., del Rey A. Physiology of psychoneuroimmunology: a personal view // Brain Behav. Immun. — 2007. — Vol. 21, N 1. — P. 34 — 44.
2. Black J.L., Oliver B.G., Roth M. Molecular mechanisms of combination therapy with inhaled corticosteroids and long-acting beta-agonists // Chest. — 2009. — Vol. 136, N 4. — P. 1095 — 1100.
3. Corthay A. How do regulatory T cells work? // Scand. J. Immunol. — 2009. — Vol. 70, N 4. — P. 326 — 336.
4. Gezici A.R., Karakas A., Ergün R., Gündüz B. Serum cortisol levels following acute experimental spinal cord injury // Neurol. Neurochir. Pol. — 2009. — Vol. 43, N 4. — P. 352 — 357.
5. Glasner A., Avraham R., Rosenne E. Improving survival rates in two models of spontaneous postoperative metastasis in mice by combined administration of a β-adrenergic antagonist and a cyclooxygenase-2 inhibitor // J. Immunol. — 2010. — Vol. 184, N 5. — P. 2449 — 2457.
6. Gusev E.Yu., Kevorkov N.N. Characteristics of T-suppressors responsible for cellular and humoral immune response competition in the spleen // Bulletin of Experimental Biology and Medicine. — 1993. — Vol. 115, N 3. — P. 312 — 314.
7. Gusev E.Yu., Kevorkov N.N. Genetic and phenotypic aspects of the interrelationship between cellular and humoral immune response to sheep erythrocytes in mice // Bulletin of Experimental Biology and Medicine. — 1993. — Vol. 115, N 3. — P. 315 — 316.
8. Liew F.Y. TH1 and TH2 cells: a historical perspective // Nat. Rev. Immunol. — 2002. — Vol. 2, N 1. — P. 55 — 60.
9. Melamed R., Rosenne E., Shakhar K. Marginating pulmonary-NK activity and resistance to experimental tumor metastasis: suppression by surgery and the prophylactic use of a β-adrenergic antagonist and a prostaglandin synthesis inhibitor // Brain Behav. Immun. — 2005. — Vol. 19, N 2. — P. 114 — 126.
10. Pignatelli D., Xiao F., Gouveia A.M. Adrenarche in the rat // J. Endocrinol. — 2006. — Vol. 191, N 1. — P. 301 —308.
11. Schneider A.M., Koven N.S., Lombardo K.A. Beta-adrenergic receptor blockade by propranolol enhances retention in a multitrial passive-avoidance procedure // Behav. Neurosci. — 2000. — Vol. 114, N 6. — P. 1256—1260.
12. Shilov Ju.I., Gein S.V., Chereshnev V.A. Influence of blockade of β-adrenoreceptors and acute stress on antibody formation, delayed type of hypersensitivity, phagocytic cell activity in local immune response // Rus. J. Immunol. — 2001. — Vol. 6, N 3. — P. 301—308.
13. Shilov Ju.I., Lanin D.V., Shilov S.Ju. et al. Influence of beta-adrenergic receptor blockade on immunomodulatory effects of hydrocortisone // New Research on Immunology / ed. by Barbara A. Veskler / Nova Biomedical Books. — New York, Inc., 2005. — P. 167—191.
14. Takahashi H.K., Morichika T., Iwagaki H. Effect of β2-adrenergic receptor stimulation on interleukin-18-induced intercellular adhesion molecule-1 expression and cytokine production // J. Pharmacol. Exp. Therap. — 2003. — Vol. 304, N 2. — P. 634 — 642.
15. Warner A., Ovadia H., Tarcic N., Weidenfeld J. The effect of restraint stress on glucocorticoid receptors in mouse spleen lymphocytes: involvement of the sympathetic nervous system // Neuroimmunomodulation. — 2010. — Vol. 17, N 5. — P. 298 — 304.
Review
For citations:
Shilov D.J., Shilov J.I. IMMUNOMODULATORY EFFECT OF SOTALOL HYDROHLORIDE UNDER ACUTE STRESS. Acta Biomedica Scientifica. 2012;(3(2)):337-342. (In Russ.)
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