EFFECT OF TRANSPLANTATION OF IMMUNOCOMPETENT CELLS TREATED WITH CAFFEINE ON THE PARAMETERS OF THE NERVOUS SYSTEM FUNCTIONAL ACTIVITY
Abstract
It was demonstrated that in vitro treatment with caffeine splenocytes of mice (CBAxC57Bl / 6) F1 with a passive type of behavior in «open field» modifies the functional activity of these cells, manifested in changes in spontaneous and induced cytokine production; the intravenous injection of these cells is accompanied by modulation of the parameters of the motor and exploratory activity of recipients, the nature of which depends on the dose of caffeine. At the same time were shown some changes in the synthesis of cytokines by brain cells of mice-recipients. Possible mechanisms for modulating effect of transplanted immune cells on recipient's behavior were discussed.
About the Authors
M. A. Knyazheva
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
S. L. Rizikova
ЗАО «Вектор-Бест»
Russian Federation
Russian Federation
T. G. Ryabicheva
ЗАО «Вектор-Бест»
Russian Federation
Russian Federation
E. V. Markova
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
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Review
For citations:
Knyazheva M.A., Rizikova S.L., Ryabicheva T.G., Markova E.V. EFFECT OF TRANSPLANTATION OF IMMUNOCOMPETENT CELLS TREATED WITH CAFFEINE ON THE PARAMETERS OF THE NERVOUS SYSTEM FUNCTIONAL ACTIVITY. Acta Biomedica Scientifica. 2012;(3(2)):284-287. (In Russ.)
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