THE PECULIARITIES OF THE IMMUNOREACTIVITY AND BLOOD LYMPHOCYTES METABOLISM DEPENDING ON THE BRONCHIAL ASTHMA PATHOGENESIS

Abstract

The aim of the study was to found the peculiarities of immunity and lymphocytes metabolism depending on the clinico-pathogenetic variants of bronchial asthma. It is found increased the leukocyte content and concentration of immunoglobulin classes G, E in both group atopic and. In the group of atopic asthma patients increased the CD4+-lymphocytes concentration and in asthmatic triad patients increased HLA-DR+-cells content. Activation of the immune system in patients with bronchial asthma is provided by appropriate adjustment of lymphocytes metabolism - the general effectors of immunity. It is reduced the intensity of the reactions of the citric acid cycle through the key and auxiliary enzymes for the intensification of malate-aspartate shunt which characterizes the increase in energy processes in lymphocyte of patients with atopic and pseudoatopic bronchial asthma. In addition, the citric acid cycle is substrate deficiency-reduced the α-ketoglutarate formation of glutamic acid, and the reverse synthesis of amino acids increased, which characterizes the amino acid synthesis activation in blood lymphocytes of pseudoatopic patients. Also in the blood lymphocytes of asthmatic triad patients reduced activity of antioxidant enzyme glutathione reductase.