CHRONIC MYELOID LEUKEMIA - CLINICAL AND IMMUNOLOGICAL PECULIARITIES IN ADULT PATIENTS
Abstract
A study of the peculiarities of clinical manifestations and immunity in patients with chronic myeloid leukemia, depending on the stage of disease was made. In patients at admission were more prevalen t shortness of breath, palpitations, lymphadenopathy, hepatomegaly, splenomegaly, hemorrhagic manifestations. Patients diagnosed at any stage had immune disturbances, with the greatest change — in the terminal stage. In patients in an expanded and in the terminal stages T-cell immunodeficiency developed. The peculiarity of the terminal stage was the reduction of NK-cells and B-lymphocytes.
About the Author
O. V. Smirnova
Research Institute of Medical Problems of the North SB RAMS
Russian Federation
Russian Federation
References
1. Антонов В.Г., Козлов В.К. Патогенез онкологических заболеваний: иммунные и биохимические феномены и механизмы. Внеклеточные и клеточные механизмы общей иммунодепрессии и иммунной резистентности // Цитокины и воспаление. - 2004. - № 1. - С. 8-19.
2. Воробьев А.И. Руководство по гематологии. - М.: Ньюдиамед, 2002. - Т. 1. - 280 с.
3. Воробьев А.И. Руководство по гематологии. - М.: Ньюдиамед, 2003. - Т. 2. - 280 с.
4. Волкова М.А. Клиническая онкогематология. - М.: Медицина, 2001. - 576 с.
5. Ярилин А.А. Основы иммунологии. - М.: Медицина, 1999. - 608 с.
6. Afar D.E., Goga A., McLaughlin J., Witte O.N. et al. Differential complementation of Bcr-Abl point mutants with c-Myc // Science. - 1994. - Vol. 264, N 5157. - P. 424-426.
7. Chiou S.H., Sheu B.C., Chang W.C. Current concepts of tumor-infiltrating lymphocytes in human malignancies // J. Reprod. Immunol. - 2005. -Vol. 67, N 1-2. - P. 35-50.
8. Issa J.P., Baylin S.B., Herman J.G. DNA methylation changes in hematologic malignancies: biologic and clinical implications // Leukemia. -1997. - Vol. 11, Suppl. 1. - P. 7-11.
9. Kotlan B., Simsa P., Teillaud J.L., Fridman W.H. et al. Novel ganglioside antigen identified by B cells in human medullary breast carcinomas: the proof of principle concerning the tumor-infiltrating B lymphocytes // J. Immunol. - 2005. - Vol. 175, N 4. - P. 2278-2285.
Review
For citations:
Smirnova O.V. CHRONIC MYELOID LEUKEMIA - CLINICAL AND IMMUNOLOGICAL PECULIARITIES IN ADULT PATIENTS. Acta Biomedica Scientifica. 2012;(3(2)):185-189. (In Russ.)
Views:
422
Email this article 
