ASSOCIATION OF DNA REPAIR GENE POLYMORPHISM WITH CHROMOSOMAL ABERRATIONS IN THE BLOOD LYMPHOCYTES OF PATIENTS WITH LUNG CANCER
Abstract
Analysis of association, between several DNA repair gene polymorphisms and the level of chromosomal aberrations (CAs) in lymphocytes was performed in two groups: a group of 215 patients with lung cancer and a control group of 152 donors. In the group patient with lung cancer the level of CAs shows a significant increase in the carrier of genotypes: XPD TG and XPD GG vs XPD TT. In the control group level of CAs shows a significant increase in the carrier of genotype ADPRT ТС vs ТТ.
About the Authors
V. I. Minina
Institute of Human Ecology SB RAMS
Russian Federation
Russian Federation
M. L. Bakanova
Institute of Human Ecology SB RAMS
Russian Federation
Russian Federation
J. A. Savchenko
Institute of Human Ecology SB RAMS
Russian Federation
Russian Federation
A. A. Timopheyeva
Institute of Human Ecology SB RAMS
Russian Federation
Russian Federation
T. P. Anosova
Institute of Human Ecology SB RAMS
Russian Federation
Russian Federation
V. A. Titov
Regional Clinical Oncology Dyspensary
Russian Federation
Russian Federation
N. E. Verghbizkaja
Pathologoanatomic bureau
Russian Federation
Russian Federation
A. N. Glushkov
Institute of Human Ecology SB RAMS
Russian Federation
Russian Federation
References
1. Животовский Л.А. Популяционная биометрия. - М.: Наука. - 1991. - 272 c.
2. Захаров А.Ф., Бенюш В.А., Кулешов Н.П., Барановская Л.И. Хромосомы человека. - М.: Медицины, 1982. - 263 c.
3. Минина В.И., Дружинин В.Г., Лунина А.А., Ларионов А.В. и др. Исследование взаимосвязи между полиморфизмом генов репарации ДНК и частотой хромосомных аберраций в лимфоцитах крови человека // Эколог. генетика. - 2011. -Т. IX, № 2. - С. 74-79.
4. Benhamou S., Sarasin A. ERCC2/XPD polymorphisms and lung cancer // Am J Epidemiol. - 2005. - Vol. 161. - P. 1-14.
5. Cottet F., Blanche H., Verasdonck P. New polymorphisms in the human poly (ADP-ribose) polymerase-1 coding sequence: lack of association with longevity or with increased cellular poly (ADP-ribosyl)ation capacity // J. Mol. Med. - 2000. -Vol. 78. - P. 471 -480.
6. Dherin C., Radicella J.P., Dizdaroglu M. Excision of oxidatively damaged DNA bases by the human αhOGG1 protein and the polymorphic αhOGG1 (Ser326Cys) protein which is frequently found in human population // Nucleic Acids Research. - 1999. - Vol. 27. - N 20. - P. 4001 -4007.
7. Hungerford P.A. Leukocytes cultured from small inocula of wholeblood and the preparation of metaphase chromosomes by treatment with hypotonic KCl // Stain Techn. - 1965. - Vol. 40. - P. 333-338.
8. Godon C., Cordelieres F.P., Biard D. PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility // Nucleic Acids Res. - 2008. -Vol. 36. - P. 4454-4464.
9. Lockett K., Hall M.C., Xu J. The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function // Cancer Research. - 2004. - Vol. 64. - P. 6344-6348.
10. Musak L., Soucek P., Vodickova L. Chromosomal aberrations in tire plant workers and interaction with polymorphisms of biotransformation and DNA repair genes // Mutat Res. - 2008. - Vol. 641, N 1-2. - P. 36-42.
11. Nemec A., Wallace S., Sweasy J. Variant base excision repair proteins: Contributors to genomic instability // Seminars in Cancer Biology. - 2010. -Vol. 20. - P. 320-328.
12. Park J., Chen L., Tockman M.S. The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk // Pharmacogenetics. - 2004. - Vol. 14, N 2. - P. 103-112.
13. Parshad R., Tarone R.E., Price F.M. Cytogenetic evidence for differences in DNA incision activity in xeroderma pigmentosum group A, C and D cells after X-irradiation during G2 phase // Mutat. Res. - 1993. - Vol. 294. - P. 149-155.
14. Weiss J.M., Goode E.L., Ladiges W.C. Polymorphic variation in hOGG1 and risk of cancer: a review of the functional and epidemiologic literature // Mol. Carcinog. - 2005. - Vol. 42. - P. 127-141.
15. Zhang X., Miao X., Liang G. Polymorphisms in DNA Base Excision Repair Genes ADPRT and XRCC1 and Risk of Lung Cancer // Cancer Res. - 2005. -Vol. 65, N 3. - P. 722-726.
Review
For citations:
Minina V.I., Bakanova M.L., Savchenko J.A., Timopheyeva A.A., Anosova T.P., Titov V.A., Verghbizkaja N.E., Glushkov A.N. ASSOCIATION OF DNA REPAIR GENE POLYMORPHISM WITH CHROMOSOMAL ABERRATIONS IN THE BLOOD LYMPHOCYTES OF PATIENTS WITH LUNG CANCER. Acta Biomedica Scientifica. 2012;(3(2)):121-124. (In Russ.)
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