CLINICAL-IMMUNOLOGY EFFICIENCY OF CONSERVATIVE TREATMENT OF PATIENTS WITH CHRONIC TONSILLITIS ASSOCIATED WITH EPSTEIN - BARR VIRUS INFECTION
Abstract
To assess clinical-immunological efficiency of an immunomodulator reaferon-ES-lipinta 70 people with chronic tonsillitis (41 women and 29 men) were surveyed in dynamics. Among them. 30 people had Epstein — Barr virus infection (1st group), and in 40 people (the 2nd group) Streptococcus pyogenes was diagnosed. The features of local immunity at chronic tonsillitis associated with the EBV infection were revealed. They are characterized by increase of IL-10 in the high point of an illness and of IL-1β, IL-6 and IL-4 on the 7th day of research in saliva of patients with the EBV infection. Conservative treatment of patients with chronic tonsillitis associated with the EBV infection of the reaferon-EC-lipint provided acceleration of normalization of a local profile of cytokine and was clinically effective in 63,3 % of cases.
About the Authors
A. S. Krasnitskaja
Vladivostok State Medical University
Russian Federation
Russian Federation
A. S. Shitihina
Vladivostok State Medical University
Russian Federation
Russian Federation
References
1. Завгородняя Е.Г. Цитокины и их место в диагностике и лечении ряда заболеваний ЛОР-органов // Вестник оториноларингологии. — 2008. - № 3. - С. 74-76.
2. Кетлинский С.А., Симбирцев А.С. Цитокины. — СПб.: ООО «Издательство Фолиант», 2008. - 552 с.
3. Машкова Т.А., Желтова А.Н., Белобородова Л.Л. уточняющая диагностика степени декомпенсации хронического тонзиллита // Вестник оториноларингологии. - 2010. - № 5. -С. 35-37.
4. Морозова С.В. Оценка эффективности местной иммунотерапии в лечении хронического тонзиллита // Российская оториноларингология. -2010. - № 6 (49). - С. 113-115.
5. Филатова С.В., Симонова А.В., Артемьев М.Е., Голубева Н.М. иммунный статус больных хроническим тонзиллитом до и после тонзилэктомии // Вестник оториноларингологии. - 2002. - № 1. - С. 18-21.
6. Balandraud N., Roudier J., Roudier C. Epstein-Barr virus and rheumatoid arthritis // Autoimmun. Rev. - 2004. - Vol. 3. - P. 362-367.
7. Brook I. The role of beta-lactamase-producing-bacteria in mixed infection // BMC Infect. Dis. - 2009. - Vol. 9. - P. 202.
8. Perry M., Whyte A. Immunology of the tonsils // Immunology Today. - 1998. - Vol. 9. - P. 414-421.
Review
For citations:
Krasnitskaja A.S., Shitihina A.S. CLINICAL-IMMUNOLOGY EFFICIENCY OF CONSERVATIVE TREATMENT OF PATIENTS WITH CHRONIC TONSILLITIS ASSOCIATED WITH EPSTEIN - BARR VIRUS INFECTION. Acta Biomedica Scientifica. 2012;(3(2)):100-103. (In Russ.)
Views:
503
.png)
Email this article 
