PHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION
Abstract
Multiple sclerosis (RS) patients were treated with a vaccine consisted of autological mielin-reactive T-cells. Effector memory CD8+ CD45RO+CD62L- T-cells as well as central memory CD4+ CD45RO+CD62L+ and CD8+ CD45RO+CD62L+ T-cells were significantly increased in MS patients as compared with levels in healthy individuals. T-cells vaccination had no effect on the T-cells memory subpopulation composition. However, vaccine-treated RS patients had significant (by 2 fold) reduction of relative quantity of CD4+IFNγ+IL-4— and CD8+IFNγ+IL-4— memory T-cells, as well as suppression by 6 fold of CD4+ memory cells number, which produce both kinds of cytokines.
About the Authors
I. P. Ivanova
Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
I. V. Savkin
Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
G. V. Seledtsova
Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
A. A. Shishkov
Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
V. I. Seledtsov
Innovation Center of Immanuel Kant Baltic Federal University
Russian Federation
Russian Federation
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Review
For citations:
Ivanova I.P., Savkin I.V., Seledtsova G.V., Shishkov A.A., Seledtsov V.I. PHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION. Acta Biomedica Scientifica. 2012;(3(2)):79-82. (In Russ.)
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