FREQUENCY CHARACTERISTICS OF THE GENES OF THE SECOND PHASE OF DETOXIFICATION OF XENOBIOTICS IN WOMEN OF rUSSIAN AND BURYAT ETHNIC GROUPS
Abstract
The article presents the results of the analysis of the distribution of genotypes and alleles of polymorphic loci gene GSTP1 (*A, *B, *C, *D), GSTT1 (del) and GSTM1 (del) in 28 women Russian and 30 women of Buryat ethnic groups. As a result, the work showed a statistically significant difference in genotype AC gene GSTP1 among the study groups. As carriers of other genotypes of genes GSTP1, GSTT1, and GSTM1 showed no significant difference
About the Authors
E. E. Stupko
Scientific Center of Family Health Problems and Human Reproduction SB RAMS
Russian Federation
Russian Federation
T. B. Tsyrenov
Scientific Center of Family Health Problems and Human Reproduction SB RAMS
Russian Federation
Russian Federation
A. V. Labygina
Scientific Center of Family Health Problems and Human Reproduction SB RAMS
Russian Federation
Russian Federation
L. V. Suturina
Scientific Center of Family Health Problems and Human Reproduction SB RAMS
Russian Federation
Russian Federation
L. I. Kolesnikova
Scientific Center of Family Health Problems and Human Reproduction SB RAMS
Russian Federation
Russian Federation
References
1. Адамян Л.В., Спицын В.А., Андреева Е.Н. Генетические аспекты гинекологических заболеваний. — М.: ГЭОТАР-Медиа, 2008. — 192 с.
2. Генетический паспорт — основа индивидуальной и предиктивной медицины / под ред. В.С. Баранова. — СПб.: Изд-во Н-Л., 2009. — 528 с.
3. Спицын В.А. Экологическая генетика человека. — М.: Наука, 2008. — 503 с.
4. Пузырев В.П., Фрейдин М.Б., Кучер А.Н. Генетическое разнообразие народонаселения и болезни человека. — Томск: Печатная мануфактура, 2007. — 320 с.
5. Ballerini S. et al. Analysis of GSTP1-1 polymorphism using real-time polimerase chain reaction // Clinica Chimica Acta. — 2003. — Vol. 329. — P. 127—132.
6. Differential effects of glutathione S-transferase pi (GSTP1) haplotypes on cell proliferation and apoptosis Carcinogenesis / S.L. Holley [et al.] // Arcinogenesis. - 2007. - Vol. 28, № 11. -P. 2268-2273.
7. Glutathione S-transferase-μ (GSTM1) and -θ (GSTT1) genotypes in the etiology of prostate cancer / T.R. Rebbeck [et al.] // Cancer Epidemiol Biomarkers Prev. - 1999. - Vol. 8. - P. 283-297.
8. GSTT1-null genotype is a protective factor against bladder cancer / W.-J. Kim [et al.] // Urology. -2002. - Vol. 60. - P. 913-918.
9. Larvin Genetic polymorphisms of GSTT1, GSTM1, GSTP1, MnSOD, and catalase in nonhe- reditary chronic pancreatitis: evidence of xenobiotic stress and impaired antioxidant capacity / S.H. Rahman [et al.] // Dig. Dis. Sci. - 2005. - Vol. 50. -P. 1376-1383.
10. Lloyd D.R., Hanawalt P.C. p53-dependent global genomic repair of benzoa.pyrene-7, 8-diol-9, 10-epoxide adducts in human cells // Cancer Res. -2000. - Vol. 60. - P. 517-521.
11. Simultaneous identification of GSTP1 Ile105→Val105 and Ala114→Val114 substitution using an amplification refractory mutation system polymerase chain reaction assay: stadies in patients with astma / A. Hemmingsen [et al.] // Respiratory research. - 2001. - Vol. 2, № 4. - Р. 255-260.
Review
For citations:
Stupko E.E., Tsyrenov T.B., Labygina A.V., Suturina L.V., Kolesnikova L.I. FREQUENCY CHARACTERISTICS OF THE GENES OF THE SECOND PHASE OF DETOXIFICATION OF XENOBIOTICS IN WOMEN OF rUSSIAN AND BURYAT ETHNIC GROUPS. Acta Biomedica Scientifica. 2012;(3(1)):79-82. (In Russ.)
Views:
445
.png)
Email this article 
