PROTEINS OF THE ERYTHROCYTE MEMBRANE AND METABOLIC SYNDROME
Abstract
There is no literature data on the changes of structural and functional qualities of the erythrocyte membrane at the arterial hypertension (AH) complicated and non-complicated by the metabolic syndrome (MS). Although the changes of interrelation between the proteins of erythrocyte membrane at the AH can influence the deformability of the membrane itself. The aim of the work was to estimate the peculiarities of interrelation between the proteins of erythrocyte membrane in the patients with arterial hypertension complicated and non-complicated by the metabolic syndrome. The research included 51 men with AH and 29 clinically healthy men which were divided into 3 groups: group 1 - control; group 2 - men with AH complicated with MS (n = 29); group 3 - men with AH non-complicated with MS (n = 22). We studied blood lipids, biochemical and hemostasiological parameters, assessed 10 proteins of erythrocyte membrane. Patients of the 2nd and 3rd groups had different content of α- and β-spectrins, anion-transport protein (ATP), plates 4.1, glycerol-3-phosphatededehydrogenase (G-3-PDG), glutathione S-transferase (GST). The results of the research showed that metabolic syndrome at the AH can not only influence the state of vessel wall but also cause significant disorders of structural and functional qualities of the erythrocyte membrane.
About the Authors
A. S. Sergeyeva
Irkutsk Scientific Center of Surgery and Traumatology
Russian Federation
Russian Federation
Y. I. Pivovarov
Irkutsk Scientific Center of Surgery and Traumatology
Russian Federation
Russian Federation
I. V. Babushkina
Irkutsk Scientific Center of Surgery and Traumatology
Russian Federation
Russian Federation
L. B. Koryakina
Irkutsk Scientific Center of Surgery and Traumatology
Russian Federation
Russian Federation
E. O. Andreeva
Irkutsk Scientific Center of Surgery and Traumatology
Russian Federation
Russian Federation
References
1. Бабушкина И.В., Пивоваров Ю.И., Курильская Т.Е., Сергеева А.С., Ильина О.П., Боровский Г.Б. Белковый спектр мембраны эритроцитов и его изменения при патологии (мини-обзор) // Биологические мембраны. - 2015. - Т. 32, № 3. - С. 168-174
2. Кравец Е.Б., Степовая Е.А., Кощевец Т.Ю. и др. Мембраны эритроцитов при метаболическом синдроме // Проблемы эндокринологии. - 2009. - Т. 55, № 5. - C. 23-26.
3. Кузник Б.И. Клеточные и молекулярные механизмы регуляции системы гемостаза в норме и патологии. - Чита: Экспресс-издательство, 2010. - 832 с.
4. Пивоваров Ю.И., Курильская Т.Е., Сергеева А.С., Корякина Л.Б. Сфероцитарность эритроцитов и ее связь с биохимическими, гемостазиологическими и реологическими свойствами крови у больных стенокардией напряжения и гипертонической болезнью // Бюлл. ВСНЦ СО РАМН. - 2013. - № 6. - С. 38-45.
5. Пивоваров Ю.И., Сергеева А.С., Курильская Т.Е. Способ математической обработки набора белковых полос, полученных с помощью электрофореза // Бюлл. ВСНЦ СО РАМН. - 2014. - № 3 (97). - С. 101-104.
6. Постнов Ю.В., Орлов С.Н. Первичная гипертензия как патология клеточных мембран. - Москва: Медицина, 1987. - 191 с.
7. Рекомендации экспертов Всероссийского научного общества кардиологов по диагностике и лечению метаболического синдрома (второй пересмотр) / Под ред. И.Е. Чазова. - М., 2009. - 32 с.
8. An X., Mohandas N (2008). Disorders of red cell membrane. Br. J. Haematol. 141, 367-375.
9. Dodge J., Mitchell C., Hanahan D. (1963). The preparation and chemical characteristics of hemoglobin-free ghosts of erythrocytes. Arch. Biochem. Biophys. 100 (1), 119-130.
10. Laemmli U.K. (1970). Cleavege of structural proteins during the assembly of the head bacteriophage T4. Nature. 227 (5259), 680-685.
Review
For citations:
Sergeyeva A.S., Pivovarov Y.I., Babushkina I.V., Koryakina L.B., Andreeva E.O. PROTEINS OF THE ERYTHROCYTE MEMBRANE AND METABOLIC SYNDROME. Acta Biomedica Scientifica. 2015;(4):12-17. (In Russ.)
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