PECULIARITIES OF AN ASSOCIATION OF POLYMORPHOUS MARKERS -251 Т>А OF IL-8 GENE AND POLYMORPHISM OF HELICOBACTER PYLORI GENES IN NATIVE AND VISITANT POPULATION OF THE REPUBLIC OF KHAKASSIA
Abstract
We researched, polymorphism, of interleukin IL-8 gene at Helicobacter pylori-associated diseases: ulcers and chronic gastritis in native and visitant population of the Republic of Khakassia by the method, of restriction enzyme digest analysis. Prevalence of subtypes VacA+ and CagA+ of Helicobacter pylori was realized, by the method, of polymerase chain reaction. We revealed, the most widespread allelic variants of genes of cytokines among Khakas. The expediency of determination, of population, risk and. protective genotypes of Helicobacter pylori that promote development of ulcer desease in Khakas.
About the Authors
E. S. Ageeva
Khakas State University named after N.F. Katanov
Russian Federation
Russian Federation
O. V. Shtygasheva
Khakas State University named after N.F. Katanov
Russian Federation
Russian Federation
References
1. Гены и болезни хакасов / О.В. Штыгашева, Е.С. Агеева, В.Н. Харьков [и др.]. — Красноярск: Поликор, 2010. — 296 с.
2. Штыгашева О.В., Цуканов В.В. Распространенность инфекции Helicobacter pylori и частота диспептических жалоб у населения Хакасии // Российский журнал гастроэнтерологии, гепатологии и колопроктологии. — 2004. — № 2. — С. 33 — 36.
3. Aim R., Ling L.S., Moir D.T. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori // Nature. — 1999. - Vol. 397. - P. 176-180.
4. Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -251 polymorphisms in the risk for the development of distal gastric cancer / E. Garza-Gonzalez, F. J. Bosques-Padilla, S. I. Mendoza-Ibarra [et al.] // BMC Cancer. - 2007. - Vol. 7. - P. 70.
5. Audibert C., Burucoa C., Janvier B. Implication of the structure of the Helicobacter pylori Cagpathogenicity island in induction of interleukin-8 secretion // Infect. Immunol. - 2001. - Vol. 69 (3). - P. 1625-1629.
6. Comparison of CXC chemokines ENA-78 and interleukin-8 expression in Helicobacter pylori-associated gastritis / G. Rieder, W. Einsiedl, R.A. Hatz [et al.] // Infection and Immunity. - 2001. - Vol. 69. - P. 81-88.
7. Correlation between IL-8 induction, cagA status and vacA genotypes in 153 French Helicobacter Pylori isolates / C. Audibert, B. Janvier, B. Grignon [et al.] // Res. Microbiol. - 2000. - Vol. 151, N 3. - P. 191-200.
8. Crabtree J.E., Kersulyte D., Li S.D. Modulation of Helicobacter pylori induced interleukin-8 synthesis in gastric epithelial cells mediated by CagPAI encoded VirD4 homologue // J. Clin. Pathol. - 1999. - Vol. 52 (9). - P. 653-657.
9. Differential effects of multiplicity of infection on Helicobacter pylori-induced signaling pathways and interleukin-8 gene transcription / B. Ritter, P. Kilian, M.R. Reboll [et al.] // J. Clin. Immun. - 2011. -Vol. 31 (1). - P. 60-68.
10. Genetic polymorphism of interleukin-8 (IL-8) is associated with Helicobacter pylori-induced duodenal ulcer / Z. Gyulai, G. Klausz, A. Tiszai [et al.] // Eur. Cytokine Network. - 2004. - Vol. 15 (4). - P. 353-358.
11. Genetic polymorphisms of NOD1 and IL-8, but not polymorphisms of TLR4 genes, are associated with Helicobacter pylori-induced duodenal ulcer and gastritis / P. Hofner, Z. Gyulai, Z.F. Kiss [et al.] // Helicobacter. - 2007. - Vol. 12. - P. 124-131.
12. Marshall B.J., Warren W.M. Unidentified curved bacillus on gastric epithelium in active chronic gastritis // Lancet. - 1983. - Vol. 1, N 8305. - P. 1273-1275.
13. McHugh M.L. The odds ratio: calculation, usage, and interpretation The Biochemia Medica // J. Croatian Soc. Med. Biochemists. - 2009. -Vol. 19 (2). - P. 120-126.
14. Polymorphism in the CagA EPIYA Motif Impact Developmentof Gatric Cancer / K.R. Jones, Y.M. Joo, S. Jang [et al.] // J. Clinical Microbiology. -2009. - Vol. 47 (4). - P. 959-968.
15. Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8 / W. Fischer, J. Puls, R. Buhrdorf [et al.] // Molecular Microbiology. - 2001. - Vol. 42. - P. 1337-1348.
16. The discrepancy between genetic polymorphism of p53 codon 72 and expression of p53 protein in Helicobacter pylori-associated gastric cancer in Korea / N. Kim, S.I. Cho, H.S. Lee [et al.] // Digestive Diseases and Sciences. - 2010. - Vol. 55 (1). - P. 101-110.
17. The effects of genetic polymorphisms of IL-6, IL-8 and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea / J.M. Kang, N. Kim, D.H. Lee [et al.] // J. Clin. Gastroenterology. -2009. - Vol. 43, N 5. - P. 420-428.
18. The interleukin-8-251 A allele is associated with increased risk of noncardia gastric adenocarcinoma in Helicobacter pylori-infected Koreans / B.D. Ye, S.G. Kim, J.H. Park [et al.] // J. Clin. Gastroenterology. -2009. - Vol. 43 (3). - P. 233-239.
19. The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population / P. Canedo, A.J. Castanheira-Vale, N. Lunet [et al.] // Eur. J. Cancer Prevent. - 2008. - Vol. 17. - P. 28-32.
20. Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus / J. Hull, H. Ackerman, K. Isles [et al.] // Am. J. Hum. Genet. - 2001. - Vol. 69. - P. 413-419.
21. Yamaoka Y., Kodama Т., Kita M. Relationship of VacA genotypes of Helicobacter pylori to CagA status, cytotoxin production, and clinical outcome // Helicobacter. - 1998. - Vol. 3 (4). - P. 241 -253.
Review
For citations:
Ageeva E.S., Shtygasheva O.V. PECULIARITIES OF AN ASSOCIATION OF POLYMORPHOUS MARKERS -251 Т>А OF IL-8 GENE AND POLYMORPHISM OF HELICOBACTER PYLORI GENES IN NATIVE AND VISITANT POPULATION OF THE REPUBLIC OF KHAKASSIA. Acta Biomedica Scientifica. 2012;(2(2)):9-12. (In Russ.)
Views:
392
.png)
Email this article 
